当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness.

Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness.

Abstract：

:Mate attraction in Aplysia involves a long-distance water-borne signal (the protein pheromone attractin), which is released during egg laying. Aplysia californica attractin attracts species that produce closely related attractins, such as Aplysia brasiliana, whose geographic distribution does not overlap that of A. californica. This finding suggests that other mollusks release attractin-related pheromones to form and maintain breeding aggregations. We describe four additional members of the attractin family: A. brasiliana, Aplysia fasciata, Aplysia depilans (which aggregates with A. fasciata aggregations), and Aplysia vaccaria (which aggregates with A. californica aggregations). On the basis of their sequence similarity with A. californica attractin, the attractin proteins fall into two groups: A. californica, A. brasiliana, and A. fasciata (91-95% identity), and A. depilans and A. vaccaria (41-43% identity). The sequence similarity within the attractin family, the conserved six cysteines, and the compact fold of the NMR solution structure of A. californica attractin suggest a common fold for this pheromone family containing two antiparallel helices. The second helix contains the IEECKTS sequence conserved in Aplysia attractins. Mutating surface-exposed charged residues within this heptapeptide sequence abolishes attractin activity, suggesting that the second helix is an essential part of the receptor-binding interface.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Painter SD,Cummins SF,Nichols AE,Akalal DB,Schein CH,Braun W,Smith JS,Susswein AJ,Levy M,de Boer PA,ter Maat A,Miller MW,Scanlan C,Milberg RM,Sweedler JV,Nagle GT

doi

10.1073/pnas.0306339101

keywords:

subject

Has Abstract

pub_date

2004-05-04 00:00:00

pages

6929-33

issue

18

eissn

0027-8424

issn

1091-6490

pii

0306339101

journal_volume

101

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Gene-based vaccines and immunotherapeutics.

    abstract：:DNA vaccines, comprised of plasmid DNA encoding proteins from pathogens, allergens, and tumors, are being evaluated as prophylactic vaccines and therapeutic treatments for infectious diseases, allergies, and cancer; plasmids encoding normal human proteins are likewise being tested as vaccines and treatments for autoim...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,评审

    doi：10.1073/pnas.0404845101

    authors： Liu M,Acres B,Balloul JM,Bizouarne N,Paul S,Slos P,Squiban P

    更新日期：2004-10-05 00:00:00

  • Seasonal hysteresis of surface urban heat islands.

    abstract：:Temporal dynamics of urban warming have been extensively studied at the diurnal scale, but the impact of background climate on the observed seasonality of surface urban heat islands (SUHIs) remains largely unexplored. On seasonal time scales, the intensity of urban-rural surface temperature differences ([Formula: see ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1917554117

    authors： Manoli G,Fatichi S,Bou-Zeid E,Katul GG

    更新日期：2020-03-31 00:00:00

  • Estrogen receptor has enhanced affinity for bromodeoxyuridine-substituted DNA.

    abstract：:The estrogen receptor (E2R) from rabbit uterus has an enhanced affinity for BrdUrd-substituted DNA compared to unsubstituted DNA. Increasing levels of BrdUrd substitution (from 0 to 100%) in a DNA sample are associated with increasingly tighter binding of E2R to that DNA as measured by equilibrium competition experime...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.10.4896

    authors： Kallos J,Fasy TM,Hollander VP,Bick MD

    更新日期：1978-10-01 00:00:00

  • Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

    abstract：:Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.87.10.3899

    authors： Hengerer B,Lindholm D,Heumann R,Rüther U,Wagner EF,Thoenen H

    更新日期：1990-05-01 00:00:00

  • Polymorphism of HLA-DR beta chains in DR4, -7, and -9 haplotypes: implications for the mechanisms of allelic variation.

    abstract：:We have isolated and sequenced cDNA clones corresponding to the DR beta 1 and DR beta 2 loci from two homozygous B-cell lines typed as DR7 (Burkhart) and DR9 (ISK). These nucleotide sequences were compared to beta 1 and beta 2 chains of other DR haplotypes. The first-domain sequences of beta 2 chains are identical in ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.23.9149

    authors： Gregersen PK,Moriuchi T,Karr RW,Obata F,Moriuchi J,Maccari J,Goldberg D,Winchester RJ,Silver J

    更新日期：1986-12-01 00:00:00

  • Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

    abstract：:Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite--the deadliest of those that cause malaria--is able to develop resistance to antimalarial drugs, thwarting present efforts to control it. Genome-wide association studies (GWAS) provide a critical hypothesis-generating tool for u...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1210585109

    authors： Park DJ,Lukens AK,Neafsey DE,Schaffner SF,Chang HH,Valim C,Ribacke U,Van Tyne D,Galinsky K,Galligan M,Becker JS,Ndiaye D,Mboup S,Wiegand RC,Hartl DL,Sabeti PC,Wirth DF,Volkman SK

    更新日期：2012-08-07 00:00:00

  • DNA polymerization in the absence of exonucleolytic proofreading: in vivo and in vitro studies.

    abstract：:Classical genetic selection was combined with site-directed mutagenesis to study bacteriophage T4 DNA polymerase 3'----5' exonuclease activity. A mutant DNA polymerase with very little (less than or equal to 1%) 3'----5' exonuclease activity was generated. In vivo, the 3'----5' exonuclease-deficient DNA polymerase pro...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.6.2417

    authors： Reha-Krantz LJ,Stocki S,Nonay RL,Dimayuga E,Goodrich LD,Konigsberg WH,Spicer EK

    更新日期：1991-03-15 00:00:00

  • Forming giant vesicles with controlled membrane composition, asymmetry, and contents.

    abstract：:Growing knowledge of the key molecular components involved in biological processes such as endocytosis, exocytosis, and motility has enabled direct testing of proposed mechanistic models by reconstitution. However, current techniques for building increasingly complex cellular structures and functions from purified com...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1016410108

    authors： Richmond DL,Schmid EM,Martens S,Stachowiak JC,Liska N,Fletcher DA

    更新日期：2011-06-07 00:00:00

  • Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.

    abstract：:Depressed contractile function plays a primary role in the pathophysiology of acute myocardial ischemia. Intracellular acidification is an important factor underlying the inhibition of force production in the ischemic myocardium. The effect of acidosis to depress contractility is markedly greater in cardiac as compare...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.19.9036

    authors： Metzger JM,Parmacek MS,Barr E,Pasyk K,Lin WI,Cochrane KL,Field LJ,Leiden JM

    更新日期：1993-10-01 00:00:00

  • Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.

    abstract：:Homing endonucleases stimulate gene conversion by generating site-specific DNA double-strand breaks that are repaired by homologous recombination. These enzymes are potentially valuable tools for targeted gene correction and genome engineering. We have engineered a variant of the I-AniI homing endonuclease that nicks ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0810588106

    authors： McConnell Smith A,Takeuchi R,Pellenz S,Davis L,Maizels N,Monnat RJ Jr,Stoddard BL

    更新日期：2009-03-31 00:00:00

  • Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli.

    abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.172226299

    authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

    更新日期：2002-08-20 00:00:00

  • Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

    abstract：:Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1708420114

    authors： Ludwig B,Ludwig S,Steffen A,Knauf Y,Zimerman B,Heinke S,Lehmann S,Schubert U,Schmid J,Bleyer M,Schönmann U,Colton CK,Bonifacio E,Solimena M,Reichel A,Schally AV,Rotem A,Barkai U,Grinberg-Rashi H,Kaup FJ,Avni Y,J

    更新日期：2017-10-31 00:00:00

  • Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa.

    abstract：:During the last several decades corals have been in decline and at least one-third of all coral species are now threatened with extinction. Coral disease has been a major contributor to this threat, but little is known about the responsible pathogens. To date most research has focused on bacterial and fungal diseases;...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0808985105

    authors： Vega Thurber RL,Barott KL,Hall D,Liu H,Rodriguez-Mueller B,Desnues C,Edwards RA,Haynes M,Angly FE,Wegley L,Rohwer FL

    更新日期：2008-11-25 00:00:00

  • Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.

    abstract：:Comparative vertebrate genome sequencing offers a powerful method for detecting conserved regulatory sequences. We propose that the compact genome of the teleost Fugu rubripes is well suited for this purpose. The evolutionary distance of teleosts from other vertebrates offers the maximum stringency for such evolutiona...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.5.1684

    authors： Aparicio S,Morrison A,Gould A,Gilthorpe J,Chaudhuri C,Rigby P,Krumlauf R,Brenner S

    更新日期：1995-02-28 00:00:00

  • The ovary as a source of alpha-ecdysone in an adult mosquito.

    abstract：:The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct dete...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.72.8.3255

    authors： Hagedorn HH,O'Connor JD,Fuchs MS,Sage B,Schlaeger DA,Bohm MK

    更新日期：1975-08-01 00:00:00

  • The "eRF" clone corresponds to tryptophanyl-tRNA synthetase, not mammalian release factor.

    abstract：:To study the similarity between a putative cloned mammalian release factor (RF) and tryptophanyl-tRNA synthetase (TRS), a recombinant rabbit RF fusion protein was expressed from prokaryotic expression vectors. Purified fractions of the fusion proteins were tested for TRS and RF activities. Addition of the fusion prote...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.7.2777

    authors： Timchenko L,Caskey CT

    更新日期：1994-03-29 00:00:00

  • Subunits of purified calcium channels: a 212-kDa form of alpha 1 and partial amino acid sequence of a phosphorylation site of an independent beta subunit.

    abstract：:Antibodies prepared against peptides CP2, CP4, and CP5, which occur within the first 1522 amino acid residues of the alpha 1 subunit of dihydropyridine-sensitive skeletal muscle calcium channels, specifically recognized a 175-kDa form of the alpha 1 subunit in immunoblots and immunoprecipitation experiments. In contra...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.21.8585

    authors： De Jongh KS,Merrick DK,Catterall WA

    更新日期：1989-11-01 00:00:00

  • Assembly, subunit composition, and footprint of human DNA repair excision nuclease.

    abstract：:The assembly and composition of human excision nuclease were investigated by electrophoretic mobility shift assay and DNase I footprinting. Individual repair factors or any combination of up to four repair factors failed to form DNA-protein complexes of high specificity and stability. A stable complex of high specific...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.12.6669

    authors： Wakasugi M,Sancar A

    更新日期：1998-06-09 00:00:00

  • Host specificity of DNA produced by Escherichia coli. XI. In vitro modification of phage fd replicative form.

    abstract：:An enzymatic activity, having the properties expected of a B-specific host-controlled modification enzyme, has been purified from an extract of Escherichia coli strain B. This activity renders the unmodified replicative form of phage fd resistant to B-specific restriction and is only present in strains carrying intact...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.63.2.556

    authors： Kühnlein U,Linn S,Arber W

    更新日期：1969-06-01 00:00:00

  • Uncoupling reproduction from metabolism extends chronological lifespan in yeast.

    abstract：:Studies of replicative and chronological lifespan in Saccharomyces cerevisiae have advanced understanding of longevity in all eukaryotes. Chronological lifespan in this species is defined as the age-dependent viability of nondividing cells. To date this parameter has only been estimated under calorie restriction, mimi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1323918111

    authors： Nagarajan S,Kruckeberg AL,Schmidt KH,Kroll E,Hamilton M,McInnerney K,Summers R,Taylor T,Rosenzweig F

    更新日期：2014-04-15 00:00:00

  • CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.

    abstract：:Recent findings demonstrated proinflammatory functions of interleukin (IL)-9-producing T helper type (Th) 9 cells in the pathogenesis of intestinal bowel diseases (IBDs). However, also antiinflammatory properties have been ascribed to Th9 cells, pointing to a functional heterogeneity. To dissect the specific expressio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1708329115

    authors： Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B

    更新日期：2018-03-27 00:00:00

  • Place recognition and heading retrieval are mediated by dissociable cognitive systems in mice.

    abstract：:A lost navigator must identify its current location and recover its facing direction to restore its bearings. We tested the idea that these two tasks--place recognition and heading retrieval--might be mediated by distinct cognitive systems in mice. Previous work has shown that numerous species, including young childre...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1424194112

    authors： Julian JB,Keinath AT,Muzzio IA,Epstein RA

    更新日期：2015-05-19 00:00:00

  • Initiation, release, and reinitiation of RNA chains by bacteriophage-T3-induced polymerase from T3 DNA templates (E. coli-guanosine triphosphate terminus-purified polymerase).

    abstract：:Bacteriophage T3-induced RNA polymerase, upon copying its specific template, native T3 DNA, initiates RNA chains only with GTP. Denaturation of the DNA results in loss of template specificity for the polymerase. With denatured T3 DNA as template, T3 polymerase initiates RNA chains with both ATP and GTP, and the averag...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.69.1.55

    authors： Maitra U,Huang HH

    更新日期：1972-01-01 00:00:00

  • Neural representation of expected value in the adolescent brain.

    abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1319762111

    authors： Barkley-Levenson E,Galván A

    更新日期：2014-01-28 00:00:00

  • The inositol polyphosphate 5-phosphatase Ocrl associates with endosomes that are partially coated with clathrin.

    abstract：:The subcellular localization of Ocrl, the inositol polyphosphate 5-phosphatase that is mutated in Lowe syndrome, was investigated by fluorescence microscopy. Ocrl was localized to endosomes and Golgi membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early endosomal antigen ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0405664101

    authors： Ungewickell A,Ward ME,Ungewickell E,Majerus PW

    更新日期：2004-09-14 00:00:00

  • Critical review of host specificity and its coevolutionary implications in the fig/fig-wasp mutualism.

    abstract：:Figs (Ficus spp., Moraceae) and their pollinating wasps (Agaonidae, Chalcidoidea) constitute perhaps the most tightly integrated pollination mutualism that is known. Figs are characterized by extraordinarily high global and local species diversity. It has been proposed that the diversification of this mutualism has oc...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,评审

    doi：10.1073/pnas.0501840102

    authors： Machado CA,Robbins N,Gilbert MT,Herre EA

    更新日期：2005-05-03 00:00:00

  • Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

    abstract：:We analyzed variability in outer surface protein B (OspB) from Borrelia burgdorferi (Bb), the causative agent of Lyme disease, to determine how Bb escapes immune destruction. We have shown that vaccination with OspB from Bb strain B31 protected mice from infection with Bb B31 but not against Bb N40. The present study ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.9.4092

    authors： Fikrig E,Tao H,Kantor FS,Barthold SW,Flavell RA

    更新日期：1993-05-01 00:00:00

  • A model of clonal attenuation.

    abstract：:Two formal models of clonal attenuation [Kirkwood, T. B. L. & Holliday, R. (1975) J. Theor. Biol. 53, 481-496; Shall, S. & Stein, W. D. (1979) J. Theor. Biol. 76, 219-231] are considered in the light of recent data on the changing distribution of replicative potential among individual cultured fibroblasts on subclonin...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.1.333

    authors： Prothero J,Gallant JA

    更新日期：1981-01-01 00:00:00

  • Functional profiling of neurons through cellular neuropharmacology.

    abstract：:We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root ganglion neurons from mice were exposed to various pharmacological agents (challenge compounds), while ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1118833109

    authors： Teichert RW,Smith NJ,Raghuraman S,Yoshikami D,Light AR,Olivera BM

    更新日期：2012-01-31 00:00:00

  • Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.

    abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.14.8247

    authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

    更新日期：1999-07-06 00:00:00