Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.

abstract：:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins MK,Rozengurt E

更新日期：1983-04-01 00:00:00

abstract：:Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein, myelin-associated glycoprotein (MAG). MAG is also thought to be a major inhibitor of neurite outgrowth (axon regenerati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang LJ,Zeller CB,Shaper NL,Kiso M,Hasegawa A,Shapiro RE,Schnaar RL

更新日期：1996-01-23 00:00:00

abstract：:The role of RNA silencing as an antiviral defense mechanism in fungi was examined by testing the effect of dicer gene disruptions on mycovirus infection of the chestnut blight fungus Cryphonectria parasitica. C. parasitica dicer-like genes dcl-1 and dcl-2 were cloned and shown to share a high level of predicted amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segers GC,Zhang X,Deng F,Sun Q,Nuss DL

更新日期：2007-07-31 00:00:00

abstract：:Mutations in the visA gene of Escherichia coli cause the mutant bacteria to die upon illumination with visible light. We confirmed genetically that the visA gene is a structural gene for ferrochelatase (protoheme ferro-lyase, EC 4.99.1.1). Since other mutations in the genes involved in the biosynthesis of heme can cur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakahigashi K,Nishimura K,Miyamoto K,Inokuchi H

更新日期：1991-12-01 00:00:00

abstract：:The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic anion-binding protein] have been isolated from the basolateral plasma-membrane domain of the hepatocyte. To investigate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres AM,Lunazzi GC,Stremmel W,Tiribelli C

更新日期：1993-09-01 00:00:00

abstract：:Seasonal oxygen depletion (hypoxia) in coastal bottom waters can lead to the release and persistence of free sulfide (euxinia), which is highly detrimental to marine life. Although coastal hypoxia is relatively common, reports of euxinia are less frequent, which suggests that certain environmental controls can delay t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seitaj D,Schauer R,Sulu-Gambari F,Hidalgo-Martinez S,Malkin SY,Burdorf LD,Slomp CP,Meysman FJ

更新日期：2015-10-27 00:00:00

abstract：:Reduced serum testosterone (T), or hypogonadism, affects millions of men and is associated with many pathologies, including infertility, cardiovascular diseases, metabolic syndrome, and decreased libido and sexual function. Administering T-replacement therapy (TRT) reverses many of the symptoms associated with low T l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li Y,Sottas C,Culty M,Fan J,Hu Y,Cheung G,Chemes HE,Papadopoulos V

更新日期：2019-11-12 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:Methane seeps are widespread seafloor ecosystems shaped by the emission of gas from seabed reservoirs. The microorganisms inhabiting methane seeps transform the chemical energy in methane to products that sustain rich benthic communities around the gas leaks. Despite the biogeochemical relevance of microbial methane r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruff SE,Biddle JF,Teske AP,Knittel K,Boetius A,Ramette A

更新日期：2015-03-31 00:00:00

abstract：:Neuropilin-1 (NRP1) is a 130-kDa transmembrane receptor for semaphorins, mediators of neuronal guidance, and for vascular endothelial growth factor 165 (VEGF(165)), an angiogenesis factor. A 2.2-kb truncated NRP1 cDNA was cloned that encodes a 644-aa soluble NRP1 (sNRP1) isoform containing just the a/CUB and b/coagula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gagnon ML,Bielenberg DR,Gechtman Z,Miao HQ,Takashima S,Soker S,Klagsbrun M

更新日期：2000-03-14 00:00:00

abstract：:We have identified a murine gene, metaxin, that spans the 6-kb interval separating the glucocerebrosidase gene (GC) from the thrombospondin 3 gene on chromosome 3E3-F1. Metaxin and GC are transcribed convergently; their major polyadenylylation sites are only 431 bp apart. On the other hand, metaxin and the thrombospon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein P,McKinney CE,LaMarca ME,Winfield S,Shingu T,Devarayalu S,Vos HL,Ginns EI

更新日期：1995-05-09 00:00:00

abstract：:The class of neurons within the visual cortex of normal adult cats that has the smallest receptive fields (less than or equal to 2.25 degrees2) and that responds only to low rates of stimulus motion (less than or equal to 50 degrees / sec) responds preferentially to lines oriented about either the horizontal axis (+/-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leventhal AG,Hirsch HV

更新日期：1977-03-01 00:00:00

abstract：:The 24-hr intracarotid infusion of plasma-treated glycyl-L-glutamine (3 microM) produced significant enhancement of the monomeric G1 and tetrameric G4 forms of acetylcholinesterase of the cat superior cervical ganglion 48 hr after denervation, in comparison with denervated, noninfused controls. No significant effect o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koelle GB,Skau KA,Thampi NS,Hymel DM,Han MS

更新日期：1988-08-01 00:00:00

abstract：:Antigenic variation of African trypanosomes results from the periodic activation of a single new variant cell surface glycoprotein (VSG) gene out of a repertoire of about a 1000 VSG genes. In spite of the apparently random genetic basis of the process of antigenic variation, the relapsing parasitemias are characterize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agur Z,Abiri D,Van der Ploeg LH

更新日期：1989-12-01 00:00:00

abstract：:The role of anti-peripheral nerve myelin antibody (anti-PNM Ab) in the pathogenesis of acquired demyelination of peripheral nerve is unclear, in part, due to the poor correlation between antibody and disease activity. Previous studies show that only 27-50% of patients with acute demyelinating neuropathy or Guillain-Ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koski CL,Humphrey R,Shin ML

更新日期：1985-02-01 00:00:00

abstract：:We use computer simulations to study the thermodynamic properties of a glass-former in which a fraction c of the particles has been permanently frozen. By thermodynamic integration, we determine the Kauzmann, or ideal glass transition, temperature [Formula: see text] at which the configurational entropy vanishes. This...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozawa M,Kob W,Ikeda A,Miyazaki K

更新日期：2015-06-02 00:00:00

abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkley-Levenson E,Galván A

更新日期：2014-01-28 00:00:00

abstract：:Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral analgesia. However, the mechanisms underlying this peripheral action of morphine have not yet been fully elucidated. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cunha TM,Roman-Campos D,Lotufo CM,Duarte HL,Souza GR,Verri WA Jr,Funez MI,Dias QM,Schivo IR,Domingues AC,Sachs D,Chiavegatto S,Teixeira MM,Hothersall JS,Cruz JS,Cunha FQ,Ferreira SH

更新日期：2010-03-02 00:00:00

abstract：:Infants born prematurely risk significant life-long cognitive disability, representing a major pediatric health crisis. The neuropathology of this cohort is accurately modeled in mice subjected to sublethal postnatal hypoxia. Massively parallel transcriptome analysis using cDNA microchips (9,262 genes), combined with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curristin SM,Cao A,Stewart WB,Zhang H,Madri JA,Morrow JS,Ment LR

更新日期：2002-11-26 00:00:00

abstract：:Natively unfolded proteins play key roles in normal and pathological biochemical processes. Despite their importance for function, this category of proteins remains beyond the reach of classical structural biology because of their inherent conformational heterogeneity. We present a description of the intrinsic conform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bernadó P,Blanchard L,Timmins P,Marion D,Ruigrok RW,Blackledge M

更新日期：2005-11-22 00:00:00

abstract：:Among the most striking aspects of the movement of many animal groups are their sudden coherent changes in direction. Recent observations of locusts and starlings have shown that this directional switching is an intrinsic property of their motion. Similar direction switches are seen in self-propelled particle and othe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yates CA,Erban R,Escudero C,Couzin ID,Buhl J,Kevrekidis IG,Maini PK,Sumpter DJ

更新日期：2009-04-07 00:00:00

abstract：:Rat, but not human, erythrocytes undergo fusion promoted by the membrane-mobility agent 2-(2-methoxyethoxy)-ethyl cis-8-(2-octylcyclopropyl)octanoate (A2C). The difference in behavior is correlated with rat erythrocyte membrane protein degradation caused by Ca2+-activated proteases. The human erythrocyte is deficient ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kosower NS,Glaser T,Kosower EM

更新日期：1983-12-01 00:00:00

abstract：:Melittin messenger RNA from queen bee venom glands has been translated in a cell-free system from wheat germ. A product larger than promelittin is formed which has the carboxy-terminal sequence-Gln-Gln-GlyCOOH. Melittin and promelittin from venom glands terminate in -Gln-GlnCONH2. The possible role of the extra glycin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suchanek G,Kreil G

更新日期：1977-03-01 00:00:00

abstract：:Male oriental fruit flies (Dacus dorsalis) from colonies in Taiwan and Hawaii were evaluated for limit of response to various analogues of methyl eugenol. The results are interpreted in terms of the geometry and allosteric requirements of the antennal receptor that triggers the characteristic methyl eugenol reflex. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf RL,Metcalf ER,Mitchell WC,Lee LW

更新日期：1979-04-01 00:00:00

abstract：:Ubiquitination, the crucial posttranslational modification that regulates the eukaryotic proteome, is carried out by a trio of enzymes, known as E1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase). Although most E2s can work with any of the three mechanistically distinct classes of E3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dove KK,Kemp HA,Di Bona KR,Reiter KH,Milburn LJ,Camacho D,Fay DS,Miller DL,Klevit RE

更新日期：2017-08-08 00:00:00

abstract：:A major challenge in research on executive control is to reveal its functional decomposition into underlying neural mechanisms. A typical assumption is that this decomposition occurs solely through anatomically based dissociations. Here we tested an alternative hypothesis that different cognitive control processes may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braver TS,Paxton JL,Locke HS,Barch DM

更新日期：2009-05-05 00:00:00

abstract：:Oncolytic viruses constitute a promising therapy against malignant gliomas (MGs). However, virus-induced type I IFN greatly limits its clinical application. The kinase mammalian target of rapamycin (mTOR) stimulates type I IFN production via phosphorylation of its effector proteins, 4E-BPs and S6Ks. Here we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alain T,Lun X,Martineau Y,Sean P,Pulendran B,Petroulakis E,Zemp FJ,Lemay CG,Roy D,Bell JC,Thomas G,Kozma SC,Forsyth PA,Costa-Mattioli M,Sonenberg N

更新日期：2010-01-26 00:00:00

abstract：:The satellite sequences (AGGGAG)(n) and Ty3/gypsy-like retrotransposons are known to localize at the barley centromeres. Using a gametocidal system, which induces chromosomal mutations in barley chromosomes added to common wheat, we obtained an isochromosome for the short arm of barley chromosome 7H (7HS) that lacked ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nasuda S,Hudakova S,Schubert I,Houben A,Endo TR

更新日期：2005-07-12 00:00:00

abstract：:The ability to grow the marine molluse Aplysia under laboratory conditions allows a detailed study of the formation of the nervous system and of the development of specific identified cells. I have found that the ganglia develop in a specific temporal order. Cerebral and pedal ganglia develop at hatching, the abdomina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriegstein AR

更新日期：1977-01-01 00:00:00

abstract：:From 25 to 29 April 2020, the state of Indiana undertook testing of 3,658 randomly chosen state residents for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the agent causing COVID-19 disease. This was the first statewide randomized study of COVID-19 testing in the United States. Both PC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yiannoutsos CT,Halverson PK,Menachemi N

更新日期：2021-02-02 00:00:00