Optically functional isoxanthopterin crystals in the mirrored eyes of decapod crustaceans.

abstract：:Thermus thermophilus possesses an aspartyl-tRNA synthetase (AspRS2) able to aspartylate efficiently tRNAAsp and tRNAAsn. Aspartate mischarged on tRNAAsn then is converted into asparagine by an omega amidase that differs structurally from all known asparagine synthetases. However, aspartate is not misincorporated into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker HD,Kern D

更新日期：1998-10-27 00:00:00

abstract：:The time course of thermal reactions after illumination of 100% humidified bacteriorhodopsin films was followed with FTIR spectroscopy between 125 and 195 K. We monitored the conversion of the initial photoproduct, K, to the next, L intermediate, and a shunt reaction of the L state directly back to the initial BR stat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dioumaev AK,Lanyi JK

更新日期：2007-06-05 00:00:00

abstract：:Seed development in plants involves the coordinated growth of the embryo, endosperm, and maternal tissue. Several genes have been identified that influence seed size by acting maternally, such as AUXIN RESPONSE FACTOR2, APETALA2, and DA1. However, given the lack of gain-of-function effects of these genes on seed size,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamski NM,Anastasiou E,Eriksson S,O'Neill CM,Lenhard M

更新日期：2009-11-24 00:00:00

abstract：:DNA and protein determinants of nucleosome positioning have been examined after in vitro reconstitutions of native or modified histone octamers onto tandem repeats of 207- and 172-base-pair DNA sequences containing the Lytechinus variegatus 5S rRNA gene and onto monomeric sequences derived from these by digestion with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong F,Hansen JC,van Holde KE

更新日期：1990-08-01 00:00:00

abstract：:DNA sequence complementary to Trypanosoma brucei mRNAs coding for the synthesis of the variant-specific antigens AnTat 1.1 and AnTat 1.8 have been cloned and characterized. These sequences have been used as probes to analyze the corresponding genes in the nuclear DNA. The two genes seem to be represented in several (t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pays E,Van Meirvenne N,Le Ray D,Steinert M

更新日期：1981-05-01 00:00:00

abstract：:In many human cancers, tumor-specific chromosomal rearrangements are known to create chimeric products with the ability to transform cells. The EWS/WT1 protein is such a fusion product, resulting from a t(11;22) chromosomal translocation in desmoplastic small round cell tumors, where 265 aa from the EWS amino terminus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim J,Lee JM,Branton PE,Pelletier J

更新日期：1999-12-07 00:00:00

abstract：:Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23.8 to 28.1 months and preserves aspects of their youthful state. Similar results were seen in New Zealand Black females beginning at 5 months and C57BL/6 males ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pierpaoli W,Regelson W

更新日期：1994-01-18 00:00:00

abstract：:There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (GH) cells are arranged in functionally organized networks raises the possibility that the responses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez-Cardenas C,Fontanaud P,He Z,Lafont C,Meunier AC,Schaeffer M,Carmignac D,Molino F,Coutry N,Bonnefont X,Gouty-Colomer LA,Gavois E,Hodson DJ,Le Tissier P,Robinson IC,Mollard P

更新日期：2010-12-14 00:00:00

abstract：:Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian syste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris CJ,Purvis TE,Hu K,Scheer FA

更新日期：2016-03-08 00:00:00

abstract：:Skin fibroblasts from two patients who had symptoms of the Sanfilippo syndrome (mucopolysaccharidosis III) accumulated excessive amounts of heparan sulfate and were unable to release sulfate from N-acetylglucosamine-6-sulfate linkages in heparan sulfate-derived oligosaccharides. Keratan sulfate-derived oligosaccharide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kresse H,Paschke E,von Figura K,Gilberg W,Fuchs W

更新日期：1980-11-01 00:00:00

abstract：:There is a tightly coupled bidirectional interaction between visual cortex and visual thalamus [lateral geniculate nucleus (LGN)]. Using drifting sinusoidal grating stimuli, we compared the response of cells in the LGN with and without feedback from the visual cortex. Raster plots revealed a striking difference in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andolina IM,Jones HE,Wang W,Sillito AM

更新日期：2007-01-30 00:00:00

abstract：:BALB/c mice immunized with syngeneic methylcholanthrene-induced fibrosarcomas did not have antibodies against the unique tumor-specific transplantation antigens, even though they were capable of rejecting a lethal dose of tumor cells. Endogenous murine leukemia virus antigens expressed by certain of the tumors did, ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JP,Klitzman JM,Hellström I,Nowinski RC,Hellström KE

更新日期：1978-02-01 00:00:00

abstract：:Hitherto it has not been possible to obtain spore and stalk cell differentiation of the cellular slime molds in submerged cultures. It is shown here that cells, when placed in roller tubes under an atmosphere of oxygen, will form clumps and differentiate in 48-72 hr into mature spores and stalk cells. Although differe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternfeld J,Bonner JT

更新日期：1977-01-01 00:00:00

abstract：:The observation that the age-specific incidence curve of many carcinomas is approximately linear on a double logarithmic plot has led to much speculation regarding the number and nature of the critical events involved in carcinogenesis. By a consideration of colorectal and pancreatic cancers in the Surveillance Epidem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meza R,Jeon J,Moolgavkar SH,Luebeck EG

更新日期：2008-10-21 00:00:00

abstract：:The underlying structure is taken as a strongly superharmonic cone [unk], defined as a partially ordered abelian semigroup with identity 0 which admits a multiplication by nonnegative scalars and satisfies two fundamental axioms of a potentialtheoretic character. In terms of a fixed nonzero element e there is introduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsove M,Leutwiler H

更新日期：1975-07-01 00:00:00

abstract：:The nucleotide sequence of a 1,163-base-pair fragment that encodes the entire thyA gene of Escherichia coli K-12 was determined. The strategy involved sequence determination of both DNA strands by using overlapping deletions that had been generated in vitro from the two ends of the fragment with BAL-31 nuclease. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belfort M,Maley G,Pedersen-Lane J,Maley F

更新日期：1983-08-01 00:00:00

abstract：:High-accuracy ab initio folding has remained an elusive objective despite decades of effort. To explore the folding landscape of villin headpiece subdomain HP35, we conducted two sets of replica exchange molecular dynamics for 200 ns each and three sets of conventional microsecond-long molecular dynamics simulations, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lei H,Wu C,Liu H,Duan Y

更新日期：2007-03-20 00:00:00

abstract：:Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bons N,Mestre-Frances N,Belli P,Cathala F,Gajdusek DC,Brown P

更新日期：1999-03-30 00:00:00

abstract：:To investigate the mechanisms of asbestos-induced carcinogenesis, expression of c-fos and c-jun protooncogenes was examined in rat pleural mesothelial cells and hamster tracheal epithelial cells after exposure to crocidolite or chrysotile asbestos. In contrast to phorbol 12-myristate 13-acetate, which induces rapid an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heintz NH,Janssen YM,Mossman BT

更新日期：1993-04-15 00:00:00

abstract：:Salicylic acid (SA) plays an important role in activating various plant defense responses, including expression of the pathogenesis-related (PR) genes and systemic acquired resistance. A critical positive regulator of the SA signaling pathway in Arabidopsis is encoded by the NPR1 gene. However, there is growing eviden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kachroo P,Shanklin J,Shah J,Whittle EJ,Klessig DF

更新日期：2001-07-31 00:00:00

abstract：:Injection of rat kidney cortex mRNA into Xenopus laevis oocytes leads to a stimulation of Na(+)-dependent SO4(2-) uptake. Based on this information, we have isolated from a corresponding library a cDNA (NaSi-1) that is most likely related to a Na+/SO4(2-) cotransport system. NaSi-1 cRNA leads in a time- and dose-depen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markovich D,Forgo J,Stange G,Biber J,Murer H

更新日期：1993-09-01 00:00:00

abstract：:An unbiased survey has been made of the stable, most abundant multi-protein complexes in Desulfovibrio vulgaris Hildenborough (DvH) that are larger than Mr approximately 400 k. The quaternary structures for 8 of the 16 complexes purified during this work were determined by single-particle reconstruction of negatively ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han BG,Dong M,Liu H,Camp L,Geller J,Singer M,Hazen TC,Choi M,Witkowska HE,Ball DA,Typke D,Downing KH,Shatsky M,Brenner SE,Chandonia JM,Biggin MD,Glaeser RM

更新日期：2009-09-29 00:00:00

abstract：:Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback-controlled confinement of single cells w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cattin CJ,Düggelin M,Martinez-Martin D,Gerber C,Müller DJ,Stewart MP

更新日期：2015-09-08 00:00:00

abstract：:The patterns of variations in fisheries time series are known to result from a complex combination of species and fisheries dynamics all coupled with environmental forcing (including climate, trophic interactions, etc.). Disentangling the relative effects of these factors has been a major goal of fisheries science for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouyer T,Fromentin JM,Ménard F,Cazelles B,Briand K,Pianet R,Planque B,Stenseth NC

更新日期：2008-04-08 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chemically diverse substrates across the lipid bilayer. The precise molecular mechanism underlying transport is not fully understood. Here, we present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 from Cyanidi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodan A,Yamaguchi T,Nakatsu T,Sakiyama K,Hipolito CJ,Fujioka A,Hirokane R,Ikeguchi K,Watanabe B,Hiratake J,Kimura Y,Suga H,Ueda K,Kato H

更新日期：2014-03-18 00:00:00

abstract：:Sparse sensor placement is a central challenge in the efficient characterization of complex systems when the cost of acquiring and processing data is high. Leading sparse sensing methods typically exploit either spatial or temporal correlations, but rarely both. This work introduces a sparse sensor optimization that i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohren TL,Daniel TL,Brunton SL,Brunton BW

更新日期：2018-10-16 00:00:00

abstract：:Mobilization of the T-cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to harness antigen-presenting cells optimally to achieve an effective antitumor T-cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tseng D,Volkmer JP,Willingham SB,Contreras-Trujillo H,Fathman JW,Fernhoff NB,Seita J,Inlay MA,Weiskopf K,Miyanishi M,Weissman IL

更新日期：2013-07-02 00:00:00

abstract：:The Suppressor of Fused [Su(fu)] protein plays a conserved role in the regulation of Gli transcription factors of the hedgehog (Hh) signaling pathway that controls cell fate and tissue patterning during development. In both Drosophila and mammals, Su(fu) represses Gli-mediated transcription, but the mode of its action...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng SY,Bishop JM

更新日期：2002-04-16 00:00:00

abstract：:The enzymic activity of crystalline mitochondrial aspartate aminotransferase (L-aspartate:2-oxoglutarate aminotransferase, EC 2.6.1.1) was determined in suspensions of noncrosslinked microcrystals in 30% (wt/vol) polyethylene glycol. The crystals (average dimensions, 22 x 5 x 0.8 micron) were small enough to preclude ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirsten H,Gehring H,Christen P

更新日期：1983-04-01 00:00:00