Abstract:
:We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
journal_name
Proc Natl Acad Sci U S Aauthors
Jones T,Federspiel NA,Chibana H,Dungan J,Kalman S,Magee BB,Newport G,Thorstenson YR,Agabian N,Magee PT,Davis RW,Scherer Sdoi
10.1073/pnas.0401648101keywords:
subject
Has Abstractpub_date
2004-05-11 00:00:00pages
7329-34issue
19eissn
0027-8424issn
1091-6490pii
0401648101journal_volume
101pub_type
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