Metabolic cost as a unifying principle governing neuronal biophysics.

abstract：:Fifteen tumor-containing specimens were obtained directly from patients with small cell carcinoma of the lung and tested for their ability to grow in serum-supplemented medium and in serum-free medium supplemented with hydrocortisone, insulin, transferrin, estrogen, and selenium (HITES). The tumor cells replicated in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carney DN,Bunn PA Jr,Gazdar AF,Pagan JA,Minna JD

更新日期：1981-05-01 00:00:00

abstract：:Alkylation of DNA by 7r,8t-dihydroxy,9t,10t-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (anti-BPDE) forms mainly trans adducts (with respect to the C-9/10 positions). We recently described a halide-catalyzed pathway that preferentially generates cis adducts and now report that the trans chlorohydrin of anti-BPDE (trans-BP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meehan T,Wolfe AR,Negrete GR,Song Q

更新日期：1997-03-04 00:00:00

abstract：:The treatment of PC12 cells with either nerve growth factor or phorbol 12-myristate 13-acetate caused a decrease in the phosphorylation of a soluble 100-kDa protein (Nsp100). After treatment with nerve growth factor, the activity of Ca2+/phospholipid-dependent protein kinase (protein kinase C) in the cytosol was incre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hama T,Huang KP,Guroff G

更新日期：1986-04-01 00:00:00

abstract：:Wnt and Shh signaling pathways are critical for the development and maturation of many epithelial tissues. Both pathways have roles in stem cell maintenance, tissue development, and tumorigenesis. However, linkage between these pathways in mammalian systems had not been well established. Here, we report that Shh expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwatsuki K,Liu HX,Grónder A,Singer MA,Lane TF,Grosschedl R,Mistretta CM,Margolskee RF

更新日期：2007-02-13 00:00:00

abstract：:Optimization theory has been used to analyze evolutionary adaptation. This theory has explained many features of biological systems, from the genetic code to animal behavior. However, these systems show important deviations from optimality. Typically, these deviations are large in some particular components of the sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Escudero A,Rivera-Alba M,de Polavieja GG

更新日期：2009-12-01 00:00:00

abstract：:Our understanding of the molecular control of many disease pathologies requires the identification of direct substrates targeted by specific protein kinases. Here we describe an integrated proteomic strategy, termed kinase assay linked with phosphoproteomics, which combines a sensitive kinase reaction with endogenous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue L,Wang WH,Iliuk A,Hu L,Galan JA,Yu S,Hans M,Geahlen RL,Tao WA

更新日期：2012-04-10 00:00:00

abstract：:Better understanding myelination of peripheral nerves would benefit patients affected by peripheral neuropathies, including Charcot-Marie-Tooth disease. Little is known about the role the Golgi compartment plays in Schwann cell (SC) functions. Here, we studied the role of Golgi in myelination of peripheral nerves in m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baba T,Alvarez-Prats A,Kim YJ,Abebe D,Wilson S,Aldworth Z,Stopfer MA,Heuser J,Balla T

更新日期：2020-11-10 00:00:00

abstract：:Voltage-dependent anion channels (VDACs) are pore-forming proteins (porins) that form the major pathway for movement of adenine nucleotides through the outer mitochondrial membrane. Electrophysiological studies indicate that VDAC-like channel activity is also prevalent in the cell membranes of many mammalian cells. Ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buettner R,Papoutsoglou G,Scemes E,Spray DC,Dermietzel R

更新日期：2000-03-28 00:00:00

abstract：:The importance of identifying VEGF-independent pathways in pathological angiogenesis is increasingly recognized as a result of the emerging drug resistance to anti-VEGF therapies. PDGF-CC is the third member of the PDGF family discovered after more than two decades of studies on PDGF-AA and PDGF-BB. The biological fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou X,Kumar A,Lee C,Wang B,Arjunan P,Dong L,Maminishkis A,Tang Z,Li Y,Zhang F,Zhang SZ,Wardega P,Chakrabarty S,Liu B,Wu Z,Colosi P,Fariss RN,Lennartsson J,Nussenblatt R,Gutkind JS,Cao Y,Li X

更新日期：2010-07-06 00:00:00

abstract：:The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle. The activity of APC/C in mitosis and in G1 requires interaction with the activator proteins Cdc20 and C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Moshe Y,Braunstein I,Hershko A

更新日期：2006-02-14 00:00:00

abstract：:The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manella G,Aviram R,Bolshette N,Muvkadi S,Golik M,Smith DF,Asher G

更新日期：2020-01-07 00:00:00

abstract：:Incubation of O6-[3H]ethylguanine-containing DNA with a rat liver chromatin fraction resulted in a decrease in the O6-ethylguanine content of the DNA. Analysis of the products of this reaction showed that the ethyl group had been transferred from the O6-ethylguanine to a protein acceptor. When the incubation mixture w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta JR,Ludlum DB,Renard A,Verly WG

更新日期：1981-11-01 00:00:00

abstract：:Von Willebrand factor-binding protein (VWbp), secreted by Staphylococcus aureus, displays secondary structural homology to the 3-helix bundle, D1 and D2 domains of staphylocoagulase (SC), a potent conformational activator of the blood coagulation zymogen, prothrombin (ProT). In contrast to the classical proteolytic ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroh HK,Panizzi P,Bock PE

更新日期：2009-05-12 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:The traditional morphologically grounded placement of South American guinea pig-like rodents (Caviomorpha) within one of the two rodent suborders, Hystricognathi, has been disputed by recent analysis of protein and nucleic acid sequence data. The Caviomorpha and possibly all Hystricognathi would be considered a separa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martignetti JA,Brosius J

更新日期：1993-10-15 00:00:00

abstract：:We have used fast time-resolved infrared spectroscopy to characterize a series of organometallic methane and ethane complexes in solution at room temperature: W(CO)5(CH4) and M(eta5-C5R5)(CO)2(L) [where M = Mn or Re, R = H or CH3 (Re only); and L = CH4 or C2H6]. In all cases, the methane complexes are found to be shor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cowan AJ,Portius P,Kawanami HK,Jina OS,Grills DC,Sun XZ,McMaster J,George MW

更新日期：2007-04-24 00:00:00

abstract：:In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barducci A,Bonomi M,Prakash MK,Parrinello M

更新日期：2013-12-03 00:00:00

abstract：:Reinforcement learning models now provide principled guides for a wide range of reward learning experiments in animals and humans. One key learning (error) signal in these models is experiential and reports ongoing temporal differences between expected and experienced reward. However, these same abstract learning mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lohrenz T,McCabe K,Camerer CF,Montague PR

更新日期：2007-05-29 00:00:00

abstract：:Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER-) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been described as independent predictors of disease outcome. We further explore these findings by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basudhar D,Glynn SA,Greer M,Somasundaram V,No JH,Scheiblin DA,Garrido P,Heinz WF,Ryan AE,Weiss JM,Cheng RYS,Ridnour LA,Lockett SJ,McVicar DW,Ambs S,Wink DA

更新日期：2017-12-05 00:00:00

abstract：:Inflammatory diseases are characterized by dysregulated cytokine production. Altered functions for most risk loci, including the inflammatory bowel disease and leprosy-associated tumor necrosis factor ligand superfamily member 15 (TNFSF15) region, are unclear. Regulation of pattern-recognition-receptor (PRR)-induced s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedl M,Abraham C

更新日期：2014-09-16 00:00:00

abstract：:Recent studies on proteins whose N and C termini are in close proximity have demonstrated that folding of polypeptide chains and assembly of oligomers can be accomplished with circularly permuted chains. As yet no methodical study has been conducted to determine how extensively new termini can be introduced and where ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graf R,Schachman HK

更新日期：1996-10-15 00:00:00

abstract：:Mahler proved the following quantitative result supplementing the Lindemann-Weierstrass theorem: Sigma(i=0) (n)C(i)e(ri) > H(-n-epsilon) for any distinct rational numbers r(0),r(1),..., r(n) and rational integers C(0),C(1),...,C(n) with H = max(0

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chudnovsky GV

更新日期：1983-05-01 00:00:00

abstract：:Four cell types from Vicia faba Linnaeus "Long Pod" leaflets were assayed for three enzymes unique to the photosynthetic carbon reduction pathway. The enzymes were ribulosebisphosphate carboxylase [3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39], phosphoribulokinase (ATP:D-ribulose-5-phosphate 1-phospho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Outlaw WH,Manchester J,Dicamelli CA,Randall DD,Rapp B,Veith GM

更新日期：1979-12-01 00:00:00

abstract：:In making sense of the visual world, the brain's processing is driven by two factors: the physical information provided by the eyes ("bottom-up" data) and the expectancies driven by past experience ("top-down" influences). We use degraded stimuli to tease apart the effects of bottom-up and top-down processes because t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorlin S,Meng M,Sharma J,Sugihara H,Sur M,Sinha P

更新日期：2012-05-15 00:00:00

abstract：:There is now abundant evidence to substantiate an important role of hepatitis C virus (HCV) core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular localization of this protein has important implications. However, several studies have shown controversial results: the HCV core has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barba G,Harper F,Harada T,Kohara M,Goulinet S,Matsuura Y,Eder G,Schaff Z,Chapman MJ,Miyamura T,Bréchot C

更新日期：1997-02-18 00:00:00

abstract：:Calcium-dependent protein kinases (CDPKs) comprise the major group of Ca2+-regulated kinases in plants and protists. It has long been assumed that CDPKs are activated, like other Ca2+-regulated kinases, by derepression of the kinase domain (KD). However, we found that removal of the autoinhibitory domain from Toxoplas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ingram JR,Knockenhauer KE,Markus BM,Mandelbaum J,Ramek A,Shan Y,Shaw DE,Schwartz TU,Ploegh HL,Lourido S

更新日期：2015-09-08 00:00:00

abstract：:Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meltzer SJ,Yin J,Huang Y,McDaniel TK,Newkirk C,Iseri O,Vogelstein B,Resau JH

更新日期：1991-06-01 00:00:00

abstract：:Many of the world's around 6,000 languages are in danger of disappearing as people give up use of a minority language in favor of the majority language in a process called language shift. Language shift can be monitored on a large scale through the use of mathematical models by way of differential equations, for examp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prochazka K,Vogl G

更新日期：2017-04-25 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia (ATL). To elucidate the role of HTLV-I in leukemogenesis, we examined the biological activity of a defective HTLV-I provirus with the env-pX 3' long terminal repeat region cloned from leukemic cells of an ATL patient. Transfectio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka A,Takahashi C,Yamaoka S,Nosaka T,Maki M,Hatanaka M

更新日期：1990-02-01 00:00:00

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00