Abstract:
:I demonstrate the existence in protein domain sequences of sets of statistically significant periodic signals, characteristic of the architectures of those domains. It is shown that, although the frequencies of the signals characteristic of a particular architecture have definite wave numbers, they can occur in any physical property. The characteristic signals define sequence units, which may correspond to specific structural features. Study of signals in different architectures suggests that symmetric structures are characterized by sets of sequence signals, which are members of harmonic series and which therefore impose commensurate periodicities on the structure. Asymmetric structures are characterized by mutually incommensurate sets of sequence signals. It is pointed out that, although these periodic sequence units can be very short, their existence is a property of the entire sequence.
journal_name
Proc Natl Acad Sci U S Aauthors
Rackovsky Sdoi
10.1073/pnas.95.15.8580subject
Has Abstractpub_date
1998-07-21 00:00:00pages
8580-4issue
15eissn
0027-8424issn
1091-6490journal_volume
95pub_type
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