Pineal control of aging: effect of melatonin and pineal grafting on aging mice.

abstract：:Particle tracking is a powerful biophysical tool that requires conversion of large video files into position time series, i.e., traces of the species of interest for data analysis. Current tracking methods, based on a limited set of input parameters to identify bright objects, are ill-equipped to handle the spectrum o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newby JM,Schaefer AM,Lee PT,Forest MG,Lai SK

更新日期：2018-09-04 00:00:00

abstract：:During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Knaak T,Satkamp L,Humbert O,Falkow S,Ramakrishnan L

更新日期：2002-03-19 00:00:00

abstract：:Induction, maintenance, and amplification of tumor-protective immunity after cytokine gene therapy is essential for the clinical success of immunotherapeutic approaches. We investigated whether this could be achieved by single-chain IL-12 (scIL-12) gene therapy followed by tumor-targeted IL-2 using a fusion protein co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Xiang R,Duncan SR,Theofilopoulos AN,Gillies SD,Reisfeld RA

更新日期：1999-07-20 00:00:00

abstract：:The massive forests of central Amazonia are often considered relatively resilient against climatic variation, but this view is challenged by the wildfires invoked by recent droughts. The impact of such fires that spread from pervasive sources of ignition may reveal where forests are less likely to persist in a drier f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores BM,Holmgren M,Xu C,van Nes EH,Jakovac CC,Mesquita RCG,Scheffer M

更新日期：2017-04-25 00:00:00

abstract：:I summarize recent computational and experimental work that addresses the inherent variability in the synaptic and intrinsic conductances in normal healthy brains and shows that multiple solutions (sets of parameters) can produce similar circuit performance. I then discuss a number of issues raised by this observation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E

更新日期：2011-09-13 00:00:00

abstract：:Structural information about rat enteroglucagon, intestinal peptides containing the pancreatic glucagon sequence, has been based previously on cDNA, immunologic, and chromatographic data. Our interests in testing the physiological actions of synthetic enteroglucagon peptides in rats required that we identify precisely...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collie NL,Walsh JH,Wong HC,Shively JE,Davis MT,Lee TD,Reeve JR Jr

更新日期：1994-09-27 00:00:00

abstract：:Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AM,Milner B,Petrides M,Evans AC

更新日期：1996-08-20 00:00:00

abstract：:Midbrain dopamine neurons play central roles in reward processing. It is widely assumed that all dopamine neurons encode the same information. Some evidence, however, suggests functional differences between subgroups of dopamine neurons, particularly with respect to processing nonrewarding, aversive stimuli. To direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brischoux F,Chakraborty S,Brierley DI,Ungless MA

更新日期：2009-03-24 00:00:00

abstract：:IL-27-induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10. Signal transducer and activator of transcription (STAT) 1 and STAT3 have been described as key transcription factors that promote IL-10 secretion from Tr1 cells induced by IL-27. However, the molecular pathways for negatively regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu C,Pot C,Apetoh L,Thalhamer T,Zhu B,Murugaiyan G,Xiao S,Lee Y,Rangachari M,Yosef N,Kuchroo VK

更新日期：2013-05-07 00:00:00

abstract：:Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Zhu LL,Lu P,Yuen T,Li J,Ma R,Baliram R,Moonga SS,Liu P,Zallone A,New MI,Davies TF,Zaidi M

更新日期：2013-06-11 00:00:00

abstract：:Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ros-Bernal F,Hunot S,Herrero MT,Parnadeau S,Corvol JC,Lu L,Alvarez-Fischer D,Carrillo-de Sauvage MA,Saurini F,Coussieu C,Kinugawa K,Prigent A,Höglinger G,Hamon M,Tronche F,Hirsch EC,Vyas S

更新日期：2011-04-19 00:00:00

abstract：:MAD2 inhibits the anaphase-promoting complex when chromosomes are unattached to the mitotic spindle. It acts as a tumor suppressor gene because MAD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung tumors in mice. Complete MAD2 inactivation has not been identified in hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michel L,Diaz-Rodriguez E,Narayan G,Hernando E,Murty VV,Benezra R

更新日期：2004-03-30 00:00:00

abstract：:Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

更新日期：2000-01-04 00:00:00

abstract：:Compared with the U.S., Japan is believed to have a collectivist culture that nurtures high trust. Results from laboratory and survey research, however, show that Americans are more likely to trust strangers than are Japanese. Why would trust be lower in a collectivist culture? We use an agent-based computational mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macy MW,Sato Y

更新日期：2002-05-14 00:00:00

abstract：:The present study investigated whether neural structures become less functionally differentiated and specialized with age. We studied ventral visual cortex, an area of the brain that responds selectively to visual categories (faces, places, and words) in young adults, and that shows little atrophy with age. Functional...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park DC,Polk TA,Park R,Minear M,Savage A,Smith MR

更新日期：2004-08-31 00:00:00

abstract：:A library of amphiphilic Janus dendrimers including two that are fluorescent and one glycodendrimer presenting lactose were used to construct giant dendrimersomes and glycodendrimersomes. Coassembly with the components of bacterial membrane vesicles by a dehydration-rehydration process generated giant cell-like hybrid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Q,Yadavalli SS,Zhang S,Sherman SE,Fiorin E,da Silva L,Wilson DA,Hammer DA,André S,Gabius HJ,Klein ML,Goulian M,Percec V

更新日期：2016-03-01 00:00:00

abstract：:The effect of plasmin-derived fibrinogen fragments on the biosynthesis of fibrinogen was investigated in cultured monolayers of rat hepatocytes. Incubating the cells with several concentrations of either fibrinogen or fibrin fragment D or E had no effect on the synthesis and secretion of fibrinogen by these cells. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ritchie DG,Levy BA,Adams MA,Fuller GM

更新日期：1982-03-01 00:00:00

abstract：:Over the past five decades, ultra high vacuum (uhv) techniques applied to well-defined single-crystal samples (the "surface science paradigm") have transformed our understanding of fundamental surface chemistry. To translate this success to the world of realistic heterogeneous catalysis, however, requires one seriousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyngaran P,Madden DC,Jenkins SJ,King DA

更新日期：2011-01-18 00:00:00

abstract：:Transient expression of either alpha or alpha + beta subunits of the high-conductance Ca2+-activated K+ (maxi-K) channel has been achieved in COS-1 cells. Expression has been studied using charybdotoxin (ChTX), a peptidyl inhibitor that binds in the pore on the alpha subunit. Although some properties of monoiodotyrosi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanner M,Schmalhofer WA,Munujos P,Knaus HG,Kaczorowski GJ,Garcia ML

更新日期：1997-04-01 00:00:00

abstract：:Studies on the structure-function relationship of diphtheria toxin are reported. New methods are described for the preparation of pure intact ("unnicked") toxin and for the preparation of the individual A and B chains. A biological assay method for the B chain is also presented, as well as a method for the labelling o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Everse J,Lappi DA,Beglau JM,Lee CL,Kaplan NO

更新日期：1977-02-01 00:00:00

abstract：:Plasmids have been constructed to generate substrates for the study of proteinases 2A and 3C of poliovirus. They contain the P1 (capsomer precursor) region of the poliovirus genome or P1 and part of P2 (a nonstructural precursor), which can be transcribed and translated in vitro. A transcript containing the entire 5' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicklin MJ,Kräusslich HG,Toyoda H,Dunn JJ,Wimmer E

更新日期：1987-06-01 00:00:00

abstract：:We review a program of research that uses neuroimaging techniques to determine the functional and neural architecture of human working memory. A first set of studies indicates that verbal working memory includes a storage component, which is implemented neurally by areas in the left-hemisphere posterior parietal corte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith EE,Jonides J

更新日期：1998-09-29 00:00:00

abstract：:The plant hormone abscisic acid (ABA) is produced in response to abiotic stresses and mediates stomatal closure in response to drought via recently identified ABA receptors (pyrabactin resistance/regulatory component of ABA receptor; PYR/RCAR). SLAC1 encodes a central guard cell S-type anion channel that mediates ABA-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt B,Brodsky DE,Xue S,Negi J,Iba K,Kangasjärvi J,Ghassemian M,Stephan AB,Hu H,Schroeder JI

更新日期：2012-06-26 00:00:00

abstract：:Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callegari AJ,Kelly TJ

更新日期：2006-10-24 00:00:00

abstract：:Pith parenchyma cells store water in various plant organs. These cells are especially important for producing sugar and ethanol from the sugar juice of grass stems. In many plants, the death of pith parenchyma cells reduces their stem water content. Previous studies proposed that a hypothetical D gene might be respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujimoto M,Sazuka T,Oda Y,Kawahigashi H,Wu J,Takanashi H,Ohnishi T,Yoneda JI,Ishimori M,Kajiya-Kanegae H,Hibara KI,Ishizuna F,Ebine K,Ueda T,Tokunaga T,Iwata H,Matsumoto T,Kasuga S,Yonemaru JI,Tsutsumi N

更新日期：2018-09-11 00:00:00

abstract：:Type IV pili are thin filaments that extend from the poles of a diverse group of bacteria, enabling them to move at speeds of a few tenths of a micrometer per second. They are required for twitching motility, e.g., in Pseudomonas aeruginosa and Neisseria gonorrhoeae, and for social gliding motility in Myxococcus xanth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skerker JM,Berg HC

更新日期：2001-06-05 00:00:00

abstract：:Pituitary ablation (hypophysectomy) in rats was previously reported to cause a precipitous change in the relative abundance of two alternative splice variants of the "BK"- or "Maxi K"-encoding Slo gene in adrenal chromaffin cells. Inclusion of the optional "STREX" exon (STRess axis-regulated EXon) in a C-terminal spli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai GJ,McCobb DP

更新日期：2002-05-28 00:00:00

abstract：:We have constructed yeast strains that secrete functional mouse-human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole antibody, cDNA copies of the chimeric light-chain and heavy-chain genes of an anti-tumor antibody were inserted into vectors containing the yeast phosphoglycerate kin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horwitz AH,Chang CP,Better M,Hellstrom KE,Robinson RR

更新日期：1988-11-01 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:Telomerase is a special reverse transcriptase that extends one strand of the telomere repeat by using a template embedded in an RNA subunit. Like other polymerases, telomerase is believed to use a pair of divalent metal ions (coordinated by a triad of aspartic acid residues) for catalyzing nucleotide addition. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lue NF,Bosoy D,Moriarty TJ,Autexier C,Altman B,Leng S

更新日期：2005-07-12 00:00:00