Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.

abstract：:Interphase chromosomes were isolated in good yield from four species of fungi. In no case does the chromatin contain histones such as are characteristic of the chromosomes of other eukaryotic organisms. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leighton TJ,Dill BC,Stock JJ,Phillips C

更新日期：1971-03-01 00:00:00

abstract：:Biochemical and genetic studies have implicated alpha-gustducin as a key component in the transduction of both bitter or sweet taste. Yet, alpha-gustducin-null mice are not completely unresponsive to bitter or sweet compounds. To gain insights into how gustducin mediates responses to bitter and sweet compounds, and to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Avila L,Wong GT,Damak S,Margolskee RF

更新日期：2001-07-17 00:00:00

abstract：:An invariant substructure that forms two interlocked pairs of neighboring beta-strands occurs in essentially all known sandwich-like proteins. Eight conserved positions in these strands were recently shown to act as structural determinants. To test whether the residues at these invariant positions are conserved for me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson CJ,Wittung-Stafshede P

更新日期：2005-03-15 00:00:00

abstract：:Dictyostelium myosin II is activated by phosphorylation of its regulatory light chain by myosin light chain kinase A (MLCK-A), an unconventional MLCK that is not regulated by Ca2+/calmodulin. MLCK-A is activated by autophosphorylation of threonine-289 outside of the catalytic domain and by phosphorylation of threonine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silveira LA,Smith JL,Tan JL,Spudich JA

更新日期：1998-10-27 00:00:00

abstract：:HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few have been both biochemically and structurally characterized. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridwell-Rabb J,Kang G,Zhong A,Liu HW,Drennan CL

更新日期：2016-11-29 00:00:00

abstract：:A sequence of 14 nucleotides in one human diversity (D) minigene (D2) is identical with a sequence in complementarity-determining region 2 (CDR2) of one human gene for the variable region of the heavy chain of immunoglobulin. The finding that nucleotide segments present in a D minigene can appear in CDR2 raises the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA

更新日期：1982-08-01 00:00:00

abstract：:Voltage-gated KCNQ1 (Kv7.1) potassium channels are expressed abundantly in heart but they are also found in multiple other tissues. Differential coassembly with single transmembrane KCNE beta subunits in different cell types gives rise to a variety of biophysical properties, hence endowing distinct physiological roles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu H,Lin Z,Mattmann ME,Zou B,Terrenoire C,Zhang H,Wu M,McManus OB,Kass RS,Lindsley CW,Hopkins CR,Li M

更新日期：2013-05-21 00:00:00

abstract：:By adapting to sustained stimuli, hair cells in the internal ear retain their sensitivity to minute transient displacements. Because one model for adaptation asserts that this process is mediated by a myosin isozyme, we reasoned that we should be able to arrest adaptation by interfering with myosin's ATPase cycle thou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie PG,Hudspeth AJ

更新日期：1993-04-01 00:00:00

abstract：:Mitochondrial carriers are believed widely to be homodimers both in the inner membrane of the organelle and in detergents. The dimensions and molecular masses of the detergent and protein-detergent micelles were measured for yeast ADP/ATP carriers in a range of different detergents. The radius of the carrier at the mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamber L,Harding M,Butler PJ,Kunji ER

更新日期：2006-10-31 00:00:00

abstract：:Circular RNA replicons have been reported in plants and, in one case, in animal cells. We describe such an element in yeast. In certain yeast strains, a 20S RNA species appears on transfer of cells to acetate medium. This phenotype shows cytoplasmic (non-Mendelian) inheritance and the 20S RNA is associated with 23-kDa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumoto Y,Fishel R,Wickner RB

更新日期：1990-10-01 00:00:00

abstract：:As a dynamic property of folded proteins, protein compressibility provides important information about the forces that govern structural stability. We relate intrinsic compressibility to stability by using molecular dynamics to identify a molecular basis for the variation in compressibility among globular proteins. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dadarlat VM,Post CB

更新日期：2003-12-09 00:00:00

abstract：:Caenorhabditis elegans explores its environment by interrupting its forward movement with occasional turns and reversals. Turns and reversals occur at stable frequencies but irregular intervals, producing probabilistic exploratory behaviors. Here we dissect the roles of individual sensory neurons, interneurons, and mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray JM,Hill JJ,Bargmann CI

更新日期：2005-03-01 00:00:00

abstract：:Immigration and demographic change have become highly salient in American politics, partly because of the 2016 campaign of Donald Trump. Previous research indicates that local influxes of immigrants or unfamiliar ethnic groups can generate threatened responses, but has either focused on nonelectoral outcomes or analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill SJ,Hopkins DJ,Huber GA

更新日期：2019-12-10 00:00:00

abstract：:Mechanisms that control the levels and activities of reactive oxygen species (ROS) in normal human mammary cells are poorly understood. We show that purified normal human basal mammary epithelial cells maintain low levels of ROS primarily by a glutathione-dependent but inefficient antioxidant mechanism that uses mitoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan N,Nguyen LV,Makarem M,Dong Y,Shih K,Eirew P,Raouf A,Emerman JT,Eaves CJ

更新日期：2014-05-27 00:00:00

abstract：:Translation initiation of the hepatitis C virus (HCV) RNA genome occurs through an internal ribosome entry site in a cap-independent manner. Here, we have examined the interaction between La antigen and the HCV 5' noncoding region (5'NCR). In this analysis, competitor RNAs derived from HCV 5'NCR carrying deletions and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ali N,Siddiqui A

更新日期：1997-03-18 00:00:00

abstract：:Deuterium oxide, D(2)O, increases the temperature-tolerance of Drosophila pseudoobscura when it is administered to adult flies as a sucrose solution. The effect is very rapidly exerted; it is detected within 10 min after the flies have a brief (10 min) opportunity to drink. This increased resistance to heat-death sure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pittendrigh CS,Cosbey ES

更新日期：1974-02-01 00:00:00

abstract：:Movement over and colonization of surfaces are important survival strategies for bacteria, and many find it advantageous to perform these activities as a group, using quorum sensing to sample population size and synchronize behavior. It is puzzling however, that swarming-proficient and virulent strains of Vibrio parah...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trimble MJ,McCarter LL

更新日期：2011-11-01 00:00:00

abstract：:Human declarative memory involves a systematic organization of information that supports generalizations and inferences from acquired knowledge. This kind of memory depends on the hippocampal region in humans, but the extent to which animals also have declarative memory, and whether inferential expression of memory de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dusek JA,Eichenbaum H

更新日期：1997-06-24 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis. The underlying mechanisms are poorly understood, and investigations have been hampered by the absence of animal models that reflect the human condition of generalized atherosclerosis and lupus. We addressed this problem by transferring ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stanic AK,Stein CM,Morgan AC,Fazio S,Linton MF,Wakeland EK,Olsen NJ,Major AS

更新日期：2006-05-02 00:00:00

abstract：:Na(+)-NQR is a unique respiratory enzyme that couples the free energy of electron transfer reactions to electrogenic pumping of sodium across the cell membrane. This enzyme is found in many marine and pathogenic bacteria where it plays an analogous role to the H(+)-pumping complex I. It has generally been assumed that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juárez O,Morgan JE,Nilges MJ,Barquera B

更新日期：2010-07-13 00:00:00

abstract：:In higher eukaryotic cells, mitochondria are essential subcellular organelles for energy production, cell signaling, and the biosynthesis of biomolecules. The mitochondrial DNA (mtDNA) genome is indispensable for mitochondrial function because it encodes protein subunits of the electron transport chain and a full set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu W,Boyd RM,Tree MO,Samkari F,Zhao L

更新日期：2019-09-03 00:00:00

abstract：:Nonenzymatic manganese was first shown to provide protection against superoxide toxicity in vivo in 1981, but the chemical mechanism responsible for this protection subsequently became controversial due to conflicting reports concerning the ability of Mn to catalyze superoxide disproportionation in vitro. In a recent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnese K,Gralla EB,Valentine JS,Cabelli DE

更新日期：2012-05-01 00:00:00

abstract：:Coagulation factor V is a high molecular weight plasma glycoprotein that participates as a cofactor in the conversion of prothrombin to thrombin by factor Xa. A phage lambda gt11 Hep G2 cell cDNA expression library was screened by using an affinity-purified antibody to human factor V, and 11 positive clones were isola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kane WH,Davie EW

更新日期：1986-09-01 00:00:00

abstract：:A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to the site of injury, produce and secrete large amounts of this protein, so that by 3 weeks after injury, it represents 2-5% of the total sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ignatius MJ,Gebicke-Härter PJ,Skene JH,Schilling JW,Weisgraber KH,Mahley RW,Shooter EM

更新日期：1986-02-01 00:00:00

abstract：:The impact of rapid climate change on contemporary human populations is of global concern. To contextualize our understanding of human responses to rapid climate change it is necessary to examine the archeological record during past climate transitions. One episode of abrupt climate change has been correlated with soc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armit I,Swindles GT,Becker K,Plunkett G,Blaauw M

更新日期：2014-12-02 00:00:00

abstract：:Mate attraction in Aplysia involves a long-distance water-borne signal (the protein pheromone attractin), which is released during egg laying. Aplysia californica attractin attracts species that produce closely related attractins, such as Aplysia brasiliana, whose geographic distribution does not overlap that of A. ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painter SD,Cummins SF,Nichols AE,Akalal DB,Schein CH,Braun W,Smith JS,Susswein AJ,Levy M,de Boer PA,ter Maat A,Miller MW,Scanlan C,Milberg RM,Sweedler JV,Nagle GT

更新日期：2004-05-04 00:00:00

abstract：:Wnt/beta-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of Ezh2 in adi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Jin Q,Lee JE,Su IH,Ge K

更新日期：2010-04-20 00:00:00

abstract：:Two major DNA double-strand break repair pathways exist in all eukaryotes, nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Although both pathways can function throughout the cell cycle, NHEJ predominates in G0/G1) (when a replicated sister chromatid is unavailable), whereas HR makes a more subs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Convery E,Shin EK,Ding Q,Wang W,Douglas P,Davis LS,Nickoloff JA,Lees-Miller SP,Meek K

更新日期：2005-02-01 00:00:00

abstract：:The generalized seizures of status epilepticus (SE) trigger a series of molecular and cellular events that produce cognitive deficits and can culminate in the development of epilepsy. Known early events include opening of the blood-brain barrier (BBB) and astrocytosis accompanied by activation of brain microglia. Wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varvel NH,Neher JJ,Bosch A,Wang W,Ransohoff RM,Miller RJ,Dingledine R

更新日期：2016-09-20 00:00:00

abstract：:A molecular dynamics study was performed to compare the differences in the active-site dynamics of the wild-type and W137F mutant enzymes of 4-chlorobenzoyl-CoA dehalogenase. Only in the wild-type simulation are conformations formed between the catalytic Asp-145 and 4-chlorobenzoyl-CoA, which resemble the ab initio ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau EY,Bruice TC

更新日期：2001-08-14 00:00:00