Critical review of host specificity and its coevolutionary implications in the fig/fig-wasp mutualism.

abstract：:In many plants, osmotic stress induces a rapid accumulation of proline through de novo synthesis from glutamate. This response is thought to play a pivotal role in osmotic stress tolerance [Kishor, P. B. K., Hong, Z., Miao, G.-H., Hu, C.-A. A. and Verma, D. P. S. (1995) Plant Physiol. 108, 1387-1394]. During recovery ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verbruggen N,Hua XJ,May M,Van Montagu M

更新日期：1996-08-06 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence. We have identified the amino acid substitutions in three different types of proalbumins designated Ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi N,Takahashi Y,Putnam FW

更新日期：1987-11-01 00:00:00

abstract：:A stable complex between pentaammineruthenium(III) and histidine-33 in horse heart ferricytochrome c is formed in the reaction between aquopentaammineruthenium(II) and the protein at pH 7. HPLC of the tryptic hydrolysate of the modified protein was employed to identify the pentaammineruthenium binding site. Spectrosco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yocom KM,Shelton JB,Shelton JR,Schroeder WA,Worosila G,Isied SS,Bordignon E,Gray HB

更新日期：1982-11-01 00:00:00

abstract：:Active opioid binding proteins were solubilized from rat brain membranes in high yield with sodium deoxycholate in the presence of NaCl. Purification of opioid binding proteins was accomplished by opioid antagonist affinity chromatography. Chromatography using the delta-opioid antagonist N,N-diallyl-Tyr-D-Leu-Gly-Tyr-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loukas S,Mercouris M,Panetsos F,Zioudrou C

更新日期：1994-05-10 00:00:00

abstract：:A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roder JC,Rosén A,Fenyö EM,Troy FA

更新日期：1979-03-01 00:00:00

abstract：:IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by IFN-alpha/beta are the ubiquitin-like ISG15 protein and its E1- (Ube1L) and E2- (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins. It is likely that ISG15 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Denison C,Huibregtse JM,Gygi S,Krug RM

更新日期：2005-07-19 00:00:00

abstract：:Ultrastructural immunocytochemical studies of the expression of major histocompatibility complex class I antigens in the placentas of inbred rats were performed using placentas derived from natural matings and from embryo transfers into females made pseudopregnant by mechanical stimulation. The studies utilized the WF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanbour-Shakir A,Zhang X,Rouleau A,Armstrong DT,Kunz HW,Macpherson TA,Gill TJ 3rd

更新日期：1990-01-01 00:00:00

abstract：:Replication of the murine leukemia viruses is strongly suppressed in mouse embryonic stem (ES) cells. Proviral DNAs are formed normally but are then silenced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809. We show here that ZFP809 expression is not regulated by transcription but rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Goff SP

更新日期：2017-02-07 00:00:00

abstract：:To define the T-cell receptor signal transduction motif, we have transfected human and murine T-cell lines with a chimeric receptor consisting of the extracellular and transmembrane domains of human CD8 alpha and the membrane-proximal portion of CD3 zeta containing at its C terminus either an 18-amino acid segment (NQ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyasu S,Tse AG,Moingeon P,Hussey RE,Mildonian A,Hannisian J,Clayton LK,Reinherz EL

更新日期：1994-07-05 00:00:00

abstract：:Two-dimensional gel electrophoresis has allowed the detection of proteins characteristic of inner cell mass and trophectoderm in mouse blastocyst. Certain of the proteins characterizing trophectoderm copurify with intermediate filaments from trophectoderm and a trophoblastoma cell line. A monoclonal antibody prepared ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brûlet P,Babinet C,Kemler R,Jacob F

更新日期：1980-07-01 00:00:00

abstract：:We have developed a simple yet powerful technique for delineating the morphological events of tumor-induced angiogenesis and other tumor-induced host processes with dual-color fluorescence. The method clearly images implanted tumors and adjacent stroma, distinguishing unambiguously the host and tumor-specific componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Li L,Jiang P,Moossa AR,Penman S,Hoffman RM

更新日期：2003-11-25 00:00:00

abstract：:Inducer-mediated murine erythroleukemia cell (MELC) differentiation provides a model for examining factors determining terminal cell differentiation. The nuclear protein, p53, has been implicated as a potential determinant of cell cycle progression and cell differentiation. In this study p53 content and synthesis, dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen DW,Real FX,DeLeo AB,Old LJ,Marks PA,Rifkind RA

更新日期：1983-10-01 00:00:00

abstract：:Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeman P,Weinshenker D,Quirion R,Srivastava LK,Bhardwaj SK,Grandy DK,Premont RT,Sotnikova TD,Boksa P,El-Ghundi M,O'dowd BF,George SR,Perreault ML,Männistö PT,Robinson S,Palmiter RD,Tallerico T

更新日期：2005-03-01 00:00:00

abstract：:A generic modeling framework to infer the failure-spreading process based on failure times of individual nodes is proposed and tested in four simulation studies: one for cascading failures in interdependent power and transportation networks, one for influenza epidemics, one benchmark test case for congestion cascade i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan X,Chen C

更新日期：2018-08-28 00:00:00

abstract：:Recent scholarship suggests that the genomes of those around us affect our own phenotypes. Much of the empirical evidence for such "metagenomic" effects comes from animal studies, where the socio-genetic environment can be easily manipulated. Among humans, it is more difficult to identify such effects given the nonran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sotoudeh R,Harris KM,Conley D

更新日期：2019-08-13 00:00:00

abstract：:Inflammatory destruction of insulin-producing beta cells in the pancreatic islets is the hallmark of insulin-dependent diabetes mellitus, a spontaneous autoimmune disease of non-obese diabetic mice resembling human juvenile (type I) diabetes. Histochemical analysis of diabetic pancreata revealed that mononuclear cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss L,Slavin S,Reich S,Cohen P,Shuster S,Stern R,Kaganovsky E,Okon E,Rubinstein AM,Naor D

更新日期：2000-01-04 00:00:00

abstract：:Synthetic pheomelanins from enzymic oxidation of the 3,4-dihydroxyphenylalanine (dopa) derivative 5-S-cysteinyldopa have been examined by ESR spectroscopy. These alkalisoluble polymers contain a novel kind of free radical that is spectroscopically distinct from that found in eumelanins. Delocalization of the unpaired ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sealy RC,Hyde JS,Felix CC,Menon IA,Prota G,Swartz HM,Persad S,Haberman HF

更新日期：1982-05-01 00:00:00

abstract：:The MAK16 gene was first defined as a gene whose mutation resulted in loss of M1 double-stranded RNA virus-like particles. The mak16-1 mutation also produces temperature-sensitive cell growth. We report here that mak16-1 cells arrest at the nonpermissive temperature in G1 phase, such that they are mating competent. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner RB

更新日期：1988-08-01 00:00:00

abstract：:Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN neurons that express the transcription factor steroidogenic-factor 1 (VMN(SF1) neurons) blocks recovery from insulin-induced hypoglycemia whereas, conversely, activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meek TH,Nelson JT,Matsen ME,Dorfman MD,Guyenet SJ,Damian V,Allison MB,Scarlett JM,Nguyen HT,Thaler JP,Olson DP,Myers MG Jr,Schwartz MW,Morton GJ

更新日期：2016-04-05 00:00:00

abstract：:Neurons in macaque ventral premotor cortex and inferior parietal lobe discharge during both the observation and the execution of motor acts. It has been claimed that these so-called mirror neurons form the basis of action understanding by matching the visual input with the corresponding motor program (direct matching)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lingnau A,Gesierich B,Caramazza A

更新日期：2009-06-16 00:00:00

abstract：:Conflict between groups of individuals is a prevalent feature in human societies. A common theoretical explanation for intergroup conflict is that it provides benefits to individuals within groups in the form of reproduction-enhancing resources, such as food, territory, or mates. However, it is not always the case tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques GJB,Simon B,Ispolatov Y,Doebeli M

更新日期：2019-07-09 00:00:00

abstract：:Mutations in the ATRX gene on the human X chromosome cause X-linked alpha-thalassemia and mental retardation. XY patients with deletions or mutations in this gene display varying degrees of sex reversal, implicating ATRX in the development of the human testis. To explore further the role of ATRX in mammalian sex diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pask A,Renfree MB,Marshall Graves JA

更新日期：2000-11-21 00:00:00

abstract：:There are two competing hypotheses for the origin of megaliths in Europe. The conventional view from the late 19th and early 20th centuries was of a single-source diffusion of megaliths in Europe from the Near East through the Mediterranean and along the Atlantic coast. Following early radiocarbon dating in the 1970s,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz Paulsson B

更新日期：2019-02-26 00:00:00

abstract：:A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance--wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this have focused on f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vatner DF,Majumdar SK,Kumashiro N,Petersen MC,Rahimi Y,Gattu AK,Bears M,Camporez JP,Cline GW,Jurczak MJ,Samuel VT,Shulman GI

更新日期：2015-01-27 00:00:00

abstract：:Myosins are molecular motors that power diverse cellular processes, such as rapid organelle transport, muscle contraction, and tension-sensitive anchoring. The structural adaptations in the motor that allow for this functional diversity are not known, due, in part, to the lack of high-resolution structures of highly t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuman H,Greenberg MJ,Zwolak A,Lin T,Sindelar CV,Dominguez R,Ostap EM

更新日期：2014-02-11 00:00:00

abstract：:Positive allosteric modulation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represents a potential approach for the management of pain. We recently reported on positive allosteric modulators of MOPr (mu-PAMs), a class A G protein coupled receptor (GPCR). This study was designed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livingston KE,Traynor JR

更新日期：2014-12-23 00:00:00

abstract：:Less than 100 cis-regulatory DNAs have been characterized in the context of transgenic metazoan embryos. Here we investigate the feasibility of conducting a genome-wide search for tissue-specific enhancers in the ascidian Ciona intestinalis. A total of 138 random genomic DNA fragments with an average size of 1.7 kb we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harafuji N,Keys DN,Levine M

更新日期：2002-05-14 00:00:00

abstract：:For a number of viruses, oligomerization is a critical component of envelope processing and surface expression. Previously, we reported that a synthetic peptide (DP-107) corresponding to the putative leucine zipper region (aa 553-590) of the transmembrane protein (gp41) of human immunodeficiency virus type 1 (HIV-1) e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wild C,Dubay JW,Greenwell T,Baird T Jr,Oas TG,McDanal C,Hunter E,Matthews T

更新日期：1994-12-20 00:00:00

abstract：:The magnetic circular dichroism of benzene and indole derivatives was measured down to 190 nM. The following pairs of molecules have magnetic circular dichroisms of the opposite sign in the B(2u) absorption region: aniline and benzonitrile, indene and indoline, indole and 4-aminoindole, and 4-aminoindole and 5-aminoin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Eyring H

更新日期：1973-12-01 00:00:00