Differentially regulated NADPH:cytochrome P450 oxidoreductases in parsley.

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:In budding yeast, two transcription factors, Swi4 and Swi6, control the expression of important cell cycle regulatory proteins (the G1 cyclins, Cln1 and Cln2, and the cyclin-like Hcs26) as well as the HO gene, whose product initiates mating-type switching. Both Swi4 and Swi6 are components of a protein complex that fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrews BJ,Moore LA

更新日期：1992-12-15 00:00:00

abstract：:3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a competitive manner with rat pancreatic cholecystokinin (CCK) receptors as determined by Scatchard analysis of the specific binding of 125I-labeled CCK. The affinity of L-364,718 for both pancre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang RS,Lotti VJ

更新日期：1986-07-01 00:00:00

abstract：:We have investigated the differentiation potential of precursor cells within the developing spinal cord of mice and have shown that spinal cord cells from embryonic day 10 specifically give rise to neurons when plated onto an astrocytic monolayer, Ast-1. These neurons had the morphology of motor neurons and > 83% expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richards LJ,Murphy M,Dutton R,Kilpatrick TJ,Puche AC,Key B,Tan SS,Talman PS,Bartlett PF

更新日期：1995-10-24 00:00:00

abstract：:Bovine proinsulin has been crystallized under a variety of conditions at both neutral and acid pH. Microtechniques were employed with sample weights of about 200 mug and volumes of 5-20 mul. The crystalline preparations all differ from each other morphologically.X-ray photographs of one form, tetragonal bipyramids gro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fullerton WW,Potter R,Low BW

更新日期：1970-08-01 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:The transcription of genes encoding gluconeogenic enzymes is tightly regulated during the perinatal period. These genes are induced by glucagon (cAMP) and glucocorticoids and repressed by insulin. To address the role of cAMP and glucocorticoids in the physiological activation of genes encoding gluconeogenic enzymes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montoliu L,Blendy JA,Cole TJ,Schütz G

更新日期：1995-05-09 00:00:00

abstract：:Sulfur assimilation is an evolutionarily conserved pathway that plays an essential role in cellular and metabolic processes, including sulfation, amino acid biosynthesis, and organismal development. We report that loss of a key enzymatic component of the pathway, bisphosphate 3'-nucleotidase (Bpnt1), in mice, both who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudson BH,Hale AT,Irving RP,Li S,York JD

更新日期：2018-03-20 00:00:00

abstract：:The interplay of human actions and natural processes over varied spatial and temporal scales can result in abrupt transitions between contrasting land surface states. Understanding these transitions is a key goal of sustainability science because they can represent abrupt losses of natural capital. This paper recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streeter R,Dugmore AJ

更新日期：2013-04-09 00:00:00

abstract：:Pentameric ligand-gated ion channels (pLGICs), which mediate chemo-electric signal transduction in animals, have been recently found in bacteria. Despite clear sequence and 3D structure homology, the phylogenetic distance between prokaryotic and eukaryotic homologs suggests significant structural divergences, especial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duret G,Van Renterghem C,Weng Y,Prevost M,Moraga-Cid G,Huon C,Sonner JM,Corringer PJ

更新日期：2011-07-19 00:00:00

abstract：:Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung P,Kao FT,Law ML,Jones C,Puck TT,Chan L

更新日期：1984-01-01 00:00:00

abstract：:Massive datasets that capture human movements and social interactions have catalyzed rapid advances in our quantitative understanding of human behavior during the past years. One important aspect affecting both areas is the critical role space plays. Indeed, growing evidence suggests both our movements and communicati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deville P,Song C,Eagle N,Blondel VD,Barabási AL,Wang D

更新日期：2016-06-28 00:00:00

abstract：:African sleeping sickness is a fatal disease that is caused by the protozoan parasite Trypanosoma brucei. Polyamine biosynthesis is an essential pathway in the parasite and is a validated drug target for treatment of the disease. S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a key step in polyamine biosynthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willert EK,Fitzpatrick R,Phillips MA

更新日期：2007-05-15 00:00:00

abstract：:We noticed that disease-related amyloidogenic proteins and especially cellular prion proteins have the highest proportion of incompletely desolvated backbone H bonds among soluble proteins. Such bonds are vulnerable to water attack and thus represent structural weaknesses. We have measured the adsorption of proteins o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Berry RS

更新日期：2003-03-04 00:00:00

abstract：:The sense of hearing is remarkable for its auditory dynamic range, which spans more than 10(12) in acoustic intensity. The mechanisms that enable the cochlea to transduce high sound levels without damage are of key interest, particularly with regard to the broad impact of industrial, military, and recreational auditor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Housley GD,Morton-Jones R,Vlajkovic SM,Telang RS,Paramananthasivam V,Tadros SF,Wong AC,Froud KE,Cederholm JM,Sivakumaran Y,Snguanwongchai P,Khakh BS,Cockayne DA,Thorne PR,Ryan AF

更新日期：2013-04-30 00:00:00

abstract：:The CRR1 (Copper Response Regulator) locus, required for both activating and repressing target genes of a copper- and hypoxia-sensing pathway in Chlamydomonas, encodes a 1,232-residue candidate transcription factor with a plant-specific DNA-binding domain named SBP, ankyrin repeats, and a C-terminal Cys-rich region, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kropat J,Tottey S,Birkenbihl RP,Depège N,Huijser P,Merchant S

更新日期：2005-12-20 00:00:00

abstract：:neurogenin2 (ngn2) encodes a basic helix-loop-helix transcription factor and plays an important role in neurogenesis from migratory neural crest cells. Its role in retinal development is poorly understood. We observed that in the developing chick retina, ngn2 was expressed in a subpopulation of proliferating progenito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan RT,Ma WX,Wang SZ

更新日期：2001-12-18 00:00:00

abstract：:The discovery of a steadily growing number of tumor antigens (TAs) has made generic, cell-free, peptide-based cancer vaccines a possible alternative to cytokine-transfected autologous cellular cancer vaccines. The major drawback of peptide vaccines, however, is the poor immunogenicity of peptides. It is commonly thoug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buschle M,Schmidt W,Zauner W,Mechtler K,Trska B,Kirlappos H,Birnstiel ML

更新日期：1997-04-01 00:00:00

abstract：:The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chorny A,Gonzalez-Rey E,Fernandez-Martin A,Pozo D,Ganea D,Delgado M

更新日期：2005-09-20 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the master circadian clock in mammals, sends major output signals to the subparaventricular zone (SPZ) and further to the paraventricular nucleus (PVN), the neural mechanism of which is largely unknown. In this study, the intracellular calcium levels were measured continuously in cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YE,Enoki R,Oda Y,Huang ZL,Honma KI,Honma S

更新日期：2018-10-02 00:00:00

abstract：:Laser-polarized gases (3He and 129Xe) are currently being used in magnetic resonance imaging as strong signal sources that can be safely introduced into the lung. Recently, researchers have been investigating other tissues using 129Xe. These studies use xenon dissolved in a carrier such as lipid vesicles or blood. Sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chawla MS,Chen XJ,Möller HE,Cofer GP,Wheeler CT,Hedlund LW,Johnson GA

更新日期：1998-09-01 00:00:00

abstract：:The cerebral cortex of mammals differentiates into functionally distinct areas that exhibit unique cytoarchitecture, connectivity, and molecular characteristics. Molecular specification of cells fated for limbic cortical areas, based on the expression of the limbic system-associated membrane protein (LAMP), occurs dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbe MF,Levitt P

更新日期：1992-05-01 00:00:00

abstract：:GABAergic dysfunction is present in the hippocampus in schizophrenia (SZ) and bipolar disorder (BD). The trisynaptic pathway was "deconstructed" into various layers of sectors CA3/2 and CA1 and gene expression profiling performed. Network association analysis was used to uncover genes that may be related to regulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benes FM,Lim B,Matzilevich D,Walsh JP,Subburaju S,Minns M

更新日期：2007-06-12 00:00:00

abstract：:The protein-protein interaction (PPI) network is crucial for cellular information processing and decision-making. With suitable inputs, PPI networks drive the cells to diverse functional outcomes such as cell proliferation or cell death. Here, we characterize the structural controllability of a large directed human PP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vinayagam A,Gibson TE,Lee HJ,Yilmazel B,Roesel C,Hu Y,Kwon Y,Sharma A,Liu YY,Perrimon N,Barabási AL

更新日期：2016-05-03 00:00:00

abstract：:Switching from repressed to active status in chromatin regulation is part of the critical responses that plants deploy to survive in an ever-changing environment. We previously reported that HOS15, a WD40-repeat protein, is involved in histone deacetylation and cold tolerance in Arabidopsis However, it remained unknow...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park J,Lim CJ,Shen M,Park HJ,Cha JY,Iniesto E,Rubio V,Mengiste T,Zhu JK,Bressan RA,Lee SY,Lee BH,Jin JB,Pardo JM,Kim WY,Yun DJ

更新日期：2018-06-05 00:00:00

abstract：:India's northward flight and collision with Asia was a major driver of global tectonics in the Cenozoic and, we argue, of atmospheric CO(2) concentration (pCO(2)) and thus global climate. Subduction of Tethyan oceanic crust with a carpet of carbonate-rich pelagic sediments deposited during transit beneath the high-pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kent DV,Muttoni G

更新日期：2008-10-21 00:00:00

abstract：:Current therapeutic interventions for the treatment of respiratory infections are hampered by the evolution of multidrug resistance in pathogens as well as the lack of effective cellular targets. Despite the identification of multiple region-specific lung progenitor cells, the identity of molecules that might be thera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khatri A,Kraft BD,Tata PR,Randell SH,Piantadosi CA,Pendergast AM

更新日期：2019-01-29 00:00:00

abstract：:By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fathman CG,Kimoto M,Melvold R,David CS

更新日期：1981-03-01 00:00:00

abstract：:Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeVries SH,Baylor DA

更新日期：1995-11-07 00:00:00

abstract：:Most Escherichia coli promoters initiate transcription with a purine 7 or 8 nt downstream from the -10 hexamer, but some promoters, including the ribosomal RNA promoter rrnB P1, start 9 nt from the -10 element. We identified promoter and RNA polymerase determinants of this noncanonical rrnB P1 start site using biochem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winkelman JT,Chandrangsu P,Ross W,Gourse RL

更新日期：2016-03-29 00:00:00