Characterization of reconnecting vortices in superfluid helium.

abstract：:All classes of antidepressants increase hippocampal cell proliferation and neurogenesis, which contributes, in part, to the behavioral actions of these treatments. Among antidepressant treatments, electroconvulsive seizure (ECS) is the most robust stimulator of hippocampal cell proliferation and the most efficacious t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segi-Nishida E,Warner-Schmidt JL,Duman RS

更新日期：2008-08-12 00:00:00

abstract：:Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP4B), can partially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaurasiya S,Wu W,Strom AM,Warner M,Gustafsson JÅ

更新日期：2020-10-20 00:00:00

abstract：:Freshwater planarian flatworms are capable of regenerating complete organisms from tiny fragments of their bodies; the basis for this regenerative prowess is an experimentally accessible stem cell population that is present in the adult planarian. The study of these organisms, classic experimental models for investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newmark PA,Reddien PW,Cebrià F,Sánchez Alvarado A

更新日期：2003-09-30 00:00:00

abstract：:Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadkarni S,Smith J,Sferruzzi-Perri AN,Ledwozyw A,Kishore M,Haas R,Mauro C,Williams DJ,Farsky SH,Marelli-Berg FM,Perretti M

更新日期：2016-12-27 00:00:00

abstract：:Cubic cage compounds composed of Co-CN-Ru linkages have been prepared which illustrate the following features: (i) new motifs for alkali metal ion complexation (i.e., cationic receptors for cations), (ii) a new family of triaza-metalloligands, and (iii) a double box-like cage. The cages are synthesized by the condensa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contakes SM,Kuhlman ML,Ramesh M,Wilson SR,Rauchfuss TB

更新日期：2002-04-16 00:00:00

abstract：:In experiments originally designed to examine selective turnover of methylated "caps" in renal mRNA, we observed that [3H]methyl label decayed from mRNA containing poly(A) with a half-life of 1-2 hr. (Caps are blocked, methylated mRNA sequences of the general structure m7GpppNm p(1 or 2)Np.). To distinguish between me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouellette AJ,Reed SL,Malt RA

更新日期：1976-08-01 00:00:00

abstract：:The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanekiyo T,Ban T,Aritake K,Huang ZL,Qu WM,Okazaki I,Mohri I,Murayama S,Ozono K,Taniike M,Goto Y,Urade Y

更新日期：2007-04-10 00:00:00

abstract：:Familial multiple system tauopathy with presenile dementia (MSTD) is a neurodegenerative disease with an abundant filamentous tau protein pathology. It belongs to the group of familial frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17), a major class of inherited dementing disorders whose gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Murrell JR,Goedert M,Farlow MR,Klug A,Ghetti B

更新日期：1998-06-23 00:00:00

abstract：:Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong Y,Tempel W,Wang H,Yamada K,Shen L,Senisterra GA,MacKenzie F,Chishti AH,Park HW

更新日期：2010-11-23 00:00:00

abstract：:Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esposito MS

更新日期：1978-09-01 00:00:00

abstract：:Monoclonal antibodies provide an attractive alternative to small-molecule therapies for a wide range of diseases. Given the importance of G protein-coupled receptors (GPCRs) as pharmaceutical targets, there has been an immense interest in developing therapeutic monoclonal antibodies that act on GPCRs. Here we present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishchenko A,Wacker D,Kapoor M,Zhang A,Han GW,Basu S,Patel N,Messerschmidt M,Weierstall U,Liu W,Katritch V,Roth BL,Stevens RC,Cherezov V

更新日期：2017-08-01 00:00:00

abstract：:Recent advances in cell-free expression protocols have opened a new avenue toward high-resolution structural investigations of membrane proteins by x-ray crystallography and NMR spectroscopy. One of the biggest challenges for liquid-state NMR-based structural investigations of membrane proteins is the significant peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reckel S,Sobhanifar S,Schneider B,Junge F,Schwarz D,Durst F,Löhr F,Güntert P,Bernhard F,Dötsch V

更新日期：2008-06-17 00:00:00

abstract：:The radial distributions of the Calpha and side-chain atoms in a sample of 13 native proteins have been examined. It is found that there are substantial differences in behavior between different atoms of the same amino acid. In particular, the Calpha atoms of polar residues show no particular preference for being far ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Scheraga HA

更新日期：1977-12-01 00:00:00

abstract：:In diabetes, the death of insulin-producing beta-cells by apoptosis leads to insulin deficiency. The lower prevalence of diabetes in females suggests that female sex steroids protect from beta-cell injury. Consistent with this hypothesis, 17beta-estradiol (estradiol) manifests antidiabetic actions in humans and rodent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le May C,Chu K,Hu M,Ortega CS,Simpson ER,Korach KS,Tsai MJ,Mauvais-Jarvis F

更新日期：2006-06-13 00:00:00

abstract：:Deregulated production of nitric oxide (NO) has been implicated in the development of certain human diseases, including cancer. We sought to assess the damaging potential of NO produced under long-term conditions through the development of a suitable model cell culture system. In this study, we report that when murine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang JC,Wogan GN

更新日期：1997-10-28 00:00:00

abstract：:In addition to tRNA and 5S RNA, Escherichia coli contains several other small, stable RNA species; these are M1, 10Sa, 6S, and 4.5S RNA. Although these RNAs are initially synthesized as precursor molecules, relatively little is known about their maturation. The data presented here show that 3' exoribonucleolytic trimm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Pandit S,Deutscher MP

更新日期：1998-03-17 00:00:00

abstract：:Although sunlight provides the energy necessary for plants to survive and grow, light can also damage reaction centers of photosystem II (PSII) and reduce photochemical efficiency. To prevent damage, plants possess photoprotective mechanisms that dissipate excess excitation. A subset of these mechanisms is collectivel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonelli L,Brooks MD,Niyogi KK

更新日期：2017-08-15 00:00:00

abstract：:Overaccumulation of abnormally organized mitochondria in so-called "ragged-red" skeletal muscle fibers is a morphological hallmark of mitochondrial myopathies, in particular of mitochondrial encephalomyopathies. Characteristic for the abnormal mitochondria is the occurrence of highly ordered crystalline inclusions. Im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stadhouders AM,Jap PH,Winkler HP,Eppenberger HM,Wallimann T

更新日期：1994-05-24 00:00:00

abstract：:Methane emissions in the Arctic are important, and may be contributing to global warming. While methane emission rates from Arctic lakes are well documented, methods are needed to quantify the relative contribution of active layer groundwater to the overall lake methane budget. Here we report measurements of natural t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paytan A,Lecher AL,Dimova N,Sparrow KJ,Kodovska FG,Murray J,Tulaczyk S,Kessler JD

更新日期：2015-03-24 00:00:00

abstract：:We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duguid JR,Bohmont CW,Liu NG,Tourtellotte WW

更新日期：1989-09-01 00:00:00

abstract：:The nuclear receptor corepressor, silencing mediator of retinoid and thyroid hormone receptors (SMRT), is recruited by a plethora of transcription factors to mediate lineage and signal-dependent transcriptional repression. We generated a knockin mutation in the receptor interaction domain (RID) of SMRT (SMRT(mRID)) th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nofsinger RR,Li P,Hong SH,Jonker JW,Barish GD,Ying H,Cheng SY,Leblanc M,Xu W,Pei L,Kang YJ,Nelson M,Downes M,Yu RT,Olefsky JM,Lee CH,Evans RM

更新日期：2008-12-16 00:00:00

abstract：:The rat brain-derived neurotropic factor (BDNF) gene consists of four 5' exons linked to separate promoters and one 3' exon encoding the prepro-BDNF protein. To gain insights into the regulation of BDNF mRNA expression, probes specific for the different 5' exons were used to study the expression of BDNF mRNA in the br...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metsis M,Timmusk T,Arenas E,Persson H

更新日期：1993-10-01 00:00:00

abstract：:By using a mixture of synthetic oligodeoxyribonucleotides as a probe, cloned cDNA sequences specific for low molecular weight (LMW) kininogen have been isolated from a cDNA library of bovine liver mRNA sequences. Nucleotide sequence analyses of cloned cDNA inserts have revealed that bovine liver LMW kininogens are enc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nawa H,Kitamura N,Hirose T,Asai M,Inayama S,Nakanishi S

更新日期：1983-01-01 00:00:00

abstract：:Primates can store sensory stimulus parameters in working memory for subsequent manipulation, but until now, there has been no demonstration of this capacity in rodents. Here we report tactile working memory in rats. Each stimulus is a vibration, generated as a series of velocity values sampled from a normal distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fassihi A,Akrami A,Esmaeili V,Diamond ME

更新日期：2014-02-11 00:00:00

abstract：:Aggregation of p53 is initiated by first-order processes that generate an aggregation-prone state with parallel pathways of major or partial unfolding. Here, we elaborate the mechanism and explore its consequences, beginning with the core domain and extending to the full-length p53 mutant Y220C. Production of large li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Fersht AR

更新日期：2012-08-21 00:00:00

abstract：:Genetic evidence indicates that the PrlA (SecY) protein of Escherichia coli functions as a membrane integrated signal sequence receptor in protein "export"--i.e., in protein translocation across (or integration into) the plasma membrane. We have raised antibodies in rabbits against two synthetic peptides representing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe M,Blobel G

更新日期：1989-03-01 00:00:00

abstract：:The actions of various opioids were examined on calcium action potentials in the cell somata of guinea pig myenteric neurones and on the release of acetylcholine at synapses onto these cells. The opioids morphine, normorphine, and [D-Ala2, MePhe4, Met5(O)]enkephalin-ol caused membrane hyperpolarizations resulting from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherubini E,North RA

更新日期：1985-03-01 00:00:00

abstract：:Executing gene circuits by cell-free transcription-translation into cell-sized compartments, such as liposomes, is one of the major bottom-up approaches to building minimal cells. The dynamic synthesis and proper self-assembly of macromolecular structures inside liposomes, the cytoskeleton in particular, stands as a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garenne D,Libchaber A,Noireaux V

更新日期：2020-01-28 00:00:00

abstract：:We have investigated the folding dynamics of Thermus thermophilus cytochrome c(552) by time-resolved fluorescence energy transfer between the heme and each of seven site-specific fluorescent probes. We have found both an equilibrium unfolding intermediate and a distinct refolding intermediate from kinetics studies. De...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamada S,Bouley Ford ND,Keller GE,Ford WC,Gray HB,Winkler JR

更新日期：2013-01-29 00:00:00

abstract：:The regulation of glycogen metabolism is critical for the maintenance of glucose and energy homeostasis in mammals. Glycogen synthase, the enzyme responsible for glycogen production, is regulated by multisite phosphorylation in yeast and mammals. We have previously identified PAS kinase as a physiological regulator of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson WA,Skurat AV,Probst B,de Paoli-Roach A,Roach PJ,Rutter J

更新日期：2005-11-15 00:00:00