Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:Ras CAAX (C = cysteine, A = aliphatic amino acid, and X = any amino acid) peptidomimetic inhibitors of farnesyl protein transferase suppress Ras-dependent cell transformation by preventing farnesylation of the Ras oncoprotein. These compounds are potential anticancer agents for tumors associated with Ras mutations. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kauffmann RC,Qian Y,Vogt A,Sebti SM,Hamilton AD,Carthew RW

更新日期：1995-11-21 00:00:00

abstract：:Pancreatic islets regulate glucose homeostasis through coordinated actions of hormone-secreting cells. What underlies the function of the islet as a unit is the close approximation and communication among heterogeneous cell populations, but the structural mediators of islet cellular cross talk remain incompletely char...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes JW,Cho JH,Conway HE,DiGruccio MR,Ng XW,Roseman HF,Abreu D,Urano F,Piston DW

更新日期：2020-04-21 00:00:00

abstract：:Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving the chemokine receptor 4/stromal-derived cell factor 1 (CXCR4/SDF-1) axis are the major cause of ectopic overexpression of VEGF in tumors. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Nigris F,Crudele V,Giovane A,Casamassimi A,Giordano A,Garban HJ,Cacciatore F,Pentimalli F,Marquez-Garban DC,Petrillo A,Cito L,Sommese L,Fiore A,Petrillo M,Siani A,Barbieri A,Arra C,Rengo F,Hayashi T,Al-Omran M,

更新日期：2010-08-10 00:00:00

abstract：:One goal of regenerative medicine is to repair damaged tissue. This requires not only generating new cells of the proper phenotype, but also selecting for those that properly integrate into sites of injury. In our laboratory we are using a cell-migration-based in vivo selection system to generate antibodies that induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han KH,Arlian BM,Macauley MS,Paulson JC,Lerner RA

更新日期：2018-01-16 00:00:00

abstract：:Double-stranded DNA break repair by homologous recombination is initiated by resection of free DNA ends to produce a 3'-ssDNA overhang. In bacteria, this reaction is catalyzed by helicase-nuclease complexes such as AddAB in a manner regulated by specific recombination hotspot sequences called Crossover hotspot instiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrasco C,Gilhooly NS,Dillingham MS,Moreno-Herrero F

更新日期：2013-07-09 00:00:00

abstract：:The involvement of p53 in regulating diverse cellular processes dictates that it must respond to multiple signaling mechanisms, thus coordinating the response to various "stress conditions." Genotoxic stress has served as a paradigm to dissect the transactivation-dependent branch of the pathway by which p53 can induce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruaro EM,Collavin L,Del Sal G,Haffner R,Oren M,Levine AJ,Schneider C

更新日期：1997-04-29 00:00:00

abstract：:Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid compositi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmer R,van der Ploeg K,Ron D

更新日期：2013-03-19 00:00:00

abstract：:The wetting of microstructured surfaces is studied both experimentally and theoretically. Even relatively simple surface topographies such as grooves with rectangular cross section exhibit a large variety of different wetting morphologies as observed by atomic force microscopy. This polymorphism arises from liquid wed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seemann R,Brinkmann M,Kramer EJ,Lange FF,Lipowsky R

更新日期：2005-02-08 00:00:00

abstract：:The pineal organ of the lizard Anolis carolinensis can be maintained for up to 10 days in superfused organ culture. During this time it synthesizes and releases melatonin into the medium flowing slowly over it. Collection of timed aliquots of medium and subsequent analysis for melatonin by radioimmunoassay reveal circ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menaker M,Wisner S

更新日期：1983-10-01 00:00:00

abstract：:CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buters JT,Sakai S,Richter T,Pineau T,Alexander DL,Savas U,Doehmer J,Ward JM,Jefcoate CR,Gonzalez FJ

更新日期：1999-03-02 00:00:00

abstract：:Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson's disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lewy bodies and Lewy neurites is the histological hallmark of these diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao K,Lim YJ,Liu Z,Long H,Sun Y,Hu JJ,Zhao C,Tao Y,Zhang X,Li D,Li YM,Liu C

更新日期：2020-08-18 00:00:00

abstract：:The action of calmodulin (CaM) on target proteins is important for a variety of cellular functions. We demonstrate here, however, that the presence of a CaM-binding site on a protein does not necessarily imply a functional effect. The alpha-subunit of the cGMP-gated cation channel of human retinal cones has a CaM-bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunwald ME,Zhong H,Lai J,Yau KW

更新日期：1999-11-09 00:00:00

abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Yamamoto M,Akira S,Sun SC

更新日期：2009-12-08 00:00:00

abstract：:The proteolytic cleavage of sterol regulatory element-binding proteins (SREBPs) is regulated by SREBP cleavage-activating protein (SCAP), which forms complexes with SREBPs in membranes of the endoplasmic reticulum (ER). In sterol-depleted cells, SCAP facilitates cleavage of SREBPs by Site-1 protease, thereby initiatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nohturfft A,DeBose-Boyd RA,Scheek S,Goldstein JL,Brown MS

更新日期：1999-09-28 00:00:00

abstract：:In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schleede S,Meinel FG,Bech M,Herzen J,Achterhold K,Potdevin G,Malecki A,Adam-Neumair S,Thieme SF,Bamberg F,Nikolaou K,Bohla A,Yildirim AÖ,Loewen R,Gifford M,Ruth R,Eickelberg O,Reiser M,Pfeiffer F

更新日期：2012-10-30 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:Genomic clones of the human non-N-methyl-D-aspartate (non-NMDA) glutamate receptor subunit GluR5 were isolated by high-stringency screening of a cosmid library using the rat cDNA as a probe. The chromosomal localization of the human GluR5 gene has been established. Southern hybridization of DNA isolated from mapping p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eubanks JH,Puranam RS,Kleckner NW,Bettler B,Heinemann SF,McNamara JO

更新日期：1993-01-01 00:00:00

abstract：:Creatine kinase (CK; EC 2.7.3.2) plays an important role in energy metabolism in brain and muscle. Expression of CK isoenzymes is regulated during development and is tissue specific. To define the structures of canine CK isoenzymes and to elucidate the mechanism of regulation in their expression, CK cDNA clones from d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roman D,Billadello J,Gordon J,Grace A,Sobel B,Strauss A

更新日期：1985-12-01 00:00:00

abstract：:Recently, several proteins have been identified that are related in their sequence to the p53 tumor-suppressor protein. One of these proteins, which is termed p73, exhibits sequence homology to the p53 transcriptional activation, DNA binding, and oligomerization domains. The adenovirus E1B 55-kDa protein, the adenovir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higashino F,Pipas JM,Shenk T

更新日期：1998-12-22 00:00:00

abstract：:Using a proteomics screen, we have identified the methyltransferase G9a as an interacting partner of the hematopoietic activator NF-E2. We show that G9a is recruited to the beta-globin locus in a NF-E2-dependent manner and spreads over the entire locus. While G9a is often regarded as a corepressor, knocking down this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaturvedi CP,Hosey AM,Palii C,Perez-Iratxeta C,Nakatani Y,Ranish JA,Dilworth FJ,Brand M

更新日期：2009-10-27 00:00:00

abstract：:Type I interferons, a protein family of multiple IFNalphas and a single IFNbeta, initially identified on the basis of their antiviral activities have recently been attributed important roles in bacterial and parasitic infections. To assess the cellular sources of IFNbeta, the IFN produced first in most situations, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheu S,Dresing P,Locksley RM

更新日期：2008-12-23 00:00:00

abstract：:Signaling by a variety of receptor and nonreceptor tyrosine kinases is mediated by Ras, a membrane-associated GTPase. Expression of v-Src, a transforming nonreceptor tyrosine kinase, results in Ras activation, and inhibition of Ras function in NIH 3T3 cells suppresses transformation by v-Src, indicating that in these ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aftab DT,Kwan J,Martin GS

更新日期：1997-04-01 00:00:00

abstract：:Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machius M,Chuang JL,Wynn RM,Tomchick DR,Chuang DT

更新日期：2001-09-25 00:00:00

abstract：:A striking and widespread observation is that higher-order folding for many RNAs is very slow, often requiring minutes. In some cases, slow folding reflects the need to disrupt stable, but incorrect, interactions. However, a molecular explanation for slow folding in most RNAs is unknown. The specificity domain of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mortimer SA,Weeks KM

更新日期：2009-09-15 00:00:00

abstract：:Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JW,Anders E

更新日期：1980-12-01 00:00:00

abstract：:For a number of viruses, oligomerization is a critical component of envelope processing and surface expression. Previously, we reported that a synthetic peptide (DP-107) corresponding to the putative leucine zipper region (aa 553-590) of the transmembrane protein (gp41) of human immunodeficiency virus type 1 (HIV-1) e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wild C,Dubay JW,Greenwell T,Baird T Jr,Oas TG,McDanal C,Hunter E,Matthews T

更新日期：1994-12-20 00:00:00

abstract：:Proper regulation of the intracellular ion concentration is essential to maintain life and is achieved by ion transporters that transport their substrates across the membrane in a strictly regulated manner. MgtE is a Mg(2+) transporter that may function in the homeostasis of the intracellular Mg(2+) concentration. A r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishitani R,Sugita Y,Dohmae N,Furuya N,Hattori M,Nureki O

更新日期：2008-10-07 00:00:00

abstract：:The chemical dynamics of lakes and streams affect their suitability as aquatic habitats and as water supplies for human needs. Because water quality is typically monitored only weekly or monthly, however, the higher-frequency dynamics of stream chemistry have remained largely invisible. To illuminate a wider spectrum ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirchner JW,Neal C

更新日期：2013-07-23 00:00:00

abstract：:The effects of the thymic polypeptide thymopoietin (Tpo) on the properties of the nicotinic acetylcholine receptor (AcChoR) were investigated by patch clamp techniques on mouse C2 myotubes and by biochemical assays on AcChoR-rich membrane fragments purified from the Torpedo marmorata electric organ. At high concentrat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revah F,Mulle C,Pinset C,Audhya T,Goldstein G,Changeux JP

更新日期：1987-05-01 00:00:00