Dendritic field size and morphology of midget and parasol ganglion cells of the human retina.

abstract：:X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain. The IL-2R gamma chain is a common component of the IL-2, IL-4, and IL-7 receptor sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiSanto JP,Rieux-Laucat F,Dautry-Varsat A,Fischer A,de Saint Basile G

更新日期：1994-09-27 00:00:00

abstract：:Reconstructing the origin and early evolutionary history of anthropoid primates (monkeys, apes, and humans) is a current focus of paleoprimatology. Although earlier hypotheses frequently supported an African origin for anthropoids, recent discoveries of older and phylogenetically more basal fossils in China and Myanma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaimanee Y,Chavasseau O,Beard KC,Kyaw AA,Soe AN,Sein C,Lazzari V,Marivaux L,Marandat B,Swe M,Rugbumrung M,Lwin T,Valentin X,Zin-Maung-Maung-Thein,Jaeger JJ

更新日期：2012-06-26 00:00:00

abstract：:A recA-independent recombinational event is described which results in insertion of an entire plasmid genome at a unique site of another plasmid, and coincident excision of a precisely defined DNA segment originally present at the point of the insertion. The resulting recombinant molecules subsequently can undergo sit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopecko DJ,Cohen SN

更新日期：1975-04-01 00:00:00

abstract：:The plasmid construct pSVO-CAT has been used to test adenovirus promoter activities in the unmethylated or methylated state. We have now observed that the E2A late promoter of adenovirus type 2 (Ad2) DNA also activated the chloramphenicol acetyltransferase (CAT) gene upon transfection of the pAd2E2A-CAT construct into...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langner KD,Weyer U,Doerfler W

更新日期：1986-03-01 00:00:00

abstract：:Rod-shaped "ghosts" that are free of murein have been isolated from E. coli. The shape of these "ghosts" is maintained by a unit membrane soluble in sodium dodecyl sulfate. Ghosts consist of about 20-30% phospholipid (almost exclusively phosphatidylethanolamine) and 50-60% protein; a large fraction of the remaining ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henning U,Rehn K,Hoehn B

更新日期：1973-07-01 00:00:00

abstract：:In the present study the complete amino acid sequence of human plasma Zn-alpha 2-glycoprotein was determined. This protein whose biological function is unknown consists of a single polypeptide chain of 276 amino acid residues including 8 tryptophan residues and has a pyroglutamyl residue at the amino terminus. The loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki T,Gejyo F,Takagaki K,Haupt H,Schwick HG,Bürgi W,Marti T,Schaller J,Rickli E,Brossmer R

更新日期：1988-02-01 00:00:00

abstract：:Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carcamo-Noriega EN,Sathyamoorthi S,Banerjee S,Gnanamani E,Mendoza-Trujillo M,Mata-Espinosa D,Hernández-Pando R,Veytia-Bucheli JI,Possani LD,Zare RN

更新日期：2019-06-25 00:00:00

abstract：:Methane is a major greenhouse gas linked to global warming; however, patterns of in situ methane oxidation by methane-oxidizing bacteria (methanotrophs), nature's main biological mechanism for methane suppression, are often inconsistent with laboratory predictions. For example, one would expect a strong relationship b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knapp CW,Fowle DA,Kulczycki E,Roberts JA,Graham DW

更新日期：2007-07-17 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:In virtually every real-life situation humans are confronted with complex and cluttered visual environments that contain a multitude of objects. Because of the limited capacity of the visual system, objects compete for neural representation and cognitive processing resources. Previous work has shown that such attentio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser D,Stein T,Peelen MV

更新日期：2014-07-29 00:00:00

abstract：:A mechanism of ion transport across membranes is reported. Microbial transport of Fe(3+) generally delivers iron, a growth-limiting nutrient, to cells via highly specific siderophore-mediated transport systems. In contrast, iron transport in the fresh water bacterium Aeromonas hydrophila is found to occur by means of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stintzi A,Barnes C,Xu J,Raymond KN

更新日期：2000-09-26 00:00:00

abstract：:HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few have been both biochemically and structurally characterized. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridwell-Rabb J,Kang G,Zhong A,Liu HW,Drennan CL

更新日期：2016-11-29 00:00:00

abstract：:An excised patch of embryonic muscle membrane was used as a probe for measuring the release of acetylcholine (AcCho) from growing spinal neurons in Xenopus cell culture. The neuron was stimulated extracellularly at the soma, and the evoked AcCho release was monitored at the growth cone, along the neurite, and near the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun YA,Poo MM

更新日期：1987-04-01 00:00:00

abstract：:Rad51 is the primary eukaryotic recombinase responsible for initiating DNA strand exchange during homologous recombination. Although the subject of intense study for over a decade, many molecular details of the reactions promoted by Rad51 and related recombinases remain unknown. Using total internal reflection fluores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granéli A,Yeykal CC,Robertson RB,Greene EC

更新日期：2006-01-31 00:00:00

abstract：:Mutations in BRCA1 are present in 45% of families that segregate with susceptibility for breast cancer and in 80-90% of families with both breast and ovarian cancer. Here we report that BRCA1 stimulates artificial and genomic promoter constructs containing p53-responsive elements. This activity of BRCA1 depends on the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Monteiro AN,August A,Aaronson SA,Hanafusa H

更新日期：1998-03-03 00:00:00

abstract：:Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 --> Arg + Ser-117 --> Asn) s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsaeree P,Khongsuk P,Leartsakulpanich U,Chitnumsub P,Tarnchompoo B,Walkinshaw MD,Yuthavong Y

更新日期：2005-09-13 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:Kirsten sarcoma virus (Ki-MSV) and Harvey sarcoma virus (Ha-MSV) are mouse-rat recombinant viruses that were originally isolated by experimental inoculation of rats with helper-independent mouse type C viruses. We have recently identified in cells transformed by Ki-MSV or Ha-MSV, a phosphoprotein, p21, coded for by Ki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young HA,Shih TY,Scolnick EM,Rasheed S,Gardner MB

更新日期：1979-07-01 00:00:00

abstract：:In contrast to the Hox genes in arthropods and vertebrates, those in molluscs show diverse expression patterns with differences reported among lineages. Here, we investigate 2 phylogenetically distant molluscs, a gastropod and a polyplacophoran, and show that the Hox expression in both species can be divided into 2 ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huan P,Wang Q,Tan S,Liu B

更新日期：2020-01-07 00:00:00

abstract：:Biological processes such as circadian rhythms, cell division, metabolism, and development occur as ordered sequences of events. The synchronization of these coordinated events is essential for proper cell function, and hence the determination of critical time points in biological processes is an important component o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan N,Tadepalli S,Watson LT,Helm RF,Antoniotti M,Mishra B

更新日期：2010-07-13 00:00:00

abstract：:We present here a shorter version of the proof of our earlier work, showing that the von Neumann factor associated with the group Z(2)SL(2,Z) has trivial fundamental group. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popa S

更新日期：2004-01-20 00:00:00

abstract：:The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiswell BP,Zhang R,Murphy JW,Boggon TJ,Calderwood DA

更新日期：2008-12-30 00:00:00

abstract：:Extracellular matrix (ECM) profoundly influences the growth and differentiation of the mammary gland epithelium, both in culture and in vivo. Utilizing a clonal population of mouse mammary epithelial cells that absolutely requires an exogenous ECM for function, we developed a rapid assay to study signal transduction b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskelley CD,Desprez PY,Bissell MJ

更新日期：1994-12-20 00:00:00

abstract：:One of the major surprises of the molecular analysis of major histocompatibility complex (MHC) genes is the large number of class I (K/D)-related sequences in the genome. Both restriction fragment length polymorphisms and cosmid cloning experiments showed them all to be closely linked to the MHC. Until now little info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schepart BS,Woodward JG,Palmer MJ,Macchi MJ,Basta P,McLaughlin-Taylor E,Frelinger JA

更新日期：1985-08-01 00:00:00

abstract：:HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85-99) was previously found to bind to purified HLA-DR2 (DRA, DRB1*1501) and to be recognized by human MBP-specific T cell clones. Soluble HLA-DR2 was expressed in the baculovirus system by re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gauthier L,Smith KJ,Pyrdol J,Kalandadze A,Strominger JL,Wiley DC,Wucherpfennig KW

更新日期：1998-09-29 00:00:00

abstract：:Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype dictates soluble antibody function, but how mIg isotype influences B cell behavior is not well defined. We examined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong P,Granato A,Zuo T,Chaudhary N,Zuiani A,Han SS,Donthula R,Shrestha A,Sen D,Magee JM,Gallagher MP,van der Poel CE,Carroll MC,Wesemann DR

更新日期：2017-10-03 00:00:00

abstract：:Myelin basic proteins (MBP) are major constituents of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. We previously showed that MBP-related transcripts are present in the bone marrow and the immune system. These mRNAs are transcribe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marty MC,Alliot F,Rutin J,Fritz R,Trisler D,Pessac B

更新日期：2002-06-25 00:00:00

abstract：:We have inserted the sequence 5'-AAG-GAGGU-3', which is complementary to the 3' terminus of Escherichia coli 16S rRNA, in a reading frame and analyzed its effect on the accuracy and overall rate of translation in vivo. Translation over the sequence yields a 50% ribosomal frameshift if the reading phase is A-AGG-AGG-U....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanjaard RA,van Duin J

更新日期：1988-11-01 00:00:00

abstract：:Recent functional imaging studies have revealed coactivation in a distributed network of cortical regions that characterizes the resting state, or default mode, of the human brain. Among the brain regions implicated in this network, several, including the posterior cingulate cortex and inferior parietal lobes, have al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greicius MD,Srivastava G,Reiss AL,Menon V

更新日期：2004-03-30 00:00:00

abstract：:The relationship between the compositions of the Earth and chondritic meteorites is at the center of many important debates. A basic assumption in most models for the Earth's composition is that the refractory elements are present in chondritic proportions relative to each other. This assumption is now challenged by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang S,Jacobsen SB,Mukhopadhyay S

更新日期：2013-03-26 00:00:00