Crossover from interaction to driven regimes in quantum vortex reconnections.

abstract：:Highly purified RNA polymerase II was found to be able to weakly recognize the initiator (Inr) present in the adenovirus IVa2 and major late promoters. The association of RNA polymerase II with the Inr was enhanced by the general transcription factors. The Inr was capable of directing the formation of a DNA-protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo J,Buckbinder L,Reinberg D

更新日期：1991-09-15 00:00:00

abstract：:It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter JC,Ijames CF,Wang TC,Markey SP

更新日期：1995-06-06 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important cellular effector whose functions include the regulation of ion channels and membrane trafficking. Aberrant PIP2 metabolism has also been implicated in a variety of human disease states, e.g., cancer and diabetes. Here we report that familial Alzheimer's dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landman N,Jeong SY,Shin SY,Voronov SV,Serban G,Kang MS,Park MK,Di Paolo G,Chung S,Kim TW

更新日期：2006-12-19 00:00:00

abstract：:3H-Labeled complementary DNA specific for the envelope glycoprotein (env) gene of avian leukosis-sarcoma viruses was isolated by selective nucleic acid hybridization techniques, and used to analyze the expression of the endogenous provirus. The endogenous provirus in certain cell types termed chicken helper factor pos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayward WS,Hanafusa H

更新日期：1976-07-01 00:00:00

abstract：:Microinjection of progesterone dissolved in paraffin oil induces the reinitiation of meiotic maturation in the Xenopus oocyte; 50% maturation is obtained when 50 nl of a 50 microM solution is microinjected into the oocyte. The kinetics of the response to microinjected progesterone are similar to the kinetics of respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tso J,Thibier C,Mulner O,Ozon R

更新日期：1982-09-01 00:00:00

abstract：:Ectopic activation of the Wnt signaling pathway is highly oncogenic for many human tissues. Here, we show that ectopic Wnt signaling increases the effective stem cell activity in mouse mammary glands in vivo. Furthermore, Wnt effectors induce the accumulation of mouse mammary epithelial progenitors (assayed by Hoechst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu BY,McDermott SP,Khwaja SS,Alexander CM

更新日期：2004-03-23 00:00:00

abstract：:The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores, preventing unregul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang R,Pérez F,Kay LE

更新日期：2017-11-14 00:00:00

abstract：:One way to dissect the antibody response to an invading microorganism is to clone the antibody repertoire from immune donors and subsequently characterize the specific antibodies. Recently, methodological advances have allowed investigations of neutralizing antibodies against hepatitis C virus (HCV) in vitro. We have ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansson DX,Voisset C,Tarr AW,Aung M,Ball JK,Dubuisson J,Persson MA

更新日期：2007-10-09 00:00:00

abstract：:Sublethal insults can induce tolerance to subsequent stressors in neurons. As cell death activators such as ROS generation and decreased ATP can initiate tolerance, we tested whether other cellular elements normally associated with neuronal injury could add to this process. In an in vivo model of ischemic tolerance, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLaughlin B,Hartnett KA,Erhardt JA,Legos JJ,White RF,Barone FC,Aizenman E

更新日期：2003-01-21 00:00:00

abstract：:Focal cerebral ischemia and traumatic brain injury induce an escalating amount of cell death because of harmful mediators diffusing from the original lesion site. Evidence suggests that healthy cells surrounding these lesions attempt to protect themselves by producing endocannabinoids (eCBs) and activating cannabinoid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witting A,Chen L,Cudaback E,Straiker A,Walter L,Rickman B,Möller T,Brosnan C,Stella N

更新日期：2006-04-18 00:00:00

abstract：:The human retinoic acid receptor (hRAR) is a member of the nuclear receptor superfamily that regulates the transcription of target genes in a ligand-dependent manner. The three hRAR isotypes are targets for retinoids that are used in the treatment of various diseases, including breast cancer and skin diseases. Drug ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klaholz BP,Mitschler A,Belema M,Zusi C,Moras D

更新日期：2000-06-06 00:00:00

abstract：:Synapsin I is a neuron-specific phosphoprotein associated with the membranes of small synaptic vesicles. Its function is not entirely clear, but evidence points to a possible role in the regulation of neurotransmitter release. Its biosynthesis is under developmental control. Assignment of the human synapsin I gene to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,DeGennaro LJ,Francke U

更新日期：1986-11-01 00:00:00

abstract：:We derive more than 80 embeddings of 2D hyperbolic honeycombs in Euclidean 3 space, forming 3-periodic infinite polyhedra with cubic symmetry. All embeddings are "minimally frustrated," formed by removing just enough isometries of the (regular, but unphysical) 2D hyperbolic honeycombs [Formula: see text], [Formula: se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pedersen MC,Hyde ST

更新日期：2018-07-03 00:00:00

abstract：:Beta nerve growth factor (NGF), a target-derived protein necessary for survival and development of sympathetic and sensory neurons, can also affect subpopulations of neurons in the central nervous system (CNS). Using a blot hybridization assay capable of detecting 10 fg of mRNA, we measured the levels of NGF mRNA in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shelton DL,Reichardt LF

更新日期：1986-04-01 00:00:00

abstract：:Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its activated form, it participates in blood coagulation by activating factor X and/or factor IX in the presence of tissue factor and calcium. Clones coding for factor VII were obtained from two cDNA libraries prepared from poly(A) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen FS,Gray CL,O'Hara P,Grant FJ,Saari GC,Woodbury RG,Hart CE,Insley M,Kisiel W,Kurachi K

更新日期：1986-04-01 00:00:00

abstract：:A structural gene for the alpha-subunit of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6) has been identified and mapped between spcA and trkA, near 64 min on the E. coli chromosome. It appears to be coordinately expressed and possibly cotranscribed with the genes for ribosomal proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaskunas SR,Burgess RR,Nomura M

更新日期：1975-12-01 00:00:00

abstract：:Free hydrogen (H2) is a basal energy source underlying chemosynthetic activity within igneous ocean crust. In an attempt to systematically account for all H2 within young oceanic lithosphere (<10 Ma) near the Mid-Ocean Ridge (MOR), we construct a box model of this environment. Within this control volume, we assess abi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Worman SL,Pratson LF,Karson JA,Schlesinger WH

更新日期：2020-06-16 00:00:00

abstract：:Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Huang MT,Chang RL,Newmark HL,Lehr RE,Yagi H,Sayer JM,Jerina DM,Conney AH

更新日期：1982-09-01 00:00:00

abstract：:Efforts are underway to construct several recoded genomes anticipated to exhibit multivirus resistance, enhanced nonstandard amino acid (nsAA) incorporation, and capability for synthetic biocontainment. Although our laboratory pioneered the first genomically recoded organism (Escherichia coli strain C321.∆A), its fitn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wannier TM,Kunjapur AM,Rice DP,McDonald MJ,Desai MM,Church GM

更新日期：2018-03-20 00:00:00

abstract：:The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating amyloid β (Aβ)-peptides, e.g., Aβ1-42, is considered a critical step in the pathogenesis of Alzheimer's disease (AD). Although APP is a well-known membrane glycoprotein carrying both N- and O-glycans, nothing is known about th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halim A,Brinkmalm G,Rüetschi U,Westman-Brinkmalm A,Portelius E,Zetterberg H,Blennow K,Larson G,Nilsson J

更新日期：2011-07-19 00:00:00

abstract：:Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatara AM,Koons GL,Watson E,Piepergerdes TC,Shah SR,Smith BT,Shum J,Melville JC,Hanna IA,Demian N,Ho T,Ratcliffe A,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2019-04-02 00:00:00

abstract：:The self-assembled heterocapsule 1.2, which is formed by the hydrogen bonds of tetra(4-pyridyl)-cavitand 1 and tetrakis(4-hydroxyphenyl)-cavitand 2, encapsulates 1 molecule of guests such as 1,4-diacetoxybenzene 3a, 1,4-diacetoxy-2,5-dimethylbenzene 3b, 1,4-diacetoxy-2,5-dialkoxybenzenes (3c, OCH(3); 3d, OC(2)H(5); 3e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitagawa H,Kobori Y,Yamanaka M,Yoza K,Kobayashi K

更新日期：2009-06-30 00:00:00

abstract：:Interleukin 2 (IL-2) plays a critical role in the growth and differentiation of lymphoid cells. The IL-2 signal is delivered intracellularly by the IL-2 receptor beta chain (IL-2R beta); however, the mechanism by which the signal reaches the nucleus remains unclear. In this study, we demonstrate the rapid activation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hatakeyama M,Kawahara A,Mori H,Shibuya H,Taniguchi T

更新日期：1992-03-15 00:00:00

abstract：:Achieving long-term pancellular expression of a transferred gene at therapeutic level in a given hematopoietic lineage remains an important goal of gene therapy. Advances have recently been made in the genetic correction of the hemoglobinopathies by means of lentiviral vectors and large locus control region (LCR) deri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imren S,Payen E,Westerman KA,Pawliuk R,Fabry ME,Eaves CJ,Cavilla B,Wadsworth LD,Beuzard Y,Bouhassira EE,Russell R,London IM,Nagel RL,Leboulch P,Humphries RK

更新日期：2002-10-29 00:00:00

abstract：:Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Zhou J,Liu X,Lu D,Shen C,Du Y,Wei FZ,Song B,Lu X,Yu Y,Wang L,Zhao Y,Wang H,Yang Y,Akiyama Y,Zhang H,Zhu WG

更新日期：2013-04-02 00:00:00

abstract：:A high proportion of human B cells carry B-cell receptors (BCRs) that are autoreactive. Inhibitory receptors such as CD22 can downmodulate autoreactive BCR responses. With its extracellular domain, CD22 binds to sialic acids in α2,6 linkages in cis, on the surface of the same B cell or in trans, on other cells. Sialic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller J,Obermeier I,Wöhner M,Brandl C,Mrotzek S,Angermüller S,Maity PC,Reth M,Nitschke L

更新日期：2013-07-23 00:00:00

abstract：:Sex differences in parenting are common in species where both males and females provide care. Although there is a considerable body of game and optimality theory for why the sexes should differ in parental care, genetics can also play a role, and no study has examined how genetic influences might influence differences...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walling CA,Stamper CE,Smiseth PT,Moore AJ

更新日期：2008-11-25 00:00:00

abstract：:Most new genes are thought to evolve from preexisting genes but duplications of entire genes or shuffling of preexisting exons provides only a limited repertoire of new sequences that can be presented to a cell. Only pieces that previously existed can be used in the construction and any further divergence depends on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golding GB,Tsao N,Pearlman RE

更新日期：1994-08-02 00:00:00

abstract：:Memory CD4(+) T helper (Th) cells are central to long-term protection against pathogens, but they can also be pathogenic and drive chronic inflammatory disorders. How these pathogenic memory Th cells are maintained, particularly at sites of local inflammation, remains unclear. We found that ectopic lymphoid-like struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinoda K,Hirahara K,Iinuma T,Ichikawa T,Suzuki AS,Sugaya K,Tumes DJ,Yamamoto H,Hara T,Tani-Ichi S,Ikuta K,Okamoto Y,Nakayama T

更新日期：2016-05-17 00:00:00

abstract：:Rat serine dehydratase cDNA clones were isolated from a lambda gt11 cDNA library on the basis of their reactivity with monospecific immunoglobulin to the purified enzyme. Using the cDNA insert from a clone that encoded the serine dehydratase subunit as a probe, additional clones were isolated from the same library by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa H,Miller DA,Dunn T,Su Y,Burcham JM,Peraino C,Fujioka M,Babcock K,Pitot HC

更新日期：1988-08-01 00:00:00