The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

abstract：:In oxygenic photosynthetic eukaryotes, the hydroxylated carotenoid zeaxanthin is produced from preexisting violaxanthin upon exposure to excess light conditions. Zeaxanthin binding to components of the photosystem II (PSII) antenna system has been investigated thoroughly and shown to help in the dissipation of excess ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballottari M,Alcocer MJ,D'Andrea C,Viola D,Ahn TK,Petrozza A,Polli D,Fleming GR,Cerullo G,Bassi R

更新日期：2014-06-10 00:00:00

abstract：:Proteases constitute the largest enzyme family, yet their biological roles are obscured by our rudimentary understanding of their cellular substrates. There are 12 human caspases that play crucial roles in inflammation and cell differentiation and drive the terminal stages of cell death. Recent N-terminomics technolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Julien O,Zhuang M,Wiita AP,O'Donoghue AJ,Knudsen GM,Craik CS,Wells JA

更新日期：2016-04-05 00:00:00

abstract：:Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid compositi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmer R,van der Ploeg K,Ron D

更新日期：2013-03-19 00:00:00

abstract：:When two vortices cross, each of them breaks into two parts and exchanges part of itself for part of the other. This process, called vortex reconnection, occurs in classical and superfluids, and in magnetized plasmas and superconductors. We present the first experimental observations of reconnection between quantized ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bewley GP,Paoletti MS,Sreenivasan KR,Lathrop DP

更新日期：2008-09-16 00:00:00

abstract：:Recent climate change has increased arctic soil temperatures and thawed large areas of permafrost, allowing for microbial respiration of previously frozen C. Furthermore, soil destabilization from melting ice has caused an increase in thermokarst failures that expose buried C and release dissolved organic C (DOC) to s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cory RM,Crump BC,Dobkowski JA,Kling GW

更新日期：2013-02-26 00:00:00

abstract：:We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into the nucleus of osteoblasts, implicating this process in the action of Oxt on osteoblast maturation. Sequential immunocytochemistry of intact cells or isolated nucleoplasts stripped of the outer nuclear membrane showed p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Benedetto A,Sun L,Zambonin CG,Tamma R,Nico B,Calvano CD,Colaianni G,Ji Y,Mori G,Grano M,Lu P,Colucci S,Yuen T,New MI,Zallone A,Zaidi M

更新日期：2014-11-18 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:Cerebellar development occurs mainly postnatally and implies cell proliferation and migration. Hepatocyte growth factor (HGF) and Met are involved in mediating these responses in other tissues and are coexpressed in the cerebellum. Here we show that Met is localized in granule cell precursors and that cultures of thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ieraci A,Forni PE,Ponzetto C

更新日期：2002-11-12 00:00:00

abstract：:Induced pluripotent stem cells (iPS cells) represent a unique tool for the study of the pathophysiology of human disease, because these cells can be differentiated into multiple cell types in vitro and used to generate patient- and tissue-specific disease models. Given the critical role for skeletal muscle insulin res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iovino S,Burkart AM,Warren L,Patti ME,Kahn CR

更新日期：2016-02-16 00:00:00

abstract：:NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glutamate binding to g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iacobucci GJ,Wen H,Helou M,Liu B,Zheng W,Popescu GK

更新日期：2021-01-12 00:00:00

abstract：:Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold BJ,Lahner B,DaCosta JM,Weisman CM,Hollister JD,Salt DE,Bomblies K,Yant L

更新日期：2016-07-19 00:00:00

abstract：:[14C]Naphthalene was given orally to rats with cannulated bile ducts and to germ-free rats. Bile and urine from the cannulated rats and urine from the germ-free rats contained no radioactive 1,2-dihydro-1-hydroxy-2-methylthionaphthalene and only trace amounts of radioactive naphthols or naphthol conjugates. Urine of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakke J,Struble C,Gustafsson JA,Gustafsson B

更新日期：1985-02-01 00:00:00

abstract：:Paired immunoglobulin-like type 2 receptor α (PILRα) and β (PILRβ) belong to the PILR family and are related to innate immune regulation in various species. Despite their high sequence identity, PILRα and PILRβ are shown to have variant sialic acid (SA) binding avidities. To explore the molecular basis of this interac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Lu G,Qi J,Wang H,Xuan Y,Wang Q,Li Y,Zhang Y,Zheng C,Fan Z,Yan J,Gao GF

更新日期：2014-06-03 00:00:00

abstract：:Linear double-stranded molecules of the circularly permuted and terminally redundant DNA of Salmonella bacteriophage P22 have been converted to oligomeric products in the presence of polynucleotide ligase coded for by the coliphage T4. The reaction has been monitored by sucrose density-gradient centrifugation and elec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sgaramella V

更新日期：1972-11-01 00:00:00

abstract：:Among the tRNA population of the archaeal parasite Nanoarchaeum equitans are five species assembled from separate 5' and 3' tRNA halves and four species derived from tRNA precursors containing introns. In both groups an intervening sequence element must be removed during tRNA maturation. A bulge-helix-bulge (BHB) moti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randau L,Calvin K,Hall M,Yuan J,Podar M,Li H,Söll D

更新日期：2005-12-13 00:00:00

abstract：:Over the past 50 years, the rising tree line along Jumpingpound Ridge in the Rocky Mountains of Alberta, Canada, has reduced the area of alpine meadows and isolated populations that reside within them. By analyzing an 11-year data set of butterfly population sizes for 17 subpopulations along the ridge, we show that fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roland J,Matter SF

更新日期：2007-08-21 00:00:00

abstract：:We recently found that the beta-adrenergic agonist 1-isoproterenol evokes a rapid (less than 5 min) Ca2+- and receptor-dependent stimulation of endocytosis, hexose transport, and amino acid transport in mouse renal cortex involving proximal tubule cells. This response is associated with increased Ca2+ fluxes and a mob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig H,Goldstone AD,Lu CY

更新日期：1983-12-01 00:00:00

abstract：:Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherer PE,Okamoto T,Chun M,Nishimoto I,Lodish HF,Lisanti MP

更新日期：1996-01-09 00:00:00

abstract：:Prostate carcinoma is the second leading cause of death from malignancy in men in the United States. Prostate cancer cells express type I insulin-like growth factor receptor (IGF-IR) and prostate cancer selectively metastazises to bone, which is an environment rich in insulin-like growth factors (IGFs), thereby suppor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burfeind P,Chernicky CL,Rininsland F,Ilan J,Ilan J

更新日期：1996-07-09 00:00:00

abstract：:Over 30 viral-specified polypeptides are translated in vitro from RNA of cells productively infected with Epstein-Barr virus (EBV). The polypeptides map to sites in EBV DNA by hybrid selection. Almost all of the polypeptides are reactive with EBV immune human serum. Several of the polypeptides are part of the early an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummel M,Kieff E

更新日期：1982-09-01 00:00:00

abstract：:The exopolysaccharide alginate is a major virulence factor in the pathogenicity of Pseudomonas aeruginosa infecting the lungs of cystic fibrosis (CF) patients. Alginate synthesis by P. aeruginosa is believed to occur in response to environmental signals present in the CF lung. Transcription of a critical alginate bios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roychoudhury S,Sakai K,Chakrabarty AM

更新日期：1992-04-01 00:00:00

abstract：:In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geck P,Maffini MV,Szelei J,Sonnenschein C,Soto AM

更新日期：2000-08-29 00:00:00

abstract：:COVID-19 has emerged as one of the deadliest and most disruptive events in recent human history. Drawing from political science and psychological theories, we examine the effects of daily confirmed cases in a country on citizens' support for the political leader through the first 120 d of 2020. Using three unique data...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yam KC,Jackson JC,Barnes CM,Lau J,Qin X,Lee HY

更新日期：2020-10-13 00:00:00

abstract：:Liquid RNA.DNA hybridization with separated strands of adenovirus type 2 DNA revealed that late nuclear RNA can hybridize to about 85% of the 1-strand and 10-15% of the h-strand, whereas late cytoplasmic RNA hybridizes to 65-70% and 25% of the l- and h-strand, respectively. With separated strands from the six EcoRI fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pettersson U,Philipson L

更新日期：1974-12-01 00:00:00

abstract：:J-domain chaperones are involved in the efficient handover of misfolded/partially folded proteins to Hsp70 but also function independently to protect against cell death. Due to their high flexibility, the mechanism by which they regulate the Hsp70 cycle and how specific substrate recognition is performed remains unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karamanos TK,Tugarinov V,Clore GM

更新日期：2019-10-22 00:00:00

abstract：:Wild-type p53 protein is a growth modulator whose inactivation has been found to be a key event in malignant transformation. Reconstitution of wild-type p53 in the p53-nonproducer, Abelson murine leukemia virus-transformed pre-B-cell line L12 gave rise to stably growing clones. Wild-type p53-producer derived cell line...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaulsky G,Goldfinger N,Peled A,Rotter V

更新日期：1991-10-15 00:00:00

abstract：:In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

更新日期：2015-02-17 00:00:00

abstract：:Detection and avoidance of impending obstacles is crucial to preventing head and body injuries in daily life. To safely avoid obstacles, locations of objects approaching the body surface are usually detected via the visual system and then used by the motor system to guide defensive movements. Mediating between visual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RS,Chen CF,Tran AT,Holstein KL,Sereno MI

更新日期：2012-10-30 00:00:00

abstract：:The localized maternal RNA Vg1 resides in the cortical region of the vegetal pole of fully grown Xenopus oocytes and is inherited by only a subset of blastomeres in the early embryo [Weeks, D. L. & Melton, D. A. (1987) Cell 51, 861-867]. Because RNA-cytoskeletal interactions may play a role in RNA localization, we hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pondel MD,King ML

更新日期：1988-10-01 00:00:00

abstract：:Myoglobin-mediated oxygen delivery to intracellular mitochondria is demonstrated in cardiac myocytes isolated from the hearts of mature rats. Myocytes are held at high ambient oxygen pressure, 40-340 torr (5-45 kPa); sarcoplasmic myoglobin is fully oxygenated. In this condition oxygen availability does not limit respi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wittenberg BA,Wittenberg JB

更新日期：1987-11-01 00:00:00