The "eRF" clone corresponds to tryptophanyl-tRNA synthetase, not mammalian release factor.

abstract：:The reversible association of alpha and beta gamma subunits of GTP-binding proteins is important for signal transmission from a variety of cell-surface receptors to intracellular effectors. Previous work showed that 1,6-bis(maleimido)hexane, which crosslinks cysteine residues, crosslinks alpha o and alpha i-1 to beta ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas TC,Schmidt CJ,Neer EJ

更新日期：1993-11-01 00:00:00

abstract：:The process by which cells select one of several specific programs of genetic information in development was examined in homoeotic mutant Antennapedia of Rappaport in Drosophila melanogaster. The results show that the alteration of determination from antenna to leg induced by this homoeotic mutation occurs in a popula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Postlethwait JH,Schneiderman HA

更新日期：1969-09-01 00:00:00

abstract：:It is shown that, under certain standard assumptions, such as extended Riemann hypotheses, the scattering matrix varphi(s) for generic Gamma

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshouillers JM,Iwaniec H,Phillips RS,Sarnak P

更新日期：1985-06-01 00:00:00

abstract：:To create a universal system for the control of gene expression, we have studied methods for the construction of novel polydactyl zinc finger proteins that recognize extended DNA sequences. Elsewhere we have described the generation of zinc finger domains recognizing sequences of the 5'-GNN-3' subset of a 64-member zi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerli RR,Segal DJ,Dreier B,Barbas CF 3rd

更新日期：1998-12-08 00:00:00

abstract：:Mutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone prion-like domains (PrLDs) within these proteins. In this work, we examine the sequence features governing PrLD localization to stress granules u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boncella AE,Shattuck JE,Cascarina SM,Paul KR,Baer MH,Fomicheva A,Lamb AK,Ross ED

更新日期：2020-03-17 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thang MN,Thang DC,De Maeyer E,Montagnier L

更新日期：1975-10-01 00:00:00

abstract：:Seasonal oxygen depletion (hypoxia) in coastal bottom waters can lead to the release and persistence of free sulfide (euxinia), which is highly detrimental to marine life. Although coastal hypoxia is relatively common, reports of euxinia are less frequent, which suggests that certain environmental controls can delay t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seitaj D,Schauer R,Sulu-Gambari F,Hidalgo-Martinez S,Malkin SY,Burdorf LD,Slomp CP,Meysman FJ

更新日期：2015-10-27 00:00:00

abstract：:The Bam complex assembles β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. These proteins comprise cylindrical β-sheets with long extracellular loops and create pores to allow passage of nutrients and waste products across the membrane. Despite their functional importance, several questions re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wzorek JS,Lee J,Tomasek D,Hagan CL,Kahne DE

更新日期：2017-03-07 00:00:00

abstract：:Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable prec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY

更新日期：2020-03-17 00:00:00

abstract：:A three-step purification procedure for the isolation of heart muscle chalones is described. The method uses ultrafiltration followed by concanavalin A-Sepharose affinity chromatography and subsequent sucrose density gradient centrifugation. Analytical ultracentrifugation of the highly purified chalone fraction indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriek JA,van der Walt BJ,Bester AJ

更新日期：1981-07-01 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00

abstract：:To facilitate genetic analysis of the human pathogenic parvovirus B19, we constructed a hybrid B19 viral genome in which the defective B19 inverted terminal repeats were replaced with the full-length inverted terminal repeats from a nonpathogenic human parvovirus, the adeno-associated virus 2 (AAV). The hybrid AAV-B19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava CH,Samulski RJ,Lu L,Larsen SH,Srivastava A

更新日期：1989-10-01 00:00:00

abstract：:Preparations of the hemin-controlled repressor (HCR) from rabbit reticulocytes contain 3':5'-cyclic-AMP-independent protein kinase activity for the smallest subunit of the peptide initiation factor eIF-2 and for proteins of reticulocyte 40S ribosomal subunits. Binding of the ternary complex formed between Met-tRNAf, G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kramer G,Henderson AB,Pinphanichakarn P,Wallis MH,Hardesty B

更新日期：1977-04-01 00:00:00

abstract：:We have developed human cervicovaginal organ culture systems to examine the initiating events in HIV transmission after exposure to various sources of HIV infectivity, including semen. Newly infected cells were detected in the cervical submucosa 3-4 days after exposure to a primary HIV isolate. At earlier times, exten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maher D,Wu X,Schacker T,Horbul J,Southern P

更新日期：2005-08-09 00:00:00

abstract：:More than half of all Salmonella enterica serovar Typhi genes still remain unannotated. Although pathogenesis of S. Typhi is incompletely understood, treatment of typhoid fever is complicated by the emergence of drug resistance. Effectiveness of the currently available vaccines is also limited. In search of novel viru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghosh S,Chakraborty K,Nagaraja T,Basak S,Koley H,Dutta S,Mitra U,Das S

更新日期：2011-02-22 00:00:00

abstract：:Fast neurotransmission requires that docked synaptic vesicles be located near the presynaptic N-type or P/Q-type calcium channels. Specific protein-protein interactions between a synaptic protein interaction (synprint) site on N-type and P/Q-type channels and the presynaptic SNARE proteins syntaxin, SNAP-25, and synap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DK,Catterall WA

更新日期：1997-12-23 00:00:00

abstract：:The rapidly expanding network of roads into the Amazon is permanently altering the world's largest tropical forest. Most proposed road projects lack rigorous impact assessments or even basic economic justification. This study analyzes the expected environmental, social and economic impacts of 75 road projects, totalin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vilela T,Malky Harb A,Bruner A,Laísa da Silva Arruda V,Ribeiro V,Auxiliadora Costa Alencar A,Julissa Escobedo Grandez A,Rojas A,Laina A,Botero R

更新日期：2020-03-31 00:00:00

abstract：:The binding of invariant chain to major histocompatibility complex (MHC) proteins is an important step in processing of MHC class II proteins and in antigen presentation. The question of how invariant chain can bind to all MHC class II proteins is central to understanding these processes. We have employed molecular mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee C,McConnell HM

更新日期：1995-08-29 00:00:00

abstract：:Histones play a crucial role in the organization of DNA in the nucleus, but their presence can prevent interactions with DNA binding proteins responsible for repair of DNA damage. Uracil is an abundant mutagenic lesion recognized by uracil DNA glycosylase (UDG) in the first step of base excision repair (BER). In nucle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hinz JM,Rodriguez Y,Smerdon MJ

更新日期：2010-03-09 00:00:00

abstract：:The enzyme tryptophan 2,3-dioxygenase [EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)] first appears in the livers of young rats around the 15th postnatal day, and increases to the adult level by the 22nd day. Studies have shown that the appearance and subsequent development of the enzyme activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Killewich LA,Feigelson P

更新日期：1977-12-01 00:00:00

abstract：:The mammalian retina contains an endogenous circadian pacemaker that broadly regulates retinal physiology and function, yet the cellular origin and organization of the mammalian retinal circadian clock remains unclear. Circadian clock neurons generate daily rhythms via cell-autonomous autoregulatory clock gene network...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruan GX,Zhang DQ,Zhou T,Yamazaki S,McMahon DG

更新日期：2006-06-20 00:00:00

abstract：:The robustness of eight common food web properties is examined with respect to web size. We show that the current controversy concerning the scale dependence or scale invariance of these properties can be resolved by accounting for scaling constraints introduced by webs of very small size. We demonstrate statistically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bersier LF,Sugihara G

更新日期：1997-02-18 00:00:00

abstract：:Purified NADPH:cytochrome c (P-450) reductase (FpT; NADPH-ferrihemoprotein oxidoreductase, EC 1.6.2.4) can reductively activate mitomycin antibiotics through a one-electron reduction to species that alkylate DNA. To assess the involvement of FpT in the intracellular activation of the mitomycins, transfectants overexpr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcourt MF,Hodnick WF,Rockwell S,Sartorelli AC

更新日期：1996-01-09 00:00:00

abstract：:There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry DB,Lu D,Geva M,Watts JC,Bhardwaj S,Oehler A,Renslo AR,DeArmond SJ,Prusiner SB,Giles K

更新日期：2013-10-29 00:00:00

abstract：:Alcoholism causes serious neurologic disease that may be due, in part, to the ability of ethanol to interact with neural cell membranes and change neuronal function. Adenosine receptors are membrane-bound proteins that appear to mediate some of the effects of ethanol in the brain. Human lymphocytes also have adenosine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diamond I,Wrubel B,Estrin W,Gordon A

更新日期：1987-03-01 00:00:00

abstract：:The excision and reintegration of transposable elements (TEs) restructure their host genomes, generating cellular diversity involved in evolution, development, and the etiology of human diseases. Our current knowledge of TE behavior primarily results from bulk techniques that generate time and cell ensemble averages, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim NH,Lee G,Sherer NA,Martini KM,Goldenfeld N,Kuhlman TE

更新日期：2016-06-28 00:00:00

abstract：:Do people judge hurricane risks in the context of gender-based expectations? We use more than six decades of death rates from US hurricanes to show that feminine-named hurricanes cause significantly more deaths than do masculine-named hurricanes. Laboratory experiments indicate that this is because hurricane names lea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung K,Shavitt S,Viswanathan M,Hilbe JM

更新日期：2014-06-17 00:00:00

abstract：:For almost a century, alcohols have been thought to produce their effects by actions on the membrane lipids of central nervous system neurons--the well known "lipid theory" of alcohol action. The rationale for this theory is the correlation of potency with oil/water or membrane/buffer partition coefficient. Although a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Peoples RW,Weight FF

更新日期：1994-08-16 00:00:00

abstract：:Arsenic has played a key medicinal role against a variety of ailments for several millennia, but during the past century its prominence has been displaced by modern therapeutics. Recently, attention has been drawn to arsenic by its dramatic clinical efficacy against acute promyelocytic leukemia. Although toxic reactiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou WC,Jie C,Kenedy AA,Jones RJ,Trush MA,Dang CV

更新日期：2004-03-30 00:00:00