Fundamental patterns underlying gene expression profiles: simplicity from complexity.

abstract：:Recombination between unirradiated chromosomes was induced by UV or x-ray irradiation of haploids followed by a mating with heteroallelic diploids of Saccharomyces cerevisiae. The selected event of intragenic recombination did not involve the participation of the irradiated chromosome and apparently was not caused by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fabre F,Roman H

更新日期：1977-04-01 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at HS loci. Here we have employed in situ Hi-C to determine how heat stress affects long-range chromatin conformation in human and Drosophila cells. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray J,Munn PR,Vihervaara A,Lewis JJ,Ozer A,Danko CG,Lis JT

更新日期：2019-09-24 00:00:00

abstract：:Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the yeast Saccharomyces cerevisiae, are excellent models of asymmetric cell division, this phenotype occ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorpe PH,Bruno J,Rothstein R

更新日期：2009-04-21 00:00:00

abstract：:Neuroblastoma-glioma hybrid cells (NG108-15) in suspension accumulate the permeant lipophilic cation [(3)H]tetraphenylphosphonium (TPP(+)) against a concentration gradient. The steady-state level of TPP(+) accumulation is about twice as great in physiological media of low K(+) concentration (i.e., 5 mM K(+)/135 mM Na(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lichtshtein D,Kaback HR,Blume AJ

更新日期：1979-02-01 00:00:00

abstract：:A 600-base-pair region essential for ColE1 and pMBl plasmid replication contains two promoters responsible for the synthesis of two RNA molecules central to copy number control. One promoter directs synthesis of the primer RNA precursor. The second promoter directs the synthesis of a small RNA molecule, RNAl, which ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cesareni G,Muesing MA,Polisky B

更新日期：1982-10-01 00:00:00

abstract：:The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating neuroectodermal precursors that differentiate after terminal mitosis and become organized in cell strata. Genes that are specifically ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guermah M,Crisanti P,Laugier D,Dezelee P,Bidou L,Pessac B,Calothy G

更新日期：1991-05-15 00:00:00

abstract：:The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang PY,Koishi K,McGeachie AB,Kimber M,Maclaughlin DT,Donahoe PK,McLennan IS

更新日期：2005-11-08 00:00:00

abstract：:USF is a family of transcription factors characterized by a highly conserved basic-helix-loop-helix-leucine zipper (bHLH-zip) DNA-binding domain. Two different USF genes, termed USF1 and USF2, are ubiquitously expressed in both humans and mice. The USF1 and USF2 proteins contain highly divergent transcriptional activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo X,Sawadogo M

更新日期：1996-02-06 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:GTP-tubulin forms a cap on microtubule ends during aggregation. The bulk of the microtubule is GDP-tubulin. This complicates the usual simple kinetic theory of subunit exchange at microtubule ends to such an extent that Monte Carlo calculations are needed to handle the complications, except in special cases. The Monte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Hill TL

更新日期：1983-12-01 00:00:00

abstract：:Purified NADPH:cytochrome c (P-450) reductase (FpT; NADPH-ferrihemoprotein oxidoreductase, EC 1.6.2.4) can reductively activate mitomycin antibiotics through a one-electron reduction to species that alkylate DNA. To assess the involvement of FpT in the intracellular activation of the mitomycins, transfectants overexpr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcourt MF,Hodnick WF,Rockwell S,Sartorelli AC

更新日期：1996-01-09 00:00:00

abstract：:I demonstrate the existence in protein domain sequences of sets of statistically significant periodic signals, characteristic of the architectures of those domains. It is shown that, although the frequencies of the signals characteristic of a particular architecture have definite wave numbers, they can occur in any ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S

更新日期：1998-07-21 00:00:00

abstract：:2fTGH is a human cell line containing the selectable marker guanine phosphoribosyltransferase regulated by alpha interferon (IFN-alpha). Two IFN-alpha-unresponsive mutants were isolated previously at a low frequency (ca. 10(-8)) by selecting mutagenized 2fTGH cells in selective medium containing 6-thioguanine and IFN-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKendry R,John J,Flavell D,Müller M,Kerr IM,Stark GR

更新日期：1991-12-15 00:00:00

abstract：:Molecular targeting of the two receptor interaction domains of the epigenetic repressor silencing mediator of retinoid and thyroid hormone receptors (SMRT(mRID)) produced a transplantable skeletal syndrome that reduced radial bone growth, increased numbers of bone-resorbing periosteal osteoclasts, and increased bone f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong SH,Dvorak-Ewell M,Stevens HY,Barish GD,Castro GL,Nofsinger R,Frangos JA,Shoback D,Evans RM

更新日期：2013-11-19 00:00:00

abstract：:In regulating gene expression in mammalian tissues, steroid hormones bind to cytoplasmic receptors and the resulting complex associates with the nucleus. In an attempt to study this nuclear association under more precisely controlled conditions, we examined the binding of receptor-[(3)H]steroid complexes to isolated n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgins SJ,Rousseau GG,Baxter JD,Tomkins GM

更新日期：1973-12-01 00:00:00

abstract：:Efficient degradation of plant cell walls by selected anaerobic bacteria is performed by large extracellular multienzyme complexes termed cellulosomes. The spatial arrangement within the cellulosome is organized by a protein called scaffoldin, which recruits the cellulolytic subunits through interactions between cohes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barth A,Hendrix J,Fried D,Barak Y,Bayer EA,Lamb DC

更新日期：2018-11-27 00:00:00

abstract：:The conformation of L-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) has been derived from electron-density maps calculated at 2.8-A resolution with phases obtained from two heavy-atom derivatives and the bound coenzyme, NAD. Like other dehydrogenases, 3-hydroxyacyl-CoA dehydrogenase is a double-domain structure, but t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birktoft JJ,Holden HM,Hamlin R,Xuong NH,Banaszak LJ

更新日期：1987-12-01 00:00:00

abstract：:Criegee intermediates are thought to play a role in atmospheric chemistry, in particular, the oxidation of SO2, which produces SO3 and subsequently H2SO4, an important constituent of aerosols and acid rain. However, the impact of such oxidation reactions is affected by the reactions of Criegee intermediates with water...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang HL,Chao W,Lin JJ

更新日期：2015-09-01 00:00:00

abstract：:Yeast RNA polymerase II initiation factor e was purified to homogeneity and identified by biochemical criteria as the counterpart of human transcription factor IIB. Factor e was essential for initiation of transcription from yeast and mammalian promoters in a reconstituted yeast transcription system. Activity resided ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tschochner H,Sayre MH,Flanagan PM,Feaver WJ,Kornberg RD

更新日期：1992-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to HLA, but precise allelic associations have been difficult to infer due to limitations in genotyping methodology. Mapping PD risk at highest possible resolution, we performed sequencing of 11 HLA genes in 1,597 PD cases and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollenbach JA,Norman PJ,Creary LE,Damotte V,Montero-Martin G,Caillier S,Anderson KM,Misra MK,Nemat-Gorgani N,Osoegawa K,Santaniello A,Renschen A,Marin WM,Dandekar R,Parham P,Tanner CM,Hauser SL,Fernandez-Viña M,Oksenb

更新日期：2019-04-09 00:00:00

abstract：:The Rev protein of HIV-1, which facilitates the nuclear export of HIV-1 pre-mRNAs, has been a target for antiviral therapy. Here we describe a new strategy for inhibiting Rev function and HIV-1 replication. In contrast to previous approaches, we use a wild-type rather than a mutant Rev protein and covalently link this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian XY,Chen ZY,Zhang J,Rabson AB,Krug RM

更新日期：1996-08-20 00:00:00

abstract：:DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao P,LeBlanc SJ,Case BC,Elston TC,Hingorani MM,Erie DA,Weninger KR

更新日期：2020-07-28 00:00:00

abstract：:Aberrant transcription of the pericentromeric human satellite II (HSATII) repeat is present in a wide variety of epithelial cancers. In deriving experimental systems to study its deregulation, we observed that HSATII expression is induced in colon cancer cells cultured as xenografts or under nonadherent conditions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersani F,Lee E,Kharchenko PV,Xu AW,Liu M,Xega K,MacKenzie OC,Brannigan BW,Wittner BS,Jung H,Ramaswamy S,Park PJ,Maheswaran S,Ting DT,Haber DA

更新日期：2015-12-08 00:00:00

abstract：:The nature of color categories in the world's languages is contested. One major view holds that color categories are organized around universal focal colors, whereas an opposing view holds instead that categories are defined at their boundaries by linguistic convention. Both of these standardly opposed views are chall...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Regier T,Kay P,Khetarpal N

更新日期：2007-01-23 00:00:00

abstract：:In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes. TLRs also have roles in development in many species. The sea anemone Nematostella vectensis is a useful cnida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan JJ,Messerschmidt JL,Williams LM,Matthews BJ,Reynoso M,Gilmore TD

更新日期：2017-11-21 00:00:00

abstract：:Pulmonary surfactant contains two hydrophobic polypeptides, SP-B and SP-C, with known amino acid sequences and with truncated subforms lacking the N-terminal residues. Treatment of SP-C with KOH releases fatty acids (palmitic acid to more than 85%) in molar ratios of 1.8-2.0 relative to the polypeptide. Furthermore, p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curstedt T,Johansson J,Persson P,Eklund A,Robertson B,Löwenadler B,Jörnvall H

更新日期：1990-04-01 00:00:00

abstract：:Chromosome-specific gene regulation is known thus far only as a mechanism to equalize the transcriptional activity of the single male X chromosome with that of the two female X chromosomes. In Drosophila melanogaster, a complex including the five Male-Specific Lethal (MSL) proteins, "paints" the male X chromosome, med...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larsson J,Chen JD,Rasheva V,Rasmuson-Lestander A,Pirrotta V

更新日期：2001-05-22 00:00:00

abstract：:Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

更新日期：2021-01-19 00:00:00

abstract：:A method has been developed that enables us to identify intracellular degradation intermediates of fructose-bisphosphate aldolase B (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13). This method is based on the use of antibody against thoroughly denatured purified aldolase. This antibody ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reznick AZ,Rosenfelder L,Shpund S,Gershon D

更新日期：1985-09-01 00:00:00