Abstract：
:Ribosomal signatures, idiosyncrasies in the ribosomal RNA (rRNA) and/or proteins, are characteristic of the individual domains of life. As such, insight into the early evolution of the domains can be gained from a comparative analysis of their respective signatures in the translational apparatus. In this work, we identify signatures in both the sequence and structure of the rRNA and analyze their contributions to the universal phylogenetic tree using both sequence- and structure-based methods. Domain-specific ribosomal proteins can be considered signatures in their own right. Although it is commonly assumed that they developed after the universal ribosomal proteins, we present evidence that at least one may have been present before the divergence of the organismal lineages. We find correlations between the rRNA signatures and signatures in the ribosomal proteins showing that the rRNA signatures coevolved with both domain-specific and universal ribosomal proteins. Finally, we show that the genomic organization of the universal ribosomal components contains these signatures as well. From these studies, we propose the ribosomal signatures are remnants of an evolutionary-phase transition that occurred as the cell lineages began to coalesce and so should be reflected in corresponding signatures throughout the fabric of the cell and its genome.
journal_name
Proc Natl Acad Sci U S Aauthors
Roberts E,Sethi A,Montoya J,Woese CR,Luthey-Schulten Zdoi
10.1073/pnas.0804861105subject
Has Abstractpub_date
2008-09-16 00:00:00pages
13953-8issue
37eissn
0027-8424issn
1091-6490pii
0804861105journal_volume
105pub_type
杂志文章abstract：:Reelin is a key mediator of ordered neuronal alignment in the brain. Here, we demonstrate that Reelin molecules assemble with each other to form a huge protein complex both in vitro and in vivo. The Reelin-Reelin interaction clearly is inhibited by the function-blocking anti-Reelin antibody, CR-50, at a concentration ...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
pub_type： 杂志文章
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更新日期：2000-08-15 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2017-05-30 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2008-12-02 00:00:00
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更新日期：1982-01-01 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：2007-04-24 00:00:00
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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abstract：:The super-enhancers (SEs) of lineage-specific genes in B cells are off-target sites of somatic hypermutation. However, the inability to detect sufficient numbers of mutations in normal human B cells has precluded the generation of a high-resolution mutational landscape of SEs. Here we captured and sequenced 12 B cell ...
journal_title：Proceedings of the National Academy of Sciences of the United States of America
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journal_title：Proceedings of the National Academy of Sciences of the United States of America
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更新日期：1977-05-01 00:00:00
