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Metagenomic analysis indicates that stressors induce production of herpes-like viruses in the coral Porites compressa.

Abstract：

:During the last several decades corals have been in decline and at least one-third of all coral species are now threatened with extinction. Coral disease has been a major contributor to this threat, but little is known about the responsible pathogens. To date most research has focused on bacterial and fungal diseases; however, viruses may also be important for coral health. Using a combination of empirical viral metagenomics and real-time PCR, we show that Porites compressa corals contain a suite of eukaryotic viruses, many related to the Herpesviridae. This coral-associated viral consortium was found to shift in response to abiotic stressors. In particular, when exposed to reduced pH, elevated nutrients, and thermal stress, the abundance of herpes-like viral sequences rapidly increased in 2 separate experiments. Herpes-like viral sequences were rarely detected in apparently healthy corals, but were abundant in a majority of stressed samples. In addition, surveys of the Nematostella and Hydra genomic projects demonstrate that even distantly related Cnidarians contain numerous herpes-like viral genes, likely as a result of latent or endogenous viral infection. These data support the hypotheses that corals experience viral infections, which are exacerbated by stress, and that herpes-like viruses are common in Cnidarians.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Vega Thurber RL,Barott KL,Hall D,Liu H,Rodriguez-Mueller B,Desnues C,Edwards RA,Haynes M,Angly FE,Wegley L,Rohwer FL

doi

10.1073/pnas.0808985105

subject

Has Abstract

pub_date

2008-11-25 00:00:00

pages

18413-8

issue

47

eissn

0027-8424

issn

1091-6490

pii

0808985105

journal_volume

105

pub_type

杂志文章

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