Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus.

abstract：:While 9-O-acetylation of sialic acids has been reported in some mammalian tissues, the distribution of this modification on specific cell types and molecules is largely unknown. The influenza C virus hemagglutinin-esterase is a membrane-bound glycoprotein that binds specifically to 9-O-acetylated sialic acids (hemaggl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein A,Krishna M,Varki NM,Varki A

更新日期：1994-08-02 00:00:00

abstract：:Vitamin A signals play critical roles during embryonic development. In particular, heart morphogenesis depends on vitamin A signals mediated by the retinoid X receptor alpha (RXRalpha), as the systemic mutation of this receptor results in thinning of the myocardium and embryonic lethality. However, the molecular and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merki E,Zamora M,Raya A,Kawakami Y,Wang J,Zhang X,Burch J,Kubalak SW,Kaliman P,Izpisua Belmonte JC,Chien KR,Ruiz-Lozano P

更新日期：2005-12-20 00:00:00

abstract：:The formation of heparan sulfate occurs within the lumen of the endoplasmic reticulum-Golgi complex-trans-Golgi network by the concerted action of several glycosyltransferases, an epimerase, and multiple sulfotransferases. In this report, we have examined the location and interaction of tagged forms of five of the bio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinhal MA,Smith B,Olson S,Aikawa J,Kimata K,Esko JD

更新日期：2001-11-06 00:00:00

abstract：:Exocytotic membrane fusion and secretion are promoted by the concerted action of GTP and Ca2+, although the precise site(s) of action in the process are not presently known. However, the calcium-dependent membrane fusion reaction driven by synexin (annexin VII) is an in vitro model for this process, which we have now ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caohuy H,Srivastava M,Pollard HB

更新日期：1996-10-01 00:00:00

abstract：:The yeast auxiliary transcription factor GAL11, a candidate for the coactivator, was partially purified from yeast cells, and its function was characterized in a cell-free transcription system. The partially purified GAL11 protein stimulated basal transcription from the CYC1 core promoter by a factor of 4-5 at the ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakurai H,Hiraoka Y,Fukasawa T

更新日期：1993-09-15 00:00:00

abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

更新日期：1994-04-26 00:00:00

abstract：:The first step in the replication of the adenovirus genome is the covalent attachment of the 5'-terminal nucleotide, dCMP, to the virus-encoded terminal protein precursor (pTP). This reaction can be observed in vitro and has been previously shown to be dependent upon either viral DNA or linearized plasmid DNA containi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Challberg MD,Rawlins DR

更新日期：1984-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler R,Inzunza J,Suzuki H,Fujii-Kuriyama Y,Warner M,Gustafsson JÅ

更新日期：2012-01-24 00:00:00

abstract：:From a genomic library constructed from sperm DNA of the inbred BALB/c mouse, we previously isolated 54 cosmid clones that contain 36 class I genes and can be divided by restriction map analyses into 13 gene clusters. We have isolated single- and low-copy DNA probes from each of these clusters to visualize restriction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winoto A,Steinmetz M,Hood L

更新日期：1983-06-01 00:00:00

abstract：:Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burmester JK,Wiese RJ,Maeda N,DeLuca HF

更新日期：1988-12-01 00:00:00

abstract：:Antibody to poly(ADP-ribose) has been covalently coupled to Sepharose and utilized to isolate selectively oligonucleosomes undergoing the poly(ADP-ribosyl)ation reaction from the bulk of chromatin. Approximately 12% of the unfractionated oligonucleosomes were bound to the immunoaffinity column and these represented es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malik N,Miwa M,Sugimura T,Thraves P,Smulson M

更新日期：1983-05-01 00:00:00

abstract：:Neurophysiology is increasingly focused on identifying coincident activity among neurons. Strong inferences about neural computation are made from the results of such studies, so it is important that these results be accurate. However, the preliminary step in the analysis of such data, the assignment of spike waveform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura V,Gerkin RC

更新日期：2012-05-08 00:00:00

abstract：:Marine ecosystems are sensitive to stochastic environmental variability, with higher-amplitude, lower-frequency--i.e., "redder"--variability posing a greater threat of triggering large ecosystem changes. Here we show that fluctuations in the Pacific Decadal Oscillation (PDO) index have slowed down markedly over the ob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boulton CA,Lenton TM

更新日期：2015-09-15 00:00:00

abstract：:Niemann-Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann-Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, the function of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Lu F,Trinh MN,Schmiege P,Seemann J,Wang J,Blobel G

更新日期：2017-08-22 00:00:00

abstract：:The possible role of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) in protein synthesis by Escherichia coli ribosomes and protein factors was examined. Although pppGpp could effectively substitute for GTP in reactions catalyzed by initiation factor 2 (ribosomal binding of fMet-tRNA and formation of N-formylmethion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamel E,Cashel M

更新日期：1973-11-01 00:00:00

abstract：:The expression of CD5 increases progressively as thymocytes mature. We have shown that CD5 expression is controlled by a tissue-specific regulatory promoter located upstream of the CD5 translation start sites. Deletion of this regulatory promoter, which contains three potential transcription factor binding sites (CCAA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Contag CH,Felsher D,Shachaf CM,Cao Y,Herzenberg LA,Herzenberg LA,Tung JW

更新日期：2004-03-16 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:Physiological sensing of O(2) tension (partial O(2) pressure, pO(2)) plays an important role in some mammalian cellular systems, but striated muscle generally is not considered to be among them. Here we describe a molecular mechanism in skeletal muscle that acutely couples changes in pO(2) to altered calcium release t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun QA,Hess DT,Nogueira L,Yong S,Bowles DE,Eu J,Laurita KR,Meissner G,Stamler JS

更新日期：2011-09-20 00:00:00

abstract：:Cholesterol synthesis in animals is controlled by the regulated transport of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum to the Golgi, where the transcription factors are processed proteolytically to release active fragments. Transport is inhibited by either cholesterol or oxyste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radhakrishnan A,Ikeda Y,Kwon HJ,Brown MS,Goldstein JL

更新日期：2007-04-17 00:00:00

abstract：:To elucidate the function of the two nerve growth factor (NGF) receptors, p75NGFR and p140trk, chimeric molecules were constructed of tumor necrosis factor (TNF) and NGF receptors. Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras, which contain the extracellular domain of TNF receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rovelli G,Heller RA,Canossa M,Shooter EM

更新日期：1993-09-15 00:00:00

abstract：:Painful peripheral neuropathies are precipitated by nerve injury from disease or trauma. All such injuries will be accompanied by an inflammatory reaction, a neuritis, that will mobilize the immune system. The role of the inflammation itself is difficult to determine in the presence of structural damage to the nerve. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett GJ

更新日期：1999-07-06 00:00:00

abstract：:The great mass extinctions of the fossil record were a major creative force that provided entirely new kinds of opportunities for the subsequent explosive evolution and diversification of surviving clades. Today, the synergistic effects of human impacts are laying the groundwork for a comparably great Anthropocene mas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson JB

更新日期：2008-08-12 00:00:00

abstract：:Inhibitory gamma-aminobutyric acid-mediated synaptic currents were studied in dissociated primary cultures of neonatal rat cortex with the whole-cell patch-clamp technique. Immunocytochemical staining of the cultures showed the presence of a large number of glutamic acid decarboxylase-containing neurons, and electrica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vicini S,Alho H,Costa E,Mienville JM,Santi MR,Vaccarino FM

更新日期：1986-12-01 00:00:00

abstract：:Microstructural, δ(13)C isotope and C/N ratio investigations were conducted on excavated material from the black Younger Dryas boundary in Lommel, Belgium, aiming for a characterisation of the carbon content and structures. Cubic diamond nanoparticles are found in large numbers. The larger ones with diameters around o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Schryvers D,Claeys P

更新日期：2011-01-04 00:00:00

abstract：:Hybridoma technology was used for preparation of murine monoclonal antibodies of high titer against bone-Gla protein and osteonectin. A procedure of immunization and hybridization similar to that already described [Katzmann, J.A., Nesheim, M.E., Hibbard, L.S. & Mann, K.G. (1981) Proc. Natl. Acad. Sci. USA 78, 162-166;...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stenner DD,Romberg RW,Tracy RP,Katzmann JA,Riggs BL,Mann KG

更新日期：1984-05-01 00:00:00

abstract：:Outdoor ozone transported indoors initiates oxidative chemistry, forming volatile organic products. The influence of ozone chemistry on indoor air composition has not been directly quantified in normally occupied residences. Here, we explore indoor ozone chemistry in a house in California with two adult inhabitants. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Misztal PK,Arata C,Weschler CJ,Nazaroff WW,Goldstein AH

更新日期：2021-02-09 00:00:00

abstract：:Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao PK,Kumar RM,Farkhondeh M,Baskerville S,Lodish HF

更新日期：2006-06-06 00:00:00

abstract：:RNA from noninfectious virions produced by two established clonal lines of sarcoma positive-leukemia negative (S+L-)-transformed 3T3 cells has been characterized. RNA from virions or nucleoids of S+L--(C243) cells consisted of three to four sizes: +/-44 S (6%), 28 S (17%), 18 S (38%), and <18 S (39%). 28S virion RNA c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips LA,Hollis VW Jr,Bassin RH,Fischinger PJ

更新日期：1973-10-01 00:00:00

abstract：:Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimentary charcoal accumulation rates to construct long-term variations in fire during the past 3,000 y in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marlon JR,Bartlein PJ,Gavin DG,Long CJ,Anderson RS,Briles CE,Brown KJ,Colombaroli D,Hallett DJ,Power MJ,Scharf EA,Walsh MK

更新日期：2012-02-28 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are key signaling molecules and are intensely studied. Whereas GPCRs recognizing small-molecules have been successfully targeted for drug discovery, protein-recognizing GPCRs, such as the chemokine receptors, claim few drugs or even useful small molecule reagents. This reflects both...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mysinger MM,Weiss DR,Ziarek JJ,Gravel S,Doak AK,Karpiak J,Heveker N,Shoichet BK,Volkman BF

更新日期：2012-04-03 00:00:00