Abstract:
:We have identified the mutation responsible for the autosomal recessive wasted (wst) mutation of the mouse. Wasted mice are characterized by wasting and neurological and immunological abnormalities starting at 21 days after birth; they die by 28 days. A deletion of 15.8 kb in wasted mice abolishes expression of a gene called Eef1a2, encoding a protein that is 92% identical at the amino acid level to the translation elongation factor EF1alpha (locus Eef1a). We have found no evidence for the involvement of another gene in this deletion. Expression of Eef1a2 is reciprocal with that of Eef1a. Expression of Eef1a2 takes over from Eef1a in heart and muscle at precisely the time at which the wasted phenotype becomes manifest. These data suggest that there are tissue-specific forms of the translation elongation apparatus essential for postnatal survival in the mouse.
journal_name
Proc Natl Acad Sci U S Aauthors
Chambers DM,Peters J,Abbott CMdoi
10.1073/pnas.95.8.4463subject
Has Abstractpub_date
1998-04-14 00:00:00pages
4463-8issue
8eissn
0027-8424issn
1091-6490journal_volume
95pub_type
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