Catabolism of premercapturic acid pathway metabolites of naphthalene to naphthols and methylthio-containing metabolites in rats.

abstract：:Recently the definition of the metazoan RNA polymerase II and archaeal core promoters has been expanded to include a region immediately upstream of the TATA box called the B recognition element (BRE), so named because eukaryal transcription factor TFIIB and its archaeal orthologue TFB interact with the element in a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Littlefield O,Korkhin Y,Sigler PB

更新日期：1999-11-23 00:00:00

abstract：:We have obtained the resonance Raman spectrum of bacteriorhodopsin's primary photoproduct K with a novel low-temperature spinning sample technique. Purple membrane at 77 K is illuminated with spatially separated actinic (pump) and probe laser beams. The 514-nm pump beam produces a photostationary steady-state mixture ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braiman M,Mathies R

更新日期：1982-01-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1). However, mRNAs that are not NMD targets also bind UPF1. What governs the timing, position, and function of UPF1 binding to mRNAs remains unclear. We provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurosaki T,Maquat LE

更新日期：2013-02-26 00:00:00

abstract：:Methyl groups placed on varphiXsB1 replicative form DNA by the Escherichia coli B modification enzyme are located in the overlap between fragments Mbo II-3 and Alu I-2, a 61-base-pair DNA segment. Mutations that led to loss of susceptibility to restriction by E. coli B occurred within this segment at three positions s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lautenberger JA,Kan NC,Lackey D,Linn S,Edgell MH,Hutchison CA 3rd

更新日期：1978-05-01 00:00:00

abstract：:Phospholipids containing photolysable carbene precursors (beta-trifluoro-alpha-diazopropionoxy and m-diazirinophenoxy groups) in omega-positions of sn-2 fatty acyl chains were prepared. Photolysis of their vesicles produced crosslinked products in 40-60% yields. Crosslinking was mostly intermolecular and occurred by c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta CM,Radhakrishnan R,Gerber GE,Olsen WL,Quay SC,Khorana HG

更新日期：1979-06-01 00:00:00

abstract：:The complete amino acid and DNA sequences of the human 40-kDa keratin are reported. The DNA sequence encodes a protein of 44,098 Da, which is unique in that it lacks the terminal non-alpha-helical tail segment found in all other keratins. When the human 40-kDa keratin amino acid sequence is compared to the correspondi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckert RL

更新日期：1988-02-01 00:00:00

abstract：:Twenty-four hours after rats receive choline chloride (20 mmol/kg, by stomach tube) the activity of tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] increases by 31% within adrenomedullary chromaffin cells. This treatment also causes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulus IH,Hirsch MJ,Wurtman RJ

更新日期：1977-02-01 00:00:00

abstract：:Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum, including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg A,Luth MR,Winzeler EA,Behnke M,Sibley LD

更新日期：2019-12-05 00:00:00

abstract：:The underlying structure is taken as a strongly superharmonic cone [unk], defined as a partially ordered abelian semigroup with identity 0 which admits a multiplication by nonnegative scalars and satisfies two fundamental axioms of a potentialtheoretic character. In terms of a fixed nonzero element e there is introduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsove M,Leutwiler H

更新日期：1975-07-01 00:00:00

abstract：:Neutron diffraction maps have been used to assign the rotor conformations of the hydroxyl hydrogens in trypsin. Knowledge of these conformations is used to assess the relative importance of steric and electrostatic effects in conferring the H-bonding geometries of these groups. A general finding was that most hydroxyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kossiakoff AA,Shpungin J,Sintchak MD

更新日期：1990-06-01 00:00:00

abstract：:Swiftlets are small insectivorous birds, many of which nest in caves and are known to echolocate. Due to a lack of distinguishing morphological characters, the taxonomy of swiftlets is primarily based on the presence or absence of echolocating ability, together with nest characters. To test the reliability of these be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee PL,Clayton DH,Griffiths R,Page RD

更新日期：1996-07-09 00:00:00

abstract：:Rapid development of genetic variability may contribute to the pathogenicity of lentiviruses as it may allow escape from immune surveillance and/or from suppression of virus replication. Although apathogenic in African green monkeys, simian immunodeficiency virus isolated from African green monkeys is shown to display...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baier M,Dittmar MT,Cichutek K,Kurth R

更新日期：1991-09-15 00:00:00

abstract：:Eusociality is a major evolutionary innovation involving alterations in life history, morphology, and behavior. Advanced eusocial insects, such as ants, termites, and corbiculate bees, cannot provide insights into the earliest stages of eusocial evolution because eusociality in these taxa evolved long ago (in the Cret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danforth BN

更新日期：2002-01-08 00:00:00

abstract：:Paleoclimate studies suggest that increased global warmth during the Eocene epoch was greatly amplified at high latitudes, a state that climate models cannot fully reproduce. However, proxy estimates of Eocene near-Antarctic sea surface temperatures (SSTs) have produced widely divergent results at similar latitudes, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglas PM,Affek HP,Ivany LC,Houben AJ,Sijp WP,Sluijs A,Schouten S,Pagani M

更新日期：2014-05-06 00:00:00

abstract：:Arsenic, a curative agent for acute promyelocytic leukemia, induces cell apoptosis and degradation of BCR-ABL in chronic myelogenous leukemia (CML). We demonstrated that ubiquitination and degradation of BCR-ABL was mediated by c-CBL, a RING-type E3 ligase that was also shown to be involved in ubiquitination for many ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao JH,Sun XY,Liu JX,Zhang QY,Liu P,Huang QH,Li KK,Chen Q,Chen Z,Chen SJ

更新日期：2010-12-14 00:00:00

abstract：:The distribution of proenkephalin and [Met]enkephalin immunoreactivities in the bovine hypothalamo-neurohypophyseal system was studied by use of specific antisera. Proenkephalin and [Met]enkephalin immunoreactivities were found in magnocellular neuronal cell bodies in the dorsal part of the supraoptic nuclei and in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanderhaeghen JJ,Lotstra F,Liston DR,Rossier J

更新日期：1983-08-01 00:00:00

abstract：:Mutator activity associated with the common male recombination (MR) chromosomes in Drosophila melanogaster appears to be suppressed in natural populations. Crosses between geographically separated populations, however, lead to the release of mutator activity as measured by a significant increase in visible mutations. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JN Jr,Woodruff RC

更新日期：1980-02-01 00:00:00

abstract：:Point mutations in either of the two nucleotide-binding domains (NBD) of Hsp104 (NBD1 and NBD2) eliminate its thermotolerance function in vivo. In vitro, NBD1 mutations virtually eliminate ATP hydrolysis with little effect on hexamerization; analogous NBD2 mutations reduce ATPase activity and severely impair hexameriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schirmer EC,Ware DM,Queitsch C,Kowal AS,Lindquist SL

更新日期：2001-01-30 00:00:00

abstract：:Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the survival of NK-22 cells and IL-22 production in response to IL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cella M,Otero K,Colonna M

更新日期：2010-06-15 00:00:00

abstract：:The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su SS,Modrich P

更新日期：1986-07-01 00:00:00

abstract：:The expression of the human HSP70 gene is induced by a wide range of physiological stresses, including exposure to heat shock and heavy metals, or under nonstress conditions, such as in response to serum stimulation. We have previously demonstrated that in either case the regulated expression is at the primary level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu BJ,Kingston RE,Morimoto RI

更新日期：1986-02-01 00:00:00

abstract：:Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens. Mycobacterial IdeR is an iron-dependent repressor that shows 80% identity in the functional domains with its corynebacterial homologue, DtxR (diphtheria toxin repressor)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manabe YC,Saviola BJ,Sun L,Murphy JR,Bishai WR

更新日期：1999-10-26 00:00:00

abstract：:The temperature dependence of fatty acid spin label resonance spectra and freeze fracture micrographs of sonicated dipalmitoylphosphatidylcholine vesicles in the absence and presence of concanavalin A demonstrate a strong interaction of concanavalin A with these lipid membranes, which results in fusion of the vesicles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van der Bosch J,McConnell M

更新日期：1975-11-01 00:00:00

abstract：:The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. Although the receptor is well-studied, a central issue remains: How does the compositional diversity and functional diversity of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coskun Ü,Grzybek M,Drechsel D,Simons K

更新日期：2011-05-31 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00

abstract：:ATP-dependent DNA supercoiling catalyzed by Escherichia coli DNA gyrase was inhibited by oxolinic acid, a compound similar to but more potent than nalidixic acid and a known inhibitor of DNA replication in E. coli. The supercoiling activity of DNA gyrase purified from nalidixic acid-resistant mutant (nalA(R)) bacteria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gellert M,Mizuuchi K,O'Dea MH,Itoh T,Tomizawa JI

更新日期：1977-11-01 00:00:00

abstract：:Beta nerve growth factor (NGF), a target-derived protein necessary for survival and development of sympathetic and sensory neurons, can also affect subpopulations of neurons in the central nervous system (CNS). Using a blot hybridization assay capable of detecting 10 fg of mRNA, we measured the levels of NGF mRNA in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shelton DL,Reichardt LF

更新日期：1986-04-01 00:00:00

abstract：:DNase I hypersensitive regions were mapped within the 17.3-kilobase qa (quinic acid) gene cluster of Neurospora crassa. The 5'-flanking regions of the five qa structural genes and the two qa regulatory genes each contain DNase I hypersensitive sites under noninducing conditions and generally exhibit increases in DNase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baum JA,Giles NH

更新日期：1986-09-01 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth M,Eickelberg O,Kohler E,Erne P,Block LH

更新日期：1996-05-28 00:00:00

abstract：:Arginine methylation has emerged as a widespread and reversible protein modification with the potential to regulate a multitude of cellular processes, but its function is poorly understood. Endolysosomes play an important role in Wnt signaling, in which glycogen synthase kinase 3 (GSK3) becomes sequestered inside mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albrecht LV,Ploper D,Tejeda-Muñoz N,De Robertis EM

更新日期：2018-06-05 00:00:00