Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

abstract：:We have investigated the interaction of human cytomegalovirus (CMV) with cultured primary granulocyte-macrophage progenitors, a suspected natural site of viral latency, and have established conditions for latent infection and reactivation in this cell population. Progenitor cells from human fetal liver or bone marrow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo K,Kaneshima H,Mocarski ES

更新日期：1994-12-06 00:00:00

abstract：:Among yeasts that underwent whole-genome duplication (WGD), Kluyveromyces polysporus represents the lineage most distant from Saccharomyces cerevisiae. By sequencing the K. polysporus genome and comparing it with the S. cerevisiae genome using a likelihood model of gene loss, we show that these species diverged very s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scannell DR,Frank AC,Conant GC,Byrne KP,Woolfit M,Wolfe KH

更新日期：2007-05-15 00:00:00

abstract：:Programmed cell death regulates a number of biological phenomena, and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic signal from the Fas receptor. Here we report the isolation of a gene, LFG, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somia NV,Schmitt MJ,Vetter DE,Van Antwerp D,Heinemann SF,Verma IM

更新日期：1999-10-26 00:00:00

abstract：:In mammalian females, most genes on one X chromosome are transcriptionally silenced as a result of X chromosome inactivation. Whereas it is well established that some X-linked genes "escape" X inactivation and are expressed from both active (Xa) and inactive (Xi) X chromosomes, most models for the chromosomal control ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrel L,Willard HF

更新日期：1999-06-22 00:00:00

abstract：:The primate gastrointestinal tract is home to trillions of bacteria, whose composition is associated with numerous metabolic, autoimmune, and infectious human diseases. Although there is increasing evidence that modern and Westernized societies are associated with dramatic loss of natural human gut microbiome diversit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clayton JB,Vangay P,Huang H,Ward T,Hillmann BM,Al-Ghalith GA,Travis DA,Long HT,Tuan BV,Minh VV,Cabana F,Nadler T,Toddes B,Murphy T,Glander KE,Johnson TJ,Knights D

更新日期：2016-09-13 00:00:00

abstract：:Fluctuations in resting-state functional connectivity occur but their behavioral significance remains unclear, largely because correlating behavioral state with dynamic functional connectivity states (DCS) engages probes that disrupt the very behavioral state we seek to observe. Observing spontaneous eyelid closures f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Ong JL,Patanaik A,Zhou J,Chee MW

更新日期：2016-08-23 00:00:00

abstract：:X-linked hypophosphatemia is the most prevalent inherited form of rickets. In this disorder, rickets results from hyperphosphaturia and inappropriately normal levels of 1,25(OH)2-vitamin D. Current therapy with oral phosphate and vitamin D improves the rickets, but has significant morbidity and does not significantly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baum M,Loleh S,Saini N,Seikaly M,Dwarakanath V,Quigley R

更新日期：2003-09-16 00:00:00

abstract：:Temporal patterning of biological variables, in the form of oscillations and rhythms on many time scales, is ubiquitous. Altering the temporal pattern of an input variable greatly affects the output of many biological processes. We develop here a conceptual framework for a quantitative understanding of such pattern de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brezina V,Orekhova IV,Weiss KR

更新日期：1997-09-16 00:00:00

abstract：:Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansson M,Popovic M,Karlsson A,Cocchi F,Rossi P,Albert J,Wigzell H

更新日期：1996-12-24 00:00:00

abstract：:The regional chromosomal location of the human gene for plasminogen activator inhibitor type 1 (PAI1) was determined by three independent methods of gene mapping. PAI1 was localized first to 7cen-q32 and then to 7q21.3-q22 by Southern blot hybridization analysis of a panel of human and mouse somatic cell hybrids with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klinger KW,Winqvist R,Riccio A,Andreasen PA,Sartorio R,Nielsen LS,Stuart N,Stanislovitis P,Watkins P,Douglas R

更新日期：1987-12-01 00:00:00

abstract：:The E1A gene of adenovirus type 5 encodes two major proteins of 289 and 243 amino acid residues, which are identical except that the larger protein has an internal stretch of 46 amino acids required for efficient trans-activation of early viral promoters. This domain contains a consensus zinc finger motif (Cys-Xaa2-Cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culp JS,Webster LC,Friedman DJ,Smith CL,Huang WJ,Wu FY,Rosenberg M,Ricciardi RP

更新日期：1988-09-01 00:00:00

abstract：:Frizzled polypeptides are integral membrane proteins that recently were shown to function as receptors for Wnt signaling molecules. Here, we report the identification of a novel, secreted 36-kDa protein that contains a region homologous to a putative Wnt-binding domain of Frizzleds. This protein, called Frizzled-relat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finch PW,He X,Kelley MJ,Uren A,Schaudies RP,Popescu NC,Rudikoff S,Aaronson SA,Varmus HE,Rubin JS

更新日期：1997-06-24 00:00:00

abstract：:The accumulation of metal ions and amyloid-β (Aβ) aggregates found in the brain of patients with Alzheimer's disease (AD) has been suggested to be involved in AD pathogenesis. To investigate metal-Aβ-associated pathways in AD, development of chemical tools to target metal-Aβ species is desired. Only a few efforts, how...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JS,Braymer JJ,Nanga RP,Ramamoorthy A,Lim MH

更新日期：2010-12-21 00:00:00

abstract：:Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production of the toxic effector molecule nitric oxide (NO). In this study, the mechanism of IL-10 action was identified as inhibition of endogenous tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald IP,Wynn TA,Sher A,James SL

更新日期：1992-09-15 00:00:00

abstract：:Intracellular electrophysiological recordings were obtained from a specialized class of "starburst" amacrine cells by using an isolated superperfused retina-eyecup preparation of the rabbit. These cells were injected intracellularly with horseradish peroxidase and identified with light microscopy. A computer-controlle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RF,Bloomfield SA

更新日期：1983-05-01 00:00:00

abstract：:Antibodies prepared against peptides CP2, CP4, and CP5, which occur within the first 1522 amino acid residues of the alpha 1 subunit of dihydropyridine-sensitive skeletal muscle calcium channels, specifically recognized a 175-kDa form of the alpha 1 subunit in immunoblots and immunoprecipitation experiments. In contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Jongh KS,Merrick DK,Catterall WA

更新日期：1989-11-01 00:00:00

abstract：:To complete the set of synthetic analogs of the three recognized types of active sites in iron-sulfur redox proteins, the compound (Et4N)[Fe((SCH2)2C6H4)2], derived from o-xylyl-alpha,alpha'-dithiol, has been prepared and its structure has been determined by x-ray diffraction. The bischelate anion contains a near-tetr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane RW,Ibers JA,Frankel RB,Holm RH

更新日期：1975-08-01 00:00:00

abstract：:Performance on the visual paired-comparison task depends on the integrity of the hippocampal formation in humans, monkeys, and, for an analogous task, in rats. The present study sought additional evidence in healthy volunteers concerning the nature of this task. We found that performance on the visual paired-compariso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manns JR,Stark CE,Squire LR

更新日期：2000-10-24 00:00:00

abstract：:The 369-residue glycoprotein D (gD) is the entry, receptor-binding protein of herpes simplex virus 1. The common receptors for viral entry are nectin-1, HveA, and a specific O-linked sulfated proteoglycan. The major receptor-binding sites of gD are at the N terminus, whereas the domain required for fusion of viral env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou G,Roizman B

更新日期：2007-03-06 00:00:00

abstract：:Ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (iGluRs) mediate the majority of excitatory synaptic transmission in the CNS and are essential for the induction and maintenance of long-term potentiation and long-term depression, two cellular models of learning and memory. We identi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Y,Arai AC,Rumbaugh G,Srivastava AK,Turner G,Hayashi T,Suzuki E,Jiang Y,Zhang L,Rodriguez J,Boyle J,Tarpey P,Raymond FL,Nevelsteen J,Froyen G,Stratton M,Futreal A,Gecz J,Stevenson R,Schwartz CE,Valle D,Huganir

更新日期：2007-11-13 00:00:00

abstract：:Helix-hairpin-helix DNA glycosylases are typically small proteins that initiate repair of DNA by excising damaged or mispaired bases. An invariant aspartic acid in the active site is involved in catalyzing the excision reaction. Replacement of this critical residue with an asparagine severely reduces catalytic activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi Y,Harada JJ,Goldberg RB,Fischer RL

更新日期：2004-05-11 00:00:00

abstract：:Results on the subcellular localization of the mineralocorticoid receptor (MR) have been controversial. To determine the subcellular distribution and trafficking of the MR in living cells after binding of agonists and antagonists, we expressed a MR-green fluorescent protein (GFP) chimera in mammalian cells lacking end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fejes-Tóth G,Pearce D,Náray-Fejes-Tóth A

更新日期：1998-03-17 00:00:00

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:A theory is proposed to study the sensitivity of cylindrical explosives. Using the equations governing the conservation of mass, energy, and momentum, the equation of state, and Newtonian mechanics, we have derived the expression D = D(o)e(-a2/d), in which the apparent length of the reaction zone, a, takes into accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyring H,Walker FE,Ma SM,Coon N

更新日期：1980-05-01 00:00:00

abstract：:Natural killer (NK) cells are key players in the innate response to viruses, including herpesviruses. In particular, the variety of viral strategies to modulate the recognition of certain herpesviruses witnesses the importance of NK cells in the control of this group of viruses. Still, NK evasion strategies have remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grauwet K,Cantoni C,Parodi M,De Maria A,Devriendt B,Pende D,Moretta L,Vitale M,Favoreel HW

更新日期：2014-11-11 00:00:00

abstract：:A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dear TN,Sanchez-Garcia I,Rabbitts TH

更新日期：1993-05-15 00:00:00

abstract：:The SOS-inducible ruvA and ruvB gene products of Escherichia coli are required for normal levels of genetic recombination and DNA repair. In vitro, RuvA protein interacts specifically with Holliday junctions and, together with RuvB (an ATPase), promotes their movement along DNA. This process, known as branch migration...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaneva IR,Müller B,West SC

更新日期：1993-02-15 00:00:00

abstract：:Positional cloning has already produced the sequences of more than 70 human genes associated with specific diseases. In addition to their medical importance, these genes are of interest as a set of human genes isolated solely on the basis of the phenotypic effect of the respective mutations. We analyzed the protein se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mushegian AR,Bassett DE Jr,Boguski MS,Bork P,Koonin EV

更新日期：1997-05-27 00:00:00

abstract：:The primary structure and phosphorylation pattern of the tandem Y(1)S(2)P(3)T(4)S(5)P(6)S(7) repeats of the RNA polymerase II carboxyl-terminal domain (CTD) convey information about the transcription apparatus--a CTD code--to a large ensemble of CTD-binding receptor proteins. Four of the seven coding "letters" of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwer B,Sanchez AM,Shuman S

更新日期：2012-10-30 00:00:00

abstract：:Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the chemok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contento RL,Molon B,Boularan C,Pozzan T,Manes S,Marullo S,Viola A

更新日期：2008-07-22 00:00:00