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Energy depletion retards the loss of membrane transport during reticulocyte maturation.

Abstract：

:The effect of metabolic depletion on the maturation-associated loss of membrane functions has been studied by using sheep reticulocytes incubated in vitro at 37 degrees C for periods up to 41 hr. ATP was either maintained with glucose, adenosine plus inosine, or depleted with 2-deoxyglucose plus arsenate. Two membrane transport systems were studied: Na+-dependent glycine transport activity and the sodium pump, estimated from measurements of the number of [3H]ouabain binding sites per cell. Both transport systems were decreased during maturation. However, the decrease was much less in ATP-depleted cells compared to ATP-replete cells. It is concluded that the loss of certain functions during reticulocyte maturation is retarded by metabolic depletion.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Weigensberg AM,Blostein R

doi

10.1073/pnas.80.16.4978

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

4978-82

issue

16

eissn

0027-8424

issn

1091-6490

journal_volume

80

pub_type

杂志文章

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