Seasonal hysteresis of surface urban heat islands.

abstract：:Failure of embryo implantation accounts for a significant percentage of female infertility. Exquisitely coordinated molecular programs govern the interaction between the competent blastocyst and the receptive uterus. Decidualization, the rapid proliferation and differentiation of endometrial stromal cells into decidua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller M,Yin Y,Ma L

更新日期：2019-09-24 00:00:00

abstract：:The complexity and specificity of metazoan transcription are determined by combinatorial control of the composition and activity of regulatory complexes. To investigate the basis of this specificity, we focused on the glucocorticoid receptor (GR), a single regulatory factor that integrates multiple signals to give ris...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SH,Masuno K,Cooper SB,Yamamoto KR

更新日期：2013-01-29 00:00:00

abstract：:The emerging method of femtosecond crystallography (FX) may extend the diffraction resolution accessible from small radiation-sensitive crystals and provides a means to determine catalytically accurate structures of acutely radiation-sensitive metalloenzymes. Automated goniometer-based instrumentation developed for us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AE,Soltis SM,González A,Aguila L,Alonso-Mori R,Barnes CO,Baxter EL,Brehmer W,Brewster AS,Brunger AT,Calero G,Chang JF,Chollet M,Ehrensberger P,Eriksson TL,Feng Y,Hattne J,Hedman B,Hollenbeck M,Holton JM,Keab

更新日期：2014-12-02 00:00:00

abstract：:Populations of isogenic embryonic stem cells or clonal bacteria often exhibit extensive phenotypic heterogeneity that arises from intrinsic stochastic dynamics of cells. The phenotypic state of a cell can be transmitted epigenetically in cell division, leading to correlations in the states of cells related by descent....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hormoz S,Desprat N,Shraiman BI

更新日期：2015-05-05 00:00:00

abstract：:A gamma-trace variant protein is the major constituent of the amyloid fibrils in patients from Iceland with hereditary cerebral hemorrhage with amyloidosis. The protein consists of 110 residues and is similar to human urinary gamma-trace basic protein (or cystatin C) beginning at its 11th amino-terminal residue. It ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghiso J,Jensson O,Frangione B

更新日期：1986-05-01 00:00:00

abstract：:Specific rearrangement of internal chromosomal regions occurs during development of the somatic macronucleus in Tetrahymena thermophila and results in elimination of germ-line (micronuclear) DNA sequences. The timing and mechanism of genome rearrangement within one particular 9.3-kilobase region, which contains three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austerberry CF,Allis CD,Yao MC

更新日期：1984-12-01 00:00:00

abstract：:The osteopontin (Opn) glycoprotein has been implicated in diverse physiological processes, including vascularization, bone formation, and inflammatory responses. Studies of its role in immune responses has suggested that Opn can set the early stage of type-1 immune (cell-mediated) responses through differential regula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara ML,Jansson M,Hwang ES,Werneck MB,Glimcher LH,Cantor H

更新日期：2005-11-22 00:00:00

abstract：:Antibodies prepared against peptides CP2, CP4, and CP5, which occur within the first 1522 amino acid residues of the alpha 1 subunit of dihydropyridine-sensitive skeletal muscle calcium channels, specifically recognized a 175-kDa form of the alpha 1 subunit in immunoblots and immunoprecipitation experiments. In contra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Jongh KS,Merrick DK,Catterall WA

更新日期：1989-11-01 00:00:00

abstract：:Somatic LINE-1 (L1) retrotransposition has been detected in early embryos, adult brains, and the gastrointestinal (GI) tract, and many cancers, including epithelial GI tumors. We previously found numerous somatic L1 insertions in paired normal and GI cancerous tissues. Here, using a modified method of single-cell anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Soares AO,Goff LA,Talasila A,Choi JA,Ivenitsky D,Karma S,Brophy B,Devine SE,Meltzer SJ,Kazazian HH Jr

更新日期：2020-12-22 00:00:00

abstract：:The superficial gray layer of the superior colliculus contains a map that represents the visual field, whereas the underlying intermediate gray layer contains a vector map of the saccades that shift the direction of gaze. These two maps are aligned so that a particular region of the visual field is represented directl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PH,Helms MC,Augustine GJ,Hall WC

更新日期：1997-11-25 00:00:00

abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

更新日期：2001-07-03 00:00:00

abstract：:All organisms contain thioredoxin (TRX), a regulatory thiol:disulfide protein that reduces disulfide bonds in target proteins. Unlike animals and yeast, plants contain numerous TRXs for which no function has been assigned in vivo. Recent in vitro proteomic approaches have opened the way to the identification of >100 T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vignols F,Bréhélin C,Surdin-Kerjan Y,Thomas D,Meyer Y

更新日期：2005-11-15 00:00:00

abstract：:General optimization results from physics indicate that maximum efficiency of a process, in the sense of minimum overall entropy production, is achieved when the rate of entropy production is constant over time, however not in ordinary clock time but on an, in general varying, "eigen time" scale, intrinsic to the syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andresen B,Shiner JS,Uehlinger DE

更新日期：2002-04-30 00:00:00

abstract：:Many bacterial pathogens of plants and animals have evolved a specialized protein-secretion system termed type III to deliver bacterial proteins into host cells. These proteins stimulate or interfere with host cellular functions for the pathogen's benefit. The Salmonella typhimurium pathogenicity island 1 encodes one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kubori T,Sukhan A,Aizawa SI,Galán JE

更新日期：2000-08-29 00:00:00

abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

更新日期：2018-02-20 00:00:00

abstract：:Tandem gene duplication is an important mutational process in evolutionary adaptation and human disease. Hypothetically, two tandem gene copies should produce twice the output of a single gene, but this expectation has not been rigorously investigated. Here, we show that tandem duplication often results in more than d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loehlin DW,Carroll SB

更新日期：2016-05-24 00:00:00

abstract：:Previous studies in Saccharomyces cerevisiae have defined an essential role for the Dbf4-Cdc7 kinase complex in the initiation of DNA replication presumably by phosphorylation of target proteins, such as the minichromosome maintenance (Mcm) complex. We have examined the phosphorylation of the Mcm complex by the Dfp1-H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JK,Seo YS,Hurwitz J

更新日期：2003-03-04 00:00:00

abstract：:An essential element in the web-trap architecture, the capture silk spun by ecribellate orb spiders consists of glue droplets sitting astride a silk filament. Mechanically this thread presents a mixed solid-liquid behavior unknown to date. Under extension, capture silk behaves as a particularly stretchy solid, owing t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elettro H,Neukirch S,Vollrath F,Antkowiak A

更新日期：2016-05-31 00:00:00

abstract：:The mechanism of phospholipase C regulation by inhibitory receptors was analyzed both in intact and in permeabilized rat thyroid cells (FRTL5). In this system, the muscarinic agonist carbachol inhibited phospholipase C, as indicated by the decrease in the basal levels of inositol 1,4,5-trisphosphate as well as by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bizzarri C,Di Girolamo M,D'Orazio MC,Corda D

更新日期：1990-06-01 00:00:00

abstract：:It has recently been recognized that human serum contains a protein that specifically binds human growth hormone (hGH). This protein has the same restricted specificity for hGH as the membrane-bound GH receptor. To determine whether the GH-binding protein is a derivative of, or otherwise related to, the GH receptor, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daughaday WH,Trivedi B

更新日期：1987-07-01 00:00:00

abstract：:Human neutrophils respond to chemoattractants, resulting in their accumulation at an inflammatory site. Chemoattractants such as the C5a peptide, derived from the C5 complement factor, bind to inhibitory guanine nucleotide binding protein (Gi)-coupled seven membrane-spanning receptors expressed in neutrophils. C5a rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buhl AM,Avdi N,Worthen GS,Johnson GL

更新日期：1994-09-13 00:00:00

abstract：:Extracellular potassium concentration is actively maintained within narrow limits in all higher organisms. Slight variations in extracellular potassium levels can induce major alterations of essential physiological functions in excitable tissues. Here we describe that superfusion of cultured rat hippocampal neurones w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo LA,Heinemann SH,Terlau H,Ludewig U,Lorra C,Pongs O,Stühmer W

更新日期：1992-03-15 00:00:00

abstract：:The numbers and proportion of neurons in areas and regions of cortex were determined for a single cortical hemisphere from two prosimian galagos, one New World owl monkey, one Old World macaque monkey, and one baboon. The results suggest that there is a common plan of cortical organization across the species examined ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins CE,Airey DC,Young NA,Leitch DB,Kaas JH

更新日期：2010-09-07 00:00:00

abstract：:During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene expression designed to ameliorate the underlying cellular disturbance. Central to this stress response is the transcriptional regulator activating transcription factor, ATF4. Here we describe the mechanism regulating ATF4 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vattem KM,Wek RC

更新日期：2004-08-03 00:00:00

abstract：:A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szeto DP,Ryan AK,O'Connell SM,Rosenfeld MG

更新日期：1996-07-23 00:00:00

abstract：:Several inhibitors of gamma-glutamyl transpeptidase in vitro [L-serine plus borate, 6-diazo-5-oxo-L-norleucine, and L- and D-gamma-glutamyl-(o-carboxy)phenylhydrazide] are active in vivo, as indicated by their effect in decreasing the conversion of administered D-gamma-glutamyl-L-alpha-amino[(14)C]butyrate to respirat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith OW,Meister A

更新日期：1979-01-01 00:00:00

abstract：:Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells will respond, but a role for receptor-stimulated death in controlling responses of mature T cells is controversial. Mutant lpr/lpr mice exhibit an autoimmune synd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell JH,Rush B,Weaver C,Wang R

更新日期：1993-05-15 00:00:00

abstract：:The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe developmental abnormalities leadi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveira JB,Bidère N,Niemela JE,Zheng L,Sakai K,Nix CP,Danner RL,Barb J,Munson PJ,Puck JM,Dale J,Straus SE,Fleisher TA,Lenardo MJ

更新日期：2007-05-22 00:00:00

abstract：:The neo (neomycin-resistance) gene of transposon Tn5 encodes the enzyme neomycin phosphotransferase II (EC 2.7.1.95), which confers resistance to various aminoglycoside antibiotics, including kanamycin and G418. The gene is widely used as a selectable marker in the transformation of organisms as diverse as bacteria, y...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yenofsky RL,Fine M,Pellow JW

更新日期：1990-05-01 00:00:00

abstract：:The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein that has been identified recently as the neutral endopeptidase 24.11 [NEP (EC 3.4.24.11)]. Herein, we characterize the organization of the human CALLA/NEP gene and show that it spans more than 80 kilobases (kb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： D'Adamio L,Shipp MA,Masteller EL,Reinherz EL

更新日期：1989-09-01 00:00:00