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Selective inhibition of growth of transformed cells by protease inhibitors.

Abstract：

:Five protease inhibitors with different modes of action were found to reduce the growth of transformed mouse (Py3T3, SV3T3, and 3T12) and hamster (PyBHK) cells. Some of these inhibitors caused the transformed cells to cease growth at saturation densities characteristic for nontransformed cells. The protease inhibitors were strikingly selective with regard to the transformed cells; they had essentially no effect on the growth of the nontransformed cells. From this result, it is concluded that the inhibitors block a protease-like activity that is required for the unrestrained growth of transformed cells. The inhibitors exerted their effect directly on the cells; they did not affect growth by interacting with serum components of the medium.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Schnebli HP,Burger MM

doi

10.1073/pnas.69.12.3825

subject

Has Abstract

pub_date

1972-12-01 00:00:00

pages

3825-7

issue

12

eissn

0027-8424

issn

1091-6490

journal_volume

69

pub_type

杂志文章

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