Analysis of perinatal gene expression: hormone response elements mediate activation of a lacZ reporter gene in liver of transgenic mice.

abstract：:X-ray absorption spectra near the Kalpha edge have been measured in various iron group compounds using the intense synchrotron radiation at the Stanford Synchrotron Research Project. In the cubic compounds KMF3 where M = Mn+2, Fe+2, Co+2, Ni+2, and Zn+2, well resolved lines were observed and assigned to the 1s leads t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shulman GR,Yafet Y,Eisenberger P,Blumberg WE

更新日期：1976-05-01 00:00:00

abstract：:Intrinsic horizontal axon collaterals in the striate cortex of adult cats specifically link columns having the same preferred orientation; consequently, retrograde tracer injections result in intrinsic labeling that is sharply clustered. We have previously shown that the normal development of this circuitry involves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callaway EM,Katz LC

更新日期：1991-02-01 00:00:00

abstract：:Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tessé S,Storlazzi A,Kleckner N,Gargano S,Zickler D

更新日期：2003-10-28 00:00:00

abstract：:The genomes of hyperthermophilic Archaea encode dozens of methylation guide, C/D box small RNAs that guide 2'-O-methylation of ribose to specific sites in rRNA and various tRNAs. The genes encoding the Sulfolobus homologues of eukaryotic proteins that are known to be present in C/D box small nucleolar ribonucleoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Omer AD,Ziesche S,Ebhardt H,Dennis PP

更新日期：2002-04-16 00:00:00

abstract：:Grain yield in many cereal crops is largely determined by grain size. Here we report the genetic and molecular characterization of GS3, a major quantitative trait locus for grain size. It functions as a negative regulator of grain size and organ size. The wild-type isoform is composed of four putative domains: a plant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Sun S,Yao J,Wang C,Yu S,Xu C,Li X,Zhang Q

更新日期：2010-11-09 00:00:00

abstract：:Animal models of human cytomegalovirus (CMV) infections have not been available to study pathogenesis or to evaluate antiviral drugs. Severe combined immunodeficient mice implanted with human fetal tissues (SCID-hu) were found to support CMV replication and may provide a model for this species-specific virus. When con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mocarski ES,Bonyhadi M,Salimi S,McCune JM,Kaneshima H

更新日期：1993-01-01 00:00:00

abstract：:We have studied the genetic interactions between mutant alleles in 12 genes, designated PER1-PER12, which are essential for peroxisome biogenesis in the yeast Hansenula polymorpha. Recessive mutations in any of these genes determined three different morphological phenotypes: (i) complete absence of peroxisomes (Per-);...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Titorenko VI,Waterham HR,Cregg JM,Harder W,Veenhuis M

更新日期：1993-08-15 00:00:00

abstract：:The ability of long-term cultured and monoclonal T cell populations to provide antigen-specific help was assessed in a system of Ir gene-controlled in vitro antibody responses to soluble antigens. T-cell colonies and monoclonal T-cell lines were generated which proliferated specifically in response to poly(LTyr,Glu)-p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hodes RJ,Kimoto M,Hathcock KS,Fathman CG,Singer A

更新日期：1981-10-01 00:00:00

abstract：:During clathrin-mediated endocytosis, adaptor proteins recognize specific internalization signals on cargo receptors, either recruiting cargos into clathrin-coated pits (CCPs) or initiating clathrin-coat assembly around the cargo molecules. Here, we identify epsin 1, a clathrin-, ubiquitin-, and phospholipid-interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Zhuang X

更新日期：2008-08-19 00:00:00

abstract：:Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped homohexamers that enclose an internal degradation chamber. Here, we demonstrate that hexamers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieux EF,Wohlever ML,Chen JZ,Sauer RT,Baker TA

更新日期：2013-05-28 00:00:00

abstract：:As 3D culture has become central to investigation of tissue biology, mammary epithelial organoids have emerged as powerful tools for investigation of epithelial cell polarization and carcinogenesis. However, most current protocols start from single cells suspended in Matrigel, which can also restrict cell differentiat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Florian S,Iwamoto Y,Coughlin M,Weissleder R,Mitchison TJ

更新日期：2019-06-04 00:00:00

abstract：:Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu H,Fagnant PM,Bookwalter CS,Joel P,Trybus KM

更新日期：2015-08-04 00:00:00

abstract：:A debate has recently surfaced concerning the degree of precommitment attained by alpha beta and gamma delta T-cell precursors prior to T-cell receptor (TCR) gene rearrangement. It has been suggested that precursors may be precommitted to rearrange either alpha or delta genes, but not both, thus giving rise to alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson SD,Pelkonen J,Hurwitz JL

更新日期：1990-07-01 00:00:00

abstract：:Faithful transmission of genetic material to daughter cells involves a characteristic temporal order of DNA replication, which may play a significant role in the inheritance of epigenetic states. We developed a genome-scale approach--Repli Seq--to map temporally ordered replicating DNA using massively parallel sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen RS,Thomas S,Sandstrom R,Canfield TK,Thurman RE,Weaver M,Dorschner MO,Gartler SM,Stamatoyannopoulos JA

更新日期：2010-01-05 00:00:00

abstract：:Art forgeries have existed since antiquity, but with the recent rapidly expanding commercialization of art, the approach to art authentication has demanded increasingly sophisticated detection schemes. So far, the most conclusive criterion in the field of counterfeit detection is the scientific proof of material anach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendriks L,Hajdas I,Ferreira ESB,Scherrer NC,Zumbühl S,Smith GD,Welte C,Wacker L,Synal HA,Günther D

更新日期：2019-07-02 00:00:00

abstract：:A synthetic polymer has been prepared which contains dodecyl groups (to bind small substrate molecules) and methyleneimidazole side chains (as nucleophilic catalytic sites) linked to a polyethyleneimine framework. This macromolecule, with a high local concentration of binding and catalytic groups, catalyzes the hydrol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klotz IM,Royer GP,Scarpa IS

更新日期：1971-02-01 00:00:00

abstract：:Cells obtained from normal human skin synthesize predominantly type I collogen in culture. Cells obtained from the skin of an infant with a severe form of osteogenesis imperfecta were found to synthesize as much type III as type I collagen. Decreased synthesis of type I collagen could explain the tissue fragility obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penttinen RP,Lichtenstein JR,Martin GR,McKusick VA

更新日期：1975-02-01 00:00:00

abstract：:Secondary (i.e., heterotrophic or animal) production is a main pathway of energy flow through an ecosystem as it makes energy available to consumers, including humans. Its estimation can play a valuable role in the examination of linkages between ecosystem functions and services. We found that oil and gas platforms of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claisse JT,Pondella DJ 2nd,Love M,Zahn LA,Williams CM,Williams JP,Bull AS

更新日期：2014-10-28 00:00:00

abstract：:It is well established that exposure to solar UVB (290-320 nm) gives rise to mutations in oncogenes and tumor suppressor genes that initiate the molecular cascade toward skin cancer. Although UVA (320-400 nm) has also been implicated in multistage photocarcinogenesis, its potential contribution to sunlight mutagenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drobetsky EA,Turcotte J,Châteauneuf A

更新日期：1995-03-14 00:00:00

abstract：:The effect of metabolic depletion on the maturation-associated loss of membrane functions has been studied by using sheep reticulocytes incubated in vitro at 37 degrees C for periods up to 41 hr. ATP was either maintained with glucose, adenosine plus inosine, or depleted with 2-deoxyglucose plus arsenate. Two membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigensberg AM,Blostein R

更新日期：1983-08-01 00:00:00

abstract：:Some of the most important impacts of global climate change will be felt among the populations, predominantly in developing countries, referred to as "subsistence" or "smallholder" farmers. Their vulnerability to climate change comes both from being predominantly located in the tropics, and from various socioeconomic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton JF

更新日期：2007-12-11 00:00:00

abstract：:Cytochrome P450IIC5 (rabbit liver 21-hydroxylase) is unusual among hepatic forms of cytochromes P450 because it catalyzes the conversion of one active steroid hormone (progesterone) to another active hormone (deoxycorticosterone). Another interesting aspect of this steroid-hydroxylating enzyme is the ability to conver...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trant JM,Lorence MC,Johnson EF,Shackleton CH,Mason JI,Estabrook RW

更新日期：1990-12-01 00:00:00

abstract：:All decisions, whether they are personal, public, or business-related, are based on the decision maker's beliefs and values. Science can and should help decision makers by shaping their beliefs. Unfortunately, science is not easily accessible to decision makers, and scientists often do not understand decision makers' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Winterfeldt D

更新日期：2013-08-20 00:00:00

abstract：:We propose approaching prediction from a framework grounded in the theoretical correct prediction rate of a variable set as a parameter of interest. This framework allows us to define a measure of predictivity that enables assessing variable sets for, preferably high, predictivity. We first define the prediction rate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lo A,Chernoff H,Zheng T,Lo SH

更新日期：2016-12-13 00:00:00

abstract：:A duplex 21 nucleotide small interfering RNA (siRNA) against human Keap1 is described that represents a unique class of cancer chemopreventive agent. This siRNA can knockdown Keap1 mRNA and thereby relieve negative regulation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-mediated gene expression. The siRNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devling TW,Lindsay CD,McLellan LI,McMahon M,Hayes JD

更新日期：2005-05-17 00:00:00

abstract：:Originally identified as an essential component of the herpes simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory circuits. The protein mediates activation through multiple interactions with tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narayanan A,Ruyechan WT,Kristie TM

更新日期：2007-06-26 00:00:00

abstract：:T-regulatory cells (Treg) and mast cells (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions and autoimmunity. Here, we demonstrate that in both human CRC and murine polyposis the outcome of this interaction is the generation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatner NR,Bonertz A,Beckhove P,Cheon EC,Krantz SB,Strouch M,Weitz J,Koch M,Halverson AL,Bentrem DJ,Khazaie K

更新日期：2010-04-06 00:00:00

abstract：:We have identified two chromosomal genes of Escherichia coli K12 that are required for the expression of conjugative plasmid functions in the presence of normal plasmid DNA. Hfr cells with mutations in both of these genes are resistant to donor-specific bacteriophage and defective as conjugal donors. These characteris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McEwen J,Silverman P

更新日期：1980-01-01 00:00:00

abstract：:Mutations in the GABA(A) receptor gamma2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a mouse model harboring a gamma2 subunit point mutation (R43Q) found in a large Australian family. Mice heterozygous fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan HO,Reid CA,Single FN,Davies PJ,Chiu C,Murphy S,Clarke AL,Dibbens L,Krestel H,Mulley JC,Jones MV,Seeburg PH,Sakmann B,Berkovic SF,Sprengel R,Petrou S

更新日期：2007-10-30 00:00:00

abstract：:Public responses where identical T cell receptors (TCRs) are clonally dominant and shared between different individuals are a common characteristic of CD8(+) T cell-mediated immunity. Focusing on TCR sharing, we analyzed approximately 3,400 TCR beta chains (TCRbetas) from mouse CD8(+) T cells responding to the influen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venturi V,Kedzierska K,Price DA,Doherty PC,Douek DC,Turner SJ,Davenport MP

更新日期：2006-12-05 00:00:00