Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.

abstract：:Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksson P,Kallin B,van 't Hooft FM,Båvenholm P,Hamsten A

更新日期：1995-03-14 00:00:00

abstract：:The current epidemic of infections caused by antibiotic-resistant gram-positive bacteria requires the discovery of new drug targets and the development of new therapeutics. Lipoteichoic acid (LTA), a cell wall polymer of gram-positive bacteria, consists of 1,3-polyglycerol-phosphate linked to glycolipid. LTA synthase ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter SG,Elli D,Kim HK,Hendrickx AP,Sorg JA,Schneewind O,Missiakas D

更新日期：2013-02-26 00:00:00

abstract：:FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3-14.7K) that had been shown to prevent tumor necrosis factor (TNF)-alpha-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Kang J,Friedman J,Tarassishin L,Ye J,Kovalenko A,Wallach D,Horwitz MS

更新日期：1999-02-02 00:00:00

abstract：:Zif268, a zinc finger protein whose mRNA is rapidly activated in cells exposed to growth factors or other signaling agents, is thought to play a role in regulating the genetic program induced by extracellular ligands. We report that Zif268 has one of the characteristics of a transcriptional regulator, namely, sequence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christy B,Nathans D

更新日期：1989-11-01 00:00:00

abstract：:Xenotropic and polytropic murine leukemia viruses (X-MLVs and P-MLVs) cross-interfere to various extents in non-mouse species and in wild Asian mice, suggesting that they might use a common receptor for infection. Consistent with this hypothesis, the susceptibility of some wild mice to X-MLVs has been mapped to the P-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tailor CS,Nouri A,Lee CG,Kozak C,Kabat D

更新日期：1999-02-02 00:00:00

abstract：:Bruton tyrosine kinase (EC 2.7.1.112) [Btk, encoded by Btk in mice and BTK in humans (formerly known as atk, BPK, or emb)], which is variously mutated in chromosome X-linked agammaglobulinemia patients and X-linked immunodeficient (xid) mice, has the pleckstrin homology (PH) domain at its amino terminus. The PH domain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao L,Kawakami Y,Kawakami T

更新日期：1994-09-13 00:00:00

abstract：:Memory stretches over a lifetime. In controlled laboratory settings, the hippocampus and other medial temporal lobe brain structures have been shown to represent space and time on the scale of meters and seconds. It remains unclear whether the hippocampus also represents space and time over the longer scales necessary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nielson DM,Smith TA,Sreekumar V,Dennis S,Sederberg PB

更新日期：2015-09-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the efficiency of oxygenation of these substrates by COX-2 in vitro is similar, cellular biosynthesis of PGs far excee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchener MM,Hermanson DJ,Shockley EM,Brown HA,Lindsley CW,Reese J,Rouzer CA,Lopez CF,Marnett LJ

更新日期：2015-10-06 00:00:00

abstract：:Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm2 at an overpotential below 300 mV with lon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou H,Yu F,Sun J,He R,Chen S,Chu CW,Ren Z

更新日期：2017-05-30 00:00:00

abstract：:Many cell surface receptors are multimeric proteins, composed of several structural domains, some involved in ligand recognition, whereas others are responsible for signal transduction. In most cases, the mechanism of how ligand interaction in the extracellular domains leads to the activation of effector domains remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Cao J,Jiang M,Labesse G,Liu J,Pin JP,Rondard P

更新日期：2011-09-13 00:00:00

abstract：:Temporal patterning of biological variables, in the form of oscillations and rhythms on many time scales, is ubiquitous. Altering the temporal pattern of an input variable greatly affects the output of many biological processes. We develop here a conceptual framework for a quantitative understanding of such pattern de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brezina V,Orekhova IV,Weiss KR

更新日期：1997-09-16 00:00:00

abstract：:RNA transcription in Euglena gracilis chloroplasts has been characterized by hybridization of RNA from cells at different stages of chloroplast development to (3)H-labeled chloroplast DNA restriction endonuclease fragments. Chloroplast DNA was digested into five fragments of 53,000, 35,000, 25,000, 10,000, and 6900 ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chelm BK,Hallick RB,Gray PW

更新日期：1979-05-01 00:00:00

abstract：:A generic modeling framework to infer the failure-spreading process based on failure times of individual nodes is proposed and tested in four simulation studies: one for cascading failures in interdependent power and transportation networks, one for influenza epidemics, one benchmark test case for congestion cascade i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan X,Chen C

更新日期：2018-08-28 00:00:00

abstract：:We have sequenced the mutant beta-actin gene of a tumorigenic human fibroblast cell line (HuT-14T) and found that it carries three mutations that alter the amino acids at positions 36, 83, and 244 as well as a 22-base-pair "insertion" sequence, in the 5' intron, not present in a wild-type gene. The less tumorigenic ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CS,Ng SY,Gunning P,Kedes L,Leavitt J

更新日期：1985-10-01 00:00:00

abstract：:p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of function (GOF) that promotes tumor progression and therapeutic resistance. One of the major GOF activities of mutant p53 is to suppress 2 other p53 family proteins, p63 and p73. However, the molecular basis is not fully understood. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,Sun W,Kong X,Zhang Y,Yang HJ,Ren C,Jiang Y,Chen M,Chen X

更新日期：2019-11-26 00:00:00

abstract：:Two high molecular weight heat shock proteins, HSP90 (Mr, 90,000) and HSP100 (Mr, 100,000), were separately purified from extracts of cultured cells of a mouse lymphoma cell line, L5178Y. Both of the HSPs exist in homodimeric form under physiological conditions. Their physicochemical properties are quite similar to ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyasu S,Nishida E,Kadowaki T,Matsuzaki F,Iida K,Harada F,Kasuga M,Sakai H,Yahara I

更新日期：1986-11-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription factor. Homeodomain-I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kulkarni P,Jolly MK,Jia D,Mooney SM,Bhargava A,Kagohara LT,Chen Y,Hao P,He Y,Veltri RW,Grishaev A,Weninger K,Levine H,Orban J

更新日期：2017-03-28 00:00:00

abstract：:A central question in protein-DNA recognition is the origin of the specificity that permits binding to the correct site in the presence of excess, nonspecific DNA. In the P22 Arc repressor, the Phe-10 side chain is part of the hydrophobic core of the free protein but rotates out to pack against the sugar-phosphate bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schildbach JF,Karzai AW,Raumann BE,Sauer RT

更新日期：1999-02-02 00:00:00

abstract：:Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharp DJ,Bonnelle V,De Boissezon X,Beckmann CF,James SG,Patel MC,Mehta MA

更新日期：2010-03-30 00:00:00

abstract：:Experiments were designed with the aim of understanding the mechanism whereby the lambda repressor inhibits messenger RNA synthesis. Complexes containing lambda DNA and RNA polymerase were isolated from repressed and derepressed lysogens and analyzed for the relative amounts of RNA polymerase per phage genome. The dat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayward WS,Green MH

更新日期：1969-11-01 00:00:00

abstract：:Screening of a human placenta lambda gt11 library has led to the isolation of the cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains an intronless gene for a putative receptor, was previously isolated by virtue of its cross hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frielle T,Collins S,Daniel KW,Caron MG,Lefkowitz RJ,Kobilka BK

更新日期：1987-11-01 00:00:00

abstract：:After exposure of segments of rabbit taenia coli to the nonionic detergent Triton X-100, tension could be induced by increasing the [Ca2+] in the micromolar range. In the presence of a saturating [Ca2+], this preparation developed nearly 100% of the control tetanus tension recorded from the intact muscle prior to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon AR

更新日期：1978-07-01 00:00:00

abstract：:We describe a molecular resistance biomarker to gefitinib, epithelial membrane protein-1 (EMP-1). Gefitinib is a small-molecule inhibitor that competes for the ATP-binding site on EGF receptor (EGFR) and has been approved for patients with advanced lung cancers. Treatment with gefitinib has resulted in clinical benefi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jain A,Tindell CA,Laux I,Hunter JB,Curran J,Galkin A,Afar DE,Aronson N,Shak S,Natale RB,Agus DB

更新日期：2005-08-16 00:00:00

abstract：:Multiple epidemic diseases have been designated as emerging or reemerging because the numbers of clinical cases have increased. Emerging diseases are often suspected to be driven by increased virulence or fitness, possibly associated with the gain of novel genes or mutations. However, the time period over which humans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Z,McCann A,Weill FX,Blin C,Nair S,Wain J,Dougan G,Achtman M

更新日期：2014-08-19 00:00:00

abstract：:By the combined use of DNase I footprinting, electrophoretic mobility-shift assay, and methylation interference analysis, we have identified a series of sequence-specific protein-DNA interactions in the 5' flanking region of the rat osteocalcin gene. Stimulation of osteocalcin gene expression by 1,25-dihydroxyvitamin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markose ER,Stein JL,Stein GS,Lian JB

更新日期：1990-03-01 00:00:00

abstract：:Heparanase is an endoglycosidase that cleaves heparan sulfate side chains of proteoglycans, resulting in disassembly of the extracellular matrix underlying endothelial and epithelial cells and associating with enhanced cell invasion and metastasis. Heparanase expression is induced in carcinomas and sarcomas, often ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissmann M,Arvatz G,Horowitz N,Feld S,Naroditsky I,Zhang Y,Ng M,Hammond E,Nevo E,Vlodavsky I,Ilan N

更新日期：2016-01-19 00:00:00

abstract：:Serological expression cloning of antigens eliciting a humoral immune response to a syngeneic mouse sarcoma identified pem (mouse placenta and embryonic expression gene) as a new member of the cancer/testis family. To identify the human homologue of pem, mouse pem sequences and pem-related expressed sequence tags from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ono T,Kurashige T,Harada N,Noguchi Y,Saika T,Niikawa N,Aoe M,Nakamura S,Higashi T,Hiraki A,Wada H,Kumon H,Old LJ,Nakayama E

更新日期：2001-03-13 00:00:00

abstract：:Deciding whether a set of objects are the same or different is a cornerstone of perception and cognition. Surprisingly, no principled quantitative model of sameness judgment exists. We tested whether human sameness judgment under sensory noise can be modeled as a form of probabilistically optimal inference. An optimal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Berg R,Vogel M,Josic K,Ma WJ

更新日期：2012-02-21 00:00:00

abstract：:The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dietzschold B,Kao M,Zheng YM,Chen ZY,Maul G,Fu ZF,Rupprecht CE,Koprowski H

更新日期：1992-08-01 00:00:00

abstract：:Three-dimensional topological insulators (3D TIs) represent states of quantum matters in which surface states are protected by time-reversal symmetry and an inversion occurs between bulk conduction and valence bands. However, the bulk-band inversion, which is intimately tied to the topologically nontrivial nature of 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZG,Chen RY,Zhong RD,Schneeloch J,Zhang C,Huang Y,Qu F,Yu R,Li Q,Gu GD,Wang NL

更新日期：2017-01-31 00:00:00