Regulation of human EGF receptor by lipids.

abstract：:The biotic recovery from Earth's most severe extinction event at the Permian-Triassic boundary largely reestablished the preextinction structure of marine trophic networks, with marine reptiles assuming the predator roles. However, the highest trophic level of today's marine ecosystems, i.e., macropredatory tetrapods ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fröbisch NB,Fröbisch J,Sander PM,Schmitz L,Rieppel O

更新日期：2013-01-22 00:00:00

abstract：:Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta I,Ganguly S,Rozanas CR,Stuehr DJ,Panda K

更新日期：2016-07-19 00:00:00

abstract：:Incubation of chicken embryo fibroblasts with mitogenic concentrations of insulin for 24 hr or with the tumor promoter phorbol 12-myristate 13-acetate for 6 hr stimulated lactate release and 3-O-methylglucose uptake. Insulin also increased the Vmax of 6-phosphofructo-1-kinase (ATP:D-fructose-6-phosphate 1-phosphotrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosca L,Rousseau GG,Hue L

更新日期：1985-10-01 00:00:00

abstract：:The delivery of AMPA receptors to the plasma membrane is a critical step both for the synaptic delivery of these receptors and for the regulation of synaptic transmission. To directly visualize fusion events of transport vesicles containing the AMPA receptor GluA2 subunit with the plasma membrane we used pHluorin-tagg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araki Y,Lin DT,Huganir RL

更新日期：2010-06-15 00:00:00

abstract：:The aldosterone-induced augmentation of Na+ transport in toad bladder was analyzed by comparing the hormonal actions on the transepithelial short-circuit current and on the amiloride-sensitive 22Na+ uptake in isolated membrane vesicles. Incubating bladders with 0.5 microM aldosterone for 3 hr evoked more than a 2-fold...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asher C,Garty H

更新日期：1988-10-01 00:00:00

abstract：:The properties of the virus synthesized by each of three morphologically different cell lines originating from DBA/2J fetal liver cells transformed by the anemic strain of Friend leukemia virus in vitro were analyzed. The cells of line G-1 are malignant in syngeneic DBA/2 mice, grow in suspension, and are erythroid in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuei D,Pogo BG,Friend C

更新日期：1980-10-01 00:00:00

abstract：:Signal transduction pathways activated by chemoattractants have been extensively studied, but little is known about the events mediating responses to mechanical stimuli. We discovered that acute mechanical perturbation of cells triggered transient activation of all tested components of the chemotactic signal transduct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Artemenko Y,Axiotakis L Jr,Borleis J,Iglesias PA,Devreotes PN

更新日期：2016-11-22 00:00:00

abstract：:Activation of androgen receptor (AR) via androgen in muscle cells has been closely linked to their growth and differentiation. Here, we report the cloning and characterization of supervillin (SV), a 205-kDa actin-binding protein, as an AR coregulator from the skeletal muscle cDNA library. Mammalian two-hybrid and glut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ting HJ,Yeh S,Nishimura K,Chang C

更新日期：2002-01-22 00:00:00

abstract：:Much debate has revolved around the question of whether the mode of evolutionary and ecological turnover in the fossil record of African mammals was continuous or pulsed, and the degree to which faunal turnover tracked changes in global climate. Here, we assembled and analyzed large specimen databases of the fossil re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibi F,Kiessling W

更新日期：2015-08-25 00:00:00

abstract：:It has often been suggested that the frequently observed Watson-Crick base-pair compensatory substitutions in RNA helical structures occur mainly through a slightly deleterious G.U intermediate state. We have scored base substitutions in a set of 82 related Drosophila species for the D1 and D2 variable domains of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousset F,Pélandakis M,Solignac M

更新日期：1991-11-15 00:00:00

abstract：:A double-stranded (ds) DNA which may be a replication intermediate was isolated from bean (Phaseolus vulgaris L. "Top Crop") leaves systemically infected with bean golden mosaic virus, a whitefly-transmitted plant virus with a genome of circular single-stranded (ss) DNA. The isolation method used phenol/chloroform ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikegami M,Haber S,Goodman RM

更新日期：1981-07-01 00:00:00

abstract：:Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin S,Liu M,Niu W,Zhang CL

更新日期：2011-12-27 00:00:00

abstract：:In insulin resistant states such as type 2 diabetes, there is a high demand on the β-cell to synthesize and secrete insulin, which challenges the ability of the endoplasmic reticulum (ER) to synthesize and fold nascent proteins. This creates a state of ER stress that triggers a coordinated program referred to as the u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winnay JN,Dirice E,Liew CW,Kulkarni RN,Kahn CR

更新日期：2014-01-21 00:00:00

abstract：:The total amounts of type I and type II cytoplasmic cyclic AMP-dependent protein kinase activities were measured in various tissues of intact rats and rats subjected to castration, hypophysectomy, or adrenalectomy. After castration, the total amount of type I activity decreased rapidly in classifically steroid-respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuller DJ,Byus CV,Russell DH

更新日期：1978-01-01 00:00:00

abstract：:Cell-cell interactions organize lens fiber cells into highly ordered structures to maintain transparency. However, signals regulating such interactions have not been well characterized. We report here that ephrin-A5, a ligand of the Eph receptor tyrosine kinases, plays a key role in lens fiber cell shape and cell-cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper MA,Son AI,Komlos D,Sun Y,Kleiman NJ,Zhou R

更新日期：2008-10-28 00:00:00

abstract：:Electrophysiological mapping of chronic atrial fibrillation (AF) at high throughput and high resolution is critical for understanding its underlying mechanism and guiding definitive treatment such as cardiac ablation, but current electrophysiological tools are limited by either low spatial resolution or electromechani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Zhang X,Liu Y,Rodrigo M,Loftus PD,Aparicio-Valenzuela J,Zheng J,Pong T,Cyr KJ,Babakhanian M,Hasi J,Li J,Jiang Y,Kenney CJ,Wang PJ,Lee AM,Bao Z

更新日期：2020-06-30 00:00:00

abstract：:Development of the vertebrate eye has been found to require the activity of several genes encoding homeodomain proteins (Freund, C., Horsford, D. J. & McInnes, R. R. (1996) Hum. Mol. Genet. 5, 1471-1488). Some of these genes, or portions thereof, are highly conserved across phyla. In this paper, we report the identifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furukawa T,Kozak CA,Cepko CL

更新日期：1997-04-01 00:00:00

abstract：:Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contribu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pomié C,Vicente R,Vuddamalay Y,Lundgren BA,van der Hoek M,Enault G,Kagan J,Fazilleau N,Scott HS,Romagnoli P,van Meerwijk JP

更新日期：2011-07-26 00:00:00

abstract：:Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that the LDLR mediates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillian-Daniel DL,Bates PW,Tebon A,Attie AD

更新日期：2002-04-02 00:00:00

abstract：:Overproduction or deficiency of many chaperones and other cellular components cure the yeast prions [PSI+] (formed by Sup35p) or [URE3] (based on Ure2p). However, at normal expression levels, Btn2p and Cur1p eliminate most newly arising [URE3] variants but do not cure [PSI+], even after overexpression. Deficiency or o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorkovskiy A,Reidy M,Masison DC,Wickner RB

更新日期：2017-05-23 00:00:00

abstract：:To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higuchi H,Muto E,Inoue Y,Yanagida T

更新日期：1997-04-29 00:00:00

abstract：:Regulation of biological phenomena occurs in all types of systems, being manifested in many different reaction types, from allosteric behavior in proteins, through modulation in energy and information transfer, to the control of growth and differentiation in cells, organelles, and organisms. In this communication, a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sligar SG,Gunsalus IC

更新日期：1976-04-01 00:00:00

abstract：:When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson EA,Neel JV

更新日期：1978-03-01 00:00:00

abstract：:Using a novel technique of modulated photo-dissociation of carbon monoxide from hemoglobin, we have obtained the rates for conversion between the two quaternary states, R, and T, at 3-fold ligation. Our measurements at pH 7 and 22 degrees give rates of 780 +/- 40 sec-1 for going from R to T, and 2500 +/- 200 sec-1 fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrone FA,Hopfield JJ

更新日期：1976-12-01 00:00:00

abstract：:Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus E,Yalow RS

更新日期：1978-01-01 00:00:00

abstract：:Unqualified, the statement that approximately 1.3% of the approximately 10,000 presently known bird species have become extinct since A.D. 1500 yields an estimate of approximately 26 extinctions per million species per year (or 26 E/MSY). This is higher than the benchmark rate of approximately 1 E/MSY before human imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pimm S,Raven P,Peterson A,Sekercioglu CH,Ehrlich PR

更新日期：2006-07-18 00:00:00

abstract：:A form of autosomal dominant juvenile myoclonic epilepsy is caused by a nonconservative missense mutation, A322D, in the GABAA receptor alpha1 subunit M3 transmembrane helix. We reported previously that the A322D mutation reduced total and surface alpha1(A322D) subunit protein and that residual alpha1(A322D) subunit r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallagher MJ,Ding L,Maheshwari A,Macdonald RL

更新日期：2007-08-07 00:00:00

abstract：:Coatomer, the major component of the coat of COPI transport vesicles, binds both to the dilysine motif of resident membrane proteins of the endoplasmic reticulum and to the cytoplasmic domain of p23, a major type I membrane protein of COPI vesicles. Using a photocrosslinking approach, we find that under native conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harter C,Wieland FT

更新日期：1998-09-29 00:00:00

abstract：:Expressions are developed for weak single pair emission probability and strong emission average number of pairs. The water transparency cutoff is closely realized, showing that the fundamental time scale is even shorter. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1993-05-15 00:00:00

abstract：:DNA sequence motifs that affect RNA polymerase transcription elongation are well studied in prokaryotic organisms and contribute directly to regulation of gene expression. Despite significant work on the regulation of eukaryotic transcription, the effect of DNA template sequence on RNA polymerase I (Pol I) transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarke AM,Engel KL,Giles KE,Petit CM,Schneider DA

更新日期：2018-12-11 00:00:00