Intermolecular crosslinking of fatty acyl chains in phospholipids: use of photoactivable carbene precursors.

abstract：:Increased DNA levels in centrally located endosperm nuclei are shown to be related to endosperm development in Zea mays. Mitotic activity sharply decreases in endosperm cells 10-12 days after pollination. At this time nuclear size and DNA content per nucleus (where C = haploid content) sharply increase until peak leve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowles RV,Phillips RL

更新日期：1985-10-01 00:00:00

abstract：:Female Utetheisa ornatrix exercise postcopulatory mate selection, favoring sperm of larger males. Larger males also produce larger spermatophores, raising the question whether males are selected on the basis of body size or the size of their spermatophore. We here present evidence, based on matings in which males were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaMunyon CW,Eisner T

更新日期：1994-07-19 00:00:00

abstract：:Awareness that our planet is a self-supporting biosphere with sunlight as its major source of energy for life has resulted in a long-term historical fascination with the workings of self-supporting ecological systems. However, the studies of such systems have never entered the canon of ecological or evolutionary tools...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rillig MC,Antonovics J

更新日期：2019-06-04 00:00:00

abstract：:The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed SI,Wittenberg C

更新日期：1990-08-01 00:00:00

abstract：:The ability of a series of anions to inhibit [(3)H]strychnine binding to spinal cord synaptic membranes correlates closely with their neurophysiologic capacity to reverse inhibitory postsynaptic potentials in the mammalian spinal cord. Seven neurophysiologically active anions are also effective inhibitors of [(3)H]str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young AB,Snyder SH

更新日期：1974-10-01 00:00:00

abstract：:Transcription in eukaryotic nuclei is carried out by DNA-dependent RNA polymerases I, II, and III. Human RNA polymerase III (Pol III) transcribes small untranslated RNAs that include tRNAs, 5S RNA, U6 RNA, and some microRNAs. Increased Pol III transcription has been reported to accompany or cause cell transformation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haurie V,Durrieu-Gaillard S,Dumay-Odelot H,Da Silva D,Rey C,Prochazkova M,Roeder RG,Besser D,Teichmann M

更新日期：2010-03-02 00:00:00

abstract：:Despite structural knowledge of broadly neutralizing monoclonal antibodies (NMAbs) complexed to HIV-1 gp120 and gp41 envelope glycoproteins, virus inactivation mechanisms have been difficult to prove, in part because neutralization assays are complex and were previously not understood. Concordant with recent evidence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Platt EJ,Gomes MM,Kabat D

更新日期：2012-05-15 00:00:00

abstract：:Diminished Sonic Hedgehog (Shh) signaling is associated with the most common forebrain defect in humans, holoprosencephaly (HPE), which includes cyclopia, a phenotype also seen in mice and other vertebrates with defective Shh signaling. The secreted protein Shh acts as a crucial factor that patterns the ventral forebr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roessler E,Du YZ,Mullor JL,Casas E,Allen WP,Gillessen-Kaesbach G,Roeder ER,Ming JE,Ruiz i Altaba A,Muenke M

更新日期：2003-11-11 00:00:00

abstract：:In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DH,Sung S

更新日期：2010-09-28 00:00:00

abstract：:A hybrid bacteriophage, P420, was constructed in vitro; it contains part of bacteriophage P4 and a 3.6-kilobase derivative of plasmid ColE1. In Escherichia coli, the plasmid-phage hybrid can exist as a stable plasmid or can be packaged into infective bacteriophage particles. Replication of P420, directed by the ColE1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn M,Helinski DR

更新日期：1978-05-01 00:00:00

abstract：:The Abeta peptide of Alzheimer disease is derived from the proteolytic processing of the amyloid precursor proteins (APP), which are considered type I transmembrane glycoproteins. Recently, however, soluble forms of full-length APP were also detected in several systems including chromaffin granules. In this report we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efthimiopoulos S,Vassilacopoulou D,Ripellino JA,Tezapsidis N,Robakis NK

更新日期：1996-07-23 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian W,Kumar N,Roginskaya V,Fouquerel E,Opresko PL,Shiva S,Watkins SC,Kolodieznyi D,Bruchez MP,Van Houten B

更新日期：2019-09-10 00:00:00

abstract：:Ferritin has a protein shell of 5 X 10(6) Da consisting of 24 subunits of two types, a heavier (H) chain of 21,000 Da and a lighter (L) chain of 19,000 Da. A cDNA clone of the messenger for the L subunit has been isolated from a human monocyte-like leukemia cell line. The clone contains an open reading frame of 522 nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dörner MH,Salfeld J,Will H,Leibold EA,Vass JK,Munro HN

更新日期：1985-05-01 00:00:00

abstract：:In the troposphere, methanol (CH3OH) is present ubiquitously and second in abundance among organic gases after methane. In the surface ocean, methanol represents a supply of energy and carbon for marine microbes. Here we report direct measurements of air-sea methanol transfer along a ∼10,000-km north-south transect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Nightingale PD,Beale R,Liss PS,Blomquist B,Fairall C

更新日期：2013-12-10 00:00:00

abstract：:Molecular hybridization with (125)I-labeled citrus exocortis viroid RNA has been used to survey nucleic acid preparations from Gynura aurantiaca for viroid complementary molecules. A differential hybridization effect was detected between nucleic acid extracts from healthy and infected tissue in which significant RNase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grill LK,Semancik JS

更新日期：1978-02-01 00:00:00

abstract：:We have noted consistent structural similarities among unrelated proteases. In comparison with other proteins of similar size, proteases have smaller than average surface areas, smaller radii of gyration, and higher C(alpha) densities. These findings imply that proteases are, as a group, more tightly packed than other...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stawiski EW,Baucom AE,Lohr SC,Gregoret LM

更新日期：2000-04-11 00:00:00

abstract：:Coral bleaching, caused by heat stress, is accompanied by the light-induced loss of photosynthetic pigments in in situ symbiotic dinoflagellate algae (Symbiodinium spp.). However, the molecular mechanisms responsible for pigment loss are poorly understood. Here, we show that moderate heat stress causes photobleaching ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi S,Whitney S,Itoh S,Maruyama T,Badger M

更新日期：2008-03-18 00:00:00

abstract：:The ability of a specialized herbivore to overcome the chemical defense of a particular plant taxon not only makes it accessible as a food source but may also provide metabolites to be exploited for communication or chemical defense. Phyllotreta flea beetles are adapted to crucifer plants (Brassicales) that are defend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beran F,Pauchet Y,Kunert G,Reichelt M,Wielsch N,Vogel H,Reinecke A,Svatoš A,Mewis I,Schmid D,Ramasamy S,Ulrichs C,Hansson BS,Gershenzon J,Heckel DG

更新日期：2014-05-20 00:00:00

abstract：:Viral infection leads to activation of the transcription factors interferon regulatory factor-3 and NF-kappaB, which collaborate to induce type I IFNs. The RNA helicase proteins RIG-I and MDA5 were recently identified as two cytoplasmic viral RNA sensors that recognize different species of viral RNAs produced during v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diao F,Li S,Tian Y,Zhang M,Xu LG,Zhang Y,Wang RP,Chen D,Zhai Z,Zhong B,Tien P,Shu HB

更新日期：2007-07-10 00:00:00

abstract：:Failure of embryo implantation accounts for a significant percentage of female infertility. Exquisitely coordinated molecular programs govern the interaction between the competent blastocyst and the receptive uterus. Decidualization, the rapid proliferation and differentiation of endometrial stromal cells into decidua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller M,Yin Y,Ma L

更新日期：2019-09-24 00:00:00

abstract：:Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de novo PC synthesis by the Kennedy pathway is well established, but less is known about the physiological functions of PC. We identified two unrelated patients wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne F,Lim K,Girousse A,Brown RJ,Kory N,Robbins A,Xue Y,Sleigh A,Cochran E,Adams C,Dev Borman A,Russel-Jones D,Gorden P,Semple RK,Saudek V,O'Rahilly S,Walther TC,Barroso I,Savage DB

更新日期：2014-06-17 00:00:00

abstract：:Due to the small size of a nanoconfinement, the property of water contained inside is rather challenging to probe. Herein, we measured the amount of water molecules released during the folding of individual G-quadruplex and i-motif structures, from which water activities are estimated in the DNA nanocages prepared by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonchhe S,Pandey S,Emura T,Hidaka K,Hossain MA,Shrestha P,Sugiyama H,Endo M,Mao H

更新日期：2018-09-18 00:00:00

abstract：:The structural features that determine tRNA(Ala) acceptor identity have been studied with amber-suppressor tRNAs in Escherichia coli cells. Previous work established that a wobble pair composed of guanosine at position 3 and uridine at position 70 (G3-U70) in the acceptor helix of tRNA(Ala) is a determinant of the mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClain WH,Foss K,Jenkins RA,Schneider J

更新日期：1991-10-15 00:00:00

abstract：:Protein tyrosine phosphorylation in purified synaptic vesicles from rat forebrain has been studied in the presence of Mn2+ and orthovanadate. High levels of endogenous protein tyrosine phosphorylation were observed. Four major phosphoproteins, with apparent molecular masses of 105, 94, 38, and 30 kDa, were shown to co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pang DT,Wang JK,Valtorta F,Benfenati F,Greengard P

更新日期：1988-02-01 00:00:00

abstract：:In this paper we extend the well-known Vitali-Hahn-Saks and Nikodým theorems for measures to finitely additive vector-valued set functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JK,Jewett RS

更新日期：1970-11-01 00:00:00

abstract：:Although preterm delivery is a major global health issue, its causes and underlying mechanism remain elusive. Using mutant mice, mimicking aspects of human preterm birth, we show here that uterine decidual senescence early in pregnancy via heightened mammalian target of rapamycin complex 1 (mTORC1) signaling is a sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirota Y,Cha J,Yoshie M,Daikoku T,Dey SK

更新日期：2011-11-01 00:00:00

abstract：:After fertilization of the sea urchin, Strongyl-ocentrotus purpuratus, a crosslinked fertilization membrane is formed; the crosslinks (dityrosine residues) are synthesized in a reaction catalyzed by an ovoperoxidase that is released from the cortical granules during fertilization. The substrate for ovoperoxidase activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foerder CA,Klebanoff SJ,Shapiro BM

更新日期：1978-07-01 00:00:00

abstract：:The location of renin (EC 3.4.99.19) in rat pituitary was determined by the peroxidase-antiperoxidase immunohistochemical technique. By using antisera prepared with purified rat renal renin, an immunoreactive substance was localized within ovoid cells scattered throughout the anterior pituitary. These cells were shown...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naruse K,Takii Y,Inagami T

更新日期：1981-12-01 00:00:00

abstract：:The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiswell BP,Zhang R,Murphy JW,Boggon TJ,Calderwood DA

更新日期：2008-12-30 00:00:00

abstract：:Although most nuclear hormone receptors are ligand-dependent transcriptional activators, certain members of this superfamily, such as thyroid hormone receptor (TR) and retinoic acid receptor (RAR), are involved in transcriptional repression. The silencing function of these receptors has been localized to the ligand bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nawaz Z,Tsai MJ,O'Malley BW

更新日期：1995-12-05 00:00:00