A thermodynamic model of regulation: modulation of redox equilibria in camphor monoxygenase.

abstract：:A sensitive target binding assay has recently been shown to detect natural killer (NK) cells in the mouse. Preincubation of NK cells with detergent-solubilized cell-surface proteins of YAC lymphoma cells prevented subsequent binding to intact YAC targets. The NK target structures (NK-TS) consisted of three molecular s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roder JC,Rosén A,Fenyö EM,Troy FA

更新日期：1979-03-01 00:00:00

abstract：:A mutation partially suppressing the UV sensitivity caused by recF143 in a uvrA6 background was located at codon 37 of recA where GTG (valine) became ATG (methionine). This mutation, originally named srf-803, was renamed recA803. Little if any suppression of the recF143 defect in UV induction of a lexA regulon promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madiraju MV,Templin A,Clark AJ

更新日期：1988-09-01 00:00:00

abstract：:The dnaX gene (previously called dnaZX) of Escherichia coli has only one open reading frame for a 71-kDa polypeptide from which two distinct DNA polymerase III holoenzyme subunits, tau (71 kDa) and gamma (47 kDa), are produced. To determine how the gamma subunit is generated, we examined the influence of mutations in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuchihashi Z,Kornberg A

更新日期：1990-04-01 00:00:00

abstract：:This note presents the derivation of generalized Ambartsumian-Chandrasekhar X and Y functions for stationary transfer in a plane-parallel slab. An algebraic formula relating these functions to the usual reflection function is also presented, together with the appropriate generalization of the Chandrasekhar H-equations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casti J

更新日期：1975-03-01 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are IP(3)-gated Ca(2+) channels that are located on intracellular Ca(2+) stores. We previously identified an IP(3)R binding protein, termed IP(3)R binding protein released with IP(3) (IRBIT). Because IRBIT is released from IP(3)R by physiological concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shirakabe K,Priori G,Yamada H,Ando H,Horita S,Fujita T,Fujimoto I,Mizutani A,Seki G,Mikoshiba K

更新日期：2006-06-20 00:00:00

abstract：:The chromophore of photoactive yellow protein (PYP) (i.e., 4-hydroxycinnamic acid) has been replaced by an analogue with a triple bond, rather than a double bond (by using 4-hydroxyphenylpropiolic acid in the reconstitution, yielding hybrid I) and by a "locked" chromophore (through reconstitution with 7-hydroxycoumari...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cordfunke R,Kort R,Pierik A,Gobets B,Koomen GJ,Verhoeven JW,Hellingwerf KJ

更新日期：1998-06-23 00:00:00

abstract：:Local tissue stem cells have been described in airways of the lung but their contribution to normal epithelial maintenance is currently unknown. We therefore developed aggregation chimera mice and a whole-lung imaging method to determine the relative contributions of progenitor (Clara) and bronchiolar stem cells to ep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR

更新日期：2009-06-09 00:00:00

abstract：:T-cell migration into tissue depends on a cascade of rapid and selective adhesive interactions with endothelium. "Triggering" is a step in that cascade required to activate T-cell integrins. Hepatocyte growth factor (HGF) may be a physiologically relevant trigger, since we demonstrate that HGF can induce both adhesion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adams DH,Harvath L,Bottaro DP,Interrante R,Catalano G,Tanaka Y,Strain A,Hubscher SG,Shaw S

更新日期：1994-07-19 00:00:00

abstract：:No microorganism capable of anaerobic growth on methane as the sole carbon source has yet been cultivated. Consequently, information about these microbes has been inferred from geochemical and microbiological observations of field samples. Stable isotope analysis of lipid biomarkers and rRNA gene surveys have implicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orphan VJ,House CH,Hinrichs KU,McKeegan KD,DeLong EF

更新日期：2002-05-28 00:00:00

abstract：:The origin-binding protein (OBP) from herpes simplex virus 1 is a member of the SF2 helicase superfamily and is required for the initiation of DNA synthesis from a viral origin of DNA replication (oriS). The high-affinity binding sites for OBP in oriS, boxes I and II, are separated by an A+T-rich spacer. We used the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafsson CM,Hammarsten O,Falkenberg M,Elias P

更新日期：1994-05-24 00:00:00

abstract：:The yeast fatty acid synthase (M(r) = 2.5 x 10(6)) is organized in an alpha 6 beta 6 complex. In these studies, the synthase structure has been examined by negative-stain and cryo-electron microscopy. Side and end views of the structure indicate that the molecule, shaped similar to a prolate ellipsoid, has a high-dens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoops JK,Kolodziej SJ,Schroeter JP,Bretaudiere JP,Wakil SJ

更新日期：1992-07-15 00:00:00

abstract：:The HB-19 pseudopeptide 5[Kpsi(CH(2)N)PR]-TASP, psi(CH(2)N) for reduced peptide bond, is a specific inhibitor of HIV infection in different CD4(+) cell lines and in primary T-lymphocytes and macrophages. It blocks virus-particle attachment to permissive cells by binding and forming a stable complex with nucleolin expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krust B,Vienet R,Cardona A,Rougeot C,Jacotot E,Callebaut C,Guichard G,Briand JP,Grognet JM,Hovanessian AG,Edelman L

更新日期：2001-11-20 00:00:00

abstract：:Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callegari AJ,Kelly TJ

更新日期：2006-10-24 00:00:00

abstract：:Viruses modulate biochemical cellular pathways to permit infection. A recently described mechanism mediates selective protein interactions between acidic domain readers and unacetylated, lysine-rich regions, opposite of bromodomain function. Kaposi´s sarcoma (KS)-associated herpesvirus (KSHV) is tightly linked with KS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juillard F,de Miranda MP,Li S,Franco A,Seixas AF,Liu B,Álvarez ÁL,Tan M,Szymula A,Kaye KM,Simas JP

更新日期：2020-09-08 00:00:00

abstract：:To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

更新日期：1989-12-01 00:00:00

abstract：:Initial attempts to correlate the distribution of gene density (number of gene loci per unit length on the linkage map) with the distribution of lengths of coding sequences have led to the observation that 46% of approximately 1000 sampled proteins in Escherichia coli have molecular masses of n X 14,000 +/- 2500 dalto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Savageau MA

更新日期：1986-03-01 00:00:00

abstract：:Bacteriophage lambda integrates into the chromosome of its Escherichia coli host by means of a site-specific recombination between a locus on the phage chromosome (phage att site) and a locus on the bacterial chromosome (bacterial att site). The nucleotide sequence of four lambda att sites altered in site-specific rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoess RH,Landy A

更新日期：1978-11-01 00:00:00

abstract：:Zea mays plasma membrane intrinsic proteins (ZmPIPs) fall into two groups, ZmPIP1s and ZmPIP2s, that exhibit different water channel activities when expressed in Xenopus oocytes. ZmPIP1s are inactive, whereas ZmPIP2s induce a marked increase in the membrane osmotic water permeability coefficient, P(f). We previously s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelazny E,Borst JW,Muylaert M,Batoko H,Hemminga MA,Chaumont F

更新日期：2007-07-24 00:00:00

abstract：:Psychostimulant use is an ever-increasing socioeconomic burden, including a dramatic rise during pregnancy. Nevertheless, brain-wide effects of psychostimulant exposure are incompletely understood. Here, we performed Fos-CreERT2-based activity mapping, correlated for pregnant mouse dams and their fetuses with amphetam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuzik J,Rehman S,Girach F,Miklosi AG,Korchynska S,Arque G,Romanov RA,Hanics J,Wagner L,Meletis K,Yanagawa Y,Kovacs GG,Alpár A,Hökfelt TGM,Harkany T

更新日期：2019-12-17 00:00:00

abstract：:The bacterial pathogen Shigella flexneri causes bacillary dysentery in humans by invading coloncytes. Upon contact with epithelial cells, S. flexneri elicits localized plasma membrane projections sustained by long actin filaments which engulf the microorganism. The products necessary for Shigella entry include three s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ménard R,Prévost MC,Gounon P,Sansonetti P,Dehio C

更新日期：1996-02-06 00:00:00

abstract：:We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10. The antibody showed strong reactivity to a wide variety of cancer cells, but only to a limited number of normal cells including lymphocytes, endothelial cells, and basal cells of stratified squamous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ino Y,Gotoh M,Sakamoto M,Tsukagoshi K,Hirohashi S

更新日期：2002-01-08 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00

abstract：:Breast cancer remains the cancer with the highest mortality among women in the United States. Peptides derived from the oncogenic Tac1 gene (full transcript: betaPPT-A) stimulate the proliferation of breast cancer cells (BCCs) via seven-transmembrane G protein-coupled neurokinin 1 (NK1) and NK2 receptors. The NK1 gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel HJ,Ramkissoon SH,Patel PS,Rameshwar P

更新日期：2005-11-29 00:00:00

abstract：:The free radicals nitric oxide and superoxide anion react to form peroxynitrite (ONOO-), a highly toxic oxidant species. In vivo formation of ONOO- has been demonstrated in shock and inflammation. Herein we provide evidence that cytotoxicity in cells exposed to ONOO- is mediated by DNA strand breakage and the subseque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szabó C,Zingarelli B,O'Connor M,Salzman AL

更新日期：1996-03-05 00:00:00

abstract：:Collective animal behavior studies have led the way in developing models that account for a large number of individuals, but mostly have considered situations in which alignment and attraction play a key role, such as in schooling and flocking. By quantifying how animals react to one another's presence, when interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giuggioli L,Potts JR,Rubenstein DI,Levin SA

更新日期：2013-10-15 00:00:00

abstract：:All science has uncertainty. Unless that uncertainty is communicated effectively, decision makers may put too much or too little faith in it. The information that needs to be communicated depends on the decisions that people face. Are they (i) looking for a signal (e.g., whether to evacuate before a hurricane), (ii) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischhoff B,Davis AL

更新日期：2014-09-16 00:00:00

abstract：:The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS. Studies have shown that a +8 charged sequence of amino acids in the protein, called the TAT peptide, enables the TAT protein to penetrate cell membranes. To probe mechanisms of binding and translocation of the TAT pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao Y,Kwok SJ,Lombardi J,Turro NJ,Eisenthal KB

更新日期：2014-09-02 00:00:00

abstract：:Mild oxidation of human serum low-density lipoprotein (LDL) converts the apoprotein from a nearly homogeneous component of high apparent molecular weight to a mixture of apparently lower molecular weight polypeptide components, as characterized by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. This protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schuh J,Fairclough GF Jr,Haschemeyer RH

更新日期：1978-07-01 00:00:00

abstract：:Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harkins J,Arsenault M,Schlesinger K,Kates J

更新日期：1972-11-01 00:00:00

abstract：:Interspersed repeated sequences (Alu and Kpn) were used as probes to detect a set of Not I restriction fragments of human chromosome 21 from the hybrid cell line WAV17. Forty different Not I fragments, ranging in size from less than 0.05 megabase (Mb) to 7.0 Mb, were identified. The total length of these fragments was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sainz J,Pevny L,Wu Y,Cantor CR,Smith CL

更新日期：1992-02-01 00:00:00