Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.

abstract：:Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Hastak K,Ahmad N,Lewin JS,Mukhtar H

更新日期：2001-08-28 00:00:00

abstract：:Murine-virus-infected erythroleukemia cells cultured in a medium with dimethylsulfoxide or N,N-dimethylformamide are induced to differentiate to erythroid cells. A number of highly polar compounds have a similar effect in inducing erythroid differentiation of the virus-infected cells, as assayed by the appearance of h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka M,Levy J,Terada M,Breslow R,Rifkind RA,Marks PA

更新日期：1975-03-01 00:00:00

abstract：:Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm2 at an overpotential below 300 mV with lon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou H,Yu F,Sun J,He R,Chen S,Chu CW,Ren Z

更新日期：2017-05-30 00:00:00

abstract：:The evolutionary stability of cooperation is a problem of fundamental importance for the biological and social sciences. Different claims have been made about this issue: whereas Axelrod and Hamilton's [Axelrod, R. & Hamilton, W. (1981) Science 211, 1390-1398] widely recognized conclusion is that cooperative rules suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bendor J,Swistak P

更新日期：1995-04-11 00:00:00

abstract：:Human workers ensure the functioning of governments around the world. The efficacy of human workers, in turn, is linked to the climatic conditions they face. Here we show that the same weather that amplifies human health hazards also reduces street-level government workers' oversight of these hazards. To do so, we emp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Obradovich N,Tingley D,Rahwan I

更新日期：2018-08-28 00:00:00

abstract：:Thioredoxins are 12-kDa proteins functional in the regulation of cellular processes throughout the animal, plant, and microbial kingdoms. Growing evidence with seeds suggests that an h-type of thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds of target proteins and thereby acts as a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano H,Wong JH,Lee YM,Cho MJ,Buchanan BB

更新日期：2001-04-10 00:00:00

abstract：:In the traditional Z scheme of photosynthesis the Emerson effects of red drop (decline in yield of photosynthesis in far-red light) and enhancement (of far-red yield by supplementary short-wavelength light) are taken to be evidence for the coupling in series of two photosystems that absorb unsymmetrically in the far-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner JW,Berry RS

更新日期：1987-06-01 00:00:00

abstract：:We developed two solid-phase reagent systems for microscopic visualization and characterization of melanocyte-stimulating hormone (MSH) receptors of melanoma cells. Multiple copies of [Nle-4,D-Phe-7]-alpha-MSH, a potent analog of alpha-MSH, were conjugated to microspheres (latex beads) or macrospheres (polyamide beads...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SD,Jiang J,Hadley ME,Bentley DL,Hruby VJ

更新日期：1996-11-26 00:00:00

abstract：:The integrase protein of human immunodeficiency virus type 1 is necessary for the stable integration of the viral genome into host DNA. Integrase catalyzes the 3' processing of the linear viral DNA and the subsequent DNA strand transfer reaction that inserts the viral DNA ends into host DNA. Although full-length integ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenkins TM,Hickman AB,Dyda F,Ghirlando R,Davies DR,Craigie R

更新日期：1995-06-20 00:00:00

abstract：:We examine a nonreciprocally coupled dynamical model of a mixture of two diffusing species. We demonstrate that nonreciprocity, which is encoded in the model via antagonistic cross-diffusivities, provides a generic mechanism for the emergence of traveling patterns in purely diffusive systems with conservative dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： You Z,Baskaran A,Marchetti MC

更新日期：2020-08-18 00:00:00

abstract：:The SecY protein of Escherichia coli is an integral membrane component of the protein export apparatus. Suppressor mutations in the secY gene (prlA alleles) have been isolated that restore the secretion of precursor proteins with defective signal sequences. These mutations have never been shown to affect the transloca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nouwen N,de Kruijff B,Tommassen J

更新日期：1996-06-11 00:00:00

abstract：:Due to its remarkably long half-life, together with its wide in vivo distribution and its lack of enzymatic or immunological functions, human serum albumin (HSA) represents an optimal carrier for therapeutic peptides/proteins aimed at interacting with cellular or molecular components of the vascular and interstitial c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh P,Landais D,Lemaître M,Maury I,Crenne JY,Becquart J,Murry-Brelier A,Boucher F,Montay G,Fleer R

更新日期：1992-03-01 00:00:00

abstract：:The minimal size of the recombination site required for efficient FLP recombinase-catalyzed recombination in vitro is no more than 28 base pairs, which includes parts of two 13-base-pair inverted repeats and all of an 8-base-pair spacer. The FLP recombinase cleaves the DNA at the boundaries of the spacer, becomes cova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senecoff JF,Bruckner RC,Cox MM

更新日期：1985-11-01 00:00:00

abstract：:Given the slow unfolding of what may become catastrophic changes to Earth's climate, many are understandably distraught by failures of public policy to rise to the magnitude of the challenge. Few in the science community would think to question the scientific response to the unfolding changes. However, is the science ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmer T,Stevens B

更新日期：2019-12-03 00:00:00

abstract：:In adult rat testes, the blood-testis barrier (BTB) in the seminiferous epithelium must "open" (or "disassemble") to accommodate the migration of preleptotene spermatocytes from the basal to the adluminal compartment that occurs at stage VIII of the epithelial cycle. However, the molecule(s) and/or mechanism(s) that r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia W,Mruk DD,Cheng CY

更新日期：2007-03-06 00:00:00

abstract：:Selenophosphate, an activated form of selenium that can serve as a selenium donor, is generated by the selD gene product, selenophosphate synthetase (SPS). Selenophosphate is required by several bacteria and by mammals for the specific synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. Although...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogasawara Y,Lacourciere GM,Ishii K,Stadtman TC

更新日期：2005-01-25 00:00:00

abstract：:DsRed, a brilliantly red fluorescent protein, was recently cloned from Discosoma coral by homology to the green fluorescent protein (GFP) from the jellyfish Aequorea. A core question in the biochemistry of DsRed is the mechanism by which the GFP-like 475-nm excitation and 500-nm emission maxima of immature DsRed are r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gross LA,Baird GS,Hoffman RC,Baldridge KK,Tsien RY

更新日期：2000-10-24 00:00:00

abstract：:Tumor necrosis factor-related, activation-induced cytokine (TRANCE), a tumor necrosis factor family member, mediates survival of dendritic cells in the immune system and is required for osteoclast differentiation and activation in the skeleton. We report the skeletal phenotype of TRANCE-deficient mice and its rescue b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim N,Odgren PR,Kim DK,Marks SC Jr,Choi Y

更新日期：2000-09-26 00:00:00

abstract：:Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) is inevitable in metastatic EGFR-mutant lung cancers. Here, we modeled disease progression using EGFR-mutant human tumor cell lines. Although five of six models displayed alterations already found in humans, one harbored an unexpected seconda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohashi K,Sequist LV,Arcila ME,Moran T,Chmielecki J,Lin YL,Pan Y,Wang L,de Stanchina E,Shien K,Aoe K,Toyooka S,Kiura K,Fernandez-Cuesta L,Fidias P,Yang JC,Miller VA,Riely GJ,Kris MG,Engelman JA,Vnencak-Jones CL,D

更新日期：2012-07-31 00:00:00

abstract：:What are the neural bases of semantic memory? Traditional beliefs that the temporal lobes subserve the retrieval of semantic knowledge, arising from lesion studies, have been recently called into question by functional neuroimaging studies finding correlations between semantic retrieval and activity in left prefrontal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson-Schill SL,Swick D,Farah MJ,D'Esposito M,Kan IP,Knight RT

更新日期：1998-12-22 00:00:00

abstract：:We introduce a family of fast ordered upwind methods for approximating solutions to a wide class of static Hamilton-Jacobi equations with Dirichlet boundary conditions. Standard techniques often rely on iteration to converge to the solution of a discretized version of the partial differential equation. Our fast method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sethian JA,Vladimirsky A

更新日期：2001-09-25 00:00:00

abstract：:We have cloned a full-length cDNA coding for human alcohol dehydrogenase (ADH; alcohol:NAD+ oxidoreductase, EC 1.1.1.1) from a human liver cDNA library constructed in phage lambda gt11. The library was screened by using a rabbit antibody against human ADH as a first probe, by the modified method of Young and Davis [Yo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikuta T,Fujiyoshi T,Kurachi K,Yoshida A

更新日期：1985-05-01 00:00:00

abstract：:Systemic delivery of bioactive molecules in the CNS is hampered by the blood-brain barrier, which has bottlenecked noninvasive physiological study of the brain and the development of CNS drugs. Here we report that irradiation with an ultrashort pulsed laser to the blood vessel wall induces transient leakage of blood p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi M,Ku T,Chong K,Yoon J,Choi C

更新日期：2011-05-31 00:00:00

abstract：:Understanding the heritability of neural systems linked to psychopathology is not sufficient to implicate them as intergenerational neural mediators. By closely examining how individual differences in neural phenotypes and psychopathology cosegregate as they fall through the family tree, we can identify the brain syst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox AS,Oler JA,Shackman AJ,Shelton SE,Raveendran M,McKay DR,Converse AK,Alexander A,Davidson RJ,Blangero J,Rogers J,Kalin NH

更新日期：2015-07-21 00:00:00

abstract：:Exposure of 3T3/A31 cells to serum-free medium, one type of apoptotic stimulus, causes a rapid increase in the sphingosine (Sph) level, which initiates a series of processes: (i) activation of caspase 3 through an enhanced "cascade" of caspases, (ii) release of the C-terminal-half kinase domain of PKCdelta (PKCdelta K...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki E,Handa K,Toledo MS,Hakomori S

更新日期：2004-10-12 00:00:00

abstract：:Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that frequently accompanies this procedure. Recent clinical reports have implied that the use of umbilical cord blood as a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris DT,Schumacher MJ,Locascio J,Besencon FJ,Olson GB,DeLuca D,Shenker L,Bard J,Boyse EA

更新日期：1992-11-01 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:A retrovirus containing the entire human platelet-derived growth factor B-chain (PDGF-B) gene was constructed in order to investigate the in vivo biological activity of its encoded growth factor. When this virus was introduced into newborn mice, it reproducibly generated fibrosarcomas at the site of inoculation. Provi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pech M,Gazit A,Arnstein P,Aaronson SA

更新日期：1989-04-01 00:00:00

abstract：:More than 21 million prescriptions for warfarin are written yearly in the U.S. Despite its importance, warfarin's target, vitamin K epoxide reductase (VKOR), has resisted purification since its identification in 1972. Here, we report its purification and reconstitution. HPC4, a calcium-specific antibody that recognize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu PH,Huang TY,Williams J,Stafford DW

更新日期：2006-12-19 00:00:00

abstract：:The approximately 30-kb coronavirus (+)RNA genome is replicated and transcribed by a membrane-bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple enzymatic activities. The complex includes an RNA endonuclease, NendoU, that is conserved among nidoviruses but no other RNA virus, making...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ricagno S,Egloff MP,Ulferts R,Coutard B,Nurizzo D,Campanacci V,Cambillau C,Ziebuhr J,Canard B

更新日期：2006-08-08 00:00:00