Abstract:
:A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells from its inception through tumor development. The presence of the phenotype in tumors, adjacent normal cells, and in the normal prostate cells of certain older men suggests that it is a potentially critical factor in tumor development and may serve as an early biomarker for cancer risk assessment. Intervention to inhibit the development of the phenotype in healthy men, or to eliminate it once formed, may suppress or even prevent tumor formation.
journal_name
Proc Natl Acad Sci U S Aauthors
Malins DC,Gilman NK,Green VM,Wheeler TM,Barker EA,Anderson KMdoi
10.1073/pnas.0509630102keywords:
subject
Has Abstractpub_date
2005-12-27 00:00:00pages
19093-6issue
52eissn
0027-8424issn
1091-6490pii
0509630102journal_volume
102pub_type
杂志文章abstract::The qualities of perception depend not only on the sensory inputs but also on the brain state before stimulus presentation. Although the collective evidence from neuroimaging studies for a relation between prestimulus state and perception is strong, the interpretation in the context of sensory computations or decision...
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abstract::We demonstrate two kinds of visual stimuli that exhibit motion in one direction when viewed from near and in the opposite direction from afar. These striking reversals occur because each kind of stimulus is constructed to simultaneously activate two different mechanisms: a short-range mechanism that computes motion fr...
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更新日期:2008-08-19 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
pub_type: 杂志文章
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:2003-05-13 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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