Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.

abstract：:Insects have diversified through more than 450 million y of Earth's changeable climate, yet rapidly shifting patterns of temperature and precipitation now pose novel challenges as they combine with decades of other anthropogenic stressors including the conversion and degradation of land. Here, we consider how insects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halsch CA,Shapiro AM,Fordyce JA,Nice CC,Thorne JH,Waetjen DP,Forister ML

更新日期：2021-01-12 00:00:00

abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

更新日期：1994-03-15 00:00:00

abstract：:The structure of respiratory cytochrome c551 of Pseudomonas aeruginosa, with 82 amino acids, has been solved by x-ray analysis and refined to a crystallographic R factor of 16.2%. It has the same basic folding pattern and hydrophobic heme environment as cytochromes c, c2, and c550, except for a large deletion at the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almassy RJ,Dickerson RE

更新日期：1978-06-01 00:00:00

abstract：:An antigen histochemically localized in the nuclei and cytoplasmic granules of normal and leukemic human myeloid cells has been identified as myeloperoxidase (MPO; EC 1.11.1.7). The localization and amount of the enzyme was determined by using a murine monoclonal antibody designated H-43-5 raised against nuclear prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murao S,Stevens FJ,Ito A,Huberman E

更新日期：1988-02-01 00:00:00

abstract：:We have identified a major T-cell epitope, amino acids 48-54 (DRAHYNI, in one-letter code) in the E7 open reading frame protein of human papillomavirus (HPV) type 16. Lymph node cells from mice immunized with synthetic peptides containing DRAHYNI proliferated and produced interleukin when challenged in vitro with pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tindle RW,Fernando GJ,Sterling JC,Frazer IH

更新日期：1991-07-01 00:00:00

abstract：:Unlike the dominant role of one class II invariant chain peptide (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of differentiation (CD) proteins CD1a, CD1b, CD1c, and CD1d bind lipids corresponding to hundreds of diverse accurate mass retention time values. Although most ions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Cheng TY,Young DC,Layre E,Madigan CA,Shires J,Cerundolo V,Altman JD,Moody DB

更新日期：2011-11-29 00:00:00

abstract：:A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JZ,Bunney BG,Meng F,Hagenauer MH,Walsh DM,Vawter MP,Evans SJ,Choudary PV,Cartagena P,Barchas JD,Schatzberg AF,Jones EG,Myers RM,Watson SJ Jr,Akil H,Bunney WE

更新日期：2013-06-11 00:00:00

abstract：:The frequencies of diverse rearrangements of variable (V)lambda to joining (J)lambda gene segments were examined by Southern blot hybridization in 30 murine B-cell lines, each producing an immunoglobulin lambda light chain of known subtype (lambda 1, lambda 2, or lambda 3). For 11 out of 12 lambda 1 chains, the rearra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reilly EB,Blomberg B,Imanishi-Kari T,Tonegawa S,Eisen HN

更新日期：1984-04-01 00:00:00

abstract：:Within the basal ganglia, acetylcholine and dopamine play a central role in the extrapyramidal control of motor function. The physiologic effects of these neurotransmitters are mediated by a diversity of receptor subtypes, several of which have now been cloned. Muscarinic acetylcholine receptors are encoded by five ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner DM,Levey AI,Brann MR

更新日期：1990-09-01 00:00:00

abstract：:CD4 can physically associate with the CD3-T-cell receptor complex as visualized in cocapping experiments. This association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate with CD4. Similar as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojo JM,Saizawa K,Janeway CA Jr

更新日期：1989-05-01 00:00:00

abstract：:In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

更新日期：2015-02-17 00:00:00

abstract：:We have used oligonucleotide-directed mutagenesis to make a specific change in the beta-lactamase (EC 3.5.2.6) (ampicillin resistance) gene of the plasmid pBR322. Evidence suggests that the active site for this enzyme may include a serine-threonine dyad (residues 70 and 71). By priming in vitro DNA synthesis with a ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dalbadie-McFarland G,Cohen LW,Riggs AD,Morin C,Itakura K,Richards JH

更新日期：1982-11-01 00:00:00

abstract：:The with-no-lysine (K) (WNK) kinases are an atypical family of protein kinases that regulate ion transport across cell membranes. Mutations that result in their overexpression cause hypertension-related disorders in humans. Of the four mammalian WNKs, only WNK1 is expressed throughout the body. We report that WNK1 inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallolu Kankanamalage S,Lee AY,Wichaidit C,Lorente-Rodriguez A,Shah AM,Stippec S,Whitehurst AW,Cobb MH

更新日期：2016-12-13 00:00:00

abstract：:Throughout time, operational laws and concepts from complex systems have been employed to quantitatively model important aspects and interactions in nature and society. Nevertheless, it remains enigmatic and challenging, yet inspiring, to predict the actual interdependencies that comprise the structure of such systems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stavroglou SK,Pantelous AA,Stanley HE,Zuev KM

更新日期：2020-04-07 00:00:00

abstract：:A central unresolved issue in evolutionary biology is how metabolic innovations emerge. Low-level enzymatic side activities are frequent and can potentially be recruited for new biochemical functions. However, the role of such underground reactions in adaptation toward novel environments has remained largely unknown a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Notebaart RA,Szappanos B,Kintses B,Pál F,Györkei Á,Bogos B,Lázár V,Spohn R,Csörgő B,Wagner A,Ruppin E,Pál C,Papp B

更新日期：2014-08-12 00:00:00

abstract：:Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harkins J,Arsenault M,Schlesinger K,Kates J

更新日期：1972-11-01 00:00:00

abstract：:For reasons that are unclear the production of embryonic stem cells from ungulates has proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, hOCT4, hSOX2, hKLF4, and hc-MYC, the combination commonly used to create...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ezashi T,Telugu BP,Alexenko AP,Sachdev S,Sinha S,Roberts RM

更新日期：2009-07-07 00:00:00

abstract：:Peroxisome proliferators (PP) induce a highly predictable pleiotropic response in rat and mouse liver that is characterized by hepatomegaly, increase in peroxisome number in hepatocytes, and induction of certain peroxisomal enzymes. The PP-binding protein (PPbP) was purified from rat liver cytosol by a two-step proced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalwani ND,Alvares K,Reddy MK,Reddy MN,Parikh I,Reddy JK

更新日期：1987-08-01 00:00:00

abstract：:The neural mechanisms used by the human brain to identify phonemes remain unclear. We recorded the EEG signals evoked by repeated presentation of 12 American English phonemes. A support vector machine model correctly recognized a high percentage of the EEG brain wave recordings represented by their phases, which were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang R,Perreau-Guimaraes M,Carvalhaes C,Suppes P

更新日期：2012-12-11 00:00:00

abstract：:Complex three-dimensional biophotonic nanostructures produce the vivid structural colors of many butterfly wing scales, but their exact nanoscale organization is uncertain. We used small angle X-ray scattering (SAXS) on single scales to characterize the 3D photonic nanostructures of five butterfly species from two fam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saranathan V,Osuji CO,Mochrie SG,Noh H,Narayanan S,Sandy A,Dufresne ER,Prum RO

更新日期：2010-06-29 00:00:00

abstract：:Paleoclimate studies suggest that increased global warmth during the Eocene epoch was greatly amplified at high latitudes, a state that climate models cannot fully reproduce. However, proxy estimates of Eocene near-Antarctic sea surface temperatures (SSTs) have produced widely divergent results at similar latitudes, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglas PM,Affek HP,Ivany LC,Houben AJ,Sijp WP,Sluijs A,Schouten S,Pagani M

更新日期：2014-05-06 00:00:00

abstract：:NifEN is a key player in the biosynthesis of nitrogenase MoFe protein. It not only shares a considerable degree of sequence homology with the MoFe protein, but also contains clusters that are homologous to those found in the MoFe protein. Here we present an investigation of the catalytic activities of NifEN. Our data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Y,Yoshizawa JM,Fay AW,Lee CC,Wiig JA,Ribbe MW

更新日期：2009-10-06 00:00:00

abstract：:The eyes of some aquatic animals form images through reflective optics. Shrimp, lobsters, crayfish, and prawns possess reflecting superposition compound eyes, composed of thousands of square-faceted eye units (ommatidia). Mirrors in the upper part of the eye (the distal mirror) reflect light collected from many ommati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmer BA,Hirsch A,Brumfeld V,Aflalo ED,Pinkas I,Sagi A,Rosenne S,Oron D,Leiserowitz L,Kronik L,Weiner S,Addadi L

更新日期：2018-03-06 00:00:00

abstract：:Exocytotic membrane fusion and secretion are promoted by the concerted action of GTP and Ca2+, although the precise site(s) of action in the process are not presently known. However, the calcium-dependent membrane fusion reaction driven by synexin (annexin VII) is an in vitro model for this process, which we have now ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caohuy H,Srivastava M,Pollard HB

更新日期：1996-10-01 00:00:00

abstract：:The region of human chromosome 22q11 is prone to rearrangements. The resulting chromosomal abnormalities are involved in Velo-cardio-facial and DiGeorge syndromes (VCFS and DGS) (deletions), "cat eye" syndrome (duplications), and certain types of tumors (translocations). As a prelude to the development of mouse models...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puech A,Saint-Jore B,Funke B,Gilbert DJ,Sirotkin H,Copeland NG,Jenkins NA,Kucherlapati R,Morrow B,Skoultchi AI

更新日期：1997-12-23 00:00:00

abstract：:Periodicities in the polar/apolar character of the amino acid sequence of a protein can be examined by assigning to each residue a numerical hydrophobicity and searching for periodicity in the resulting one-dimensional function. The strength of each periodic component is the quantity that has been termed the hydrophob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenberg D,Weiss RM,Terwilliger TC

更新日期：1984-01-01 00:00:00

abstract：:The receptor-like tyrosine kinase (Ryk), a Wnt receptor, is important for cell fate determination during corticogenesis. During neuronal differentiation, the Ryk intracellular domain (ICD) is cleaved. Cleavage of Ryk and nuclear translocation of Ryk-ICD are required for neuronal differentiation. However, the mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang WH,Choi SH,Moon BS,Cai M,Lyu J,Bai J,Gao F,Hajjali I,Zhao Z,Campbell DB,Weiner LP,Lu W

更新日期：2017-12-12 00:00:00

abstract：:Networks are widely used in the biological, physical, and social sciences as a concise mathematical representation of the topology of systems of interacting components. Understanding the structure of these networks is one of the outstanding challenges in the study of complex systems. Here we describe a general techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newman ME,Leicht EA

更新日期：2007-06-05 00:00:00

abstract：:The action of cyclin-dependent kinases (CDKs) is regulated by phosphorylation, cyclin levels, the abundance of CDK inhibitors, and, as recently has been shown for cyclin B/cdc2, their localization. It is unclear how localization regulates the action of cyclin E/Cdk2 and its inhibitors. Here, we show that the closest k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson C,Ross J,Jackson PK

更新日期：2000-07-05 00:00:00

abstract：:We report here that component members of the keratin intermediate filament (IF) type I and type II gene families of sheep are closely linked but apparently the two families are not. Nine genes, accounting for up to half of the keratin IF gene repertoire, were mapped in four cosmid clones and the linkage between the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powell BC,Cam GR,Fietz MJ,Rogers GE

更新日期：1986-07-01 00:00:00