Restoration of motility to an Escherichia coli fliA flagellar mutant by a Bacillus subtilis sigma factor.

abstract：:Tropical birds are relatively long-lived and produce few offspring, which develop slowly and mature relatively late in life, the slow end of the life-history axis, whereas temperate birds lie at the opposite end of this continuum. We tested the hypothesis that tropical birds have evolved a reduced basal metabolic rate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiersma P,Muñoz-Garcia A,Walker A,Williams JB

更新日期：2007-05-29 00:00:00

abstract：:Insulin binding to insulin receptors, on skin fibroblasts established in culture from an infant with insulin resistance and clinical features of leprechaunism was markedly decreased in comparison with cultures from an age-matched control. By contrast, the binding of epidermal growth factor, a polypeptide growth factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schilling EE,Rechler MM,Grunfeld C,Rosenberg AM

更新日期：1979-11-01 00:00:00

abstract：:The bacterio-opsin gene was introduced into a "blind" Halobacterium salinarium mutant that (i) lacked all the four retinal proteins [bacteriorhodopsin (BR), halorhodopsin, and sensory rhodopsins (SRs) I and II] and the transducer protein for SRI and (ii) showed neither attractant response to long wavelength light nor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibikov SI,Grishanin RN,Kaulen AD,Marwan W,Oesterhelt D,Skulachev VP

更新日期：1993-10-15 00:00:00

abstract：:Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish NF,Gao F,Li H,Giorgi EE,Barbian HJ,Parrish EH,Zajic L,Iyer SS,Decker JM,Kumar A,Hora B,Berg A,Cai F,Hopper J,Denny TN,Ding H,Ochsenbauer C,Kappes JC,Galimidi RP,West AP Jr,Bjorkman PJ,Wilen CB,Doms RW

更新日期：2013-04-23 00:00:00

abstract：:Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug resistance conferred by a second mutation, T790M. Threonine 790 is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun CH,Mengwasser KE,Toms AV,Woo MS,Greulich H,Wong KK,Meyerson M,Eck MJ

更新日期：2008-02-12 00:00:00

abstract：:Neuroglobin (Ngb), a vertebrate globin expressed primarily in neurons, is induced by and protects against neuronal hypoxia and cerebral ischemia. To investigate the spectrum and mechanism of Ngb's neuroprotective action, we studied the effect of transgenic overexpression of Ngb on NMDA and beta-amyloid (Abeta) toxicit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AA,Mao XO,Banwait S,Jin K,Greenberg DA

更新日期：2007-11-27 00:00:00

abstract：:Highly multiplexed assays using antibody coated, fluorescent (xMap) beads are widely used to measure quantities of soluble analytes, such as cytokines and antibodies in clinical and other studies. Current analyses of these assays use methods based on standard curves that have limitations in detecting low or high abund...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Won JH,Goldberger O,Shen-Orr SS,Davis MM,Olshen RA

更新日期：2012-02-21 00:00:00

abstract：:Coatomer, the coat protein of coat protein complex (COP)I-vesicles, is a soluble protein complex made up of seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP. Higher eukaryotes have two paralogous versions of the gamma- and zeta- subunits, termed gamma1- and gamma2-COP and zeta1- and zeta2-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moelleken J,Malsam J,Betts MJ,Movafeghi A,Reckmann I,Meissner I,Hellwig A,Russell RB,Söllner T,Brügger B,Wieland FT

更新日期：2007-03-13 00:00:00

abstract：:Policy folklists present a set of alleged historical facts seen as relevant to some social issue. Although the validity of these folklists is dubious, leaders and writers circulate them in the media, variants arise, and the lists continue on, sometimes for decades. Folklists are repeated because their messages are app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill B

更新日期：2014-07-22 00:00:00

abstract：:Xenotropic and polytropic murine leukemia viruses (X-MLVs and P-MLVs) cross-interfere to various extents in non-mouse species and in wild Asian mice, suggesting that they might use a common receptor for infection. Consistent with this hypothesis, the susceptibility of some wild mice to X-MLVs has been mapped to the P-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tailor CS,Nouri A,Lee CG,Kozak C,Kabat D

更新日期：1999-02-02 00:00:00

abstract：:Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rupprecht CE,Wiktor TJ,Johnston DH,Hamir AN,Dietzschold B,Wunner WH,Glickman LT,Koprowski H

更新日期：1986-10-01 00:00:00

abstract：:T cell recognition typically involves both the engagement of a specific T cell receptor with a peptide/major histocompatibility complex (MHC) and a number of accessory interactions. One of the most important interactions is between the integrin lymphocyte function-associated antigen 1 (LFA-1) on the T cell and intrace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wülfing C,Sjaastad MD,Davis MM

更新日期：1998-05-26 00:00:00

abstract：:The actin cytoskeleton is a critical regulator of cytoplasmic architecture and mechanics, essential in a myriad of physiological processes. Here we demonstrate a liquid phase of actin filaments in the presence of the physiological cross-linker, filamin. Filamin condenses short actin filaments into spindle-shaped dropl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weirich KL,Banerjee S,Dasbiswas K,Witten TA,Vaikuntanathan S,Gardel ML

更新日期：2017-02-28 00:00:00

abstract：:The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larner AC,Jonak G,Cheng YS,Korant B,Knight E,Darnell JE Jr

更新日期：1984-11-01 00:00:00

abstract：:ARGONAUTE (AGO) RNA-binding proteins are involved in RNA silencing. They bind to short interfering RNAs (siRNAs) and microRNAs (miRNAs) through a conserved PAZ domain, and, in animals, they assemble into a multisubunit RNA-induced silencing complex (RISC). The mammalian AGO2, termed Slicer, directs siRNA- and miRNA-me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baumberger N,Baulcombe DC

更新日期：2005-08-16 00:00:00

abstract：:The membrane glycoproteins specified by herpes simplex virus are synthesized concurrently with structural viral proteins and accumulate in the cytoplasm and in the membranes lining it. Analyses of free and membranebound polyribosomes, the cytoplasmic pool of soluble proteins, and purified smooth membranes showed that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spear PG,Roizman B

更新日期：1970-07-01 00:00:00

abstract：:Infectious RNA transcripts were generated from full-length cDNA clones of the tobacco etch potyvirus genome containing an insertion of the bacterial beta-glucuronidase (GUS) gene between the polyprotein-coding sequences for the N-terminal 35-kDa proteinase and the helper component-proteinase. The recombinant virus was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolja VV,McBride HJ,Carrington JC

更新日期：1992-11-01 00:00:00

abstract：:The laccase (benzenediol:oxygen oxidoreductase, EC 1.10.3.2) gene from Neurospora crassa was cloned and part of its nucleotide sequence corresponding to the carboxyl-terminal region of the protein has been determined. The gene was cloned by cDNA synthesis with a laccase-specific synthetic deoxyundecanucleotide as prim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Germann UA,Lerch K

更新日期：1986-12-01 00:00:00

abstract：:Molecular dynamics simulations of the response to oscillating electric field elicited from an altitudinal dipolar molecular rotor mounted on the Au(111) surface and previously studied experimentally in static fields show unidirectional rotation in one of the three pairs of conformational enantiomers. The simulations a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horinek D,Michl J

更新日期：2005-10-04 00:00:00

abstract：:Small molecules of biological origin continue to yield the most promising leads for drug design, but systematic approaches for exploring nature's cache of structural diversity are lacking. Here, we demonstrate the use of 2D NMR spectroscopy to screen a library of biorationally selected insect metabolite samples for pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deyrup ST,Eckman LE,McCarthy PH,Smedley SR,Meinwald J,Schroeder FC

更新日期：2011-06-14 00:00:00

abstract：:Peptide nucleic acid (PNA) is a DNA mimic that has shown considerable promise as a lead compound for developing gene therapeutic drugs. We report that PNAs targeted to functional and accessible sites in ribosomal RNA can inhibit translation in an Escherichia coli cell-free transcription/translation system, with 50% re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Good L,Nielsen PE

更新日期：1998-03-03 00:00:00

abstract：:The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to humans. Mutations of amino acid L13 within this domain rescue the essential function of the helicase protein Prp28p. Prp28p has been implicated in unwinding the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du H,Tardiff DF,Moore MJ,Rosbash M

更新日期：2004-10-12 00:00:00

abstract：:The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasenstaub A,Otte S,Callaway E,Sejnowski TJ

更新日期：2010-07-06 00:00:00

abstract：:Cloned DNA probes containing genes coding for the large subunit of ribulose-1,5-bisphosphate carboxylase (rbcA) of corn and of Chlamydomonas were used to identify, by heterologous hybridization, DNA fragments from Anabaena 7120 carrying the corresponding gene sequence. The same probes were used to isolate, from a reco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curtis SE,Haselkorn R

更新日期：1983-04-01 00:00:00

abstract：:Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu ZQ,Du Bois GC,Song SP,Kulikovskaya I,Virgilio L,Rothstein JL,Croce CM,Weber IT,Harrison RW

更新日期：1998-03-31 00:00:00

abstract：:Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These compounds are taken up by cells in a saturable, size-dependent manner compatible with receptor-mediated endocytosis. Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke SL,Stein CA,Zhang XH,Mori K,Nakanishi M,Subasinghe C,Cohen JS,Neckers LM

更新日期：1989-05-01 00:00:00

abstract：:Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherer PE,Okamoto T,Chun M,Nishimoto I,Lodish HF,Lisanti MP

更新日期：1996-01-09 00:00:00

abstract：:Learning to read requires the acquisition of an efficient visual procedure for quickly recognizing fine print. Thus, reading practice could induce a perceptual learning effect in early vision. Using functional magnetic resonance imaging (fMRI) in literate and illiterate adults, we previously demonstrated an impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pegado F,Comerlato E,Ventura F,Jobert A,Nakamura K,Buiatti M,Ventura P,Dehaene-Lambertz G,Kolinsky R,Morais J,Braga LW,Cohen L,Dehaene S

更新日期：2014-12-09 00:00:00

abstract：:Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muhich ML,Iida CT,Horikoshi M,Roeder RG,Parker CS

更新日期：1990-12-01 00:00:00

abstract：:Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence. We have identified the amino acid substitutions in three different types of proalbumins designated Ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1987-11-01 00:00:00