High-resolution optical imaging of functional brain architecture in the awake monkey.

abstract：:Naked mole-rats form eusocial colonies consisting of a single breeding female (the queen), several breeding males, and sexually immature adults (subordinates). Subordinates are cooperative and provide alloparental care by huddling and retrieving pups to the nest. However, the physiological mechanism(s) underlying allo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watarai A,Arai N,Miyawaki S,Okano H,Miura K,Mogi K,Kikusui T

更新日期：2018-09-11 00:00:00

abstract：:Organ graft rejection is a T-cell-dependent process. The activation of alloreactive T cells requires stimulation of the T-cell receptor/CD3 complex by foreign major histocompatibility complex (MHC)-encoded gene products. However, accumulating evidence suggests that, in addition to T-cell receptor occupancy, other cost...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turka LA,Linsley PS,Lin H,Brady W,Leiden JM,Wei RQ,Gibson ML,Zheng XG,Myrdal S,Gordon D

更新日期：1992-11-15 00:00:00

abstract：:Incubation of sickle cells with cystamine, a thiol reagnet, resulted in the formation of an intracellular S-ethylamine derivative. The rate of the reaction was dependent upon the cystamine concentration, the temperature, and the duration of the incubation. The cystamine-treated cells demonstrated a marked inhibition o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassan W,Beuzard Y,Rosa J

更新日期：1976-09-01 00:00:00

abstract：:To understand the biogeochemical roles of microorganisms in the environment, it is important to determine when and under which conditions they are metabolically active. Bioorthogonal noncanonical amino acid tagging (BONCAT) can reveal active cells by tracking the incorporation of synthetic amino acids into newly synth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hatzenpichler R,Connon SA,Goudeau D,Malmstrom RR,Woyke T,Orphan VJ

更新日期：2016-07-12 00:00:00

abstract：:We previously reported that long-term cyclic estrogen (E) treatment reverses age-related impairment of cognitive function mediated by the dorsolateral prefrontal cortex (dlPFC) in ovariectomized (OVX) female rhesus monkeys, and that E induces a corresponding increase in spine density in layer III dlPFC pyramidal neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao J,Rapp PR,Janssen WG,Lou W,Lasley BL,Hof PR,Morrison JH

更新日期：2007-07-03 00:00:00

abstract：:Distribution studies disclosed that all major cerebral arteries and cortical arterioles of the cat were invested with fine varicose nerve fibers that contained calcitonin gene-related peptide (CGRP)-like immunoreactivity; the trigeminal ganglia likewise contained CGRP immunoreactivity. Sequential immunostaining with a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCulloch J,Uddman R,Kingman TA,Edvinsson L

更新日期：1986-08-01 00:00:00

abstract：:There is no theoretical limit in using molecular networks to harvest diffusive sun photons on large areas and funnel them onto much smaller areas of highly efficient but also precious energy-converting materials. The most effective concept reported so far is based on a pool of randomly oriented, light-harvesting donor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willich MM,Wegener L,Vornweg J,Hohgardt M,Nowak J,Wolter M,Jacob CR,Walla PJ

更新日期：2020-12-29 00:00:00

abstract：:We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamnes MA,Craighead MW,Hoe MH,Lampen N,Geromanos S,Tempst P,Rothman JE

更新日期：1995-08-15 00:00:00

abstract：:Combinatorial transcription codes generate the myriad of cell types during development and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Cuvillier JM,Lee B,Shen R,Lee JW,Lee SK

更新日期：2012-02-28 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:There has been much confusion recently about the relative merits of different approaches, osmotic stress, preferential interaction, and crowding, to describe the indirect effect of solutes on macromolecular conformations and reactions. To strengthen all interpretations of measurements and to forestall further unnecess...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsegian VA,Rand RP,Rau DC

更新日期：2000-04-11 00:00:00

abstract：:Switch from non-syncytium-inducing (NSI) to syncytium-inducing (SI) HIV type 1 (HIV-1) is associated with accelerated CD4(+) T cell depletion, which might partially be explained by higher virulence of SI variants compared with NSI variants. Because NSI and SI variants use different coreceptors for entry of target cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaak H,van't Wout AB,Brouwer M,Hooibrink B,Hovenkamp E,Schuitemaker H

更新日期：2000-02-01 00:00:00

abstract：:Ontogenetic changes in the protein phosphorylation/dephosphorylation systems in rat brain were investigated. It was found that the activity level of phospholipid-sensitive Ca2+-dependent protein kinase (PL-Ca-PK) in the particulate fraction of grey and white matter and the soluble fraction of grey matter increased rap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner RS,Raynor RL,Mazzei GJ,Girard PR,Kuo JF

更新日期：1984-05-01 00:00:00

abstract：:In many species that form pair bonds, males display to their mate after pair formation. These displays elevate the female's investment into the brood. This is a form of cooperation because without the display, female investment is reduced to levels that are suboptimal for both sexes. The presence of such displays is p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Servedio MR,Powers JM,Lande R,Price TD

更新日期：2019-11-12 00:00:00

abstract：:Certain chemical systems which differ greatly in many of their chemical properties may nevertheless exhibit stereochemically isomorphic behavior, i.e., they may be stereochemically correspondent. Two such systems are spirocyclic pentacoordinate molecules and molecules of the type Ar(2)ZX. The consequences of stereoche...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gust D,Finocchiaro P,Mislow K

更新日期：1973-12-01 00:00:00

abstract：:Monosynaptic excitatory connections between cerebellar granule and Purkinje cells were studied in dissociated cell cultures, and identification of the transmitter and the postsynaptic receptor at this synapse was pharmacologically investigated. The presynaptic granule cell and the postsynaptic Purkinje cell were volta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano T,Hagiwara S

更新日期：1988-02-01 00:00:00

abstract：:The type specimen for Australopithecus africanus (Taung) includes a natural endocast that reproduces most of the external morphology of the right cerebral hemisphere and a fragment of fossilized face that articulates with the endocast. Despite the fact that Taung died between 3 and 4 y of age, the endocast reproduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falk D,Zollikofer CP,Morimoto N,Ponce de León MS

更新日期：2012-05-29 00:00:00

abstract：:By using the maximum likelihood method, we made a genome-wide comparison of the evolutionary rates in the lineages leading to the laboratory strain (S288c) and a wild strain (YJM789) of Saccharomyces cerevisiae and found that genes in the laboratory strain tend to evolve faster than in the wild strain. The pattern of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu Z,David L,Petrov D,Jones T,Davis RW,Steinmetz LM

更新日期：2005-01-25 00:00:00

abstract：:Single cortical neurons in the mammalian brain receive signals arising from multiple sensory input channels. Dendritic integration of these afferent signals is critical in determining the amplitude and time course of the neurons' output signals. As of yet, little is known about the spatial and temporal organization of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varga Z,Jia H,Sakmann B,Konnerth A

更新日期：2011-09-13 00:00:00

abstract：:Accounting for enzyme-mediated active sliding, disassembly, and sequence-dependent positioning of nucleosomes, we simulate nucleosome occupancy over cell-cycle-scale times using a stochastic kinetic model. We show that ATP-dependent active nucleosome sliding and nucleosome removal processes are essential to obtain in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padinhateeri R,Marko JF

更新日期：2011-05-10 00:00:00

abstract：:Threats to species from commercial fishing are rarely identified until species have suffered large population declines, by which time remedial actions can have severe economic consequences, such as closure of fisheries. Many of the species most threatened by fishing are caught in multispecies fisheries, which can rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgess MG,Polasky S,Tilman D

更新日期：2013-10-01 00:00:00

abstract：:Targeted ablation of the surfactant protein D (SP-D) gene caused chronic inflammation, emphysema, and fibrosis in the lungs of SP-D (-/-) mice. Although lung morphology was unperturbed during the first 2 weeks of life, airspace enlargement was observed by 3 weeks and progressed with advancing age. Inflammation consist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wert SE,Yoshida M,LeVine AM,Ikegami M,Jones T,Ross GF,Fisher JH,Korfhagen TR,Whitsett JA

更新日期：2000-05-23 00:00:00

abstract：:The measurement of any nonchromosomal genetic contribution to the heritability of a trait is often confounded by the inability to control both the chromosomal and nonchromosomal information in a population. We have designed a unique system in yeast where we can control both sources of information so that the phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards MD,Symbor-Nagrabska A,Dollard L,Gifford DK,Fink GR

更新日期：2014-05-27 00:00:00

abstract：:Allostery, the coupling between ligand binding and protein conformational change, is the heart of biological network and it has often been explained by two representative models, the induced-fit and the population-shift models. Here, we clarified for what systems one model fits better than the other by performing mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazaki K,Takada S

更新日期：2008-08-12 00:00:00

abstract：:ErbB2 interacting protein (Erbin) is a widely expressed protein and participates in inhibition of several intracellular signaling pathways. Its mRNA has been found to be present in relatively high levels in the heart. However, its physiological role in the heart has not been explored. In the present work, we elucidate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rachmin I,Tshori S,Smith Y,Oppenheim A,Marchetto S,Kay G,Foo RS,Dagan N,Golomb E,Gilon D,Borg JP,Razin E

更新日期：2014-04-22 00:00:00

abstract：:In vivo, G protein-coupled receptors (GPCR) for neurotransmitters undergo complex intracellular trafficking that contribute to regulate their abundance at the cell surface. Here, we report a previously undescribed alteration in the subcellular localization of D1 dopamine receptor (D1R) that occurs in vivo in striatal ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dumartin B,Jaber M,Gonon F,Caron MG,Giros B,Bloch B

更新日期：2000-02-15 00:00:00

abstract：:There is evidence both for and against Na(+)- and Cl(-)-dependent neurotransmitter transporters forming oligomers. We found that cross-linking the human dopamine transporter (DAT), which is heterologously expressed in human embryonic kidney 293 cells, either with copper phenanthroline (CuP) or the bifunctional reagent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hastrup H,Karlin A,Javitch JA

更新日期：2001-08-28 00:00:00

abstract：:Arc repressor forms a homodimer in which the subunits intertwine to create a single globular domain. To obtain Arc sequences that fold preferentially as heterodimers, variants with surface patches of excess positive or negative charge were designed. Several but not all oppositely charged sequence pairs showed preferen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nohaile MJ,Hendsch ZS,Tidor B,Sauer RT

更新日期：2001-03-13 00:00:00

abstract：:Harvey and Kirsten murine sarcoma viruses each encode a structurally and functionally related 21-kilodalton protein (p21), which is the transforming protein of each virus. Using probes from the 0.9-kilobase (kb) p21-coding region of each virus (called v-Ha-ras and v-Ki-ras, respectively), we have molecularly cloned fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang EH,Gonda MA,Ellis RW,Scolnick EM,Lowy DR

更新日期：1982-08-01 00:00:00

abstract：:We demonstrate that single interneurons can toggle the output neurons of the cerebellar cortex (the Purkinje cells) between their two states. The firing of Purkinje cells has previously been shown to alternate between an "up" state in which the cell fires spontaneous action potentials and a silent "down" state. We sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldfield CS,Marty A,Stell BM

更新日期：2010-07-20 00:00:00