Resistance of primary isolates of human immunodeficiency virus type 1 to soluble CD4 is independent of CD4-rgp120 binding affinity.

abstract：:The wetting of microstructured surfaces is studied both experimentally and theoretically. Even relatively simple surface topographies such as grooves with rectangular cross section exhibit a large variety of different wetting morphologies as observed by atomic force microscopy. This polymorphism arises from liquid wed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seemann R,Brinkmann M,Kramer EJ,Lange FF,Lipowsky R

更新日期：2005-02-08 00:00:00

abstract：:The light-entrained master central circadian clock (CC) located in the suprachiasmatic nucleus (SCN) not only controls the diurnal alternance of the active phase (the light period of the human light-dark cycle, but the mouse dark period) and the rest phase (the human dark period, but the mouse light period), but also ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherji A,Kobiita A,Damara M,Misra N,Meziane H,Champy MF,Chambon P

更新日期：2015-12-01 00:00:00

abstract：:There are many sources of genetic diversity, ranging from programmed mutagenesis in antibody genes to random mutagenesis during species evolution or development of cancer. We propose that mutations in DNA sequence-specific transcription factors that target response elements (REs) in many genes can also provide for rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Resnick MA,Inga A

更新日期：2003-08-19 00:00:00

abstract：:Our group recently demonstrated that autoimmune T cells directed against central nervous system-associated myelin antigens protect neurons from secondary degeneration. We further showed that the synthetic peptide copolymer 1 (Cop-1), known to suppress experimental autoimmune encephalomyelitis, can be safely substitute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schori H,Kipnis J,Yoles E,WoldeMussie E,Ruiz G,Wheeler LA,Schwartz M

更新日期：2001-03-13 00:00:00

abstract：:ATP and UTP can function as extracellular signaling molecules by activating plasma membrane receptors termed P2 purinergic receptors. In the present study a P2U receptor cDNA has been expressed in K-562 human leukemia cells, one of the few available mammalian cell lines that lacks an endogenous P2U receptor. In stably...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erb L,Lustig KD,Sullivan DM,Turner JT,Weisman GA

更新日期：1993-11-15 00:00:00

abstract：:We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malissen M,Malissen B,Jordan BR

更新日期：1982-02-01 00:00:00

abstract：:A model for the chain melting phase transition in dilute aqueous phospholipid bilayer dispersions is presented. This model includes interactions between head groups, between hydrocarbon chains, and within the chains. The head groups are modeled as hard disks which are constrained to lie on a two-dimensional surface se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs RE,Hudson B,Andersen HC

更新日期：1975-10-01 00:00:00

abstract：:The capacity of a so-called male recombination (MR) chromosome in Drosophila melanogaster to generate mutations at 14 X-chromosome loci specifying visible phenotypes was investigated. Appreciable increases in mutation were found at three loci y, sn, and ras. Tests of represnetative mutants generated at each locus esta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green MM

更新日期：1977-08-01 00:00:00

abstract：:We have shown that cellular inhibitor of apoptosis proteins (cIAPs) impair clearance of hepatitis B virus (HBV) infection by preventing TNF-mediated killing/death of infected cells. A key question, with profound therapeutic implications, is whether this finding can be translated to the development of drugs that promot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebert G,Allison C,Preston S,Cooney J,Toe JG,Stutz MD,Ojaimi S,Baschuk N,Nachbur U,Torresi J,Silke J,Begley CG,Pellegrini M

更新日期：2015-05-05 00:00:00

abstract：:Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eulitz M,Weiss DT,Solomon A

更新日期：1990-09-01 00:00:00

abstract：:A somatic hybrid of ASL-1 leukemia cells [H-2a, thymus leukemia (TL)1,2,3, Thy-1b] and LM(TK)-cells [H-2-k, TL(-), Thy-1 (-), thymidine kinase deficient] was formed with the aid of inactivated Sendai virus. The selection of hybrid cell clones was facilitated by the inability of ASL-1 cells to grow in vitro and of LM(T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang W,Cohen EP

更新日期：1975-05-01 00:00:00

abstract：:Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eom J,Kim JJ,Yoon SG,Jeong H,Son S,Lee JB,Yoo J,Seo HJ,Cho Y,Kim KS,Choi KM,Kim IY,Lee HY,Nam KT,Cresswell P,Seong JK,Seo JY

更新日期：2019-08-27 00:00:00

abstract：:We present a model to explain how the neurosecretory system of aquatic mollusks generates their diversity of shell structures and pigmentation patterns. The anatomical and physiological basis of this model sets it apart from other models used to explain shape and pattern. The model reproduces most known shell shapes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boettiger A,Ermentrout B,Oster G

更新日期：2009-04-21 00:00:00

abstract：:Geckos can run rapidly on walls and ceilings, requiring high friction forces (on walls) and adhesion forces (on ceilings), with typical step intervals of approximately 20 ms. The rapid switching between gecko foot attachment and detachment is analyzed theoretically based on a tape model that incorporates the adhesion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian Y,Pesika N,Zeng H,Rosenberg K,Zhao B,McGuiggan P,Autumn K,Israelachvili J

更新日期：2006-12-19 00:00:00

abstract：:Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by modulating chromatin structure. In Drosophila, they have been found to be associated with transcriptionally inactive loci but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d Graaff W,Tomotsune D,Oosterveen T,Takihara Y,Koseki H,Deschamps J

更新日期：2003-11-11 00:00:00

abstract：:We have tested the effect of increased ribosomal fidelity on a modified version of the programmed release factor 2 (RF2) translational frameshift. In the constructs tested, the original UGA codon at the site of the shift was replaced by either of two sense codons, UGG (tryptophan), which allows a frameshift of approxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sipley J,Goldman E

更新日期：1993-03-15 00:00:00

abstract：:Organic reaction networks are formalized by representing chemical species as points in a space and representing reactions by connectivity rules. Using the generalized network, the behavior of the system is investigated under conditions of electronically exciting input and output to a thermal reservoir. Under steady-st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morowitz HJ

更新日期：1974-06-01 00:00:00

abstract：:Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug resistance conferred by a second mutation, T790M. Threonine 790 is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun CH,Mengwasser KE,Toms AV,Woo MS,Greulich H,Wong KK,Meyerson M,Eck MJ

更新日期：2008-02-12 00:00:00

abstract：:RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal uridines. This localized RNA recording approach yields ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medina-Munoz HC,Lapointe CP,Porter DF,Wickens M

更新日期：2020-09-22 00:00:00

abstract：:Host factor protein Cyclophilin A (CypA) regulates HIV-1 viral infectivity through direct interactions with the viral capsid, by an unknown mechanism. CypA can either promote or inhibit viral infection, depending on host cell type and HIV-1 capsid (CA) protein sequence. We have examined the role of conformational dyna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu M,Hou G,Zhang H,Suiter CL,Ahn J,Byeon IJ,Perilla JR,Langmead CJ,Hung I,Gor'kov PL,Gan Z,Brey W,Aiken C,Zhang P,Schulten K,Gronenborn AM,Polenova T

更新日期：2015-11-24 00:00:00

abstract：:This investigation was undertaken to determine the possible role of growth hormone (GH) in the hormonal regulation of hepatic low density lipoprotein (LDL) receptor expression. Treatment of normal rats with estrogen (ethynylestradiol, 5 mg/kg per day) increased the number of hepatic LDL receptors, and the LDL receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudling M,Norstedt G,Olivecrona H,Reihnér E,Gustafsson JA,Angelin B

更新日期：1992-08-01 00:00:00

abstract：:We performed combinatorial peptide library screening in vivo on a novel human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bonelike matrix and soft tissue. We found two peptides, PKRGFQD and SNTRVAP, which were enriched in the tumors, targeted the cell surface of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandelin J,Cardó-Vila M,Driessen WH,Mathew P,Navone NM,Lin SH,Logothetis CJ,Rietz AC,Dobroff AS,Proneth B,Sidman RL,Pasqualini R,Arap W

更新日期：2015-03-24 00:00:00

abstract：:Protein-binding DNA sequence elements encode a variety of regulated functions of genomes. Information about such elements is currently in a state of rapid growth, but improved methods are required to characterize the sequence specificity of DNA-binding proteins. We have established an in vitro method for specific and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafsdottir SM,Schlingemann J,Rada-Iglesias A,Schallmeiner E,Kamali-Moghaddam M,Wadelius C,Landegren U

更新日期：2007-02-27 00:00:00

abstract：:Patent ductus arteriosus (PDA) is a common congenital heart disease that results when the ductus arteriosus, a muscular artery, fails to remodel and close after birth. A syndromic form of this disorder, Char syndrome, is caused by mutation in TFAP2B, the gene encoding a neural crest-derived transcription factor. Estab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani A,Radhakrishnan J,Farhi A,Carew KS,Warnes CA,Nelson-Williams C,Day RW,Pober B,State MW,Lifton RP

更新日期：2005-02-22 00:00:00

abstract：:The activated human Ha-ras oncogene was subjected to the control of the promoter region of the murine whey acidic protein (Wap) gene, which is expressed in mammary epithelial cells in response to lactogenic hormones. The Wap-ras gene was stably introduced into the mouse germ line of five transgenic mice (one male and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andres AC,Schönenberger CA,Groner B,Hennighausen L,LeMeur M,Gerlinger P

更新日期：1987-03-01 00:00:00

abstract：:Changes in external light patterns can alter cell activities in peripheral tissues through slow entrainment of the central clock in suprachiasmatic nucleus (SCN). It remains unclear whether cells in otherwise photo-insensitive tissues can achieve rapid responses to changes in external light. Here we show that light st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan SM,Chang YT,Chen CL,Wang WH,Pan MK,Chen WP,Huang WY,Xu Z,Huang HE,Chen T,Plikus MV,Chen SK,Lin SJ

更新日期：2018-07-17 00:00:00

abstract：:Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of the present study w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leclercq S,Matamoros S,Cani PD,Neyrinck AM,Jamar F,Stärkel P,Windey K,Tremaroli V,Bäckhed F,Verbeke K,de Timary P,Delzenne NM

更新日期：2014-10-21 00:00:00

abstract：:Synapse formation at the neuromuscular junction (NMJ) requires an alternatively spliced variant of agrin (Z(+) agrin) that is produced only by neurons. Here, we show that Nova1 and Nova2, neuron-specific splicing factors identified as targets in autoimmune motor disease, are essential regulators of Z(+) agrin. Nova1/N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruggiu M,Herbst R,Kim N,Jevsek M,Fak JJ,Mann MA,Fischbach G,Burden SJ,Darnell RB

更新日期：2009-03-03 00:00:00

abstract：:The origins of the five groups of living seed plants, including the single relictual species Ginkgo biloba, are poorly understood, in large part because of very imperfect knowledge of extinct seed plant diversity. Here we describe well-preserved material from the Early Cretaceous of Mongolia of the previously enigmati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrera F,Shi G,Ichinnorov N,Takahashi M,Bugdaeva EV,Herendeen PS,Crane PR

更新日期：2017-03-21 00:00:00

abstract：:Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of first-cleavage metaphases. The maximum difference in repair capability be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Generoso WM,Cain KT,Krishna M,Huff SW

更新日期：1979-01-01 00:00:00