Expression cloning of rat renal Na+/SO4(2-) cotransport.

abstract：:Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases. Here, we present drug-like inhibitors of a key enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amaro RE,Schnaufer A,Interthal H,Hol W,Stuart KD,McCammon JA

更新日期：2008-11-11 00:00:00

abstract：:Aryloxyphenoxypropionates, inhibitors of the plastid acetyl-CoA carboxylase (ACC) of grasses, also inhibit Toxoplasma gondii ACC. Clodinafop, the most effective of the herbicides tested, inhibits growth of T. gondii in human fibroblasts by 70% at 10 microM in 2 days and effectively eliminates the parasite in 2-4 days ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuther E,Johnson JJ,Haselkorn R,McLeod R,Gornicki P

更新日期：1999-11-09 00:00:00

abstract：:Changes in hippocampal function seem critical for cognitive impairment in Alzheimer's disease (AD). Although there is eventual loss of synapses in both AD and animal models of AD, deficits in spatial memory and inhibition of long-term potentiation (LTP) precede morphological alterations in the models, suggesting earli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitolo OV,Sant'Angelo A,Costanzo V,Battaglia F,Arancio O,Shelanski M

更新日期：2002-10-01 00:00:00

abstract：:Arrestins are regulatory molecules for G-protein coupled receptor function. In visual rhodopsin, selective binding of arrestin to the cytoplasmic side of light-activated, phosphorylated rhodopsin (P-Rh*) terminates signaling via the G-protein transducin. While the "phosphate-sensor" of arrestin for the recognition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirchberg K,Kim TY,Möller M,Skegro D,Dasara Raju G,Granzin J,Büldt G,Schlesinger R,Alexiev U

更新日期：2011-11-15 00:00:00

abstract：:Fibrocytes are collagen-type-I-producing cells that arise at low frequency from hematopoietic cells. We have analyzed in mice which leukocyte subsets are required for generation of fibrocytes and show that murine fibrocytes develop from the subpopulation of CD11b(+) CD115(+) Gr1(+) monocytes under the control of CD4(+...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niedermeier M,Reich B,Rodriguez Gomez M,Denzel A,Schmidbauer K,Göbel N,Talke Y,Schweda F,Mack M

更新日期：2009-10-20 00:00:00

abstract：:Over the past decade or more, contradictory evidence of Martian climate, indicating that surface temperatures seldom if ever approach the melting point of water at midlatitudes, and geomorphic features, consistent with liquid flows at these same latitudes, have proven difficult to reconcile. In this article, we demons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinbrot T,Duong NH,Kwan L,Alvarez MM

更新日期：2004-06-08 00:00:00

abstract：:Extensive regeneration of the vertebrate body plan is found in salamander and fish species. In these organisms, regeneration takes place through reprogramming of differentiated cells, proliferation, and subsequent redifferentiation of adult tissues. Such plasticity is rarely found in adult mammalian tissues, and this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun MH,Gates PB,Brockes JP

更新日期：2013-10-22 00:00:00

abstract：:Loquacious-PD (Loqs-PD) is required for biogenesis of many endogenous siRNAs in Drosophila In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of substrates normally refractory to cleavage. Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trettin KD,Sinha NK,Eckert DM,Apple SE,Bass BL

更新日期：2017-09-19 00:00:00

abstract：:We describe a system for gene expression in plants based on the regulation mechanism of the yeast metallothionein (MT) gene. The system consists of two elements: (i) the yeast ace1 (activating copper-MT expression) gene encoding a transcription factor under control of the cauliflower mosaic virus (CaMV) 35S RNA promot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mett VL,Lochhead LP,Reynolds PH

更新日期：1993-05-15 00:00:00

abstract：:Tropical deforestation for the establishment of tree cash crop plantations causes significant alterations to soil organic carbon (SOC) dynamics. Despite this recognition, the current Intergovernmental Panel on Climate Change (IPCC) tier 1 method has a SOC change factor of 1 (no SOC loss) for conversion of forests to p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Straaten O,Corre MD,Wolf K,Tchienkoua M,Cuellar E,Matthews RB,Veldkamp E

更新日期：2015-08-11 00:00:00

abstract：:P elements have been cloned and sequenced from Drosophila nebulosa. Their sequences have diverged less than 6% from P elements of Drosophila melanogaster. However D. nebulosa P elements have nucleotide changes that close all four open reading frames found in the D. melanogaster P element. Microinjection experiments sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansman RA,Shade RO,Grigliatti TA,Brock HW

更新日期：1987-09-01 00:00:00

abstract：:There is pronounced seasonal plasticity in the morphology of the neural circuits that regulate song behavior in adult songbirds, primarily in response to changes in plasma testosterone (T) levels. Most song nuclei have androgen receptors. Afferent input from the telencephalic nucleus HVc (also known as the "high vocal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brenowitz EA,Lent K

更新日期：2002-09-17 00:00:00

abstract：:Two strains that overproduce endonuclease III were found in a colony bank containing hybrid ColE1-Escherichia coli plasmids. The enzyme was identified in crude extracts by the degradation of partially depyrimidinated DNA in the presence of EDTA, by its sedimentation velocity, and by its associated thymine glycol-DNA g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunningham RP,Weiss B

更新日期：1985-01-01 00:00:00

abstract：:The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer DJ,Stephenson EW,Johnson L,Cochran BH,Schwartz J

更新日期：1993-07-15 00:00:00

abstract：:We have assayed carbonic anhydrase activity (carbonate dehydratase, carbonate hydro-lyase, EC 4.2.1.1) and bicarbonate permeability in suspensions of broken and intact guinea pig mitochondria by monitoring the disappearance of C16O18O. We found significant activity in preparations from liver and skeletal muscle, but n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodgson SJ,Forster RE 2nd,Storey BT,Mela L

更新日期：1980-09-01 00:00:00

abstract：:An enconuclease activity that reacts with x-irradiated DNA is present in extracts of E. coli. By using centrifugal methods to monitor the conversion of the supercoiled, circular double-stranded DNA for phage phi-x-174 (replicative form) or PM2 to the relaxed circular form it was possible to quantitate the rate of radi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strniste GF,Wallace SS

更新日期：1975-06-01 00:00:00

abstract：:Vibrio cholerae O1 exists as two major serotypes, Inaba and Ogawa, which are associated with the O antigen of the lipopolysaccharide and are capable of unequal reciprocal interconversion. The 20-kilobase rfb regions encoding O-antigen biosynthesis in strains 569B (Inaba) and O17 (Ogawa) have been cloned in Escherichia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stroeher UH,Karageorgos LE,Morona R,Manning PA

更新日期：1992-04-01 00:00:00

abstract：:Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junín and Tacaribe virus, suggesting that zoonosis via these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarute N,Ross SR

更新日期：2020-08-11 00:00:00

abstract：:Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Several lines of evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinicke AT,Laban K,Sachs M,Kraus V,Walden M,Damme M,Sachs W,Reichelt J,Schweizer M,Janiesch PC,Duncan KE,Saftig P,Rinschen MM,Morellini F,Meyer-Schwesinger C

更新日期：2019-04-16 00:00:00

abstract：:Tikal has long been viewed as one of the leading polities of the ancient Maya realm, yet how the city was able to maintain its substantial population in the midst of a tropical forest environment has been a topic of unresolved debate among researchers for decades. We present ecological, paleoethnobotanical, hydraulic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lentz DL,Dunning NP,Scarborough VL,Magee KS,Thompson KM,Weaver E,Carr C,Terry RE,Islebe G,Tankersley KB,Grazioso Sierra L,Jones JG,Buttles P,Valdez F,Ramos Hernandez CE

更新日期：2014-12-30 00:00:00

abstract：:We evaluate the impact of anthropogenic and natural NO(x) sources over the contiguous United States on tropospheric NO(x) and O(3) levels by using a global 3D chemical transport model. The effects of major U.S. surface NO(x) emission sources (including anthropogenic, biomass burning, and soil emissions) are compared w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Tie X,Bond DW

更新日期：2003-02-18 00:00:00

abstract：:The mechanism by which cells recognize and complete replicated regions at their precise doubling point must be remarkably efficient, occurring thousands of times per cell division along the chromosomes of humans. However, this process remains poorly understood. Here we show that, in Escherichia coli, the completion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wendel BM,Courcelle CT,Courcelle J

更新日期：2014-11-18 00:00:00

abstract：:The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Cai W,Liu Y,Li H,Fu L,Liu Z,Xu L,Liu H,Xu T,Xiong Y

更新日期：2017-03-07 00:00:00

abstract：:A glnB gene is identified in the cyanobacterium Synechococcus sp. PCC 7942, and its gene product is found to be covalently modified as a result of imbalance in electron transfer in photosynthesis, where photosystem II is favored over photosystem I. The gene was cloned and sequenced and found to encode a polypeptide of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsinoremas NF,Castets AM,Harrison MA,Allen JF,Tandeau de Marsac N

更新日期：1991-06-01 00:00:00

abstract：:Phycobilisomes isolated from eight different species of cyanobacteria contain in addition to the light-harvesting phycobiliproteins, a small number of colorless polypeptides with molecular weights higher than those of the chromopolypeptide subunits of the phycobiliproteins. In the phycobilisomes of the species examin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Marsac NT,Cohen-bazire G

更新日期：1977-04-01 00:00:00

abstract：:The lipid monogalactosyl diacylglycerol (MGD) is a major structural component of photosynthetic membranes in chloroplasts. Its formation is catalyzed by the enzyme MGD synthase. In many plants, MGD derives from two different biosynthetic pathways: the prokaryotic pathway, which operates entirely within the plastid, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis P,Dörmann P,Peto CA,Lutes J,Benning C,Chory J

更新日期：2000-07-05 00:00:00

abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

更新日期：2007-04-03 00:00:00

abstract：:The S1-nuclease analysis was used to investigate the pattern of inhibin expression in the rat. In a first series of experiments, expression of the alpha, beta A, and beta B subunits of inhibin were monitored in various tissues from male and female rats. Two observations emerge from these studies. First, expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meunier H,Rivier C,Evans RM,Vale W

更新日期：1988-01-01 00:00:00

abstract：:Developmental hemoglobin switching involves sequential globin gene activations and repressions that are incompletely understood. Earlier observations, described herein, led us to hypothesize that nuclear ferritin is a repressor of the adult beta-globin gene in embryonic erythroid cells. Our data show that a ferritin-f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broyles RH,Belegu V,DeWitt CR,Shah SN,Stewart CA,Pye QN,Floyd RA

更新日期：2001-07-31 00:00:00

abstract：:Development of the vertebrate eye has been found to require the activity of several genes encoding homeodomain proteins (Freund, C., Horsford, D. J. & McInnes, R. R. (1996) Hum. Mol. Genet. 5, 1471-1488). Some of these genes, or portions thereof, are highly conserved across phyla. In this paper, we report the identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furukawa T,Kozak CA,Cepko CL

更新日期：1997-04-01 00:00:00