Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain.

abstract：:Natural-abundance (13)C nuclear magnetic resonance spectra of ten common nucleotides in neutral, aqueous solutions have been determined and interpreted. The spectra of two of these substances were also determined in acidic solutions, and several of the carbon chemical shifts were found to depend markedly on pH. Within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman DE,Roberts JD

更新日期：1970-01-01 00:00:00

abstract：:Silicate melts at the top of the transition zone and the core-mantle boundary have significant influences on the dynamics and properties of Earth's interior. MgSiO3-rich silicate melts were among the primary components of the magma ocean and thus played essential roles in the chemical differentiation of the early Eart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SK,Lin JF,Cai YQ,Hiraoka N,Eng PJ,Okuchi T,Mao HK,Meng Y,Hu MY,Chow P,Shu J,Li B,Fukui H,Lee BH,Kim HN,Yoo CS

更新日期：2008-06-10 00:00:00

abstract：:Employing a cell-free chromatin transcription system that recapitulates progesterone receptor (PR)-mediated transcription in vivo, we have investigated further the coactivator functions of steroid receptor coactivator-1 (SRC-1) in terms of its functional domains as well as cooperation with other coactivators in PR tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Wong J,Tsai SY,Tsai MJ,O'Malley BW

更新日期：2001-10-23 00:00:00

abstract：:Improving global yields of important agricultural crops is a complex challenge. Enhancing yield and resource use by engineering improvements to photosynthetic carbon assimilation is one potential solution. During the last 40 million years C(4) photosynthesis has evolved multiple times, enabling plants to evade the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney SM,Sharwood RE,Orr D,White SJ,Alonso H,Galmés J

更新日期：2011-08-30 00:00:00

abstract：:Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adja...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickinson LA,Gulizia RJ,Trauger JW,Baird EE,Mosier DE,Gottesfeld JM,Dervan PB

更新日期：1998-10-27 00:00:00

abstract：:DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao P,LeBlanc SJ,Case BC,Elston TC,Hingorani MM,Erie DA,Weninger KR

更新日期：2020-07-28 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:A major challenge in interpreting genome sequences is understanding how the genome encodes the information that specifies when and where a gene will be expressed. The first step in this process is the identification of regions of the genome that contain regulatory information. In higher eukaryotes, this cis-regulatory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berman BP,Nibu Y,Pfeiffer BD,Tomancak P,Celniker SE,Levine M,Rubin GM,Eisen MB

更新日期：2002-01-22 00:00:00

abstract：:The major histocompatibility complex class-I (MHC-I) peptide-loading complex (PLC) is a cornerstone of the human adaptive immune system, being responsible for processing antigens that allow killer T cells to distinguish between healthy and compromised cells. Based on a recent low-resolution cryo-electron microscopy (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisette O,Schröder GF,Schäfer LV

更新日期：2020-08-25 00:00:00

abstract：:One approach to understanding common human diseases is to determine the genetic defects responsible for similar diseases in animal models and place those defective genes in their corresponding biochemical pathways. Our laboratory is working with an animal model for human rheumatoid arthritis called collagen-induced ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McIndoe RA,Bohlman B,Chi E,Schuster E,Lindhardt M,Hood L

更新日期：1999-03-02 00:00:00

abstract：:Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rall LB,Pictet RL,Williams RH,Rutter WJ

更新日期：1973-12-01 00:00:00

abstract：:Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein. To examine the physical basis for the apparent disproportion between LDL cholesterol and apoB characteristic of this syndrome, we used density...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng B,Thompson GR,Sniderman AD,Forte TM,Krauss RM,Kwiterovich PO Jr

更新日期：1983-11-01 00:00:00

abstract：:Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is angiogenesis-dependent. We revisited this concept by using fibroblast growth factor 2 (FGF-2) (80 ng) to stimulate the growth of both vessel types in the mouse ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang LK,Garcia-Cardeña G,Farnebo F,Fannon M,Chen EJ,Butterfield C,Moses MA,Mulligan RC,Folkman J,Kaipainen A

更新日期：2004-08-10 00:00:00

abstract：:We show that bromoacetaldehyde, which reacts selectively at the N-1 and N-6 positions of unpaired adenine and at the N-3 and N-4 positions of unpaired cytosine residues reacts with chromosomal DNA in intact cells at probable regulatory sequences near active genes. A region of about 200 base pairs 5' to the chicken bet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohwi-Shigematsu T,Gelinas R,Weintraub H

更新日期：1983-07-01 00:00:00

abstract：:Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a repressor protein, the iron regulatory element-binding protein. From measurements mad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenstein RS,Garcia-Mayol D,Pettingell W,Munro HN

更新日期：1991-02-01 00:00:00

abstract：:Numerous relatively short regions within intrinsically disordered proteins (IDPs) serve as molecular recognition elements (MoREs). They fold into ordered structures upon binding to their partner molecules. Currently, there is still a lack of in-depth understanding of how coupled binding and folding occurs in MoREs. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Chu X,Longhi S,Roche P,Han W,Wang E,Wang J

更新日期：2013-10-01 00:00:00

abstract：:Mechanisms that enabled primitive cell membranes to self-reproduce have been discussed based on the physicochemical properties of fatty acids; however, there must be a transition to modern cell membranes composed of phospholipids [Budin I, Szostak JW (2011) Proc Natl Acad Sci USA 108:5249-5254]. Thus, a growth-divisio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terasawa H,Nishimura K,Suzuki H,Matsuura T,Yomo T

更新日期：2012-04-17 00:00:00

abstract：:Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2 at 2.9 A, has about 37% molecular mass of the transmembrane portion not resolved. In this study, by applying a novel no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Wang Q,Ni F,Ma J

更新日期：2010-06-22 00:00:00

abstract：:Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Runguphan W,Maresh JJ,O'Connor SE

更新日期：2009-08-18 00:00:00

abstract：:Various tissues and cells in culture contain a specific inhibitor of DNase I (EC 3.1.4.5). In this paper evidence is presented that this inhibitor is actin, one of the major structural proteins of muscle and nonmuscle cells. (a) The inhibitor is a major cellular component constituting 5-10% of the soluble protein. (b)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lazarides E,Lindberg U

更新日期：1974-12-01 00:00:00

abstract：:Proteins of plant cell walls serve as structural macromolecules and play important roles in morphogenesis and development but have not been reported to be the origins of peptide signals that activate genes for plant defense. We report here that the mRNA coding the tomato leaf polyprotein precursor of three hydroxyprol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narváez-Vásquez J,Pearce G,Ryan CA

更新日期：2005-09-06 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:Resistance to ionizing radiation (IR), which is a conventional treatment for osteosarcoma that cannot be resected, undermines the efficacy of this therapy. However, the mechanism by which IR induces radioresistance in osteosarcoma is not defined. Here, we report that CR6-interacting factor-1 (CRIF1) is highly expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ran Q,Jin F,Xiang Y,Xiang L,Wang Q,Li F,Chen L,Zhang Y,Wu C,Zhou L,Xiao Y,Chen L,Wu J,Zhong JF,Li SC,Li Z

更新日期：2019-10-08 00:00:00

abstract：:gamma-Aminobutyric acid (GABA)-modulin is a brain protein of Mr 16,500 that down-regulates the high-affinity binding site for GABA which is located in crude synaptic membranes. This protein can be phosphorylated in vitro by the catalytic subunit of cAMP-dependent protein kinase and by a partially purified preparation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise BC,Guidotti A,Costa E

更新日期：1983-02-01 00:00:00

abstract：:Isochorismate synthase (ICS) converts chorismate to isochorismate for the biosynthesis of phylloquinone, an essential cofactor for photosynthetic electron transport. ICS is also required for salicylic acid (SA) synthesis during Arabidopsis defense. In several other species, including Populus, SA is derived primarily f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yuan Y,Chung JD,Fu X,Johnson VE,Ranjan P,Booth SL,Harding SA,Tsai CJ

更新日期：2009-12-22 00:00:00

abstract：:Efforts to understand the dramatic declines in mortality over the past century have focused on life expectancy. However, understanding changes in disparity in age of death is important to understanding mechanisms of mortality improvement and devising policy to promote health equity. We derive a novel decomposition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seligman B,Greenberg G,Tuljapurkar S

更新日期：2016-07-26 00:00:00

abstract：:In a subtropical gyre, the convergent Ekman layer forces water downward into the geostrophic flow below. The properties and depth of the mixed layer vary considerably during the course of the year, but this variability does not penetrate into the geostrophic region. Evidently there is some process at work that selects...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stommel H

更新日期：1979-07-01 00:00:00

abstract：:Pathogenic infections and tissue injuries trigger the assembly of inflammasomes, cytosolic protein complexes that activate caspase-1, leading to cleavage of pro-IL-1β and pro-IL-18 and to pyroptosis, a proinflammatory cell death program. Although microbial recognition by Toll-like receptors (TLRs) is known to induce t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin KM,Hu W,Troutman TD,Jennings M,Brewer T,Li X,Nanda S,Cohen P,Thomas JA,Pasare C

更新日期：2014-01-14 00:00:00

abstract：:The Drosophila splicing factor RBP1 participates together with TRA and TRA-2 in the regulation of alternative splicing of doublesex (dsx) pre-mRNA. It does so by recognizing RBP1 RNA target sequences in the dsx pre-mRNA. RBP1 belongs to the Ser-Arg-rich (SR) protein family of splicing factors, which have in common a N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinrichs V,Baker BS

更新日期：1997-01-07 00:00:00

abstract：:F1, a water-soluble portion of FoF1-ATP synthase, is an ATP hydrolysis-driven rotary motor. The central gamma-subunit rotates in the alpha 3 beta 3 cylinder by repeating the following four stages of rotation: ATP-binding dwell, rapid 80 degrees substep rotation, interim dwell, and rapid 40 degrees substep rotation. At...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimabukuro K,Yasuda R,Muneyuki E,Hara KY,Kinosita K Jr,Yoshida M

更新日期：2003-12-09 00:00:00