Phosphorylation induces a decrease in the biological activity of the protein inhibitor (GABA-modulin) of gamma-aminobutyric acid binding sites.

abstract：:Plants require metals for essential functions ranging from respiration to photosynthesis. These metals also contribute to the nutritional value of plants for both humans and livestock. Additionally, plants have the ability to accumulate nonessential metals such as cadmium and lead, and this ability could be harnessed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers EE,Eide DJ,Guerinot ML

更新日期：2000-10-24 00:00:00

abstract：:Hypnotic analgesia in some respects resembles opiate analgesia. We tested the hypothesis that some features of hypnotic analgesia are mediated through neuronal pathways activating specific opiate receptors in brain. The opiate antagonist naloxone had no effect on hypnotic analgesia in three subjects. Thus, the hypothe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Hilgard ER

更新日期：1975-06-01 00:00:00

abstract：:The sporulation of Saccharomyces cerevisiae in the presence of [2-13C]acetate was studied by 13C NMR spectroscopy. The fate of 13C label was analyzed in vivo and in cell extracts. During the first 4 hr of sporulation the major metabolite produced from [2-13C]acetate utilization was glutamate. From the labeling pattern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickinson JR,Dawes IW,Boyd AS,Baxter RL

更新日期：1983-10-01 00:00:00

abstract：:In electron microscopy studies of the endothelial vesicles in frog mesenteric capillaries, an accidental observation was made concerning vesicular organization. When tannic acid was added to already fixed tissue, the mordant reached apparently free vesicles in the cytoplasm under conditions in which vesicular movement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundgaard M,Frøkjaer-Jensen J,Crone C

更新日期：1979-12-01 00:00:00

abstract：:Mutualisms between fungi and fungus-growing animals are model systems for studying coevolution and complex interactions between species. Fungal growing behavior has enabled cultivating animals to rise to major ecological importance, but evolution of farming symbioses is thought to be restricted to three terrestrial in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silliman BR,Newell SY

更新日期：2003-12-23 00:00:00

abstract：:Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58alpha subunit of bovine phosphatidyl-inositol-3'-kinase (PI3-SH3), can be converted in vitro into assemblies with st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura S,Zurdo J,Narayanan S,Parreño M,Mangues R,Reif B,Chiti F,Giannoni E,Dobson CM,Aviles FX,Serrano L

更新日期：2004-05-11 00:00:00

abstract：:Genetic analysis of Parkinson disease (PD) has identified several genes whose mutation causes inherited parkinsonism, as well as risk loci for sporadic PD. PTEN-induced kinase 1 (PINK1) and parkin, linked to autosomal recessive PD, act in a common genetic pathway regulating the autophagic degradation of mitochondria, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivatt RM,Sanchez-Martinez A,Godena VK,Brown S,Ziviani E,Whitworth AJ

更新日期：2014-06-10 00:00:00

abstract：:Relatively little is known about neurobiological changes attributable to early-life stressors (e.g., orphanage rearing), even though they have been associated with a heightened risk for later psychopathology. Human neuroimaging and animal studies provide complementary insights into the neural basis of problem behavior...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malter Cohen M,Jing D,Yang RR,Tottenham N,Lee FS,Casey BJ

更新日期：2013-11-05 00:00:00

abstract：:The mechanisms by which phosphorus homeostasis is preserved in mammals are not completely understood. We demonstrate the presence of a mechanism by which the intestine detects the presence of increased dietary phosphate and rapidly increases renal phosphate excretion. The mechanism is of physiological relevance becaus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berndt T,Thomas LF,Craig TA,Sommer S,Li X,Bergstralh EJ,Kumar R

更新日期：2007-06-26 00:00:00

abstract：:Methods to acutely manipulate protein interactions at the subcellular level are powerful tools in cell biology. Several blue-light-dependent optical dimerization tools have been developed. In these systems one protein component of the dimer (the bait) is directed to a specific subcellular location, while the other com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benedetti L,Barentine AES,Messa M,Wheeler H,Bewersdorf J,De Camilli P

更新日期：2018-03-06 00:00:00

abstract：:The C-terminal domains of the two alpha-subunits (alphaCTD) in Escherichia coli RNA polymerase (RNAP) recognize specific sequences called UP elements in some promoters. These interactions can increase transcription dramatically. Previously, effects of upstream DNA-alphaCTD interactions on transcription were quantified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross W,Gourse RL

更新日期：2005-01-11 00:00:00

abstract：:We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei B,England L,Ames BN

更新日期：1989-08-01 00:00:00

abstract：:High vein density, a distinctive trait of C4 leaves, is central to both C3-to-C4 evolution and conversion of C3 to C4-like crops. We tested the hypothesis that high vein density in C4 leaves is due to elevated auxin biosynthesis and transport in developing leaves. Up-regulation of genes in auxin biosynthesis pathways ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CF,Yu CP,Wu YH,Lu MJ,Tu SL,Wu SH,Shiu SH,Ku MSB,Li WH

更新日期：2017-08-15 00:00:00

abstract：:We have studied the effects of recombinant (r) interleukin 7 (IL-7) on growth and differentiation of marrow pro-B-lymphocyte clones (CB/Bm7, LyD9, LyB9), marrow pro-T-lymphocyte clones (C4-77/3, C4-86/18, C4-95/16), and fetal thymocyte clones (FTH5, FTA2, FTD5) in the presence or absence of the bone marrow stroma clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeda S,Gillis S,Palacios R

更新日期：1989-03-01 00:00:00

abstract：:Turbulence in fluids is a ubiquitous, fascinating, and complex natural phenomenon that is not yet fully understood. Unraveling turbulence in high density, high temperature plasmas is an even bigger challenge because of the importance of electromagnetic forces and the typically violent environments. Fascinating and nov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondal S,Narayanan V,Ding WJ,Lad AD,Hao B,Ahmad S,Wang WM,Sheng ZM,Sengupta S,Kaw P,Das A,Kumar GR

更新日期：2012-05-22 00:00:00

abstract：:We have established a large panel of T-cell clones (TCCs) specific for Dermatophagoides pteronyssinus and Lolium perenne group I grass pollen allergens (total, 61) and for tetanus toxoid and protein purified derivative bacterial antigens (total, 38) from the peripheral blood of two atopic individuals and then analyzed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parronchi P,Macchia D,Piccinni MP,Biswas P,Simonelli C,Maggi E,Ricci M,Ansari AA,Romagnani S

更新日期：1991-05-15 00:00:00

abstract：:In vitro translation of Rous sarcoma virus (RSV) virion RNA in the messenger-dependent reticulocyte lysate system yielded polypeptides that were not synthesized by translation of RNA from a transformation-defective deletion mutant of RSV. These RSV-specific products migrated on sodium dodecyl sulfate/polyacrylamide ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beemon K,Hunter T

更新日期：1977-08-01 00:00:00

abstract：:Noncompliance with social distancing during the early stage of the coronavirus disease 2019 (COVID-19) pandemic poses a great challenge to the public health system. These noncompliance behaviors partly reflect people's concerns for the inherent costs of social distancing while discounting its public health benefits. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie W,Campbell S,Zhang W

更新日期：2020-07-28 00:00:00

abstract：:Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. HGF has two natural splice v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tolbert WD,Daugherty-Holtrop J,Gherardi E,Vande Woude G,Xu HE

更新日期：2010-07-27 00:00:00

abstract：:The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delfini MC,Dubrulle J,Malapert P,Chal J,Pourquié O

更新日期：2005-08-09 00:00:00

abstract：:Chromosome rearrangements, such as large deletions, inversions, or translocations, mediate migration of large DNA segments within or between chromosomes, which can have major effects on cellular genetic control. A method for chromosome manipulation would be very useful for studying the consequences of large-scale DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Deursen J,Fornerod M,Van Rees B,Grosveld G

更新日期：1995-08-01 00:00:00

abstract：:p21(WAF1/Cip1) is one of the best characterized downstream targets of p53, and the growth suppressing function of this cyclin-dependent kinase inhibitor is well established. However, whether p21 exerts a tumor-suppressing function of its own remains to be established. We report here that, similarly to loss of p53, dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Topley GI,Okuyama R,Gonzales JG,Conti C,Dotto GP

更新日期：1999-08-03 00:00:00

abstract：:We have studied androgen binding characteristics of cells for androgen insensitivity from an obligate heterozygote, who is the mother of three male pseudohermaphrodites with dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) receptor deficiency. Specific dihydrotestosterone binding by skin fibroblasts from he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer WJ 3rd,Migeon BR,Migeon CJ

更新日期：1975-04-01 00:00:00

abstract：:Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padinhateeri R,Marko JF

更新日期：2011-05-10 00:00:00

abstract：:Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The "planetary boundaries" concept [Rockström J, et al. (2009) Nature 461(7263):472-475], and its extension through the addition of social well-being indicators t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole MJ,Bailey RM,New MG

更新日期：2014-10-21 00:00:00

abstract：:Epstein-Barr virus infection in vitro immortalizes primary B cells. EBNA2 is an Epstein-Barr virus-encoded transcriptional transactivator that mimics the effects of activated Notch signaling and is essential for this proliferative response. An assay using Sindbis virus (SV) as a cell death inducer revealed that, like ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JM,Lee KH,Weidner M,Osborne BA,Hayward SD

更新日期：2002-09-03 00:00:00

abstract：:The mahogany (mg) locus originally was identified as a recessive suppressor of agouti, a locus encoding a skin peptide that modifies coat color by antagonizing the melanocyte-stimulating hormone receptor or MC1-R. Certain dominant alleles of agouti cause an obesity syndrome when ectopic expression of the peptide aberr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinulescu DM,Fan W,Boston BA,McCall K,Lamoreux ML,Moore KJ,Montagno J,Cone RD

更新日期：1998-10-13 00:00:00

abstract：:Ca2+ is a powerful inhibitor (Ki is congruent to 16 muM) of basal and prostaglandin E1 (PGE1)-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1] activity in membranes obtained from homogenized human platelets. Ca2+ (but not the ionophore A23,187) decreased V(max) of the reaction without an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodan GA,Feinstein MB

更新日期：1976-06-01 00:00:00

abstract：:Hydrocortisone at physiological concentrations reversibly inhibits DNA synthesis in ST1 cells (a line of mouse fibroblasts possessing 40 chromosomes and derived from Swiss 3T3 cells). This inhibitory activity is a property of glucocorticoids, but the beta-OH of C-11 of glucocorticoids is not essential for the inhibiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armelin MC,Armelin HA

更新日期：1978-06-01 00:00:00

abstract：:Duplication of genomic segments provides a primary resource for the origin of evolutionary novelties. However, most previous studies have focused on duplications of complete protein-coding genes, whereas little is known about the significance of duplication segments that are entirely internal to genes. Our examination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Lynch M

更新日期：2009-12-08 00:00:00