Allosteric activation of apicomplexan calcium-dependent protein kinases.

abstract：:The mouse adipsin gene encodes a member of the serine protease family that is expressed predominantly in adipose tissue and is secreted into the bloodstream. Adipsin expression is sharply down-regulated in several models of genetic and acquired obesity, representing the first example of an adipocyte gene whose express...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Platt KA,Min HY,Ross SR,Spiegelman BM

更新日期：1989-10-01 00:00:00

abstract：:Climate change impacts island communities all over the world. Sea-level rise, an increase in the frequency and intensity of severe weather events, and changes in distribution and health of marine organisms are among the most significant processes affecting island communities worldwide. On islands of the Caribbean and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglass K,Cooper J

更新日期：2020-04-14 00:00:00

abstract：:Although common in birds, social monogamy, or pair-living, is rare among mammals because internal gestation and lactation in mammals makes it advantageous for males to seek additional mating opportunities. A number of hypotheses have been proposed to explain the evolution of social monogamy among mammals: as a male ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Opie C,Atkinson QD,Dunbar RI,Shultz S

更新日期：2013-08-13 00:00:00

abstract：:After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gais S,Albouy G,Boly M,Dang-Vu TT,Darsaud A,Desseilles M,Rauchs G,Schabus M,Sterpenich V,Vandewalle G,Maquet P,Peigneux P

更新日期：2007-11-20 00:00:00

abstract：:Membrane proteins of cytotoxic T cells specifically reorganize to form an immunological synapse (IS) on interaction with their specific target. In this paper, we investigated the redistribution of Kv1.3 channels, which are the dominant voltage-gated potassium channels, in the plasma membrane of allogen-activated human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panyi G,Vámosi G,Bacsó Z,Bagdány M,Bodnár A,Varga Z,Gáspár R,Mátyus L,Damjanovich S

更新日期：2004-02-03 00:00:00

abstract：:The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)+ intestinal stem cell (ISC) survival through NOD2 activation upon an otherwise lethal oxid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levy A,Stedman A,Deutsch E,Donnadieu F,Virgin HW,Sansonetti PJ,Nigro G

更新日期：2020-01-28 00:00:00

abstract：:The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research. One of the most compelling next steps will be learning the functional roles of all proteins. Achievement of this goal depends in part on the rapid expression a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braun P,Hu Y,Shen B,Halleck A,Koundinya M,Harlow E,LaBaer J

更新日期：2002-03-05 00:00:00

abstract：:The bacterial pathogen Vibrio parahaemolyticus utilizes a type III secretion system to cause death of host cells within hours of infection. We report that cell death is completely independent of apoptosis and occurs by a mechanism in which injection of multiple type III effectors causes induction of autophagy, cell ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burdette DL,Yarbrough ML,Orvedahl A,Gilpin CJ,Orth K

更新日期：2008-08-26 00:00:00

abstract：:The importance of alternative splicing in regulating apoptosis has been suggested by findings of functionally antagonistic proteins generated by alternative splicing of several genes involved in apoptosis. Among these, Ich-1 (also named as caspase-2) encodes a member of the caspase family of proteases. Two forms of Ic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang ZH,Zhang WJ,Rao Y,Wu JY

更新日期：1998-08-04 00:00:00

abstract：:I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the matur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutcliffe JG

更新日期：1978-08-01 00:00:00

abstract：:A fundamental question in the study of human language acquisition centers around apportioning explanatory force between the experience of the learner and the core knowledge that allows learners to represent that experience. We provide a previously unidentified kind of data identifying children's contribution to langua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han CH,Musolino J,Lidz J

更新日期：2016-01-26 00:00:00

abstract：:The induction of heat shock proteins (HSP) by cellular stress and the activation of the hypothalamic-pituitary-adrenal axis by physiologic stress are biological responses that aid in the maintenance of cellular and organismal homeostasis, respectively. In this report, restraint stress, known to activate the hypothalam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake MJ,Udelsman R,Feulner GJ,Norton DD,Holbrook NJ

更新日期：1991-11-01 00:00:00

abstract：:Over the past decade, seafood mislabeling has been increasingly documented, raising public concern over the identity, safety, and sustainability of seafood. Negative outcomes from seafood mislabeling are suspected to be substantial and pervasive as seafood is the world's most highly traded food commodity. Here we prov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroetz K,Luque GM,Gephart JA,Jardine SL,Lee P,Chicojay Moore K,Cole C,Steinkruger A,Donlan CJ

更新日期：2020-12-01 00:00:00

abstract：:An RNA-directed DNA polymerase was isolated from the peripheral blood leukocytes of a patient with acute myelomonocytic leukemia by successive purification of a particulate cytoplasmic fraction with endogenous, ribonuclease-sensitive DNA polymerase activity. Like RNA-directed DNA polymerase from mammalian type-C virus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallagher RE,Todaro GJ,Smith RG,Livingston DM,Gallo RC

更新日期：1974-04-01 00:00:00

abstract：:We have previously linked aging, carcinogenesis, and de novo methylation within the promoter of the estrogen receptor (ER) gene in human colon. We now examine the dynamics of this process for the imprinted gene for insulin-like growth factor II (IGF2). In young individuals, the P2-4 promoters of IGF2 are methylated ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Issa JP,Vertino PM,Boehm CD,Newsham IF,Baylin SB

更新日期：1996-10-15 00:00:00

abstract：:Mouse L929 cells were incubated with antibody-targeted liposomes containing oligodeoxyribonucleotides (oligomers). When the oligomer was a 15-mer complementary to the 5'-end region of the mRNA encoding the N protein of vesicular stomatitis virus, the cells became less permissive for multiplication of that virus; great...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonetti JP,Machy P,Degols G,Lebleu B,Leserman L

更新日期：1990-04-01 00:00:00

abstract：:A method is presented for variational calculation of the energy and the spin densities derived from a single-determinant wavefunction. Sum and difference coordinates [unk]R = (1/2)([unk]r(1) + [unk]r(1)) and [unk]r = [unk]r(1) - [unk]r(1) are introduced, and the density matrix P([unk]r(1),[unk]r(1)) is expanded in par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne PW

更新日期：1980-11-01 00:00:00

abstract：:Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell TR

更新日期：1979-09-01 00:00:00

abstract：:Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song J,Bishop BL,Li G,Grady R,Stapleton A,Abraham SN

更新日期：2009-09-01 00:00:00

abstract：:Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prescott EM,Proudfoot NJ

更新日期：2002-06-25 00:00:00

abstract：:Unit electrical activity was recorded from single neurons in the isolated lumbo-sacral spinal cord of 14- to 19-day chick embryos, in situ. Spinal cord transection was combined with transection of all lumbo-sacral dorsal roots. The spontaneous discharge of cells is confined, for the most part, to the lower two thirds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SC,Provine RR,Hamburger V,Sandel TT

更新日期：1970-05-01 00:00:00

abstract：:We have identified the mutation responsible for the autosomal recessive wasted (wst) mutation of the mouse. Wasted mice are characterized by wasting and neurological and immunological abnormalities starting at 21 days after birth; they die by 28 days. A deletion of 15.8 kb in wasted mice abolishes expression of a gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chambers DM,Peters J,Abbott CM

更新日期：1998-04-14 00:00:00

abstract：:Preliminary x-ray diffraction data from single crystals of the MoFe proteins of nitrogenase from Clostridium pasteurianum and Azotobacter vinelandii have been obtained. Both protein crystals belong to the P2(1) space group. The MoFe protein crystals from C. pasteurianum and A. vinelandii diffract to angles correspondi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weininger MS,Mortenson LE

更新日期：1982-01-01 00:00:00

abstract：:Tikal has long been viewed as one of the leading polities of the ancient Maya realm, yet how the city was able to maintain its substantial population in the midst of a tropical forest environment has been a topic of unresolved debate among researchers for decades. We present ecological, paleoethnobotanical, hydraulic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lentz DL,Dunning NP,Scarborough VL,Magee KS,Thompson KM,Weaver E,Carr C,Terry RE,Islebe G,Tankersley KB,Grazioso Sierra L,Jones JG,Buttles P,Valdez F,Ramos Hernandez CE

更新日期：2014-12-30 00:00:00

abstract：:We have used in vitro motility assays to investigate the mechanism of kinetochore function in the budding yeast Saccharomyces cerevisiae. Functional centromeric DNA plus a tripartite centromere binding protein complex, CBF3, was found to be necessary but not sufficient for in vitro kinetochore activity. A fourth requi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Middleton K,Carbon J

更新日期：1994-07-19 00:00:00

abstract：:After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason GM,Poole E,Sissons JG,Wills MR,Sinclair JH

更新日期：2012-09-04 00:00:00

abstract：:Saccharomyces cerevisiae cells reproduce by budding to yield a mother cell and a smaller daughter cell. Although both mother and daughter begin G1 simultaneously, the mother cell progresses through G1 more rapidly. Daughter cell G1 delay has long been thought to be due to a requirement for attaining a certain critical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laabs TL,Markwardt DD,Slattery MG,Newcomb LL,Stillman DJ,Heideman W

更新日期：2003-09-02 00:00:00

abstract：:The inositol 1,4,5-trisphosphate receptor (IP3R) associated with plasma membranes of lymphocytes differs in terminal sugar content and binding specificity from the cerebellar receptor, which is localized to endoplasmic reticulum. Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AA,Steiner JP,Snyder SH

更新日期：1992-04-01 00:00:00

abstract：:The Rhizobium common nod gene products NodABC are involved in the synthesis of the core lipochitooligosaccharide (Nod factor) structure, whereas the products of the host-specific nod genes are necessary for diverse structural modifications, which vary in different Rhizobium species. The sulfate group attached to the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultze M,Staehelin C,Röhrig H,John M,Schmidt J,Kondorosi E,Schell J,Kondorosi A

更新日期：1995-03-28 00:00:00

abstract：:Fourier transform infrared (FTIR) spectroscopy provides a unique molecular fingerprint of tissue from endogenous sources of light absorption; however, specific molecular components of the overall FTIR signature of precancer have not been characterized. In attenuated total reflectance mode, infrared light penetrates on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang TD,Triadafilopoulos G,Crawford JM,Dixon LR,Bhandari T,Sahbaie P,Friedland S,Soetikno R,Contag CH

更新日期：2007-10-02 00:00:00