Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II.

abstract：:Knowledge of normal human cardiac excitation stems from isolated heart or intraoperative mapping studies under nonphysiological conditions. Here, we use a noninvasive imaging modality (electrocardiographic imaging) to study normal activation and repolarization in intact unanesthetized healthy adults under complete phy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramanathan C,Jia P,Ghanem R,Ryu K,Rudy Y

更新日期：2006-04-18 00:00:00

abstract：:Optimal flowering time is critical to the success of modern agriculture. Sorghum is a short-day tropical species that exhibits substantial photoperiod sensitivity and delayed flowering in long days. Genotypes with reduced photoperiod sensitivity enabled sorghum's utilization as a grain crop in temperate zones worldwid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RL,Klein RR,Morishige DT,Brady JA,Rooney WL,Miller FR,Dugas DV,Klein PE,Mullet JE

更新日期：2011-09-27 00:00:00

abstract：:Evidence indicates that the modulatory effects of the adrenergic stress hormone epinephrine as well as several other neuromodulatory systems on memory storage are mediated by activation of beta-adrenergic mechanisms in the amygdala. In view of our recent findings indicating that the amygdala is involved in mediating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quirarte GL,Roozendaal B,McGaugh JL

更新日期：1997-12-09 00:00:00

abstract：:Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allred BE,Rupert PB,Gauny SS,An DD,Ralston CY,Sturzbecher-Hoehne M,Strong RK,Abergel RJ

更新日期：2015-08-18 00:00:00

abstract：:Bifidobacteria comprise a significant proportion of the human gut microbiota. Several bifidobacterial strains are currently used as therapeutic interventions, claiming various health benefits by acting as probiotics. However, the precise mechanisms by which they maintain habitation within their host and consequently p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fanning S,Hall LJ,Cronin M,Zomer A,MacSharry J,Goulding D,Motherway MO,Shanahan F,Nally K,Dougan G,van Sinderen D

更新日期：2012-02-07 00:00:00

abstract：:To test whether a 30S ribosomal subunitformylmethionyl-tRNA-mRNA complex is an obligatory intermediate in protein synthesis, 70S ribosomes from Escherichia coli were crosslinked with the bifunctional imidoester, dimethylsuberimidate. Crosslinked ribosomes contained covelently joined 30S and 50S subunits, as judged by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slobin LI

更新日期：1972-12-01 00:00:00

abstract：:The endodermis acts as a "second skin" in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks extracellular diffusion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosmani PS,Kamiya T,Danku J,Naseer S,Geldner N,Guerinot ML,Salt DE

更新日期：2013-08-27 00:00:00

abstract：:To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines. Dasatinib, a multikinase inhibitor, was ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scuoppo C,Wang J,Persaud M,Mittan SK,Basso K,Pasqualucci L,Rabadan R,Inghirami G,Grandori C,Bosch F,Dalla-Favera R

更新日期：2019-08-20 00:00:00

abstract：:Agents that act as anion channel blockers (ACBs) and do not permeate cells appear to inhibit exocytosis in platelets, parathyroid cells, and neutrophils. Based in large part on these observations, anion influx through plasma membrane channels has been considered a factor controlling cellular secretion, but there have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vostal JG,Reid DM,Jones CE,Shulman NR

更新日期：1989-08-01 00:00:00

abstract：:Aberrant glucose metabolism is one of the hallmarks of cancer that facilitates cancer cell survival and proliferation. Here, we demonstrate that MUC1, a large, type I transmembrane protein that is overexpressed in several carcinomas including pancreatic adenocarcinoma, modulates cancer cell metabolism to facilitate gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaika NV,Gebregiworgis T,Lewallen ME,Purohit V,Radhakrishnan P,Liu X,Zhang B,Mehla K,Brown RB,Caffrey T,Yu F,Johnson KR,Powers R,Hollingsworth MA,Singh PK

更新日期：2012-08-21 00:00:00

abstract：:Although some important advances in the modeling of sorption and hygrothermal deformations of nanoporous materials such as hydrated cement paste, shale, coal, and some other rocks and soils have already been made, a comprehensive nanoporomechanics theory remains elusive. Here we strive to formulate it based on Gibb's ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen H,Rahimi-Aghdam S,Bažant ZP

更新日期：2020-02-18 00:00:00

abstract：:Massively parallel signature sequencing (MPSS) generates millions of short sequence tags corresponding to transcripts from a single RNA preparation. Most MPSS tags can be unambiguously assigned to genes, thereby generating a comprehensive expression profile of the tissue of origin. From the comparison of MPSS data fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YT,Scanlan MJ,Venditti CA,Chua R,Theiler G,Stevenson BJ,Iseli C,Gure AO,Vasicek T,Strausberg RL,Jongeneel CV,Old LJ,Simpson AJ

更新日期：2005-05-31 00:00:00

abstract：:The problem of Congressional apportionment is explained together with a brief history of the methods used or considered for its solution. Reasons are given for rejecting the presently used method of equal proportions and for accepting a new method, the quota method, which is the unique method satisfying three essentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balinski ML,Young HP

更新日期：1974-11-01 00:00:00

abstract：:Minimally invasive detection of cell death could prove an invaluable resource in many physiologic and pathologic situations. Cell-free circulating DNA (cfDNA) released from dying cells is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. However, existing methods rely on differences in DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann-Werman R,Neiman D,Zemmour H,Moss J,Magenheim J,Vaknin-Dembinsky A,Rubertsson S,Nellgård B,Blennow K,Zetterberg H,Spalding K,Haller MJ,Wasserfall CH,Schatz DA,Greenbaum CJ,Dorrell C,Grompe M,Zick A,Hubert A,M

更新日期：2016-03-29 00:00:00

abstract：:The first step in poliovirus replication is binding of virus to a cellular receptor. Mouse L cells, which are resistant to poliovirus infection because they do not bear a poliovirus receptor, were transformed with HeLa cell (human) DNA to poliovirus sensitivity at a frequency of approximately 1 in 50,000 transformants...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mendelsohn C,Johnson B,Lionetti KA,Nobis P,Wimmer E,Racaniello VR

更新日期：1986-10-01 00:00:00

abstract：:On a planet experiencing global environmental change, the governance of natural resources depends on sustained collective action by diverse populations. Engaging in such collective action can only build upon the foundation of human cognition in social-ecological settings. To help understand this foundation, we assess ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman J,Baggio JA,Coyle TR

更新日期：2020-04-07 00:00:00

abstract：:The North Atlantic northern right whale (Eubalaena glacialis) is considered the most endangered large whale species. Its population has recovered only slowly since the cessation of commercial whaling and numbers about 300 individuals. We applied mark-recapture statistics to a catalog of photographically identified ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caswell H,Fujiwara M,Brault S

更新日期：1999-03-16 00:00:00

abstract：:Loss of function of CDKN2A/B, also known as INK4/ARF [encoding p16INK4A, p15INK4B, and p14ARF (mouse p19Arf)], confers susceptibility to cancers, whereas its up-regulation during organismal aging provokes cellular senescence and tissue degenerative disorders. To better understand the transcriptional regulation of p16 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Hyle J,Wright S,Shao Y,Zhao X,Zhang H,Li C

更新日期：2019-12-09 00:00:00

abstract：:Natural killer (NK) cells mediate vital control of cancer and viral infection. They rely on MHC class I (MHC I)-specific self-receptors to identify and lyse diseased cells without harming self-MHC I-bearing host cells. NK cells bearing inhibitory self-receptors for host MHC I also undergo education, referred to as lic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamache A,Cronk JM,Nash WT,Puchalski P,Gillespie A,Wei H,Gray L,Hammarskjold ML,Xu W,Brown MG

更新日期：2019-12-16 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT*3A, the most common variant allele for low activity, an allele that encodes a protein with two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Nguyen TV,McLaughlin RW,Sikkink LA,Ramirez-Alvarado M,Weinshilboum RM

更新日期：2005-06-28 00:00:00

abstract：:The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties of the system can be analyzed analytically by using the usual master equation approach when the external parameter is f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD

更新日期：1987-02-01 00:00:00

abstract：:The blood-aqueous barrier plays a key role in regulating aqueous humor homeostasis by selectively restricting passage of proteins into the eye. The kinetics of aqueous flow are traditionally measured using artificial markers; however, these marker molecules do not address the barrier's selective permeability to plasma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu P,Thomson BR,Khalatyan N,Feng L,Liu X,Savas JN,Quaggin SE,Jin J

更新日期：2018-09-04 00:00:00

abstract：:Tridymite, a low-pressure, high-temperature (>870 °C) SiO2 polymorph, was detected in a drill sample of laminated mudstone (Buckskin) at Marias Pass in Gale crater, Mars, by the Chemistry and Mineralogy X-ray diffraction instrument onboard the Mars Science Laboratory rover Curiosity The tridymitic mudstone has ∼40 wt....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris RV,Vaniman DT,Blake DF,Gellert R,Chipera SJ,Rampe EB,Ming DW,Morrison SM,Downs RT,Treiman AH,Yen AS,Grotzinger JP,Achilles CN,Bristow TF,Crisp JA,Des Marais DJ,Farmer JD,Fendrich KV,Frydenvang J,Graff TG,Mo

更新日期：2016-06-28 00:00:00

abstract：:A vaccine capable of stimulating protective antiviral antibody responses is needed to curtail the global AIDS epidemic caused by HIV-1. Although rarely elicited during the course of natural infection or upon conventional vaccination, the membrane-proximal ectodomain region (MPER) of the HIV-1 glycoprotein of M(r) 41,0...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song L,Sun ZY,Coleman KE,Zwick MB,Gach JS,Wang JH,Reinherz EL,Wagner G,Kim M

更新日期：2009-06-02 00:00:00

abstract：:In earlier studies with the acetylcholine receptor (AcChoR) of Electrophorus electricus the rate and equilibrium constants for a model that relates the ligand binding to ion translocation were determined, and the dependence of these constants on the concentrations of carbamoylcholine and acetylcholine, over a 200- and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess GP,Pasquale EB,Walker JW,McNamee MG

更新日期：1982-02-01 00:00:00

abstract：:Although microtubules (MTs) frequently form highly dynamic networks, subsets of MTs become stabilized in response to environmental cues and function as specialized tracks for vesicle and macromolecular trafficking. MT stabilization is controlled by specialized plus-end tracking proteins (+TIPs) whose accumulation at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naghavi MH,Gundersen GG,Walsh D

更新日期：2013-11-05 00:00:00

abstract：:This work describes a multifunctional phage lambda expression vector system, lambda YES, designed to facilitate gene isolation from eukaryotes by complementation of Escherichia coli and Saccharomyces cerevisiae mutations. lambda YES vectors have a selection for cDNA inserts using an oligo adaptor strategy and are capa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elledge SJ,Mulligan JT,Ramer SW,Spottswood M,Davis RW

更新日期：1991-03-01 00:00:00

abstract：:We have obtained long-term cultures of differentiated proliferating follicular cells from normal adult human thyroid glands. In vitro growth of such human cells has been sustained by a modified F-12 medium, supplemented with bovine hypothalamus and pituitary extracts and no added thyrotropin. Cultures have been expand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curcio F,Ambesi-Impiombato FS,Perrella G,Coon HG

更新日期：1994-09-13 00:00:00

abstract：:We report the direct measurement of thermodynamic properties of colloidal hard spheres by optical microscopy. By using confocal microscopy, we obtain three-dimensional snapshots of a colloidal hard-sphere suspension over a wide range of densities. From these snapshots, the available volume to insert an additional sphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dullens RP,Aarts DG,Kegel WK

更新日期：2006-01-17 00:00:00