Green spaces and cognitive development in primary schoolchildren.

abstract：:We have previously identified a cellular transcription factor, ATF, which is involved in the expression of multiple adenovirus E1a-inducible genes. Here we show that ATF also binds to regulatory elements in cellular cAMP-inducible promoters. In these cellular promoters, ATF binds to a consensus sequence that has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin YS,Green MR

更新日期：1988-05-01 00:00:00

abstract：:Malaria merozoite invasion of human erythrocytes depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium vivax merozoite invasion is totally dependent on the recognition of the Duffy blood group antigen by the parasite ligand Duffy-binding protein (DBP). Receptor recognition by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanBuskirk KM,Sevova E,Adams JH

更新日期：2004-11-02 00:00:00

abstract：:A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Garde S,García AE,Pohorille A,Pratt LR

更新日期：1996-08-20 00:00:00

abstract：:B-lymphocyte-specific class switch recombination is known to occur between pairs of 2- to 10-kb switch regions located immediately upstream of the immunoglobulin constant heavy-chain genes. Others have shown that the recombination is temporally correlated with the induction of transcription at the targeted switch regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels GA,Lieber MR

更新日期：1995-06-06 00:00:00

abstract：:The synthesis of the covalently-closed, circular DNA form of colicinogenic factor E(1) (ColE(1)) continues in Escherichia coli cells after the addition of chloramphenicol. A large portion of the purified supercoiled ColE(1) DNA molecules made in the presence of chloramphenicol are converted to the open circular DNA fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blair DG,Sherratt DJ,Clewell DB,Helinski DR

更新日期：1972-09-01 00:00:00

abstract：:In 1000 primary gastric carcinomas, 70 (7.0%) contained Epstein-Barr virus (EBV) genomic sequences detected by PCR and Southern blots. The positive tumors comprised 8 of 9 (89%) undifferentiated lymphoepithelioma-like carcinomas, 27 of 476 (5.7%) poorly differentiated adenocarcinomas, and 35 of 515 (6.8%) moderately t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imai S,Koizumi S,Sugiura M,Tokunaga M,Uemura Y,Yamamoto N,Tanaka S,Sato E,Osato T

更新日期：1994-09-13 00:00:00

abstract：:We examined the effect of the inhibition of initiation of DNA replication on the membrane association of the chromosomal origin of replication of Bacillus subtilis and the Staphylococcus aureus-Bacillus pumilus chimeric plasmid pSL103, using temperature-sensitive mutants of B. subtilis that have specifically affected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winston S,Sueoka N

更新日期：1980-05-01 00:00:00

abstract：:In a microarray-based gene profiling analysis of Müller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish, we found that 2 genes required for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated. Expression...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin Z,Barthel LK,Raymond PA

更新日期：2009-06-09 00:00:00

abstract：:Bacterial chemotaxis receptors can detect a small concentration gradient of attractants and repellents in the environment over a wide range of background concentration. The clustering of these receptors to form patches observed in vivo and in vitro has been suspected as a reason for the high sensitivity, and such wide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Wang W,Kim KK

更新日期：2002-09-03 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) like other herpesviruses, expresses sequentially immediate early (IE), early, and late genes during lytic infection. Evidence of ability to establish latent infection has not been available, but by analogy with other herpesviruses it could be expected that IE genes that regulate and transac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotola A,Ravaioli T,Gonelli A,Dewhurst S,Cassai E,Di Luca D

更新日期：1998-11-10 00:00:00

abstract：:Most simian-human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting naturally occurring simian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Wang S,Kong R,Ding W,Lee FH,Parker Z,Kim E,Learn GH,Hahn P,Policicchio B,Brocca-Cofano E,Deleage C,Hao X,Chuang GY,Gorman J,Gardner M,Lewis MG,Hatziioannou T,Santra S,Apetrei C,Pandrea I,Alam SM,Liao HX,

更新日期：2016-06-14 00:00:00

abstract：:We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo F,Adhya S

更新日期：2007-03-13 00:00:00

abstract：:The ability of estrogens to stimulate the transcriptional activity of the estrogen receptor can be inhibited by a diverse range of estrogen antagonists. Here we show that the antiestrogen ICI 164,384, N-(n-butyl)-11-[3,17 beta-dihydroxy-estra-1,3,5(10)-trien-7 alpha-yl]N-methylundecanamide, rapidly reduces the levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dauvois S,Danielian PS,White R,Parker MG

更新日期：1992-05-01 00:00:00

abstract：:Excessive activation of poly(ADP-ribose) polymerase 1 (PARP1) leads to NAD(+) depletion and cell death during ischemia and other conditions that generate extensive DNA damage. When activated by DNA strand breaks, PARP1 uses NAD(+) as substrate to form ADP-ribose polymers on specific acceptor proteins. These polymers a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ying W,Sevigny MB,Chen Y,Swanson RA

更新日期：2001-10-09 00:00:00

abstract：:Na+ channels in chick brain and heart have been directly compared by measuring binding of tritium-labeled saxitoxin ([3H]STX) to the two tissues under identical conditions. Maximum saturable uptake and toxin affinity were considerably less in chick heart than in chick brain, requiring the development of an assay metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogart RB,Regan LJ,Dziekan LC,Galper JB

更新日期：1983-02-01 00:00:00

abstract：:Ferroelectricity has long been speculated to have important biological functions, although its very existence in biology has never been firmly established. Here, we present compelling evidence that elastin, the key ECM protein found in connective tissues, is ferroelectric, and we elucidate the molecular mechanism of i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Cai HL,Zelisko M,Wang Y,Sun J,Yan F,Ma F,Wang P,Chen QN,Zheng H,Meng X,Sharma P,Zhang Y,Li J

更新日期：2014-07-08 00:00:00

abstract：:We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamnes MA,Craighead MW,Hoe MH,Lampen N,Geromanos S,Tempst P,Rothman JE

更新日期：1995-08-15 00:00:00

abstract：:In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Mishra S,Sakthivel R,Rojas M,Ranjan R,Sullivan WJ Jr,Fontoura BM,Ménard R,Dever TE,Nussenzweig V

更新日期：2012-03-06 00:00:00

abstract：:Integrated hepadnaviral DNA in livers and tumors of chronic hepatitis B patients has been reported for many years. In this study, we investigated whether hepatitis B virus DNA integration occurs preferentially at sites of cell DNA damage. A single I-SceI homing endonuclease recognition site was introduced into the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bill CA,Summers J

更新日期：2004-07-27 00:00:00

abstract：:We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu A,Tepler I,Benfey PN,Berenstein EH,Siraganian RP,Leder P

更新日期：1988-03-01 00:00:00

abstract：:Systemic delivery of bioactive molecules in the CNS is hampered by the blood-brain barrier, which has bottlenecked noninvasive physiological study of the brain and the development of CNS drugs. Here we report that irradiation with an ultrashort pulsed laser to the blood vessel wall induces transient leakage of blood p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi M,Ku T,Chong K,Yoon J,Choi C

更新日期：2011-05-31 00:00:00

abstract：:We have screened a large number of isolated human genomic clones that hybridize to a cloned HLA cDNA probe for their ability to direct the synthesis of HLA-A, -B, and -C surface antigens on mouse L cells following DNA-mediated gene transfer. The surface expression of human histocompatibility antigens, monitored by ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barbosa JA,Kamarck ME,Biro PA,Weissman SM,Ruddle FH

更新日期：1982-10-01 00:00:00

abstract：:Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not ref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin KM,Belser JA,Wadford DA,Pearce MB,Katz JM,Tumpey TM,Maines TR

更新日期：2011-05-17 00:00:00

abstract：:The 24 human chromosome types of normal diploid fibroblast cell strain were classified into 15 groups by high-resolution flow cytometry on the basis of 33258 Hoechst fluorescence. Chromosomes associated with each group were flow sorted onto microscope slides and identified by quinacrine banding analysis. DNA cytophoto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrano AV,Gray JW,Langlois RG,Burkhart-Schultz KJ,Van Dilla MA

更新日期：1979-03-01 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) involves fetal overgrowth and predisposition to a wide variety of embryonal tumors of childhood. We have previously found that BWS is genetically linked to 11p15 and that this same band shows loss of heterozygosity in the types of tumors to which children with BWS are susceptible. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoovers JM,Kalikin LM,Johnson LA,Alders M,Redeker B,Law DJ,Bliek J,Steenman M,Benedict M,Wiegant J,Lengauer C,Taillon-Miller P,Schlessinger D,Edwards MC,Elledge SJ,Ivens A,Westerveld A,Little P,Mannens M,Feinberg AP

更新日期：1995-12-19 00:00:00

abstract：:The tightly coupled nature of the reaction sequence catalyzed by monoterpene cyclases has precluded direct observation of the topologically required isomerization step leading from geranyl pyrophosphate to the presumptive, enzyme-bound, tertiary allylic intermediate linalyl pyrophosphate, which ultimately cyclizes to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wheeler CJ,Croteau RB

更新日期：1987-07-01 00:00:00

abstract：:We have developed human cervicovaginal organ culture systems to examine the initiating events in HIV transmission after exposure to various sources of HIV infectivity, including semen. Newly infected cells were detected in the cervical submucosa 3-4 days after exposure to a primary HIV isolate. At earlier times, exten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maher D,Wu X,Schacker T,Horbul J,Southern P

更新日期：2005-08-09 00:00:00

abstract：:Recent findings demonstrated proinflammatory functions of interleukin (IL)-9-producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B

更新日期：2018-03-27 00:00:00

abstract：:Unprecedented population declines and extinctions because of human activities, combined with a growing recognition that such losses affect the stability of ecosystems, underscore the need to better understand how populations persist naturally. We provide field experimental evidence that high biodiversity-in particular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carr MH,Anderson TW,Hixon MA

更新日期：2002-08-20 00:00:00

abstract：:Research on tuberculosis and leprosy was revolutionized by the development of a plasmid transformation system in the fast-growing surrogate, Mycobacterium smegmatis. This transformation system was made possible by the successful isolation of a M. smegmatis mutant strain mc(2)155, whose efficient plasmid transformation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panas MW,Jain P,Yang H,Mitra S,Biswas D,Wattam AR,Letvin NL,Jacobs WR Jr

更新日期：2014-09-16 00:00:00