Elevated auxin biosynthesis and transport underlie high vein density in C4 leaves.

abstract：:The ionophores A23187 and bromolasalocid (Br-X537A) acted synergistically in translocating Ca(2+) from an aqueous into an organic immiscible phase or in mediating Ca(2+) transport across the organic phase, the effects obtained in the simultaneous presence of both ionophores being greater than those expected from a sum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deleers M,Gelbcke M,Malaisse WJ

更新日期：1981-01-01 00:00:00

abstract：:Cardiac myosin-binding protein C (cMyBP-C) is an accessory protein of striated muscle sarcomeres that is vital for maintaining regular heart function. Its 4 N-terminal regulatory domains, C0-C1-m-C2 (C0C2), influence actin and myosin interactions, the basic contractile proteins of muscle. Using neutron contrast variat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitten AE,Jeffries CM,Harris SP,Trewhella J

更新日期：2008-11-25 00:00:00

abstract：:Proteasome activator PA200 enhances proteasome-mediated cleavage after acidic residues in vitro; however, its role within cells is not known. Here, we show that, in response to ionizing radiation, PA200 forms hybrid proteasomes with 19S caps and 20S core proteasomes that accumulate on chromatin, leading to an increase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blickwedehl J,Agarwal M,Seong C,Pandita RK,Melendy T,Sung P,Pandita TK,Bangia N

更新日期：2008-10-21 00:00:00

abstract：:Viral genome packaging into capsids is powered by high-force-generating motor proteins. In the presence of all packaging components, ATP-powered translocation in vitro expels all detectable tightly bound YOYO-1 dye from packaged short dsDNA substrates and removes all aminoacridine dye from packaged genomic DNA in vivo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dixit AB,Ray K,Black LW

更新日期：2012-12-11 00:00:00

abstract：:This paper reports the results of a randomized field experiment involving registered voters in the city of New Haven. Nonpartisan get-out-the-vote messages were delivered through personal canvassing shortly before the November 1998 election. We find that personal canvassing increased voter turnout by approximately 6. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber AS,Green DP

更新日期：1999-09-14 00:00:00

abstract：:The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report a simple altern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valéry C,Paternostre M,Robert B,Gulik-Krzywicki T,Narayanan T,Dedieu JC,Keller G,Torres ML,Cherif-Cheikh R,Calvo P,Artzner F

更新日期：2003-09-02 00:00:00

abstract：:When treated with heat-killed bacterial cells, mosquito cells in culture respond by up-regulating several proteins. Among these is a 66-kDa protein (p66) that is secreted from cells derived from both Aedes aegypti and Aedes albopictus. p66 was degraded by proteolysis and gave a virtually identical pattern of peptide p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshiga T,Hernandez VP,Fallon AM,Law JH

更新日期：1997-11-11 00:00:00

abstract：:Mice carrying mutations in either the dominant white-spotting (W) or Steel (Sl) loci exhibit deficits in melanogenesis, gametogenesis, and hematopoiesis. W encodes the Kit receptor tyrosine kinase, while Sl encodes the Kit ligand, Steel factor, and the receptor-ligand pair are contiguously expressed at anatomical site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motro B,Wojtowicz JM,Bernstein A,van der Kooy D

更新日期：1996-03-05 00:00:00

abstract：:Many important hominid-bearing fossil localities in East Africa are in regions that are extremely hot and dry. Although humans are well adapted to such conditions, it has been inferred that East African environments were cooler or more wooded during the Pliocene and Pleistocene when this region was a central stage of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Passey BH,Levin NE,Cerling TE,Brown FH,Eiler JM

更新日期：2010-06-22 00:00:00

abstract：:Small RNAs (sRNAs) are hypothesized to contribute to hybrid vigor because they maintain genome integrity, contribute to genetic diversity, and control gene expression. We used Illumina sequencing to assess how sRNA populations vary between two maize inbred lines (B73 and Mo17) and their hybrid. We sampled sRNAs from t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber WT,Zhang W,Win H,Varala KK,Dorweiler JE,Hudson ME,Moose SP

更新日期：2012-06-26 00:00:00

abstract：:We describe a method based on a phagemid vector with helper phage rescue for the construction and rapid analysis of combinatorial antibody Fab libraries. This approach should allow the generation and selection of many monoclonal antibodies. Antibody genes are expressed in concert with phage morphogenesis, thereby allo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang AS,Barbas CF,Janda KD,Benkovic SJ,Lerner RA

更新日期：1991-05-15 00:00:00

abstract：:Long QT syndrome (LQT) is an autosomal dominant disorder that can cause sudden death from cardiac arrhythmias. We recently discovered that mutations in HERG, a K+-channel gene, cause chromosome 7-linked LQT. Heterologous expression of HERG in Xenopus oocytes revealed that HERG current was similar to a well-characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanguinetti MC,Curran ME,Spector PS,Keating MT

更新日期：1996-03-05 00:00:00

abstract：:A specific lipoprotein of the E. coli outer membrane has been synthesized in a cell-free system directed by purified messenger RNA. The mRNA for the lipoprotein was purified as 7S RNA about 250-fold from exponentially growing cells. Protein synthesis of the cell-free system was totally dependent upon the addition of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirashima A,Wang S,Inouye M

更新日期：1974-10-01 00:00:00

abstract：:A protein-free nucleic acid preparation method for electron microscopy is described. The basic procedure is very similar to the classical protein monolayer spreading techniques. The carrier protein (usually cytochrome c) is replaced by benzyldimethylalkylammonium chloride. Both the hypophase method and the microdiffus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vollenweider HJ,Sogo JM,Koller T

更新日期：1975-01-01 00:00:00

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:Invasive organisms pose a global threat and are exceptionally difficult to eradicate after they become abundant in their new habitats. We report a successful multitactic strategy for combating the pink bollworm (Pectinophora gossypiella), one of the world's most invasive pests. A coordinated program in the southwester...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tabashnik BE,Liesner LR,Ellsworth PC,Unnithan GC,Fabrick JA,Naranjo SE,Li X,Dennehy TJ,Antilla L,Staten RT,Carrière Y

更新日期：2021-01-05 00:00:00

abstract：:Neurotrophins are potent survival factors for developing and injured neurons. However, they are not being used to treat neurodegenerative diseases because of difficulties in administration and numerous side effects that have been encountered in previous clinical trials. Their biological activities use Trk (tropomyosin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiese S,Jablonka S,Holtmann B,Orel N,Rajagopal R,Chao MV,Sendtner M

更新日期：2007-10-23 00:00:00

abstract：:Activation of protein kinase C (PKC) by phorbol ester facilitates hormonal secretion and transmitter release, and phorbol ester-induced synaptic potentiation (PESP) is a model for presynaptic facilitation. A variety of PKC isoforms are expressed in the central nervous system, but the isoform involved in the PESP has n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saitoh N,Hori T,Takahashi T

更新日期：2001-11-20 00:00:00

abstract：:In recent years, a large body of research has demonstrated that judgments and behaviors can propagate from person to person. Phenomena as diverse as political mobilization, health practices, altruism, and emotional states exhibit similar dynamics of social contagion. The precise mechanisms of judgment propagation are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moussaïd M,Herzog SM,Kämmer JE,Hertwig R

更新日期：2017-04-18 00:00:00

abstract：:Splice variants (SVs) of receptors for growth hormone-releasing hormone (GHRH) have been found in primary human prostate cancers and diverse human cancer cell lines. GHRH antagonists inhibit growth of various experimental human cancers, including pancreatic and colorectal, xenografted into nude mice or cultured in vit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busto R,Schally AV,Varga JL,Garcia-Fernandez MO,Groot K,Armatis P,Szepeshazi K

更新日期：2002-09-03 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle. The activity of APC/C in mitosis and in G1 requires interaction with the activator proteins Cdc20 and C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Moshe Y,Braunstein I,Hershko A

更新日期：2006-02-14 00:00:00

abstract：:We have established a large panel of T-cell clones (TCCs) specific for Dermatophagoides pteronyssinus and Lolium perenne group I grass pollen allergens (total, 61) and for tetanus toxoid and protein purified derivative bacterial antigens (total, 38) from the peripheral blood of two atopic individuals and then analyzed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parronchi P,Macchia D,Piccinni MP,Biswas P,Simonelli C,Maggi E,Ricci M,Ansari AA,Romagnani S

更新日期：1991-05-15 00:00:00

abstract：:Genomic mapping has been used to identify a region of the host genome that determines resistance to fusiform rust disease in loblolly pine where no discrete, simply inherited resistance factors had been previously found by conventional genetic analysis over four decades. A resistance locus, behaving as a single domina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilcox PL,Amerson HV,Kuhlman EG,Liu BH,O'Malley DM,Sederoff RR

更新日期：1996-04-30 00:00:00

abstract：:The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This diversity, resulting from both amino acid and glycan heterogeneity, is translated into cellular respo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith P,DiLillo DJ,Bournazos S,Li F,Ravetch JV

更新日期：2012-04-17 00:00:00

abstract：:ATP-sensitive potassium channels (K(ATP)) are involved in a diverse array of physiologic functions including protection of tissue against ischemic insult, regulation of vascular tone, and modulation of insulin secretion. To improve our understanding of the role of K(ATP) in these processes, we used a gene-targeting st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chutkow WA,Samuel V,Hansen PA,Pu J,Valdivia CR,Makielski JC,Burant CF

更新日期：2001-09-25 00:00:00

abstract：:Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture. Thus, in a liver particulate enzyme preparation, swainsonine at 0.1-1.0 microM inhibited the mannosidase that releases [3H]mannose from a high mannose glycopeptide b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elbein AD,Solf R,Dorling PR,Vosbeck K

更新日期：1981-12-01 00:00:00

abstract：:Adult rat arterial smooth muscle cells (SMC) in primary culture modulate from contractile to synthetic phenotype. This process includes partial loss of myofilaments and formation of an extensive rough endoplasmic reticulum and a large Golgi complex. It gives the cells the ability to initiate DNA synthesis and actively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nilsson J,Sjölund M,Palmberg L,Thyberg J,Heldin CH

更新日期：1985-07-01 00:00:00

abstract：:The technique of single-strand conformation polymorphism (SSCP) was used to screen a series of 37 established colorectal cell lines, 22 fresh tumor samples, and 22 normal DNA samples for mutations in the beta 2-microglobulin gene. Exon 1 (including the leader peptide sequence) and exon 2 were screened separately. Six ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bicknell DC,Rowan A,Bodmer WF

更新日期：1994-05-24 00:00:00

abstract：:The protooncogenic protein Vav has the structure of an intracellular signal transducer. It is exclusively expressed in cells of hematopoietic lineage and plays a crucial role in hematopoietic cell differentiation. Here we report that both in cell extracts and within intact mammalian cells Vav binds to Grb2 (Sem-5/ASH/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye ZS,Baltimore D

更新日期：1994-12-20 00:00:00