Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties.

abstract：:The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apcher S,Daskalogianni C,Lejeune F,Manoury B,Imhoos G,Heslop L,Fåhraeus R

更新日期：2011-07-12 00:00:00

abstract：:The mechanisms regulating clonal expansion and contraction of T cells in response to immunization remain to be identified. A recent study established that there was a log-linear relation between CD4 T-cell precursor number (PN) and factor of expansion (FE), with a slope of ∼-0.5 over a range of 3-30,000 precursors per...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bocharov G,Quiel J,Luzyanina T,Alon H,Chiglintsev E,Chereshnev V,Meier-Schellersheim M,Paul WE,Grossman Z

更新日期：2011-02-22 00:00:00

abstract：:A mathematical analysis of the formation of hemolytic plaques in agar is presented. The results can be used to calculate the rate constant for antigen-antibody association and the distribution of antibody secretion rates. The limitations of the treatment and estimates of the expected errors involved are briefly discus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Lisi CP,Bell GI

更新日期：1974-01-01 00:00:00

abstract：:The mature gag and pol proteins of human immunodeficiency virus (HIV) and all retroviruses derive from large gag and gag-pol polyprotein precursors by posttranslational cleavage. A highly specific, virally encoded protease is required for this essential proteolytic processing. In this study, the HIV protease gene prod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debouck C,Gorniak JG,Strickler JE,Meek TD,Metcalf BW,Rosenberg M

更新日期：1987-12-01 00:00:00

abstract：:We report dynamic glycoprotein recognition of gels prepared by biomolecular imprinting using lectin and antibody molecules as ligands for tumor-specific marker glycoproteins. The glycoprotein-imprinted gels prepared with minute amounts of cross-linkers could dynamically recognize tumor-specific marker glycoproteins by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyata T,Jige M,Nakaminami T,Uragami T

更新日期：2006-01-31 00:00:00

abstract：:The activation of additional promoter sites by production of an alternative sigma subunit for RNA polymerase is a common strategy for the coordinate regulation of gene expression. Many alternative sigma factors control genes for specialized, and often narrowly distributed, functions. For example, most of the alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YF,Helmann JD

更新日期：1992-06-01 00:00:00

abstract：:The nucleotide sequences of eight origin-defective mutants of simian virus 40 have been determined. All of the mutants have suffered deletions, which range in size from 4 to 241 nucleotides. Some of the mutants induce the synthesis of tumor (T) antigen, others do not. Viral mRNA extracted from rat cells transformed by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gluzman Y,Sambrook JF,Frisque RJ

更新日期：1980-07-01 00:00:00

abstract：:Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efendić S,Wajngot A,Cerasi E,Luft R

更新日期：1980-12-01 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00

abstract：:Activation of androgen receptor (AR) via androgen in muscle cells has been closely linked to their growth and differentiation. Here, we report the cloning and characterization of supervillin (SV), a 205-kDa actin-binding protein, as an AR coregulator from the skeletal muscle cDNA library. Mammalian two-hybrid and glut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ting HJ,Yeh S,Nishimura K,Chang C

更新日期：2002-01-22 00:00:00

abstract：:In aqueous solution, aldehydes, and to a lesser extent ketones, hydrate to form geminal diols. We investigate the hydration of methylglyoxal (MG) in the gas phase, a process not previously considered to occur in water-restricted environments. In this study, we spectroscopically identified methylglyoxal diol (MGD) and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Axson JL,Takahashi K,De Haan DO,Vaida V

更新日期：2010-04-13 00:00:00

abstract：:Translesion synthesis at replication-blocking lesions requires the induction of proteins that are controlled by the SOS system in Escherichia coli. Of the proteins identified so far, UmuD', UmuC, and RecA* were shown to facilitate replication across UV-light-induced lesions, yielding both error-free and mutagenic tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs RP,Napolitano RL

更新日期：1998-10-27 00:00:00

abstract：:Newly synthesized rat islet proteins have been analyzed by polyacrylamide slab gel electrophoresis and fluorography. A minor component having an apparent molecular weight of 11,100 was identified as preproinsulin by the sensitivity of its synthesis to glucose, the pattern of NH2-terminal leucine residues, and the rapi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patzelt C,Labrecque AD,Duguid JR,Carroll RJ,Keim PS,Heinrikson RL,Steiner DF

更新日期：1978-03-01 00:00:00

abstract：:A human Burkitt lymphoma cell line, Raji-HN2, made 10-fold more resistant to nitrogen mustard (HN2) than the parental Raji cell line, exhibited the following characteristics when compared to the parental Raji cells: (i) decreased HN2-induced DNA interstrand crosslinking; (ii) increased (3-fold) DNA topoisomerase II [D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan KB,Mattern MR,Boyce RA,Schein PS

更新日期：1987-11-01 00:00:00

abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

更新日期：2018-02-20 00:00:00

abstract：:In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haak W,Brandt G,de Jong HN,Meyer C,Ganslmeier R,Heyd V,Hawkesworth C,Pike AW,Meller H,Alt KW

更新日期：2008-11-25 00:00:00

abstract：:Organic hydroperoxide resistance (Ohr) enzymes are unique Cys-based, lipoyl-dependent peroxidases. Here, we investigated the involvement of Ohr in bacterial responses toward distinct hydroperoxides. In silico results indicated that fatty acid (but not cholesterol) hydroperoxides docked well into the active site of Ohr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alegria TG,Meireles DA,Cussiol JR,Hugo M,Trujillo M,de Oliveira MA,Miyamoto S,Queiroz RF,Valadares NF,Garratt RC,Radi R,Di Mascio P,Augusto O,Netto LE

更新日期：2017-01-10 00:00:00

abstract：:Self-assembled monolayer-protected nanoparticles are promising candidates for applications, such as sensing and drug delivery, in which the molecular ligands' interactions with the surrounding environment play a crucial role. We recently showed that, when gold nanoparticles are coated with a binary mixture of immiscib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Centrone A,Penzo E,Sharma M,Myerson JW,Jackson AM,Marzari N,Stellacci F

更新日期：2008-07-22 00:00:00

abstract：:S-adenosyl-L-methionine (SAM)-dependent O-methyltransferases (OMTs) catalyze the methylation of hydroxycinnamic acid derivatives for the synthesis of methylated plant polyphenolics, including lignin. The distinction in the extent of methylation of lignins in angiosperms and gymnosperms, mediated by substrate-specific ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Popko JL,Zhang XH,Osakabe K,Tsai CJ,Joshi CP,Chiang VL

更新日期：1997-05-13 00:00:00

abstract：:After the start of transcription, the 5' ends of eukaryotic mRNA molecules are modified by the addition of a guanylyl residue to form a cap structure, G(5')ppp(5')N. The guanylyltransferase (GTP:mRNA guanylyltransferase, EC 2.7.7.50) reaction responsible for cap formation usually proceeds via a covalent enzyme-GMP int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahola T,Kääriäinen L

更新日期：1995-01-17 00:00:00

abstract：:The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a stra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turroni F,Bottacini F,Foroni E,Mulder I,Kim JH,Zomer A,Sánchez B,Bidossi A,Ferrarini A,Giubellini V,Delledonne M,Henrissat B,Coutinho P,Oggioni M,Fitzgerald GF,Mills D,Margolles A,Kelly D,van Sinderen D,Ventura M

更新日期：2010-11-09 00:00:00

abstract：:Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the yeast Saccharomyces cerevisiae, are excellent models of asymmetric cell division, this phenotype occ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorpe PH,Bruno J,Rothstein R

更新日期：2009-04-21 00:00:00

abstract：:Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acetylcholine receptor (nAChR) structure and function and have potential as nervous system therapeutics as well. However, the lack of solved structures of conotoxins bound to nAChRs and the large size of these peptides ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leffler AE,Kuryatov A,Zebroski HA,Powell SR,Filipenko P,Hussein AK,Gorson J,Heizmann A,Lyskov S,Tsien RW,Poget SF,Nicke A,Lindstrom J,Rudy B,Bonneau R,Holford M

更新日期：2017-09-19 00:00:00

abstract：:CD4+ T cells recognize major histocompatibility complex (MHC) class II-bound peptides that are primarily obtained from extracellular sources. Endogenously synthesized proteins that readily enter the MHC class I presentation pathway are generally excluded from the MHC class II presentation pathway. We show here that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson S,Frauwirth K,Shastri N

更新日期：1995-08-01 00:00:00

abstract：:A method has been developed that enables us to identify intracellular degradation intermediates of fructose-bisphosphate aldolase B (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13). This method is based on the use of antibody against thoroughly denatured purified aldolase. This antibody ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reznick AZ,Rosenfelder L,Shpund S,Gershon D

更新日期：1985-09-01 00:00:00

abstract：:Bluetongue virus (BTV), a major threat to livestock, is a multilayered, nonturreted member of the Reoviridae, a family of segmented dsRNA viruses characterized by endogenous RNA transcription through an RNA-dependent RNA polymerase (RdRp). To date, the structure of BTV RdRp has been unknown, limiting our mechanistic u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Y,Shivakoti S,Ding K,Cui Y,Roy P,Zhou ZH

更新日期：2019-08-13 00:00:00

abstract：:Human low density lipoproteins (LDL) are the major cholesterol carriers in the blood. Elevated concentration of LDL is a major risk factor for atherosclerotic disease. Purified LDL particles appear heterogeneous in images obtained with a 400-kV electron cryomicroscope. Using multivariate statistical and cluster analys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orlova EV,Sherman MB,Chiu W,Mowri H,Smith LC,Gotto AM Jr

更新日期：1999-07-20 00:00:00

abstract：:Plasmons, the collective oscillations of interacting electrons, possess emergent properties that dramatically alter the optical response of metals. We predict the existence of a new class of plasmons-chiral Berry plasmons (CBPs)-for a wide range of 2D metallic systems including gapped Dirac materials. As we show, in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JC,Rudner MS

更新日期：2016-04-26 00:00:00

abstract：:H-NS and Lsr2 are nucleoid-associated proteins from Gram-negative bacteria and Mycobacteria, respectively, that play an important role in the silencing of horizontally acquired foreign DNA that is more AT-rich than the resident genome. Despite the fact that Lsr2 and H-NS proteins are dissimilar in sequence and structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon BR,Li Y,Cote A,Weirauch MT,Ding P,Hughes TR,Navarre WW,Xia B,Liu J

更新日期：2011-06-28 00:00:00

abstract：:Plant germ cells develop in specialized haploid structures, termed gametophytes. The female gametophyte patterns of flowering plants are diverse, with often unknown adaptive value. Here we present the Arabidopsis fiona mutant, which forms a female gametophyte that is structurally and functionally reminiscent of a phyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kägi C,Baumann N,Nielsen N,Stierhof YD,Gross-Hardt R

更新日期：2010-12-21 00:00:00