Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.

abstract：:Pro-Leu-Gly-NH2 (MIF) and several structural analogues, all injected in 50-microgram doses daily in mice receiving morphine chronically, were found to prevent development of physical dependence as measured by changes in body temperature associated with naloxone-induced withdrawal. Dose-response studies, using again a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walter R,Ritzmann RF,Bhargava HN,Flexner LB

更新日期：1979-01-01 00:00:00

abstract：:For centuries ecologists have studied how the diversity and functional traits of plant and animal communities vary across biomes. In contrast, we have only just begun exploring similar questions for soil microbial communities despite soil microbes being the dominant engines of biogeochemical cycles and a major pool of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fierer N,Leff JW,Adams BJ,Nielsen UN,Bates ST,Lauber CL,Owens S,Gilbert JA,Wall DH,Caporaso JG

更新日期：2012-12-26 00:00:00

abstract：:During mitosis, the mammalian Golgi vesiculates and, upon partitioning, reassembles in each daughter cell; however, it is not clear whether the disassembly process per se is important for partitioning or is merely an outcome of mitotic entry. Here, we show that Golgi vesiculation is required for progression to metapha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guizzunti G,Seemann J

更新日期：2016-10-25 00:00:00

abstract：:The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava M,Atwater I,Glasman M,Leighton X,Goping G,Caohuy H,Miller G,Pichel J,Westphal H,Mears D,Rojas E,Pollard HB

更新日期：1999-11-23 00:00:00

abstract：:The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to determine the rates. Method I obtained the spontaneous mutation rate from the increase in the mutation frequency of a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren ST,Schultz RA,Chang CC,Wade MH,Trosko JE

更新日期：1981-05-01 00:00:00

abstract：:We have recently determined that high calcium concentrations, in parallel with their suppressive effects on parathyroid hormone (PTH) secretion, reversibly and specifically decrease preproPTH mRNA in cultured bovine parathyroid cells. In order to determine whether vitamin D metabolites also regulate the content of pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silver J,Russell J,Sherwood LM

更新日期：1985-06-01 00:00:00

abstract：:The recently discovered potato tuber (Solanum tuberosum) alpha-glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in which the beta-phosphate of ATP is transferred to either the C-6 or the C-3 position of the glucosyl residue of starch. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikkelsen R,Mutenda KE,Mant A,Schürmann P,Blennow A

更新日期：2005-02-01 00:00:00

abstract：:Introduction and expression of multiple transgenes is frequently required for basic and applied studies. However, at present, multigene transformation is very difficult due to technical limitations of existing methods. Here, we describe a vector system for efficient multigene assembly and transformation. The system co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin L,Liu YG,Xu X,Li B

更新日期：2003-05-13 00:00:00

abstract：:5-enol-Pyruvylshikimate-3-phosphate synthase (EPSP synthase; phosphoenolpyruvate:3-phosphoshikimate 1-carboxyvinyltransferase, EC 2.5.1.19) is an enzyme on the pathway toward the synthesis of aromatic amino acids in plants, fungi, and bacteria and is the target of the broad-spectrum herbicide glyphosate. The three-dim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stallings WC,Abdel-Meguid SS,Lim LW,Shieh HS,Dayringer HE,Leimgruber NK,Stegeman RA,Anderson KS,Sikorski JA,Padgette SR,Kishore GM

更新日期：1991-06-01 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:Binding and uptake of alpha-fetoprotein (AFP) by mouse T-lymphoma YAC-1 cells exhibited the characteristics of receptor-mediated endocytosis. The binding saturation curve obtained by incubating YAC-1 cells at 4 degrees C with 125I-labeled AFP at different concentrations (50 ng/ml to 2.5 mg/ml) showed three saturation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naval J,Villacampa MJ,Goguel AF,Uriel J

更新日期：1985-05-01 00:00:00

abstract：:Staphylococcus aureus is a leading cause of both nosocomial and community-acquired infection. Biofilm formation at the site of infection reduces antimicrobial susceptibility and can lead to chronic infection. During biofilm formation, a subset of cells liberate cytoplasmic proteins and DNA, which are repurposed to for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeFrancesco AS,Masloboeva N,Syed AK,DeLoughery A,Bradshaw N,Li GW,Gilmore MS,Walker S,Losick R

更新日期：2017-07-18 00:00:00

abstract：:The goal of this study was to characterize and classify pulmonary neuroendocrine tumors based on array comparative genomic hybridization (aCGH). Using aCGH, we performed karyotype analysis of 33 small cell lung cancer (SCLC) tumors, 13 SCLC cell lines, 19 bronchial carcinoids, and 9 gastrointestinal carcinoids. In con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voortman J,Lee JH,Killian JK,Suuriniemi M,Wang Y,Lucchi M,Smith WI Jr,Meltzer P,Wang Y,Giaccone G

更新日期：2010-07-20 00:00:00

abstract：:Are judicial rulings based solely on laws and facts? Legal formalism holds that judges apply legal reasons to the facts of a case in a rational, mechanical, and deliberative manner. In contrast, legal realists argue that the rational application of legal reasons does not sufficiently explain the decisions of judges an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danziger S,Levav J,Avnaim-Pesso L

更新日期：2011-04-26 00:00:00

abstract：:Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnosti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yelleswarapu V,Buser JR,Haber M,Baron J,Inapuri E,Issadore D

更新日期：2019-03-05 00:00:00

abstract：:CD4-expressing T cells in lymphoid organs are infected by the primary strains of HIV and represent one of the main sources of virus replication. Gene therapy strategies are being developed that allow the transfer of exogenous genes into CD4(+) T lymphocytes whose expression might prevent viral infection or replication...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schnierle BS,Stitz J,Bosch V,Nocken F,Merget-Millitzer H,Engelstädter M,Kurth R,Groner B,Cichutek K

更新日期：1997-08-05 00:00:00

abstract：:Claspin is a homolog of Mrc1, a checkpoint protein required for the DNA replication checkpoint in yeast. In Xenopus, phosphorylated Claspin binds to xChk1 and regulates xChk1 activation in response to replication stress. In this study, we have shown that the human homolog of Claspin is required for resistance to multi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin SY,Li K,Stewart GS,Elledge SJ

更新日期：2004-04-27 00:00:00

abstract：:A simple method combining photolithography and shadow (or angle) evaporation is developed to fabricate single-walled carbon nanotube (SWCNT) devices with tube lengths of approximately 10-50 nm between metal contacts. Large numbers of such short devices are obtained without the need of complex tools such as electron be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Javey A,Qi P,Wang Q,Dai H

更新日期：2004-09-14 00:00:00

abstract：:The amphibian tetradecapeptide, bombesin (BBS) has been shown to stimulate insulin secretion both in vivo and by pancreatic islet cells in vitro. To determine whether BBS can act directly on pancreatic beta cells, we examined its effects on insulin secretion by HIT-T15 cells (HIT cells), a clonal islet cell line. Addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swope SL,Schonbrunn A

更新日期：1984-03-01 00:00:00

abstract：:The reliability of (13)C NMR chemical shift correlations in the application of the "tool of increasing electron demand" to stable long-lived carbocationic systems is demonstrated by a comprehensive analysis of 22 stable aryl-substituted carbocationic systems. The observation of slopes of less than unity in such chemic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah GA,Berrier AL,Prakash GK

更新日期：1981-04-01 00:00:00

abstract：:Atmospheric oxidation of natural and anthropogenic volatile organic compounds (VOCs) leads to secondary organic aerosol (SOA), which constitutes a major and often dominant component of atmospheric fine particulate matter (PM2.5). Recent work demonstrates that rapid autoxidation of organic peroxy radicals (RO2) formed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pye HOT,D'Ambro EL,Lee BH,Schobesberger S,Takeuchi M,Zhao Y,Lopez-Hilfiker F,Liu J,Shilling JE,Xing J,Mathur R,Middlebrook AM,Liao J,Welti A,Graus M,Warneke C,de Gouw JA,Holloway JS,Ryerson TB,Pollack IB,Thornton

更新日期：2019-04-02 00:00:00

abstract：:Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Keefe SJ,Wolfes H,Kiessling AA,Cooper GM

更新日期：1989-09-01 00:00:00

abstract：:Two operators, spatially separated from each other and from the promoters, repress the gal operon when bound to Gal repressor. Conversion of either gal operator to a lac operator results in derepression, although both Gal and Lac repressors are present, suggesting that mere occupation of operator sites is not sufficie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haber R,Adhya S

更新日期：1988-12-01 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:Originally identified as an essential component of the herpes simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory circuits. The protein mediates activation through multiple interactions with tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narayanan A,Ruyechan WT,Kristie TM

更新日期：2007-06-26 00:00:00

abstract：:Entorhinal grid cells integrate sensory and self-motion inputs to provide a spatial metric of a characteristic scale. One function of this metric may be to help localize the firing fields of hippocampal place cells during formation and use of the hippocampal spatial representation ("cognitive map"). Of theoretical imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casali G,Bush D,Jeffery K

更新日期：2019-03-05 00:00:00

abstract：:Central nervous system (CNS) trauma can result in tissue disruption, neuronal and axonal degeneration, and neurological dysfunction. The limited spontaneous CNS repair in adulthood and aging is often insufficient to overcome disability. Several investigations have demonstrated that targeting HDAC activity can protect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rivieccio MA,Brochier C,Willis DE,Walker BA,D'Annibale MA,McLaughlin K,Siddiq A,Kozikowski AP,Jaffrey SR,Twiss JL,Ratan RR,Langley B

更新日期：2009-11-17 00:00:00

abstract：:The novel immune-type receptor (NITR) genes encode a unique multigene family of leukocyte regulatory receptors, which possess an extracellular Ig variable (V) domain and may function in innate immunity. Artificial chromosomes that encode zebrafish NITRs have been assembled into a contig spanning approximately 350 kb. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoder JA,Litman RT,Mueller MG,Desai S,Dobrinski KP,Montgomery JS,Buzzeo MP,Ota T,Amemiya CT,Trede NS,Wei S,Djeu JY,Humphray S,Jekosch K,Hernandez Prada JA,Ostrov DA,Litman GW

更新日期：2004-11-02 00:00:00

abstract：:In myocardial ischemia, adrenergic nerves release excessive amounts of norepinephrine (NE), causing dysfunction and arrhythmias. With anoxia and the concomitant ATP depletion, vesicular storage of NE is impaired, resulting in accumulation of free NE in the axoplasm of sympathetic nerves. Intraneuronal acidosis activat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silver RB,Mackins CJ,Smith NC,Koritchneva IL,Lefkowitz K,Lovenberg TW,Levi R

更新日期：2001-02-27 00:00:00

abstract：:The global prevalence of prediabetes and type 2 diabetes (T2D) is increasing, and it is contributing to the susceptibility to diabetes and its related epidemic in offspring. Although the impacts of paternal impaired fasting blood glucose and glucose intolerance on the metabolism of offspring have been well established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Y,Yang CR,Wei YP,Zhao ZA,Hou Y,Schatten H,Sun QY

更新日期：2014-02-04 00:00:00