Adaptive climatic molecular evolution in wild barley at the Isa defense locus.

abstract：:Nascent precursors of phosphatidylinositol-glycan (PI-G)-linked membrane proteins contain a hydrophobic COOH-terminal sequence of 15-30 residues that is eliminated during processing to yield a newly exposed COOH terminus to which the PI-G moiety is added. There is no consensus as to the primary structure of the termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Micanovic R,Kodukula K,Gerber LD,Udenfriend S

更新日期：1990-10-01 00:00:00

abstract：:Five protease inhibitors with different modes of action were found to reduce the growth of transformed mouse (Py3T3, SV3T3, and 3T12) and hamster (PyBHK) cells. Some of these inhibitors caused the transformed cells to cease growth at saturation densities characteristic for nontransformed cells. The protease inhibitors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnebli HP,Burger MM

更新日期：1972-12-01 00:00:00

abstract：:The mechanism by which antifreeze proteins (AFPs) irreversibly bind to ice has not yet been resolved. The ice-binding site of an AFP is relatively hydrophobic, but also contains many potential hydrogen bond donors/acceptors. The extent to which hydrogen bonding and the hydrophobic effect contribute to ice binding has ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garnham CP,Campbell RL,Davies PL

更新日期：2011-05-03 00:00:00

abstract：:Myocytes in the atria contain a prohormone that gives rise to atrial natriuretic peptides (ANP), which have intrinsic hemodynamic regulatory activity. Little is known about mechanisms regulating ANP release. In rats with indwelling catheters, acute blood volume expansion with 5% (wt/vol) dextrose increases the amount ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Haass M,Dave JR,Zukowska-Grojec Z

更新日期：1987-01-01 00:00:00

abstract：:The methyl-CpG dinucleotide containing a symmetrical 5-methylcytosine (mC) is involved in gene regulation and genome stability. We report here that methylation-mediated transcriptional repressor methylated DNA-binding domain 1 (MBD1) interacts with methylpurine-DNA glycosylase (MPG), which excises damaged bases from s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe S,Ichimura T,Fujita N,Tsuruzoe S,Ohki I,Shirakawa M,Kawasuji M,Nakao M

更新日期：2003-10-28 00:00:00

abstract：:Ca channel currents were studied in freshly dispersed bovine adrenal glomerulosa cells to better understand the control of aldosterone secretion by extracellular K concentration (Ko) and angiotensin II (AII). The whole-cell variation of the patch voltage clamp technique was used. Two types of Ca channels were found. O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen CJ,McCarthy RT,Barrett PQ,Rasmussen H

更新日期：1988-04-01 00:00:00

abstract：:An analysis of taxonomic longevity for species of the two Cenozoic radiations of Caribbean planktonic foraminifera shows strong similarity in longevity for extinct taxa, though extant species of the latter radiation are biased towards longer-lived forms. In this case, the present is not the key to the past. A simple o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinton JS,Ginzburg L

更新日期：1984-09-01 00:00:00

abstract：:Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh ST,Cheng H,Bryson JW,Roder H,DeGrado WF

更新日期：1999-05-11 00:00:00

abstract：:Integrins contain two structurally homologous but distantly related domains: an I-like domain that is present in all beta-subunits and an I domain that is present in some alpha-subunits. Atomic resolution and mutagenesis studies of alpha I domains demonstrate a C-terminal, axial displacement of the alpha7-helix that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang W,Shimaoka M,Chen J,Springer TA

更新日期：2004-02-24 00:00:00

abstract：:To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe N,Katakura K,Kobayashi A,Okumura K,Ovary Z

更新日期：1988-06-01 00:00:00

abstract：:The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperekplexic congenital mutations altering the al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moraga-Cid G,Sauguet L,Huon C,Malherbe L,Girard-Blanc C,Petres S,Murail S,Taly A,Baaden M,Delarue M,Corringer PJ

更新日期：2015-03-03 00:00:00

abstract：:The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenoviru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pääbo S,Nilsson T,Peterson PA

更新日期：1986-12-01 00:00:00

abstract：:Here we study the effects of many-body interactions on rate and mechanism in protein folding by using the results of molecular dynamics simulations on numerous coarse-grained Calpha-model single-domain proteins. After adding three-body interactions explicitly as a perturbation to a Gō-like Hamiltonian with native pair...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ejtehadi MR,Avall SP,Plotkin SS

更新日期：2004-10-19 00:00:00

abstract：:Despite the prevalence of transposable elements in the genomes of higher eukaryotes, what is virtually unknown is how they amplify to very high copy numbers without killing their host. Here, we report the discovery of rice strains where a miniature inverted-repeat transposable element (mPing) has amplified from approx...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naito K,Cho E,Yang G,Campbell MA,Yano K,Okumoto Y,Tanisaka T,Wessler SR

更新日期：2006-11-21 00:00:00

abstract：:The immunoglobulin heavy-chain-associated tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), known for its phagocytosis-stimulating activity, was found to augment the antigen-specific, macrophage-dependent education of T lymphocytes. The investigation of stereospecific characteristics of the tetrapeptide, by use of structural a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzehoval E,Segal S,Stabinsky Y,Fridkin M,Spirer Z,Feldman M

更新日期：1978-07-01 00:00:00

abstract：:To investigate the role of an anchoring pocket in allele-specific peptide presentation by a major histocompatibility complex class I molecule, we "transplanted" a B pocket from HLA-A*0201 into HLA-B*2705 by site-directed mutagenesis. The resulting protein, designated B27.A2B, binds a different set of endogenous peptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colbert RA,Rowland-Jones SL,McMichael AJ,Frelinger JA

更新日期：1993-07-15 00:00:00

abstract：:Sodium influx is an important early signal during the onset of mitogenesis in many types of cells. From this observation, one would predict that a decrease in extracellular Na+ concentration might retard cell proliferation. We tested this prediction by exposing sets of cultures of monkey kidney epithelial cells (BSC-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh-Reitz MM,Gluck SL,Waack S,Toback FG

更新日期：1986-07-01 00:00:00

abstract：:Expression of amino acid biosynthesis genes in bacteria is often repressed when abundant supplies of the cognate amino acid are available. Repression of the Bacillus subtilis lysC gene by lysine was previously shown to occur at the level of premature termination of transcription. In this study we show that lysine dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grundy FJ,Lehman SC,Henkin TM

更新日期：2003-10-14 00:00:00

abstract：:We have recently demonstrated that immunization with hepatitis C virus-like particles (HCV-LPs) generated in insect cells can elicit both humoral and cellular immune responses in BALB/c mice. Here, we evaluate the immunogenicity of HCV-LPs in HLA2.1 transgenic (AAD) mice in comparison to DNA immunization. HCV-LP immun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murata K,Lechmann M,Qiao M,Gunji T,Alter HJ,Liang TJ

更新日期：2003-05-27 00:00:00

abstract：:Plasma norepinephrine and dopamine beta-hydroxylase (EC 1.14.17.1) activity were measured in rats. Adrenergic neuron blockade with bretylium for 4 hr and ganglion blockade with chlorisondamine for 72 hr lowered plasma norepinephrine. Neither treatment altered plasma dopamine beta-hydroxylase activity. Phenoxybenzamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid JL,Kopin IJ

更新日期：1974-11-01 00:00:00

abstract：:Mixed synthetic oligonucleotides encoding sequences conserved among tyrosine-specific protein kinases were used to probe the genome of the budding yeast Saccharomyces cerevisiae. Two genes with homology to protein kinases were isolated and characterized by DNA sequence analysis. These genes, designated KIN1 and KIN2, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin DE,Hammond CI,Ralston RO,Bishop JM

更新日期：1987-09-01 00:00:00

abstract：:Synaptic transmission of the light response from photoreceptors to second-order cells of the retina was studied with the whole-cell patch-clamp technique in tiger salamander (Ambystoma tigrinum) retinal slices. Synaptic strength is modulated by extracellular pH in a striking manner: Light-sensitive postsynaptic curren...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnes S,Merchant V,Mahmud F

更新日期：1993-11-01 00:00:00

abstract：:Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell line from the thymus of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ong B,Willcox N,Wordsworth P,Beeson D,Vincent A,Altmann D,Lanchbury JS,Harcourt GC,Bell JI,Newsom-Davis J

更新日期：1991-08-15 00:00:00

abstract：:The cell-surface antigen detected by the monoclonal antibody JONES is expressed in the retina and a number of other central nervous system regions of the rat during the latter part of embryonic development and the early postnatal period. In addition to the expression on certain neuroblast populations it is found on so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blum AS,Barnstable CJ

更新日期：1987-12-01 00:00:00

abstract：:Phalloidin, a toxic bicyclic peptide of rapid action from the toadstool, Amanita phalloides, gives rise to polymerization of G-actin to filamentous structures (Ph-actin) in a medium of low ionic strength. Ph-actin closely resembles the microfilaments found in liver membrane fractions (Ph-filaments) after in vivo or in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lengsfeld AM,Löw I,Wieland T,Dancker P,Hasselbach W

更新日期：1974-07-01 00:00:00

abstract：:Androgen independence is responsible for most prostate cancer lethality, yet currently there are no effective clinical treatments. We have been investigating the mechanisms underlying androgen-independent prostate cancer in Nkx3.1;Pten mutant mice, which display salient features of the disease, including a requirement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Ouyang X,Banach-Petrosky WA,Gerald WL,Shen MM,Abate-Shen C

更新日期：2006-09-26 00:00:00

abstract：:Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is angiogenesis-dependent. We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LK,Garcia-Cardeña G,Farnebo F,Fannon M,Chen EJ,Butterfield C,Moses MA,Mulligan RC,Folkman J,Kaipainen A

更新日期：2004-08-10 00:00:00

abstract：:The cationic conductances of purified bovine retinal rod membranes were studied by incorporation of vesicles into planar lipid bilayers. When the membranes were stripped of all peripheral proteins [guanine nucleotide-binding protein (G protein) and cGMP phosphodiesterase (3',5'-cyclic-GMP 5'-nucleotidohydrolase), EC 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett N,Ildefonse M,Crouzy S,Chapron Y,Clerc A

更新日期：1989-05-01 00:00:00

abstract：:We have identified a murine gene, metaxin, that spans the 6-kb interval separating the glucocerebrosidase gene (GC) from the thrombospondin 3 gene on chromosome 3E3-F1. Metaxin and GC are transcribed convergently; their major polyadenylylation sites are only 431 bp apart. On the other hand, metaxin and the thrombospon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein P,McKinney CE,LaMarca ME,Winfield S,Shingu T,Devarayalu S,Vos HL,Ginns EI

更新日期：1995-05-09 00:00:00

abstract：:The semaphorins comprise a large family of membrane-bound and secreted proteins, some of which have been shown to function in axon guidance. We have cloned a transmembrane semaphorin, Sema W, that belongs to the class IV subgroup of the semaphorin family. The mouse and rat forms of Sema W show 97% amino acid sequence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Encinas JA,Kikuchi K,Chedotal A,de Castro F,Goodman CS,Kimura T

更新日期：1999-03-02 00:00:00