Cellular mechanisms for the formation of a soluble form derivative of T-cell receptor alpha chain by suppressor T cells.

abstract：:Theoretical and experimental optical, redox, and paramagnetic results are presented for models of siroheme, the iron isobacteriochlorin prosthetic group of nitrite and sulfite reductases, and of sirohydrochlorin, the metal-free siroheme that is an intermediate in the biosynthetic pathway to vitamin B(12). The facile o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang CK,Hanson LK,Richardson PF,Young R,Fajer J

更新日期：1981-05-01 00:00:00

abstract：:To study the similarity between a putative cloned mammalian release factor (RF) and tryptophanyl-tRNA synthetase (TRS), a recombinant rabbit RF fusion protein was expressed from prokaryotic expression vectors. Purified fractions of the fusion proteins were tested for TRS and RF activities. Addition of the fusion prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Timchenko L,Caskey CT

更新日期：1994-03-29 00:00:00

abstract：:Beetle luciferases are thought to have evolved from fatty acyl-CoA synthetases present in all insects. Both classes of enzymes activate fatty acids with ATP to form acyl-adenylate intermediates, but only luciferases can activate and oxidize d-luciferin to emit light. Here we show that the Drosophila fatty acyl-CoA syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mofford DM,Reddy GR,Miller SC

更新日期：2014-03-25 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones T,Federspiel NA,Chibana H,Dungan J,Kalman S,Magee BB,Newport G,Thorstenson YR,Agabian N,Magee PT,Davis RW,Scherer S

更新日期：2004-05-11 00:00:00

abstract：:Fluorescein isothiocyanate (FITC) was used to label the rabbit intestinal brush border Na+-glucose carrier, identify the carrier protein on sodium dodecyl sulfate/polyacrylamide gel electrophoresis, and monitor the effect of ions and substrates on fluorescence quenching. Enriched brush border preparations were employe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peerce BE,Wright EM

更新日期：1984-04-01 00:00:00

abstract：:Ezrin plays a key role in coupling signal transduction to cortical cell organization. This actin-membrane linker undergoes a series of conformational changes that modulate its interactions with various partners and its localization in membrane or cytosolic pools. Its mobility and exchange rates within and between thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coscoy S,Waharte F,Gautreau A,Martin M,Louvard D,Mangeat P,Arpin M,Amblard F

更新日期：2002-10-01 00:00:00

abstract：:In earlier studies with the acetylcholine receptor (AcChoR) of Electrophorus electricus the rate and equilibrium constants for a model that relates the ligand binding to ion translocation were determined, and the dependence of these constants on the concentrations of carbamoylcholine and acetylcholine, over a 200- and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hess GP,Pasquale EB,Walker JW,McNamee MG

更新日期：1982-02-01 00:00:00

abstract：:Human embryonic stem cells have the potential to differentiate into various cell types and, thus, may be useful as a source of cells for transplantation or tissue engineering. We describe here the differentiation steps of human embryonic stem cells into endothelial cells forming vascular-like structures. The human emb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levenberg S,Golub JS,Amit M,Itskovitz-Eldor J,Langer R

更新日期：2002-04-02 00:00:00

abstract：:The broad negative consequences of habitat degradation on biodiversity have been studied, but the complex effects of natural-agricultural landscape matrices remain poorly understood. Here we used stable carbon and nitrogen isotopes to detect changes in mammal resource and habitat use and trophic structure between pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Magioli M,Moreira MZ,Fonseca RCB,Ribeiro MC,Rodrigues MG,Ferraz KMPMB

更新日期：2019-09-10 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase II (CaM-KII) regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors. To identify proteins that may interact with and modulate CaM-KII fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang BH,Mukherji S,Soderling TR

更新日期：1998-09-01 00:00:00

abstract：:To investigate the role of the myosin hinge region in muscle contraction, we examined the contraction characteristics and Mg-ATPase activity of glycerinated muscle fibers prepared from rabbit psoas in the presence and absence of polyclonal antibody directed against the subfragment 2 (S-2) region of myosin. The antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugi H,Kobayashi T,Gross T,Noguchi K,Karr T,Harrington WF

更新日期：1992-07-01 00:00:00

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:Whether the mate sampling and choice performed by females in nature influences offspring performance is a controversial issue in theory and an open empirical question. Pronghorn (Antilocapra americana) females engage in an obvious and energetically expensive mate sampling process to identify vigorous males. Although i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers JA,Waits L

更新日期：2006-10-31 00:00:00

abstract：:Among the multiple steps constituting the kinesin mechanochemical cycle, one of the most interesting events is observed when kinesins move an 8-nm step from one microtubule (MT)-binding site to another. The stepping motion that occurs within a relatively short time scale ( approximately 100 mus) is, however, beyond th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyeon C,Onuchic JN

更新日期：2007-10-30 00:00:00

abstract：:Determining trend and implementing detrending operations are important steps in data analysis. Yet there is no precise definition of "trend" nor any logical algorithm for extracting it. As a result, various ad hoc extrinsic methods have been used to determine trend and to facilitate a detrending operation. In this art...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Z,Huang NE,Long SR,Peng CK

更新日期：2007-09-18 00:00:00

abstract：:Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CTR1 gene, which enco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida S,Lee J,Thiele DJ,Herskowitz I

更新日期：2002-10-29 00:00:00

abstract：:Our main goal is to analyze the geometric and spectral properties of the Picard modular group with Gaussian integer entries acting on the two-dimensional complex hyperbolic space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francsics G,Lax PD

更新日期：2006-07-25 00:00:00

abstract：:A double-antibody radioimmunoassay has been developed for the detection of Australia antigen and antibodies to Australia antigen in human sera. The assay is simple to perform, and can be completed in 18 hr. Based on parallel studies of human sera, it is approximately 2000 times more sensitive than agar gel diffusion a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aach RD,Grisham JW,Parker CW

更新日期：1971-05-01 00:00:00

abstract：:Ca2+ is a powerful inhibitor (Ki is congruent to 16 muM) of basal and prostaglandin E1 (PGE1)-stimulated adenylate cyclase [ATP pyrophosphate-lyase (cyclizing); EC 4.6.1.1] activity in membranes obtained from homogenized human platelets. Ca2+ (but not the ionophore A23,187) decreased V(max) of the reaction without an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodan GA,Feinstein MB

更新日期：1976-06-01 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and tumorigenesis. In this report we explore the effect of phosphorylation of cell division cycle 6 (Cdc6), a DNA replication initiation factor, by polo-like kinase 1 (Plk1) on the regulation of ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yim H,Erikson RL

更新日期：2010-11-16 00:00:00

abstract：:Ribosomal signatures, idiosyncrasies in the ribosomal RNA (rRNA) and/or proteins, are characteristic of the individual domains of life. As such, insight into the early evolution of the domains can be gained from a comparative analysis of their respective signatures in the translational apparatus. In this work, we iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts E,Sethi A,Montoya J,Woese CR,Luthey-Schulten Z

更新日期：2008-09-16 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:Beta subunits of voltage-gated Ca2+ channels are encoded in four genes and display additional molecular diversity because of alternative splicing. At the functional level, all forms are very similar except for beta2a, which differs in that it does not support prepulse facilitation of alpha1C Ca2+ channels, inhibits vo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin N,Platano D,Olcese R,Costantin JL,Stefani E,Birnbaumer L

更新日期：1998-04-14 00:00:00

abstract：:Insects have diversified through more than 450 million y of Earth's changeable climate, yet rapidly shifting patterns of temperature and precipitation now pose novel challenges as they combine with decades of other anthropogenic stressors including the conversion and degradation of land. Here, we consider how insects ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halsch CA,Shapiro AM,Fordyce JA,Nice CC,Thorne JH,Waetjen DP,Forister ML

更新日期：2021-01-12 00:00:00

abstract：:Mammalian DAI (DNA-dependent activator of IFN-regulatory factors), an activator of the innate immune response, senses cytosolic DNA by using 2 N-terminal Z-DNA binding domains (ZBDs) and a third putative DNA binding domain located next to the second ZBD. Compared with other previously known ZBDs, the second ZBD of hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha SC,Kim D,Hwang HY,Rich A,Kim YG,Kim KK

更新日期：2008-12-30 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) are endogenous neuropeptide ligands for the G protein-coupled receptors NPBWR1 and NPBWR2. Here we report that the majority of NPW neurons in the mesolimbic region possess tyrosine hydroxylase immunoreactivity, indicating that a small subset of dopaminergic neurons coexpre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motoike T,Long JM,Tanaka H,Sinton CM,Skach A,Williams SC,Hammer RE,Sakurai T,Yanagisawa M

更新日期：2016-05-24 00:00:00

abstract：:O(6)-methylguanine (O(6)meG) and related modifications of guanine in double-stranded DNA are functionally severe lesions that can be produced by many alkylating agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent carcinogen. O(6)meG is repaired through its demethylation by the O(6)-alkylguanine-DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CS,Shemorry A,Varshavsky A

更新日期：2009-02-17 00:00:00

abstract：:The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively. Disruption of this locus by deletions or point mutations is a common event in human cancer, perhaps second only to the loss of p53. Using insect c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamijo T,Weber JD,Zambetti G,Zindy F,Roussel MF,Sherr CJ

更新日期：1998-07-07 00:00:00