Caspase 3 activation is essential for neuroprotection in preconditioning.

abstract：:Tritiated photoaffinity analogs of the natural lepidopteran juvenile hormones, JH I and II [epoxy[3H]bishomofarnesyl diazoacetate ([3H]EBDA) and epoxy[3H]homofarnesyl diazoacetate ([3H]EHDA)], and of the JH analog methoprene [[3H]methoprene diazoketone ([3H]MDK)] were synthesized and used to identify specific JH bindi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palli SR,Osir EO,Eng W,Boehm MF,Edwards M,Kulcsar P,Ujvary I,Hiruma K,Prestwich GD,Riddiford LM

更新日期：1990-01-01 00:00:00

abstract：:A novel type I transmembrane protein of COPI-coated vesicles, p23, has been demonstrated to be localized mainly to the Golgi complex. This protein and p24, another member of the p24 family, have been shown to bind coatomer via their short cytoplasmic tails. Here we demonstrate that p23 continuously cycles through the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nickel W,Sohn K,Bünning C,Wieland FT

更新日期：1997-10-14 00:00:00

abstract：:It is well documented that human modification of the hydrological cycle has profoundly affected the flow of liquid water across the Earth's land surface. Alteration of water vapor flows through land-use changes has received comparatively less attention, despite compelling evidence that such alteration can influence th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon LJ,Steffen W,Jönsson BF,Folke C,Falkenmark M,Johannessen A

更新日期：2005-05-24 00:00:00

abstract：:Previous work has established stargazin and its related family of transmembrane AMPA receptor regulatory proteins (TARPs) as auxiliary subunits of AMPA receptors (AMPARs) that control synaptic strength both by targeting AMPARs to synapses through an intracellular PDZ-binding motif and by modulating their gating throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milstein AD,Nicoll RA

更新日期：2009-07-07 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease in the tropics and subtropics with high morbidity and mortality. The facultative intracellular bacterium induces host cell fusion through its type VI secretion system 5 (T6SS5) as an important part of its pathogenesis in mammalian h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku JWK,Chen Y,Lim BJW,Gasser S,Crasta KC,Gan YH

更新日期：2020-07-07 00:00:00

abstract：:Retinoblastoma-related (RBR) proteins regulate cell division in higher eukaryotes by controlling the adenovirus E2 promoter binding factor (E2F)/dimerization partner (DP) family of transcription factors that regulate expression of many genes involved in cell-cycle progression. We identified a previously undescribed me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabelli PA,Dante RA,Leiva-Neto JT,Jung R,Gordon-Kamm WJ,Larkins BA

更新日期：2005-09-13 00:00:00

abstract：:Several different families of DNA viruses encode proteins that inactivate the cellular retinoblastoma tumor suppressor protein (pRb), which normally functions to bind E2F transcription factors and restrict expression of genes necessary for cellular processes including DNA replication. Human cytomegalovirus (HCMV) UL97...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamil JP,Hume AJ,Jurak I,Münger K,Kalejta RF,Coen DM

更新日期：2009-09-29 00:00:00

abstract：:A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological invest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granato DA,Fulpius BW,Moody JF

更新日期：1976-08-01 00:00:00

abstract：:Purified oat phytochrome was labeled with (125)I without altering the photoreversibility or absorbance properties of the pigment. The radiolabeled phytochrome was used in experiments in vitro to quantitate the binding of the pigment to both crude and purified membrane preparations from oat tissue. After the membranes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgevich G,Cedel TE,Roux SJ

更新日期：1977-10-01 00:00:00

abstract：:Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by modulating chromatin structure. In Drosophila, they have been found to be associated with transcriptionally inactive loci but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d Graaff W,Tomotsune D,Oosterveen T,Takihara Y,Koseki H,Deschamps J

更新日期：2003-11-11 00:00:00

abstract：:The phytochrome family of informational photoreceptors has a central role in regulating light-responsive gene expression, but the mechanism of intracellular signal transduction has remained elusive. In a genetic screen for T DNA-tagged Arabidopsis mutants affected in early signaling intermediates, we identified poc1 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halliday KJ,Hudson M,Ni M,Qin M,Quail PH

更新日期：1999-05-11 00:00:00

abstract：:Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hooper LV,Xu J,Falk PG,Midtvedt T,Gordon JI

更新日期：1999-08-17 00:00:00

abstract：:High vein density, a distinctive trait of C4 leaves, is central to both C3-to-C4 evolution and conversion of C3 to C4-like crops. We tested the hypothesis that high vein density in C4 leaves is due to elevated auxin biosynthesis and transport in developing leaves. Up-regulation of genes in auxin biosynthesis pathways ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang CF,Yu CP,Wu YH,Lu MJ,Tu SL,Wu SH,Shiu SH,Ku MSB,Li WH

更新日期：2017-08-15 00:00:00

abstract：:Synaptic transmission of the light response from photoreceptors to second-order cells of the retina was studied with the whole-cell patch-clamp technique in tiger salamander (Ambystoma tigrinum) retinal slices. Synaptic strength is modulated by extracellular pH in a striking manner: Light-sensitive postsynaptic curren...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnes S,Merchant V,Mahmud F

更新日期：1993-11-01 00:00:00

abstract：:In earlier studies with the acetylcholine receptor (AcChoR) of Electrophorus electricus the rate and equilibrium constants for a model that relates the ligand binding to ion translocation were determined, and the dependence of these constants on the concentrations of carbamoylcholine and acetylcholine, over a 200- and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess GP,Pasquale EB,Walker JW,McNamee MG

更新日期：1982-02-01 00:00:00

abstract：:The transcription of genes encoding gluconeogenic enzymes is tightly regulated during the perinatal period. These genes are induced by glucagon (cAMP) and glucocorticoids and repressed by insulin. To address the role of cAMP and glucocorticoids in the physiological activation of genes encoding gluconeogenic enzymes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montoliu L,Blendy JA,Cole TJ,Schütz G

更新日期：1995-05-09 00:00:00

abstract：:Ferredoxin was isolated from individual Leucaena glauca trees, and the distribution of amino acids at three of the four sites of sequence heterogeneity was determined. The results indicated that the most probable causes of the observed microheterogeneity are the presence of either nonallelic nuclear genes or differing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benson AM,Yasunobu KT

更新日期：1969-08-01 00:00:00

abstract：:Photoactivation of the retinal photoreceptor rhodopsin proceeds through a cascade of intermediates, resulting in protein-protein interactions catalyzing the activation of the G-protein transducin (Gt). Using stabilization and photoregeneration of the receptor's signaling state and Gt activation assays, we provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kisselev OG,Meyer CK,Heck M,Ernst OP,Hofmann KP

更新日期：1999-04-27 00:00:00

abstract：:The bright ultrafast pulses of X-ray Free-Electron Lasers allow investigation into the structure of matter under extreme conditions. We have used single pulses to ionize and probe water as it undergoes a phase transition from liquid to plasma. We report changes in the structure of liquid water on a femtosecond time sc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beyerlein KR,Jönsson HO,Alonso-Mori R,Aquila A,Bajt S,Barty A,Bean R,Koglin JE,Messerschmidt M,Ragazzon D,Sokaras D,Williams GJ,Hau-Riege S,Boutet S,Chapman HN,Tîmneanu N,Caleman C

更新日期：2018-05-29 00:00:00

abstract：:Murine embryonic stem (ES) cells were infected with a retrovirus promoter trap vector, and clones expressing lacZ fusion genes (LacZ+) were isolated by fluorescence-activated cell sorting (FACS). Of 12 fusion genes tested, 1 was repressed when ES cells were allowed to differentiate in vitro. Two of three lacZ fusion g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy S,Rayburn H,von Melchner H,Ruley HE

更新日期：1992-08-01 00:00:00

abstract：:In 2012, an unusual outbreak of urban malaria was reported from Djibouti City in the Horn of Africa and increasingly severe outbreaks have been reported annually ever since. Subsequent investigations discovered the presence of an Asian mosquito species; Anopheles stephensi, a species known to thrive in urban environme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinka ME,Pironon S,Massey NC,Longbottom J,Hemingway J,Moyes CL,Willis KJ

更新日期：2020-10-06 00:00:00

abstract：:Cancer stem cells (CSCs) sustain tumor growth through their ability to self-renew and to generate differentiated progeny. These functions endow CSCs with the potential to initiate secondary tumors bearing characteristics similar to those of the parent. Recently the hair follicle stem cell marker CD34 was used to purif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schober M,Fuchs E

更新日期：2011-06-28 00:00:00

abstract：:Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helbert W,Poulet L,Drouillard S,Mathieu S,Loiodice M,Couturier M,Lombard V,Terrapon N,Turchetto J,Vincentelli R,Henrissat B

更新日期：2019-03-26 00:00:00

abstract：:Individuals with higher educational attainment live healthier and longer lives. However, not everyone benefits equally from higher education. In particular, the black-white gap in life expectancy is greater at higher levels of educational attainment. Furthermore, recent research suggests that disadvantaged African Ame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaydosh L,Schorpp KM,Chen E,Miller GE,Harris KM

更新日期：2018-01-02 00:00:00

abstract：:The drought of progress in clinical brain tumor therapy provides an impetus for developing new treatments as well as methods for testing therapeutics in animal models. The inability of traditional assays to simultaneously measure tumor size, location, growth kinetics, and cell kill achieved by a treatment complicates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross BD,Zhao YJ,Neal ER,Stegman LD,Ercolani M,Ben-Yoseph O,Chenevert TL

更新日期：1998-06-09 00:00:00

abstract：:Ecological character displacement describes a pattern where morphological differences between sympatric species are enhanced through interspecific competition. Although widely considered a pervasive force in evolutionary ecology, few clear-cut examples have been documented. Here we report a case of ecological characte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DC,Rohlf FJ

更新日期：2000-04-11 00:00:00

abstract：:We have found that phagocytic leukocytes exposed to the tumor-promoting agent, 12-O-tetradecanoyl phorbol-13-acetate, efficiently release carbon-1 of 2-deoxyglucose in the form of CO2 with concurrent intracellular accumulation of a phosphorylated 5-carbon intermediate. In the absence of 12-O-tetradecanoyl phorbol-13-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabos P,Kyner D,Mendelsohn N,Schreiber C,Waxman S,Christman J,Acs G

更新日期：1978-11-01 00:00:00

abstract：:The primary photochemistry of Fe-depleted and Zn-reconstituted reaction centers from Rhodopseudomonas sphaeroides R-26.1 was studied by transient absorption spectroscopy and compared with native, Fe(2+)-containing reaction centers. Excitation of metal-free reaction centers with 30-ps flashes produced the initial charg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirmaier C,Holten D,Debus RJ,Feher G,Okamura MY

更新日期：1986-09-01 00:00:00

abstract：:The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand. Because macrophages play a key role in peripheral immunity, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashany D,Song X,Lacy E,Nikolic-Zugic J,Friedman SM,Elkon KB

更新日期：1995-11-21 00:00:00

abstract：:The photoproduct of carbon monoxide myoglobin generated at 4 K and lower has a resonance Raman spectrum characteristic of a high-spin heme but in which the high-frequency core size-sensitive lines are at lower frequency than those in the deoxy preparation. Such differences are not detected in the photoproduct generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousseau DL,Argade PV

更新日期：1986-03-01 00:00:00