Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein.

abstract：:Members of the LEF-1/TCF family of transcription factors have been implicated in mediating a nuclear response to Wnt signals by association with beta-catenin. Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transcription factor genes Lef1 and Tcf1 were previously found to show a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galceran J,Hsu SC,Grosschedl R

更新日期：2001-07-17 00:00:00

abstract：:Phosphoenolpyruvate carboxykinase (GTP) [GTP;oxaloacetate carboxy-lyase(transphosphorylating); EC 4.1.1.32] is absent in rat liver cytosol during fetal life and is synthesized initially at birth. De novo synthesis of the enzyme can be induced prematurely by injection of dibutyryl cyclic AMP or glucagon into fetal anim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia Ruiz JP,Ingram R,Hanson RW

更新日期：1978-09-01 00:00:00

abstract：:The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama Y,Sakaguchi M,Terabayashi T,Inenaga T,Inoue S,Kobayashi C,Oshima N,Kiyonari H,Nakagata N,Sato Y,Sekiguchi K,Miki H,Araki E,Fujimura S,Tanaka SS,Nishinakamura R

更新日期：2010-05-18 00:00:00

abstract：:The prgB gene encodes the surface protein, Asc10, which mediates cell aggregation, resulting in high-frequency conjugative transfer of the pheromone-inducible tetracycline-resistance plasmid pCF10 in Enterococcus faecalis. Messenger RNA analysis by Northern blot hybridization and primer extension indicates that prgB t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung JW,Dunny GM

更新日期：1992-10-01 00:00:00

abstract：:Upon stimulation with anti-CD3, suppressor T-cell (Ts) hybridomas and homologous transfectants of T-cell receptor a (TCRalpha) cDNA in the T-cell hybridoma formed a 55-kDa TCRalpha chain derivative that bound both the monoclonal anti-TCRalpha chain and polyclonal antibodies against glycosylation inhibiting factor (GIF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii Y,Nakano T,Ishizaka K

更新日期：1996-07-09 00:00:00

abstract：:Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Abou-Donia MM

更新日期：1975-07-01 00:00:00

abstract：:In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process have remained elusive. In the present work, we have observed that Dicer-1 depletion results in an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lozano J,Montañez R,Belles X

更新日期：2015-03-24 00:00:00

abstract：:von Willebrand factor (vWF) is a multimeric glycoprotein that mediates the adhesion of platelets to the subendothelium by binding to platelet glycoprotein Ib. For human vWF, this interaction can be induced in vitro by the antibiotic ristocetin or the snake venom protein botrocetin. A missense mutation, Gly-561-->Ser, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabinowitz I,Tuley EA,Mancuso DJ,Randi AM,Firkin BG,Howard MA,Sadler JE

更新日期：1992-10-15 00:00:00

abstract：:Prey shifts in carnivorous predators are events that can initiate the accelerated generation of new biodiversity. However, it is seldom possible to reconstruct how the change in prey preference occurred. Here we describe an evolutionary "smoking gun" that illuminates the transition from worm hunting to fish hunting am...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aman JW,Imperial JS,Ueberheide B,Zhang MM,Aguilar M,Taylor D,Watkins M,Yoshikami D,Showers-Corneli P,Safavi-Hemami H,Biggs J,Teichert RW,Olivera BM

更新日期：2015-04-21 00:00:00

abstract：:This study describes a unique function of taurocholate in bile canalicular formation involving signaling through a cAMP-Epac-MEK-Rap1-LKB1-AMPK pathway. In rat hepatocyte sandwich cultures, polarization was manifested by sequential progression of bile canaliculi from small structures to a fully branched network. Tauro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu D,Wakabayashi Y,Lippincott-Schwartz J,Arias IM

更新日期：2011-01-25 00:00:00

abstract：:The synthetic, biologically active, [Phe4Val6] analog of natural antamanide has been crystallized from a solution containing calcium nitrate, acetone, and acetonitrile. The crystal does not contain any Ca2+ ions but does contain 12 water molecules per peptide molecule. The conformation of this dodecahydrate is identic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karle IL,Duesler E

更新日期：1977-07-01 00:00:00

abstract：:We have produced a soluble form of a mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region of an immunoglobulin kappa light chain. These chimeric molecules composed of V alpha C alpha C kappa and V beta C beta C kappa chains were efficiently secreted (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grégoire C,Rebaï N,Schweisguth F,Necker A,Mazza G,Auphan N,Millward A,Schmitt-Verhulst AM,Malissen B

更新日期：1991-09-15 00:00:00

abstract：:Quiescent BALB/c 3T3 cells exposed briefly to a platelet-derived growth factor (PDGF) become "competent" to replicate their DNA but do not "progress" into S phase unless incubated with growth factors contained in platelet-poor plasma. Plasma from hypophysectomized rats is deficient in progression activity; it does not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiles CD,Capone GT,Scher CD,Antoniades HN,Van Wyk JJ,Pledger WJ

更新日期：1979-03-01 00:00:00

abstract：:The DNA sequence of 178 base pairs preceding the first structural gene of the threonine operon of Escherichia coli has been determined. A region of perfect 2-fold rotational symmetry, involving 28 base pairs, precedes the first structural gene. The structural similarity of this sequence to known RNA polymerase termina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gardner JF

更新日期：1979-04-01 00:00:00

abstract：:The study of proteolysis lies at the heart of our understanding of biocatalysis, enzyme evolution, and drug development. To understand the degree of natural variation in protease active sites, we systematically evaluated simple active site features from all serine, cysteine and threonine proteases of independent linea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buller AR,Townsend CA

更新日期：2013-02-19 00:00:00

abstract：:The 1987 Montreal Protocol on Substances that Deplete the Ozone Layer is a landmark agreement that has successfully reduced the global production, consumption, and emissions of ozone-depleting substances (ODSs). ODSs are also greenhouse gases that contribute to the radiative forcing of climate change. Using historical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Velders GJ,Andersen SO,Daniel JS,Fahey DW,McFarland M

更新日期：2007-03-20 00:00:00

abstract：:A serumless, chemically defined medium has been developed for the culture of oligodendrocytes isolated from primary neonatal rat cerebral cultures. Combined together, insulin, transferrin, and fibroblast growth factor synergistically induced an essentially homogenous population (95-98%) of cells expressing glycerol-3-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saneto RP,de Vellis J

更新日期：1985-05-01 00:00:00

abstract：:The actions of various opioids were examined on calcium action potentials in the cell somata of guinea pig myenteric neurones and on the release of acetylcholine at synapses onto these cells. The opioids morphine, normorphine, and [D-Ala2, MePhe4, Met5(O)]enkephalin-ol caused membrane hyperpolarizations resulting from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherubini E,North RA

更新日期：1985-03-01 00:00:00

abstract：:We previously demonstrated that platelets express high levels of the tyrosine protein kinase pp60c-src. By a quantitative immunoblot assay, it is shown in this report that pp60c-src represents 0.2-0.4% of total platelet protein. The expression of high levels of pp60c-src in platelets correlated with high levels of tot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golden A,Brugge JS

更新日期：1989-02-01 00:00:00

abstract：:The effects of predator intimidation on habitat use and behavior of prey species are rarely quantified for large marine vertebrates over ecologically relevant scales. Using state space movement models followed by a series of step selection functions, we analyzed movement data of concurrently tracked prey, bowhead whal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews CJD,Breed GA,LeBlanc B,Ferguson SH

更新日期：2020-03-24 00:00:00

abstract：:During the first 2 postnatal years, cortical thickness of the human brain develops dynamically and spatially heterogeneously and likely peaks between 1 and 2 y of age. The striking development renders this period critical for later cognitive outcomes and vulnerable to early neurodevelopmental disorders. However, due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang F,Lian C,Wu Z,Zhang H,Li T,Meng Y,Wang L,Lin W,Shen D,Li G

更新日期：2019-08-06 00:00:00

abstract：:In organisms possessing a dispersal phase the processes of mating, competition, feeding, and predation are often carried out within "trait-groups," defined as populations enclosed in areas smaller than the boundaries of the deme. A simple model shows that this can lead to the selection of "altruistic" traits that favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson DS

更新日期：1975-01-01 00:00:00

abstract：:The vegetative development of the maize shoot can be divided into juvenile and adult phases based on the types of leaves produced at different times in shoot development. Models for the regulation of phase change make explicit predictions about when the identity of these types of leaves is determined. To test these mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orkwiszewski JA,Poethig RS

更新日期：2000-09-12 00:00:00

abstract：:Avian homologues of mammalian gamma delta and alpha beta T-cell antigen receptors, TCR1 and TCR2, have been identified with monoclonal antibodies. These TCR isotypes are associated with the avian CD3 proteins on the T-cell surface. During chick development, T-cell subpopulations bearing CD3/TCR1 or CD3/TCR2 receptor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,Sowder JT,Lahti JM,Cihak J,Lösch U,Cooper MD

更新日期：1989-04-01 00:00:00

abstract：:Horizontal cells of the carp retina possess dopamine receptors linked to adenylate cyclase. Isolated, intact horizontal cells respond to micromolar concentrations of dopamine, whereas nanomolar concentrations of haloperidol, (+)-butaclamol, and flupenthixol block the dopamine response. Preincubation in Ringer's soluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Buskirk R,Dowling JE

更新日期：1982-05-01 00:00:00

abstract：:Humans have altered natural patterns of fire for millennia, but the impact of human-set fires is thought to have been slight in wet closed-canopy forests. In the South Island of New Zealand, Polynesians (Māori), who arrived 700-800 calibrated years (cal y) ago, and then Europeans, who settled ∼150 cal y ago, used fire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McWethy DB,Whitlock C,Wilmshurst JM,McGlone MS,Fromont M,Li X,Dieffenbacher-Krall A,Hobbs WO,Fritz SC,Cook ER

更新日期：2010-12-14 00:00:00

abstract：:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic P

更新日期：2011-03-08 00:00:00

abstract：:The replication of simian virus 40 (SV40) DNA is dependent upon a single viral protein [tumor (T) antigen] and multiple cellular proteins. To define the required cellular proteins, we have made use of a cell-free system that supports the replication of plasmid DNA molecules containing the SV40 origin of replication. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Virshup DM,Kelly TJ

更新日期：1989-05-01 00:00:00

abstract：:Little is known about how members of the indigenous microflora interact with their mammalian hosts to establish mutually beneficial relationships. We have used a gnotobiotic mouse model to show that Bacteroides thetaiotaomicron, a component of the intestinal microflora of mice and humans, uses a repressor, FucR, as a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hooper LV,Xu J,Falk PG,Midtvedt T,Gordon JI

更新日期：1999-08-17 00:00:00

abstract：:The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," which is necessary for binding to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakakura C,Yamaguchi-Iwai Y,Satake M,Bae SC,Takahashi A,Ogawa E,Hagiwara A,Takahashi T,Murakami A,Makino K

更新日期：1994-11-22 00:00:00